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The map label for this gene is ethA [H]

Identifier: 121638968

GI number: 121638968

Start: 3402990

End: 3404477

Strand: Direct

Name: ethA [H]

Synonym: BCG_3108

Alternate gene names: 121638968

Gene position: 3402990-3404477 (Clockwise)

Preceding gene: 121638966

Following gene: 121638969

Centisome position: 77.79

GC content: 65.19

Gene sequence:

>1488_bases
ATGAACCAGCATTTCGACGTCCTGATCATCGGCGCCGGCCTATCCGGCATCGGGACGGCCTGTCACGTGACGGCCGAGTT
CCCCGACAAGACAATCGCCCTCCTGGAACGACGGGAGCGCCTGGGCGGCACCTGGGACTTGTTCCGCTACCCGGGAGTTC
GTTCGGACTCCGACATGTTCACCTTCGGCTACAAGTTCCGCCCGTGGCGCGACGTGAAGGTGCTCGCCGACGGCGCGTCG
AGCCGGCAGTACATCGCCGACACCGCCACGGAGTTCGGCATCGACGAGAAGATTCACTACGGCCTGAAGGTCAACACCGC
CGAGTGGTCGAGCCGGCAGTGCCGTTGGACCGTCGCGGGCGTGCACGAGGCGACCGGCGAAACCCGGACCTACACCTGCG
ATTACCTCATCAGCTGCACCGGCTACTACAACTACGACGCGGGTTATCTGCCGGACTTCCCCGGCGTGCACCGGTTCGGC
GGCCGGTGCGTGCACCCGCAGCACTGGCCCGAAGACCTCGATTATTCCGGCAAGAAGGTCGTCGTCATCGGCAGCGGCGC
AACGGCGGTCACTTTGGTTCCGGCGATGGCCGGCTCCAACCCCGGCAGTGCCGCGCACGTGACGATGCTGCAGCGATCCC
CGTCGTACATCTTCTCGCTGCCGGCGGTCGACAAGATCTCCGAAGTCCTGGGCCGCTTCCTGCCGGATCGCTGGGTCTAC
GAGTTTGGCCGCAGGCGCAACATCGCCATCCAGCGAAAGCTCTACCAGGCCTGCCGGCGCTGGCCCAAGCTGATGCGGCG
ATTGCTGCTGTGGGAGGTACGACGCCGCCTCGGCCGCTCCGTGGACATGAGCAACTTCACCCCGAACTACCTGCCGTGGG
ACGAGCGGTTGTGCGCCGTGCCCAACGGCGATCTGTTTAAGACGCTGGCCTCGGGCGCGGCGTCGGTGGTGACCGATCAG
ATCGAGACCTTCACCGAGAAGGGCATCCTGTGCAAGTCCGGCCGGGAGATCGAGGCCGACATCATCGTCACCGCGACCGG
TCTGAACATCCAGATGCTGGGCGGGATGCGACTCATCGTGGACGGCGCCGAATACCAGCTGCCGGAGAAGATGACCTATA
AGGGTGTGCTGCTGGAAAACGCCCCCAATCTGGCCTGGATCATCGGCTACACCAACGCGTCATGGACCCTGAAGTCCGAC
ATCGCCGGCGCCTACCTGTGCCGGCTGCTGCGGCACATGGCCGACAACGGCTACACGGTGGCAACGCCGCGCGATGCGCA
GGACTGCGCGCTGGACGTTGGCATGTTCGACCAGCTGAACTCCGGCTATGTGAAGCGCGGCCAGGACATCATGCCGCGCC
AGGGCTCCAAGCATCCGTGGAGGGTGCTCATGCACTACGAGAAGGACGCCAAGATCCTGCTCGAAGACCCCATCGATGAC
GGCGTGCTGCACTTCGCCGCAGCGGCCCAAGACCACGCGGCGGCCTGA

Upstream 100 bases:

>100_bases
CGGATGAGGCTGCCCAGCTCCATCACCTCCTGTCGGAAAATGATAAAAGGCTGTCGCAAAGTGTCAATACGTGGCGGGGG
TCCTCCACCATGCTGGAGCC

Downstream 100 bases:

>100_bases
GCATCATGAACCTGCGCAAAAACGTCATCCGGTCCGTATTACGTGGTGCCCGGCCACTGTTCGCTTCCCGCCGGCTGGGT
ATTGCCGGCCGTCGAGTCCT

Product: putative monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMFTFGYKFRPWRDVKVLADGAS
SRQYIADTATEFGIDEKIHYGLKVNTAEWSSRQCRWTVAGVHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFG
GRCVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVY
EFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAVPNGDLFKTLASGAASVVTDQ
IETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIVDGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSD
IAGAYLCRLLRHMADNGYTVATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDD
GVLHFAAAAQDHAAA

Sequences:

>Translated_495_residues
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMFTFGYKFRPWRDVKVLADGAS
SRQYIADTATEFGIDEKIHYGLKVNTAEWSSRQCRWTVAGVHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFG
GRCVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVY
EFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAVPNGDLFKTLASGAASVVTDQ
IETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIVDGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSD
IAGAYLCRLLRHMADNGYTVATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDD
GVLHFAAAAQDHAAA
>Mature_495_residues
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMFTFGYKFRPWRDVKVLADGAS
SRQYIADTATEFGIDEKIHYGLKVNTAEWSSRQCRWTVAGVHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFG
GRCVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVY
EFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAVPNGDLFKTLASGAASVVTDQ
IETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIVDGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSD
IAGAYLCRLLRHMADNGYTVATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDD
GVLHFAAAAQDHAAA

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503759, Length=361, Percent_Identity=23.8227146814404, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 55471; Mature: 55471

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMF
CCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEHCCCCCCCCCCEE
TFGYKFRPWRDVKVLADGASSRQYIADTATEFGIDEKIHYGLKVNTAEWSSRQCRWTVAG
EEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECEEEECCCCCCCCEEEEEEE
VHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFGGRCVHPQHWPEDLDYSGKKV
CHHCCCCCEEEEEEEEEEEEEEECCCCCCCCCCCCHHHCCCEECCCCCCCCCCCCCCCEE
VVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVY
EEEECCCCEEEEEEHHCCCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHCCHHHHH
EFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAV
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEC
PNGDLFKTLASGAASVVTDQIETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIV
CCCHHHHHHHCCHHHHHHHHHHHHHHCCEEECCCCEEEEEEEEEEECCEEEEECCEEEEE
DGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSDIAGAYLCRLLRHMADNGYTV
ECCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCEEEHHHCCHHHHHHHHHHHCCCCEEE
ATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDD
ECCCCHHHHEECCCHHHHCCCCHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCC
GVLHFAAAAQDHAAA
CHHHHHHHHHHCCCC
>Mature Secondary Structure
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMF
CCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEHCCCCCCCCCCEE
TFGYKFRPWRDVKVLADGASSRQYIADTATEFGIDEKIHYGLKVNTAEWSSRQCRWTVAG
EEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECEEEECCCCCCCCEEEEEEE
VHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFGGRCVHPQHWPEDLDYSGKKV
CHHCCCCCEEEEEEEEEEEEEEECCCCCCCCCCCCHHHCCCEECCCCCCCCCCCCCCCEE
VVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVY
EEEECCCCEEEEEEHHCCCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHCCHHHHH
EFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAV
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEC
PNGDLFKTLASGAASVVTDQIETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIV
CCCHHHHHHHCCHHHHHHHHHHHHHHCCEEECCCCEEEEEEEEEEECCEEEEECCEEEEE
DGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSDIAGAYLCRLLRHMADNGYTV
ECCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCEEEHHHCCHHHHHHHHHHHCCCCEEE
ATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDD
ECCCCHHHHEECCCHHHHCCCCHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCC
GVLHFAAAAQDHAAA
CHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA