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The map label for this gene is clpP

Identifier: 121638344

GI number: 121638344

Start: 2728342

End: 2728944

Strand: Reverse

Name: clpP

Synonym: BCG_2481c

Alternate gene names: 121638344

Gene position: 2728944-2728342 (Counterclockwise)

Preceding gene: 121638345

Following gene: 121638343

Centisome position: 62.38

GC content: 62.19

Gene sequence:

>603_bases
GTGAGCCAAGTGACTGACATGCGTTCGAACTCGCAGGGTCTTAGCCTCACGGATTCGGTCTACGAGCGCTTGCTCTCCGA
GCGCATCATCTTCCTGGGCTCGGAGGTGAACGACGAGATCGCCAACCGGTTATGCGCTCAGATTCTGCTGCTGGCCGCCG
AAGACGCCAGCAAGGACATCAGCCTCTACATCAATTCGCCGGGTGGATCGATCAGCGCCGGCATGGCGATCTACGACACC
ATGGTGCTGGCGCCCTGTGACATCGCCACCTACGCGATGGGCATGGCCGCCTCGATGGGCGAGTTCCTGCTGGCGGCAGG
TACCAAGGGCAAGCGCTACGCGCTGCCGCATGCTCGCATCCTGATGCACCAGCCGTTGGGCGGGGTGACCGGCAGCGCGG
CCGATATCGCCATCCAGGCCGAGCAGTTCGCCGTGATCAAGAAAGAAATGTTCCGGCTCAACGCCGAATTCACCGGCCAG
CCGATCGAGCGCATTGAGGCGGATTCCGATCGCGACCGCTGGTTCACCGCCGCCGAAGCCCTGGAATACGGTTTCGTCGA
TCACATCATCACCCGCGCCCACGTCAATGGAGAAGCACAGTGA

Upstream 100 bases:

>100_bases
GCGAACGCGCCGGTTTCAGGGGGTGCGTGACCGCGAAACAGCCAGCCTGGTTGGTTAGTGTCGGAGCATAGAAGAACTCG
AGGAAAGCAGGTGCCCCACT

Downstream 100 bases:

>100_bases
ATTCCCAAAATTCTCAGATCCAGCCCCAGGCGCGCTACATCCTGCCGTCGTTCATCGAGCACTCCAGCTTCGGGGTCAAG
GAGTCCAATCCATACAACAA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MSQVTDMRSNSQGLSLTDSVYERLLSERIIFLGSEVNDEIANRLCAQILLLAAEDASKDISLYINSPGGSISAGMAIYDT
MVLAPCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPLGGVTGSAADIAIQAEQFAVIKKEMFRLNAEFTGQ
PIERIEADSDRDRWFTAAEALEYGFVDHIITRAHVNGEAQ

Sequences:

>Translated_200_residues
MSQVTDMRSNSQGLSLTDSVYERLLSERIIFLGSEVNDEIANRLCAQILLLAAEDASKDISLYINSPGGSISAGMAIYDT
MVLAPCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPLGGVTGSAADIAIQAEQFAVIKKEMFRLNAEFTGQ
PIERIEADSDRDRWFTAAEALEYGFVDHIITRAHVNGEAQ
>Mature_199_residues
SQVTDMRSNSQGLSLTDSVYERLLSERIIFLGSEVNDEIANRLCAQILLLAAEDASKDISLYINSPGGSISAGMAIYDTM
VLAPCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPLGGVTGSAADIAIQAEQFAVIKKEMFRLNAEFTGQP
IERIEADSDRDRWFTAAEALEYGFVDHIITRAHVNGEAQ

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=179, Percent_Identity=45.8100558659218, Blast_Score=175, Evalue=2e-44,
Organism=Escherichia coli, GI1786641, Length=172, Percent_Identity=55.8139534883721, Blast_Score=202, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17538017, Length=175, Percent_Identity=46.8571428571429, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20129427, Length=171, Percent_Identity=45.0292397660819, Blast_Score=162, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_MYCBO (P0A527)

Other databases:

- EMBL:   BX248342
- RefSeq:   NP_856135.1
- ProteinModelPortal:   P0A527
- SMR:   P0A527
- MEROPS:   S14.008
- EnsemblBacteria:   EBMYCT00000017541
- GeneID:   1094221
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2488c
- GeneTree:   EBGT00050000015874
- HOGENOM:   HBG558421
- OMA:   ANKLCAQ
- ProtClustDB:   PRK00277
- BioCyc:   MBOV233413:MB2488C-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21708; Mature: 21577

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVTDMRSNSQGLSLTDSVYERLLSERIIFLGSEVNDEIANRLCAQILLLAAEDASKDI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCCE
SLYINSPGGSISAGMAIYDTMVLAPCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARI
EEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHH
LMHQPLGGVTGSAADIAIQAEQFAVIKKEMFRLNAEFTGQPIERIEADSDRDRWFTAAEA
EEECCCCCCCCCCHHEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHH
LEYGFVDHIITRAHVNGEAQ
HHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SQVTDMRSNSQGLSLTDSVYERLLSERIIFLGSEVNDEIANRLCAQILLLAAEDASKDI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCCE
SLYINSPGGSISAGMAIYDTMVLAPCDIATYAMGMAASMGEFLLAAGTKGKRYALPHARI
EEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHH
LMHQPLGGVTGSAADIAIQAEQFAVIKKEMFRLNAEFTGQPIERIEADSDRDRWFTAAEA
EEECCCCCCCCCCHHEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHH
LEYGFVDHIITRAHVNGEAQ
HHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972