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The map label for this gene is mbtA [H]

Identifier: 121638263

GI number: 121638263

Start: 2640958

End: 2642655

Strand: Direct

Name: mbtA [H]

Synonym: BCG_2398

Alternate gene names: 121638263

Gene position: 2640958-2642655 (Clockwise)

Preceding gene: 121638254

Following gene: 121638264

Centisome position: 60.37

GC content: 69.2

Gene sequence:

>1698_bases
ATGCCACCGAAGGCGGCAGATGGCCGCCGACCCAGTCCCGACGGCGGACTGGGTGGCTTTGTACCGTTCCCCGCGGATCG
GGCCGCGTCGTACCGGGCGGCCGGCTATTGGTCGGGGCGAACCCTGGACACCGTGCTCTCCGATGCCGCGCGGCGCTGGC
CTGACCGCCTCGCGGTGGCCGACGCCGGTGATCGTCCCGGCCACGGCGGCCTCAGTTACGCCGAACTCGACCAGCGGGCC
GACCGGGCCGCCGCGGCGCTGCACGGCCTGGGCATCACGCCAGGCGACCGGGTACTGCTCCAGCTGCCAAACGGCTGCCA
GTTCGCGGTTGCCCTGTTCGCGTTATTGCGGGCGGGAGCGATCCCAGTGATGTGCCTGCCCGGTCACCGCGCCGCCGAAT
TGGGCCACTTCGCCGCCGTCAGCGCGGCCACCGGGCTGGTGGTCGCCGATGTGGCCAGCGGGTTCGACTATCGGCCGATG
GCGCGCGAACTTGTTGCCGATCACCCCACCCTGCGCCATGTCATCGTCGATGGCGATCCGGGACCGTTCGTGTCGTGGGC
GCAGCTGTGCGCCCAGGCCGGCACCGGTTCGCCGGCACCGCCGGCCGATCCCGGATCGCCAGCGCTGCTGCTGGTCTCCG
GCGGCACCACTGGCATGCCCAAACTCATTCCACGCACCCACGACGACTACGTGTTCAACGCGACGGCCAGCGCCGCACTC
TGTCGGCTTAGCGCCGACGACGTCTATCTGGTGGTGCTGGCCGCCGGCCACAATTTCCCGCTGGCCTGCCCGGGCCTGCT
CGGCGCGATGACCGTCGGGGCCACCGCCGTGTTCGCCCCCGATCCCAGCCCGGAGGCCGCCTTCGCCGCCATCGAGCGCC
ACGGTGTCACCGTCACCGCGTTGGTTCCGGCACTGGCCAAACTGTGGGCCCAATCCTGTGAGTGGGAGCCGGTGACACCG
AAGTCACTGCGGTTGTTGCAGGTTGGCGGGTCCAAGCTAGAACCCGAGGACGCTCGCCGGGTACGCACCGCGCTCACCCC
GGGCCTGCAGCAGGTGTTCGGCATGGCGGAGGGGCTGCTGAACTTCACCCGCATCGGCGACCCACCCGAAGTGGTGGAGC
ACACCCAGGGGCGGCCACTATGCCCGGCCGACGAACTGCGCATCGTCAACGCCGATGGTGAGCCGGTGGGGCCCGGGGAG
GAAGGCGAACTCTTGGTGCGCGGGCCCTACACGCTGAACGGCTATTTTGCTGCCGAACGCGACAACGAGCGCTGCTTCGA
TCCGGACGGCTTCTACCGCAGCGGCGACCTGGTCCGCCGCCGCGACGACGGCAATCTGGTGGTCACCGGGCGCGTCAAGG
ATGTCATCTGCCGTGCGGGAGAAACCATCGCCGCCAGCGACCTCGAAGAACAGCTGCTGAGCCATCCGGCGATCTTCTCG
GCCGCGGCGGTGGGACTACCTGACCAGTATCTGGGGGAAAAAATCTGCGCTGCAGTCGTTTTCGCTGGAGCTCCGATTAC
GCTTGCGGAGTTGAACGGCTACCTTGACCGGCGTGGTGTGGCCGCGCATACGCGACCCGACCAGCTGGTCGCGATGCCGG
CGCTGCCCACAACGCCGATCGGGAAGATCGACAAACGAGCGATCGTCCGCCAGCTCGGCATCGCGACGGGTCCCGTGACG
ACCCAGCGCTGCCATTGA

Upstream 100 bases:

>100_bases
ACAAACCCTCCCCTGTTAGCACAGGCTGCCCTAATTTTAGTGGTTACCCTATCTTCGAACCACGCACCTGCGCTACCAGC
CCCCCTGTTAAGGAGCCCAC

Downstream 100 bases:

>100_bases
CTGACGTCAACAAGTTGAATTGACTGCGTTGCATGACCGACGGTGTTCCGGCCCGCGGGTCACTTCGATCACGCGGCGCG
GTAGCGGTGAGCTCGATGGT

Product: bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase

Products: NA

Alternate protein names: Dihydroxybenzoic acid-activating enzyme [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTVLSDAARRWPDRLAVADAGDRPGHGGLSYAELDQRA
DRAAAALHGLGITPGDRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLVVADVASGFDYRPM
ARELVADHPTLRHVIVDGDPGPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAAL
CRLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAAIERHGVTVTALVPALAKLWAQSCEWEPVTP
KSLRLLQVGGSKLEPEDARRVRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELRIVNADGEPVGPGE
EGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDLVRRRDDGNLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFS
AAAVGLPDQYLGEKICAAVVFAGAPITLAELNGYLDRRGVAAHTRPDQLVAMPALPTTPIGKIDKRAIVRQLGIATGPVT
TQRCH

Sequences:

>Translated_565_residues
MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTVLSDAARRWPDRLAVADAGDRPGHGGLSYAELDQRA
DRAAAALHGLGITPGDRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLVVADVASGFDYRPM
ARELVADHPTLRHVIVDGDPGPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAAL
CRLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAAIERHGVTVTALVPALAKLWAQSCEWEPVTP
KSLRLLQVGGSKLEPEDARRVRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELRIVNADGEPVGPGE
EGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDLVRRRDDGNLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFS
AAAVGLPDQYLGEKICAAVVFAGAPITLAELNGYLDRRGVAAHTRPDQLVAMPALPTTPIGKIDKRAIVRQLGIATGPVT
TQRCH
>Mature_564_residues
PPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTVLSDAARRWPDRLAVADAGDRPGHGGLSYAELDQRAD
RAAAALHGLGITPGDRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLVVADVASGFDYRPMA
RELVADHPTLRHVIVDGDPGPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAALC
RLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAAIERHGVTVTALVPALAKLWAQSCEWEPVTPK
SLRLLQVGGSKLEPEDARRVRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELRIVNADGEPVGPGEE
GELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDLVRRRDDGNLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFSA
AAVGLPDQYLGEKICAAVVFAGAPITLAELNGYLDRRGVAAHTRPDQLVAMPALPTTPIGKIDKRAIVRQLGIATGPVTT
QRCH

Specific function: Activation of the carboxylate group of 2,3-dihydroxy- benzoate (DHB), via ATP-dependent PPi exchange reactions, to the acyladenylate [H]

COG id: COG1021

COG function: function code Q; Peptide arylation enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=547, Percent_Identity=26.691042047532, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI187761343, Length=547, Percent_Identity=26.691042047532, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI156151445, Length=552, Percent_Identity=24.2753623188406, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI38505220, Length=502, Percent_Identity=24.7011952191235, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI58082049, Length=502, Percent_Identity=23.1075697211155, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI122937307, Length=539, Percent_Identity=24.1187384044527, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI8923896, Length=556, Percent_Identity=23.9208633093525, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI157311624, Length=501, Percent_Identity=21.7564870259481, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI157311622, Length=501, Percent_Identity=21.7564870259481, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI42544132, Length=536, Percent_Identity=21.455223880597, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI253970489, Length=396, Percent_Identity=25.2525252525253, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI13325057, Length=570, Percent_Identity=25.4385964912281, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI13236579, Length=417, Percent_Identity=25.1798561151079, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1786810, Length=542, Percent_Identity=39.8523985239852, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI145693145, Length=547, Percent_Identity=29.7989031078611, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI221142682, Length=492, Percent_Identity=27.8455284552846, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1788107, Length=562, Percent_Identity=25.6227758007117, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1790505, Length=539, Percent_Identity=27.2727272727273, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786529, Length=578, Percent_Identity=24.0484429065744, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786801, Length=542, Percent_Identity=24.3542435424354, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17560308, Length=519, Percent_Identity=27.1676300578035, Blast_Score=128, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17557194, Length=517, Percent_Identity=25.9187620889749, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=517, Percent_Identity=24.3713733075435, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17538037, Length=531, Percent_Identity=25.0470809792844, Blast_Score=115, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71994703, Length=523, Percent_Identity=23.1357552581262, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71994694, Length=523, Percent_Identity=23.3269598470363, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71994690, Length=523, Percent_Identity=23.3269598470363, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71983001, Length=553, Percent_Identity=25.497287522604, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71982997, Length=553, Percent_Identity=25.497287522604, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17559526, Length=511, Percent_Identity=23.8747553816047, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=365, Percent_Identity=23.8356164383562, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17560140, Length=505, Percent_Identity=23.5643564356436, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319699, Length=350, Percent_Identity=27.7142857142857, Blast_Score=113, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6319264, Length=585, Percent_Identity=22.7350427350427, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24581924, Length=541, Percent_Identity=26.4325323475046, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21355181, Length=525, Percent_Identity=24.5714285714286, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI18859661, Length=527, Percent_Identity=25.0474383301708, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21355225, Length=541, Percent_Identity=24.9537892791128, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648253, Length=301, Percent_Identity=28.2392026578073, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24648255, Length=301, Percent_Identity=28.2392026578073, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356441, Length=549, Percent_Identity=22.2222222222222, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24648260, Length=347, Percent_Identity=24.4956772334294, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24656500, Length=518, Percent_Identity=23.9382239382239, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19922652, Length=508, Percent_Identity=23.4251968503937, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573631, Length=549, Percent_Identity=23.6794171220401, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI20130353, Length=549, Percent_Identity=23.6794171220401, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21356947, Length=316, Percent_Identity=24.3670886075949, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281365686, Length=327, Percent_Identity=23.8532110091743, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21358303, Length=297, Percent_Identity=21.8855218855219, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20130357, Length=356, Percent_Identity=23.314606741573, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR011963 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.-

Molecular weight: Translated: 59281; Mature: 59150

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTVLSDAARRWPDRLAVA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEE
DAGDRPGHGGLSYAELDQRADRAAAALHGLGITPGDRVLLQLPNGCQFAVALFALLRAGA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCC
IPVMCLPGHRAAELGHFAAVSAATGLVVADVASGFDYRPMARELVADHPTLRHVIVDGDP
CCEEEECCCCHHHHHHHHHHHHHCCEEEEHHHCCCCCCHHHHHHHHCCCCEEEEEECCCC
GPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAAL
CCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCHHHHH
CRLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAAIERHGVTVTA
EEECCCCEEEEEEEECCCCCCCCHHHHHHHHHCCEEEECCCCCCHHHHHHHHHCCCCHHH
LVPALAKLWAQSCEWEPVTPKSLRLLQVGGSKLEPEDARRVRTALTPGLQQVFGMAEGLL
HHHHHHHHHHHCCCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHH
NFTRIGDPPEVVEHTQGRPLCPADELRIVNADGEPVGPGEEGELLVRGPYTLNGYFAAER
HHHHCCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCEEEEEEEEECC
DNERCFDPDGFYRSGDLVRRRDDGNLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFS
CCCCCCCCCCCCCCCCCEEEECCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHCCCHHHH
AAAVGLPDQYLGEKICAAVVFAGAPITLAELNGYLDRRGVAAHTRPDQLVAMPALPTTPI
HHHCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCC
GKIDKRAIVRQLGIATGPVTTQRCH
CCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTVLSDAARRWPDRLAVA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEE
DAGDRPGHGGLSYAELDQRADRAAAALHGLGITPGDRVLLQLPNGCQFAVALFALLRAGA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCC
IPVMCLPGHRAAELGHFAAVSAATGLVVADVASGFDYRPMARELVADHPTLRHVIVDGDP
CCEEEECCCCHHHHHHHHHHHHHCCEEEEHHHCCCCCCHHHHHHHHCCCCEEEEEECCCC
GPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAAL
CCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCHHHHH
CRLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAAIERHGVTVTA
EEECCCCEEEEEEEECCCCCCCCHHHHHHHHHCCEEEECCCCCCHHHHHHHHHCCCCHHH
LVPALAKLWAQSCEWEPVTPKSLRLLQVGGSKLEPEDARRVRTALTPGLQQVFGMAEGLL
HHHHHHHHHHHCCCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHH
NFTRIGDPPEVVEHTQGRPLCPADELRIVNADGEPVGPGEEGELLVRGPYTLNGYFAAER
HHHHCCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCEEEEEEEEECC
DNERCFDPDGFYRSGDLVRRRDDGNLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFS
CCCCCCCCCCCCCCCCCEEEECCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHCCCHHHH
AAAVGLPDQYLGEKICAAVVFAGAPITLAELNGYLDRRGVAAHTRPDQLVAMPALPTTPI
HHHCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCC
GKIDKRAIVRQLGIATGPVTTQRCH
CCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8921902; 9384377; 8224884; 12221282 [H]