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The map label for this gene is htpG

Identifier: 121638180

GI number: 121638180

Start: 2547154

End: 2549097

Strand: Reverse

Name: htpG

Synonym: BCG_2315c

Alternate gene names: 121638180

Gene position: 2549097-2547154 (Counterclockwise)

Preceding gene: 121638181

Following gene: 121638174

Centisome position: 58.27

GC content: 62.04

Gene sequence:

>1944_bases
ATGAACGCCCATGTCGAGCAGTTGGAGTTTCAGGCGGAGGCCCGGCAACTGCTGGATTTGATGGTCCACTCGGTCTACTC
CAATAAGGACGCGTTTCTGCGGGAGTTGATCTCGAATGCCTCCGATGCGCTAGACAAGCTGCGGATTGAGGCGCTGCGGA
ACAAGGACCTGGAGGTCGACACCTCCGATCTGCACATCGAGATCGACGCAGACAAAGCTGCAAGGACTCTTACCGTTCGT
GACAACGGCATCGGGATGGCGCGCGAGGAGGTGGTGGATCTGATTGGCACGCTGGCCAAGTCGGGCACCGCCGAGCTGCG
CGCACAGCTGCGTGAGGCCAAGAACGCGGCCGCCTCCGAGGAACTGATCGGTCAGTTCGGCATCGGCTTCTACTCGTCGT
TCATGGTGGCCGACAAGGTCCAACTGCTTACCCGCAAGGCTGGCGAGAGCGCGGCCACCAGATGGGAGTCCAGCGGTGAG
GGCACCTACACCATCGAGTCCGTCGAGGATGCCCCCCAGGGCACGTCGGTCACCCTGCACCTCAAGCCGGAAGACGCCGA
GGACGACCTGCACGACTACACCTCGGAATGGAAGATCCGTAACCTGGTCAAGAAATACTCCGACTTCATCGCCTGGCCCA
TCCGGATGGACGTCGAGCGCCGCACCCCAGCCTCCCAGGAAGAAGGGGGGGAAGGCGGCGAGGAGACCGTCACCATCGAA
ACCGAAACCCTCAACTCGATGAAGGCGCTGTGGGCGAGGCCCAAAGAAGAGGTGTCTGAGCAGGAGTACAAGGAGTTCTA
CAAACACGTCGCGCACGCCTGGGACGACCCGCTCGAGATCATCGCGATGAAGGCCGAGGGCACCTTCGAGTACCAGGCCC
TGCTGTTCATCCCGTCTCATGCCCCGTTCGATCTGTTCGACCGGGACGCCCACGTCGGTATCCAGCTCTACGTCAAGCGG
GTGTTCATCATGGGCGACTGCGACCAGCTCATGCCCGAGTACTTGCGTTTTGTCAAGGGTGTGGTCGACGCGCAGGACAT
GTCGCTCAACGTTTCTCGCGAAATCCTGCAGCAGGACCGGCAGATCAAGGCCATCCGCCGGCGGCTGACCAAGAAGGTGC
TGTCCACGATCAAGGACGTGCAGTCCAGCCGGCCGGAGGACTACCGCACGTTCTGGACACAGTTCGGCAGGGTCCTCAAA
GAGGGACTGCTGTCAGACATCGATAACCGGGAGACCCTGCTCGGTATTTCTTCGTTTGTCTCCACGTACAGCGAGGAGGA
ACCCACCACGCTGGCCGAATACGTCGAGCGCATGAAGGACGGTCAGCAACAGATCTTCTACGCCACCGGCGAGACGCGCC
AACAACTGCTGAAGTCACCGCACCTGGAGGCGTTTAAGGCCAAGGGGTACGAAGTGCTGCTGCTCACCGACCCGGTCGAC
GAGGTCTGGGTGGGAATGGTGCCGGAGTTCGACGGCAAACCGCTGCAGTCGGTTGCCAAGGGCGAGGTGGACTTGAGTTC
CGAAGAGGACACCAGCGAGGCCGAGCGCGAGGAGCGGCAGAAGGAATTTGCCGACCTGCTGACCTGGTTGCAGGAGACGT
TGAGCGATCACGTCAAGGAGGTGCGGCTGTCCACCCGCCTGACCGAGTCACCGGCCTGTCTGATCACCGATGCCTTCGGG
ATGACACCCGCGCTCGCGCGCATCTACCGGGCTTCCGGCCAGGAGGTTCCGGTCGGCAAGCGGATACTTGAGCTCAACCC
GAGCCATCCGTTGGTGACCGGCCTGCGCCAAGCCCACCAGGACCGCGCAGACGATGCCGAGAAATCATTGGCCGAAACCG
CGGAATTACTTTACGGCACAGCGCTTCTCGCCGAAGGCGGCGCACTCGAGGATCCGGCGAGGTTCGCCGAGCTGCTGGCC
GAACGTCTCGCGCGTACCTTGTAG

Upstream 100 bases:

>100_bases
TATCAGCTTGCTCGCGATACGGCCTAGCCAGGCCACCCCCAGCTCGGCGCCGGATCGCAGCTCGCTAAATTCGAGTCGCT
ATGTCGTCGGAAGGAATCTC

Downstream 100 bases:

>100_bases
CGAGCTCAACGACGGCTGACCTTCTCACGCACCATGTCGGTGAGGAAGCGGCCGGTGGAAACCGGGCGAAACGCCCGGGC
GGCGTCGGTGAGCGCGTCGC

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G

Number of amino acids: Translated: 647; Mature: 647

Protein sequence:

>647_residues
MNAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRIEALRNKDLEVDTSDLHIEIDADKAARTLTVR
DNGIGMAREEVVDLIGTLAKSGTAELRAQLREAKNAAASEELIGQFGIGFYSSFMVADKVQLLTRKAGESAATRWESSGE
GTYTIESVEDAPQGTSVTLHLKPEDAEDDLHDYTSEWKIRNLVKKYSDFIAWPIRMDVERRTPASQEEGGEGGEETVTIE
TETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDDPLEIIAMKAEGTFEYQALLFIPSHAPFDLFDRDAHVGIQLYVKR
VFIMGDCDQLMPEYLRFVKGVVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKDVQSSRPEDYRTFWTQFGRVLK
EGLLSDIDNRETLLGISSFVSTYSEEEPTTLAEYVERMKDGQQQIFYATGETRQQLLKSPHLEAFKAKGYEVLLLTDPVD
EVWVGMVPEFDGKPLQSVAKGEVDLSSEEDTSEAEREERQKEFADLLTWLQETLSDHVKEVRLSTRLTESPACLITDAFG
MTPALARIYRASGQEVPVGKRILELNPSHPLVTGLRQAHQDRADDAEKSLAETAELLYGTALLAEGGALEDPARFAELLA
ERLARTL

Sequences:

>Translated_647_residues
MNAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRIEALRNKDLEVDTSDLHIEIDADKAARTLTVR
DNGIGMAREEVVDLIGTLAKSGTAELRAQLREAKNAAASEELIGQFGIGFYSSFMVADKVQLLTRKAGESAATRWESSGE
GTYTIESVEDAPQGTSVTLHLKPEDAEDDLHDYTSEWKIRNLVKKYSDFIAWPIRMDVERRTPASQEEGGEGGEETVTIE
TETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDDPLEIIAMKAEGTFEYQALLFIPSHAPFDLFDRDAHVGIQLYVKR
VFIMGDCDQLMPEYLRFVKGVVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKDVQSSRPEDYRTFWTQFGRVLK
EGLLSDIDNRETLLGISSFVSTYSEEEPTTLAEYVERMKDGQQQIFYATGETRQQLLKSPHLEAFKAKGYEVLLLTDPVD
EVWVGMVPEFDGKPLQSVAKGEVDLSSEEDTSEAEREERQKEFADLLTWLQETLSDHVKEVRLSTRLTESPACLITDAFG
MTPALARIYRASGQEVPVGKRILELNPSHPLVTGLRQAHQDRADDAEKSLAETAELLYGTALLAEGGALEDPARFAELLA
ERLARTL
>Mature_647_residues
MNAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRIEALRNKDLEVDTSDLHIEIDADKAARTLTVR
DNGIGMAREEVVDLIGTLAKSGTAELRAQLREAKNAAASEELIGQFGIGFYSSFMVADKVQLLTRKAGESAATRWESSGE
GTYTIESVEDAPQGTSVTLHLKPEDAEDDLHDYTSEWKIRNLVKKYSDFIAWPIRMDVERRTPASQEEGGEGGEETVTIE
TETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDDPLEIIAMKAEGTFEYQALLFIPSHAPFDLFDRDAHVGIQLYVKR
VFIMGDCDQLMPEYLRFVKGVVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKDVQSSRPEDYRTFWTQFGRVLK
EGLLSDIDNRETLLGISSFVSTYSEEEPTTLAEYVERMKDGQQQIFYATGETRQQLLKSPHLEAFKAKGYEVLLLTDPVD
EVWVGMVPEFDGKPLQSVAKGEVDLSSEEDTSEAEREERQKEFADLLTWLQETLSDHVKEVRLSTRLTESPACLITDAFG
MTPALARIYRASGQEVPVGKRILELNPSHPLVTGLRQAHQDRADDAEKSLAETAELLYGTALLAEGGALEDPARFAELLA
ERLARTL

Specific function: Molecular chaperone. Has ATPase activity

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family

Homologues:

Organism=Homo sapiens, GI20149594, Length=671, Percent_Identity=38.301043219076, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI154146191, Length=683, Percent_Identity=38.0673499267936, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI4507677, Length=684, Percent_Identity=38.7426900584795, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI155722983, Length=660, Percent_Identity=33.1818181818182, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI153792590, Length=405, Percent_Identity=38.7654320987654, Blast_Score=292, Evalue=6e-79,
Organism=Escherichia coli, GI1786679, Length=632, Percent_Identity=46.3607594936709, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17559162, Length=675, Percent_Identity=40, Blast_Score=465, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17542208, Length=681, Percent_Identity=35.6828193832599, Blast_Score=407, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI115535205, Length=662, Percent_Identity=32.1752265861027, Blast_Score=315, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI115535167, Length=449, Percent_Identity=32.9621380846325, Blast_Score=244, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6323840, Length=674, Percent_Identity=38.5756676557863, Blast_Score=445, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6325016, Length=678, Percent_Identity=38.2005899705015, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI17647529, Length=695, Percent_Identity=37.841726618705, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI21357739, Length=688, Percent_Identity=36.7732558139535, Blast_Score=401, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24586016, Length=665, Percent_Identity=34.5864661654135, Blast_Score=361, Evalue=1e-99,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): HTPG_MYCBO (P64412)

Other databases:

- EMBL:   BX248342
- RefSeq:   NP_855970.1
- ProteinModelPortal:   P64412
- EnsemblBacteria:   EBMYCT00000016078
- GeneID:   1094306
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2321c
- GeneTree:   EBGT00050000018140
- HOGENOM:   HBG631012
- OMA:   AIYYITA
- ProtClustDB:   PRK05218
- BioCyc:   MBOV233413:MB2321C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00505
- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.30.565.10
- PANTHER:   PTHR11528
- PIRSF:   PIRSF002583
- PRINTS:   PR00775
- SMART:   SM00387

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 72962; Mature: 72962

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRIEALRNKDLEVD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEC
TSDLHIEIDADKAARTLTVRDNGIGMAREEVVDLIGTLAKSGTAELRAQLREAKNAAASE
CCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ELIGQFGIGFYSSFMVADKVQLLTRKAGESAATRWESSGEGTYTIESVEDAPQGTSVTLH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCCCCCCCEEEEE
LKPEDAEDDLHDYTSEWKIRNLVKKYSDFIAWPIRMDVERRTPASQEEGGEGGEETVTIE
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCEEEEE
TETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDDPLEIIAMKAEGTFEYQALLFIPSH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEECCC
APFDLFDRDAHVGIQLYVKRVFIMGDCDQLMPEYLRFVKGVVDAQDMSLNVSREILQQDR
CCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHHH
QIKAIRRRLTKKVLSTIKDVQSSRPEDYRTFWTQFGRVLKEGLLSDIDNRETLLGISSFV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
STYSEEEPTTLAEYVERMKDGQQQIFYATGETRQQLLKSPHLEAFKAKGYEVLLLTDPVD
HHHCCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCHHHHHCCCEEEEEEECCHH
EVWVGMVPEFDGKPLQSVAKGEVDLSSEEDTSEAEREERQKEFADLLTWLQETLSDHVKE
HHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRLSTRLTESPACLITDAFGMTPALARIYRASGQEVPVGKRILELNPSHPLVTGLRQAHQ
HHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCHHEEECCCCHHHHHHHHHHH
DRADDAEKSLAETAELLYGTALLAEGGALEDPARFAELLAERLARTL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRIEALRNKDLEVD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEC
TSDLHIEIDADKAARTLTVRDNGIGMAREEVVDLIGTLAKSGTAELRAQLREAKNAAASE
CCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ELIGQFGIGFYSSFMVADKVQLLTRKAGESAATRWESSGEGTYTIESVEDAPQGTSVTLH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCCCCCCCEEEEE
LKPEDAEDDLHDYTSEWKIRNLVKKYSDFIAWPIRMDVERRTPASQEEGGEGGEETVTIE
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCEEEEE
TETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDDPLEIIAMKAEGTFEYQALLFIPSH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEECCC
APFDLFDRDAHVGIQLYVKRVFIMGDCDQLMPEYLRFVKGVVDAQDMSLNVSREILQQDR
CCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHHH
QIKAIRRRLTKKVLSTIKDVQSSRPEDYRTFWTQFGRVLKEGLLSDIDNRETLLGISSFV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
STYSEEEPTTLAEYVERMKDGQQQIFYATGETRQQLLKSPHLEAFKAKGYEVLLLTDPVD
HHHCCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCHHHHHCCCEEEEEEECCHH
EVWVGMVPEFDGKPLQSVAKGEVDLSSEEDTSEAEREERQKEFADLLTWLQETLSDHVKE
HHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRLSTRLTESPACLITDAFGMTPALARIYRASGQEVPVGKRILELNPSHPLVTGLRQAHQ
HHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCHHEEECCCCHHHHHHHHHHH
DRADDAEKSLAETAELLYGTALLAEGGALEDPARFAELLAERLARTL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972