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The map label for this gene is gnd1 [H]

Identifier: 121637747

GI number: 121637747

Start: 2094030

End: 2096087

Strand: Reverse

Name: gnd1 [H]

Synonym: BCG_1880c

Alternate gene names: 121637747

Gene position: 2096087-2094030 (Counterclockwise)

Preceding gene: 121637748

Following gene: 121637746

Centisome position: 47.92

GC content: 65.21

Gene sequence:

>2058_bases
ATGGGTTCCAACATCGCCCGAAACTTCGCCCGGCACGGCTACACCGTGGCAGTGCACAATCGGTCGGTCGCCAAGACCGA
CGCGCTGCTTAAGGAGCACAGCTCAGACGGCAAGTTCGTGCGCAGTGAAACGATCCCCGAATTTCTTGCCGCACTGGAAA
AACCGCGTCGGGTGCTGATCATGGTCAAGGCCGGAGAGGCCACTGACGCTGTCATCAACGAACTTGCTGACGCCATGGAA
CCCGGCGACATCATCATCGACGGCGGCAATGCGTTGTACACCGACACCATGCGCCGCGAGAAAGCGATGCGTGAGCGGGG
CTTGCACTTCGTCGGGGCCGGGATCTCCGGCGGCGAAGAGGGCGCGTTGAACGGGCCGTCGATCATGCCCGGCGGACCCG
CCGAGTCATACCAATCGCTGGGTCCGCTGCTCGAGGAGATCTCCGCGCATGTCGACGGCGTGCCGTGCTGCACCCACATT
GGCCCGGACGGCTCCGGGCACTTCGTCAAGATGGTCCACAACGGCATCGAGTACTCCGACATGCAGCTCATCGGTGAGGC
CTACCAGCTGATGCGCGACGGGCTAGGTCTGACCGCGCCGGCGATCGCCGATGTGTTCACCGAGTGGAACAATGGCGATC
TGGACAGCTACCTGGTCGAGATCACCGCCGAGGTGCTGCGGCAGACCGATGCCAAGACCGGCAAACCGCTCGTCGACGTC
ATCGTGGACCGGGCCGAGCAGAAAGGCACCGGCCGTTGGACCGTCAAGTCCGCGCTGGACCTGGGTGTGCCGGTGACCGG
CATCGCCGAAGCGGTGTTTGCCCGCGCTCTCTCGGGATCCGTGGGGCAACGCTCGGCCGCCAGCGGTCTGGCTTCGGGCA
AGCTCGGCGAGCAGCCCGCCGACCCCGCCACGTTCACCGAAGACGTCCGCCAGGCGTTGTACGCCTCCAAGATCGTGGCC
TACGCTCAGGGCTTCAACCAGATCCAGGCCGGCAGCGCCGAATTCGGCTGGGACATCACGCCGGGCGACCTGGCCACCAT
CTGGCGTGGCGGCTGCATCATCCGGGCGAAGTTCCTCAACCACATCAAGGAAGCCTTTGACGCCAGCCCGAACCTGGCCA
GTCTGATTGTGGCCCCGTATTTCCGCGCGCCGTCGAATCGGCGATCGACAGTTGGCGGCGTGTGGTGTCGACGGCGGCCC
AACTGGGTATCCCGACCCCGGGATTCTCGTCGGCCCTGTCGTATTACGACGCGCTGCGCACCGCGCGGCTGCCCGCTGCA
CTCACCCAGGCCCAGCGCGACTTCTTCGGCGCACACACCTACGGCCGGATCGACGAACCAGGCAAGTTCCACACACTATG
GAGTTCAGACCGCACCGAAGTACCGGTGTAGCGGGCTAGAACTAAAGGGGGGTAAAGGGGTAAGTGATGAGATTTCTAGA
CGGGCACCCACCCGGGTACGACCTGACATACAACGACGTGTTCATCGTTCCGAACCGATCCGAGGTCGCGTCGCGCTTCG
ACGTCGATTTGTCCACCGCCGACGGCTCGGGCACCACCATTCCGGTAGTGGTCGCCAATATGACCGCGGTAGCCGGGCGG
CGGATGGCCGAGACGGTCGCCCGCCGCGGTGGCATCGTAATCCTGCCGCAGGATCTGCCGATCCCGGCGGTAAAGCAGAC
GGTGGCGTTCGTCAAAAGCCGGGACCTGGTGCTCGACACCCCAGTGACGCTGGCACCCGACGATTCGGTGTCCGACGCCA
TGGCGCTCATCCACAAGCGCGCACATGGCGTCGCGGTGGTCATCCTCGAGGGTCGCCCGATCGGATTGGTGCGCGAATCG
TCCTGCCTGGGCGTGGATCGCTTCACCCGGGTGCGCGATATCGCCGTGACGGACTATGTGACCGCTCCAGCGGGAACCGA
GCCACGCAAGATCTTCGACCTGCTGGAGCACGCCCCGGTCGACGTTGCGGTGCTGACCGACGCCGACGGCACGTTGGCGG
GAGTGCTAAGCCGCACCGGGGCTATCCGCGCCGGTATCTACACCCCGGCCACCGATAG

Upstream 100 bases:

>100_bases
TCATCGCCTAGCGAAGCCGGGCCCAACTGAAAGGCAGGACATGAGTTCGTCGGAATCGCCAGCCGGCATCGCGCAGATCG
GCGTCACTGGCCTGGCCGTG

Downstream 100 bases:

>100_bases
CGCGGGCCGGCTGCGGATCGGCGCGGCCGTCGGCATCAACGGCGACGTGGGCGCTAAGGCCCGAGCGCTCGCCGAAGCCG
GCGTCGACGTGCTGGTCATC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 685; Mature: 684

Protein sequence:

>685_residues
MGSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFVRSETIPEFLAALEKPRRVLIMVKAGEATDAVINELADAME
PGDIIIDGGNALYTDTMRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQSLGPLLEEISAHVDGVPCCTHI
GPDGSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYLVEITAEVLRQTDAKTGKPLVDV
IVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVGQRSAASGLASGKLGEQPADPATFTEDVRQALYASKIVA
YAQGFNQIQAGSAEFGWDITPGDLATIWRGGCIIRAKFLNHIKEAFDASPNLASLIVAPYFRAPSNRRSTVGGVWCRRRP
NWVSRPRDSRRPCRITTRCAPRGCPLHSPRPSATSSAHTPTAGSTNQASSTHYGVQTAPKYRCSGLELKGGKGVSDEISR
RAPTRVRPDIQRRVHRSEPIRGRVALRRRFVHRRRLGHHHSGSGRQYDRGSRAADGRDGRPPRWHRNPAAGSADPGGKAD
GGVRQKPGPGARHPSDAGTRRFGVRRHGAHPQARTWRRGGHPRGSPDRIGARIVLPGRGSLHPGARYRRDGLCDRSSGNR
ATQDLRPAGARPGRRCGADRRRRHVGGSAKPHRGYPRRYLHPGHR

Sequences:

>Translated_685_residues
MGSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFVRSETIPEFLAALEKPRRVLIMVKAGEATDAVINELADAME
PGDIIIDGGNALYTDTMRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQSLGPLLEEISAHVDGVPCCTHI
GPDGSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYLVEITAEVLRQTDAKTGKPLVDV
IVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVGQRSAASGLASGKLGEQPADPATFTEDVRQALYASKIVA
YAQGFNQIQAGSAEFGWDITPGDLATIWRGGCIIRAKFLNHIKEAFDASPNLASLIVAPYFRAPSNRRSTVGGVWCRRRP
NWVSRPRDSRRPCRITTRCAPRGCPLHSPRPSATSSAHTPTAGSTNQASSTHYGVQTAPKYRCSGLELKGGKGVSDEISR
RAPTRVRPDIQRRVHRSEPIRGRVALRRRFVHRRRLGHHHSGSGRQYDRGSRAADGRDGRPPRWHRNPAAGSADPGGKAD
GGVRQKPGPGARHPSDAGTRRFGVRRHGAHPQARTWRRGGHPRGSPDRIGARIVLPGRGSLHPGARYRRDGLCDRSSGNR
ATQDLRPAGARPGRRCGADRRRRHVGGSAKPHRGYPRRYLHPGHR
>Mature_684_residues
GSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFVRSETIPEFLAALEKPRRVLIMVKAGEATDAVINELADAMEP
GDIIIDGGNALYTDTMRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQSLGPLLEEISAHVDGVPCCTHIG
PDGSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYLVEITAEVLRQTDAKTGKPLVDVI
VDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVGQRSAASGLASGKLGEQPADPATFTEDVRQALYASKIVAY
AQGFNQIQAGSAEFGWDITPGDLATIWRGGCIIRAKFLNHIKEAFDASPNLASLIVAPYFRAPSNRRSTVGGVWCRRRPN
WVSRPRDSRRPCRITTRCAPRGCPLHSPRPSATSSAHTPTAGSTNQASSTHYGVQTAPKYRCSGLELKGGKGVSDEISRR
APTRVRPDIQRRVHRSEPIRGRVALRRRFVHRRRLGHHHSGSGRQYDRGSRAADGRDGRPPRWHRNPAAGSADPGGKADG
GVRQKPGPGARHPSDAGTRRFGVRRHGAHPQARTWRRGGHPRGSPDRIGARIVLPGRGSLHPGARYRRDGLCDRSSGNRA
TQDLRPAGARPGRRCGADRRRRHVGGSAKPHRGYPRRYLHPGHR

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=402, Percent_Identity=48.2587064676617, Blast_Score=360, Evalue=3e-99,
Organism=Escherichia coli, GI1788341, Length=383, Percent_Identity=53.0026109660574, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17542558, Length=388, Percent_Identity=45.360824742268, Blast_Score=351, Evalue=6e-97,
Organism=Saccharomyces cerevisiae, GI6321695, Length=398, Percent_Identity=46.4824120603015, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321977, Length=385, Percent_Identity=48.8311688311688, Blast_Score=359, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24639279, Length=388, Percent_Identity=45.6185567010309, Blast_Score=335, Evalue=5e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 74183; Mature: 74052

Theoretical pI: Translated: 11.11; Mature: 11.11

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFVRSETIPEFLAALEKPRRVLI
CCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCEEEE
MVKAGEATDAVINELADAMEPGDIIIDGGNALYTDTMRREKAMRERGLHFVGAGISGGEE
EEECCCHHHHHHHHHHHHCCCCCEEEECCCEEEHHHHHHHHHHHHCCCEEEECCCCCCCC
GALNGPSIMPGGPAESYQSLGPLLEEISAHVDGVPCCTHIGPDGSGHFVKMVHNGIEYSD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHCCCCHHH
MQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYLVEITAEVLRQTDAKTGKPLVDV
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
IVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVGQRSAASGLASGKLGEQPA
HHHHHHHCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCC
DPATFTEDVRQALYASKIVAYAQGFNQIQAGSAEFGWDITPGDLATIWRGGCIIRAKFLN
CCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCHHHHHHCCCCEEHHHHHH
HIKEAFDASPNLASLIVAPYFRAPSNRRSTVGGVWCRRRPNWVSRPRDSRRPCRITTRCA
HHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHCCCCCCCCCCEEEECCC
PRGCPLHSPRPSATSSAHTPTAGSTNQASSTHYGVQTAPKYRCSGLELKGGKGVSDEISR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHH
RAPTRVRPDIQRRVHRSEPIRGRVALRRRFVHRRRLGHHHSGSGRQYDRGSRAADGRDGR
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
PPRWHRNPAAGSADPGGKADGGVRQKPGPGARHPSDAGTRRFGVRRHGAHPQARTWRRGG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHCCCCCCHHHHHCCC
HPRGSPDRIGARIVLPGRGSLHPGARYRRDGLCDRSSGNRATQDLRPAGARPGRRCGADR
CCCCCHHHCCCEEEECCCCCCCCCCHHHHCCCCCCCCCCCCHHHCCCCCCCCCHHCCHHH
RRRHVGGSAKPHRGYPRRYLHPGHR
HHHHCCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
GSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFVRSETIPEFLAALEKPRRVLI
CCHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCEEEE
MVKAGEATDAVINELADAMEPGDIIIDGGNALYTDTMRREKAMRERGLHFVGAGISGGEE
EEECCCHHHHHHHHHHHHCCCCCEEEECCCEEEHHHHHHHHHHHHCCCEEEECCCCCCCC
GALNGPSIMPGGPAESYQSLGPLLEEISAHVDGVPCCTHIGPDGSGHFVKMVHNGIEYSD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHCCCCHHH
MQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYLVEITAEVLRQTDAKTGKPLVDV
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
IVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVGQRSAASGLASGKLGEQPA
HHHHHHHCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCC
DPATFTEDVRQALYASKIVAYAQGFNQIQAGSAEFGWDITPGDLATIWRGGCIIRAKFLN
CCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCHHHHHHCCCCEEHHHHHH
HIKEAFDASPNLASLIVAPYFRAPSNRRSTVGGVWCRRRPNWVSRPRDSRRPCRITTRCA
HHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHCCCCCCCCCCEEEECCC
PRGCPLHSPRPSATSSAHTPTAGSTNQASSTHYGVQTAPKYRCSGLELKGGKGVSDEISR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHH
RAPTRVRPDIQRRVHRSEPIRGRVALRRRFVHRRRLGHHHSGSGRQYDRGSRAADGRDGR
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
PPRWHRNPAAGSADPGGKADGGVRQKPGPGARHPSDAGTRRFGVRRHGAHPQARTWRRGG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHCCCCCCHHHHHCCC
HPRGSPDRIGARIVLPGRGSLHPGARYRRDGLCDRSSGNRATQDLRPAGARPGRRCGADR
CCCCCHHHCCCEEEECCCCCCCCCCHHHHCCCCCCCCCCCCHHHCCCCCCCCCHHCCHHH
RRRHVGGSAKPHRGYPRRYLHPGHR
HHHHCCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]