Click here to switch to the map view.

The map label for this gene is mprB

Identifier: 121636909

GI number: 121636909

Start: 1127997

End: 1129511

Strand: Direct

Name: mprB

Synonym: BCG_1037

Alternate gene names: 121636909

Gene position: 1127997-1129511 (Clockwise)

Preceding gene: 121636908

Following gene: 121636910

Centisome position: 25.79

GC content: 65.08

Gene sequence:

>1515_bases
ATGTGGTGGTTCCGCCGCCGAGACCGGGCGCCGCTGCGCGCCACCAGCTCATTATCCCTGCGGTGGCGGGTCATGCTGCT
GGCGATGTCCATGGTCGCGATGGTGGTTGTGCTGATGTCGTTCGCCGTCTATGCGGTGATCTCGGCCGCGCTCTACAGCG
ACATCGACAACCAACTGCAGAGCCGGGCGCAACTGCTCATCGCCAGTGGCTCGCTGGCAGCTGATCCGGGTAAGGCAATC
GAGGGTACCGCCTATTCGGATGTCAACGCGATGCTGGTCAACCCCGGCCAGTCCATCTACACCGCTCAACAGCCGGGCCA
GACGCTGCCGGTCGGTGCTGCCGAGAAGGCGGTGATCCGTGGCGAGTTGTTCATGTCGCGGCGCACCACCGCCGACCAAC
GGGTGCTTGCCATCCGTCTGACCAACGGTAGTTCGCTGCTGATCTCCAAAAGTCTCAAGCCCACCGAAGCAGTCATGAAC
AAGCTGCGTTGGGTGCTATTGATCGTGGGTGGGATCGGGGTGGCGGTCGCCGCGGTGGCCGGGGGGATGGTCACCCGGGC
CGGGCTGAGGCCGGTGGGCCGCCTCACCGAAGCGGCCGAGCGGGTGGCGCGAACCGACGACCTGCGGCCCATCCCCGTCT
TCGGCAGCGACGAATTGGCCAGGCTGACAGAGGCATTCAATTTAATGCTGCGGGCGCTGGCCGAGTCACGGGAACGGCAG
GCAAGGCTGGTTACCGACGCCGGACATGAATTGCGTACCCCGCTAACGTCGCTGCGCACCAATGTCGAACTCTTGATGGC
CTCGATGGCCCCGGGGGCTCCGCGGCTACCCAAGCAGGAGATGGTCGACCTGCGTGCCGATGTGCTGGCTCAAATCGAGG
AATTGTCCACACTGGTAGGCGATTTGGTGGACCTGTCCCGAGGCGACGCCGGAGAAGTGGTGCACGAGCCGGTCGACATG
GCTGACGTCGTCGACCGCAGCCTGGAGCGGGTCAGGCGGCGGCGCAACGATATCCATTTCGACGTCGAGGTGATTGGGTG
GCAGGTTTATGGCGATACCGCTGGATTGTCGCGGATGGCGCTTAACCTGATGGACAACGCCGCGAAGTGGAGCCCGCCGG
GCGGCCACGTGGGTGTCAGGCTGAGCCAGCTCGACGCGTCGCACGCTGAGCTGGTGGTTTCCGACCGCGGCCCGGGCATT
CCCGTGCAGGAGCGCCGTCTGGTGTTTGAACGGTTTTACCGGTCGGCATCGGCACGGGCGTTGCCGGGTTCGGGCCTCGG
GTTGGCGATCGTCAAACAGGTGGTGCTCAACCACGGCGGATTGCTGCGCATCGAAGACACCGACCCAGGCGGCCAGCCCC
CTGGAACGTCGATTTACGTGCTGCTCCCCGGCCGTCGGATGCCGATTCCGCAGCTTCCCGGTGCGACGGCTGGCGCTCGG
AGCACGGACATCGAGAACTCTCGGGGTTCGGCGAACGTTATCTCAGTGGAATCTCAGTCCACGCGCGCAACCTAG

Upstream 100 bases:

>100_bases
ACGTCGGGTATCTACGCCGCAAGACCGAGGCCGACGGCGAGCCGCGGCTGATCCACACTGTGCGCGGAGTGGGTTACGTG
CTACGTGAAACACCACCCTG

Downstream 100 bases:

>100_bases
TTGTGCAGTTACTGTTGAAAGCCACACCCATGCCAGTCCACGCATGGCCAAGTTGGCCCGAGTAGTGGGCCTAGTACAGG
AAGAGCAACCTAGCGACATG

Product: putative two component sensor kinase mprB

Products: NA

Alternate protein names: Mycobacterial persistence regulator B

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAI
EGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMN
KLRWVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
ARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDM
ADVVDRSLERVRRRRNDIHFDVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGI
PVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGAR
STDIENSRGSANVISVESQSTRAT

Sequences:

>Translated_504_residues
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAI
EGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMN
KLRWVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
ARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDM
ADVVDRSLERVRRRRNDIHFDVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGI
PVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGAR
STDIENSRGSANVISVESQSTRAT
>Mature_504_residues
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAI
EGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMN
KLRWVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
ARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDM
ADVVDRSLERVRRRRNDIHFDVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGI
PVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGAR
STDIENSRGSANVISVESQSTRAT

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1788393, Length=289, Percent_Identity=31.4878892733564, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1786783, Length=305, Percent_Identity=27.8688524590164, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788279, Length=279, Percent_Identity=27.9569892473118, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789808, Length=310, Percent_Identity=27.741935483871, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=29.1512915129151, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1786600, Length=212, Percent_Identity=34.4339622641509, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790861, Length=295, Percent_Identity=30.8474576271186, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786912, Length=271, Percent_Identity=27.6752767527675, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789403, Length=458, Percent_Identity=23.5807860262009, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=27.0833333333333, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=241, Percent_Identity=25.3112033195021, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=276, Percent_Identity=26.8115942028986, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787374, Length=230, Percent_Identity=26.9565217391304, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI145693157, Length=267, Percent_Identity=25.4681647940075, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787894, Length=288, Percent_Identity=26.7361111111111, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MPRB_MYCBO (Q7U0X3)

Other databases:

- EMBL:   AF490842
- EMBL:   BX248337
- RefSeq:   NP_854665.1
- HSSP:   P0A5Z8
- ProteinModelPortal:   Q7U0X3
- EnsemblBacteria:   EBMYCT00000017044
- GeneID:   1093154
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1008
- GeneTree:   EBGT00050000014826
- HOGENOM:   HBG334875
- OMA:   AELRTDV
- ProtClustDB:   CLSK790870
- BioCyc:   MBOV233413:MB1008-MONOMER
- BRENDA:   2.7.13.3
- GO:   GO:0009405
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 54433; Mature: 54433

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x14f68b9c)-; HASH(0x14c6a5e0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIR
HHHHEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCHHHHHHH
GELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMNKLRWVLLIVGGIGVAVAAVA
HHHHHHHCCCCCCEEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
CCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVG
HHHHHCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DLVDLSRGDAGEVVHEPVDMADVVDRSLERVRRRRNDIHFDVEVIGWQVYGDTAGLSRMA
HHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCHHHHH
LNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGIPVQERRLVFERFYRSASARA
HHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
LPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGAR
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
STDIENSRGSANVISVESQSTRAT
CCCCCCCCCCCEEEEEECCCCCCH
>Mature Secondary Structure
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIR
HHHHEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCHHHHHHH
GELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMNKLRWVLLIVGGIGVAVAAVA
HHHHHHHCCCCCCEEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
CCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVG
HHHHHCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DLVDLSRGDAGEVVHEPVDMADVVDRSLERVRRRRNDIHFDVEVIGWQVYGDTAGLSRMA
HHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCHHHHH
LNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGIPVQERRLVFERFYRSASARA
HHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCC
LPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGAR
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
STDIENSRGSANVISVESQSTRAT
CCCCCCCCCCCEEEEEECCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14638785; 12788972