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The map label for this gene is mprA [H]

Identifier: 121636908

GI number: 121636908

Start: 1127305

End: 1127997

Strand: Direct

Name: mprA [H]

Synonym: BCG_1036

Alternate gene names: 121636908

Gene position: 1127305-1127997 (Clockwise)

Preceding gene: 121636906

Following gene: 121636909

Centisome position: 25.77

GC content: 65.37

Gene sequence:

>693_bases
GTGTCCGTGCGAATTCTTGTCGTTGACGACGATCGTGCGGTGCGCGAGTCGCTGCGCCGGTCGCTTTCCTTCAATGGCTA
TTCGGTCGAACTGGCCCACGACGGGGTTGAGGCGCTCGACATGATTGCCAGCGATCGCCCCGACGCGTTGGTCCTGGATG
TCATGATGCCGCGGCTGGACGGCCTCGAGGTGTGCCGTCAGCTCCGCAGCACCGGCGACGACCTGCCGATTCTGGTGCTG
ACCGCGCGCGACTCGGTGTCCGAGCGGGTGGCCGGGCTGGACGCCGGTGCCGACGACTACCTACCAAAGCCGTTCGCCCT
CGAAGAGCTGCTGGCACGGATGCGGGCGCTGCTGCGCCGCACCAAGCCCGAGGATGCCGCCGAGTCGATGGCCATGAGGT
TCTCCGACCTGACGCTGGACCCGGTAACCCGCGAAGTCAACCGTGGACAGCGCCGGATCAGCCTGACCCGCACCGAATTT
GCATTGCTGGAGATGCTGATCGCCAATCCGCGGCGAGTGCTGACGCGCAGCCGTATCCTGGAAGAGGTATGGGGATTCGA
CTTTCCCACCTCGGGCAACGCGCTGGAAGTCTACGTCGGGTATCTACGCCGCAAGACCGAGGCCGACGGCGAGCCGCGGC
TGATCCACACTGTGCGCGGAGTGGGTTACGTGCTACGTGAAACACCACCCTGA

Upstream 100 bases:

>100_bases
TCCATGGGGCCAATGTGGCTGATGTGGCTAAACCTCGTCGAACAAACCCGCATACCACGGCGCGCCTCTCAGGCCAGTCT
CAGGCGCTGCGACGACACTG

Downstream 100 bases:

>100_bases
TGTGGTGGTTCCGCCGCCGAGACCGGGCGCCGCTGCGCGCCACCAGCTCATTATCCCTGCGGTGGCGGGTCATGCTGCTG
GCGATGTCCATGGTCGCGAT

Product: two component response transcriptional regulatory protein MprA

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVL
TARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEF
ALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP

Sequences:

>Translated_230_residues
MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVL
TARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEF
ALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
>Mature_229_residues
SVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLT
ARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEFA
LLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=43.6681222707424, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=41.3333333333333, Blast_Score=164, Evalue=3e-42,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=38.4615384615385, Blast_Score=157, Evalue=4e-40,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=40.4545454545455, Blast_Score=157, Evalue=5e-40,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=36.8888888888889, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=37.9912663755458, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=36, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=38.1165919282511, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=35.4260089686099, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=39.3013100436681, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=33.0316742081448, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=28.6343612334802, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=29.4871794871795, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.004329004329, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=37.962962962963, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1788550, Length=161, Percent_Identity=33.5403726708075, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=40, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=125, Percent_Identity=35.2, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=36.5384615384615, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788191, Length=123, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25924; Mature: 25793

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLD
CCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCEEEHHHHHCCCC
GLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRR
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
TKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEFALLEMLIANPRRVLTRSRIL
CCCCHHHHHHHHHHHCCCCCHHHHHHHCCHHEEEHHHHHHHHHHHHHHCHHHHHHHHHHH
EEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLD
CEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCEEEHHHHHCCCC
GLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRR
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
TKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEFALLEMLIANPRRVLTRSRIL
CCCCHHHHHHHHHHHCCCCCHHHHHHHCCHHEEEHHHHHHHHHHHHHHCHHHHHHHHHHH
EEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA