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The map label for this gene is sucD

Identifier: 121636877

GI number: 121636877

Start: 1093617

End: 1094528

Strand: Direct

Name: sucD

Synonym: BCG_1006

Alternate gene names: 121636877

Gene position: 1093617-1094528 (Clockwise)

Preceding gene: 121636876

Following gene: 121636879

Centisome position: 25.0

GC content: 62.61

Gene sequence:

>912_bases
ATGACTCACATGTCCATATTTCTGAGCAGGGACAACAAGGTCATTGTGCAGGGCATCACCGGCAGTGAGGCCACCGTCCA
TACCGCGCGAATGCTGCGGGCGGGCACGCAAATCGTCGGCGGTGTGAACGCACGCAAAGCGGGCACCACCGTCACGCATG
AGGATAAGGGCGGCCGGCTGATCAAGCTGCCGGTGTTCGGCAGTGTCGCGGAGGCGATGGAAAAGACCGGCGCCGATGTG
TCGATCATCTTCGTGCCGCCGACGTTCGCCAAGGACGCCATCATCGAGGCCATCGACGCCGAAATTCCGCTGTTGGTTGT
GATCACCGAGGGAATTCCGGTGCAGGACACCGCCTATGCCTGGGCCTACAACCTCGAGGCTGGCCACAAGACCCGCATCA
TTGGCCCCAACTGTCCTGGCATTATCAGTCCCGGTCAGTCGCTGGCCGGTATCACGCCGGCCAACATCACCGGACCCGGT
CCAATTGGTCTGGTGTCCAAGTCGGGGACGTTGACCTACCAGATGATGTTCGAACTGCGCGACCTTGGATTCTCCACGGC
GATCGGCATCGGTGGTGATCCGGTGATTGGCACTACCCACATCGACGCCATCGAGGCCTTCGAGAAGGATCCGGACACCA
AGCTCATCGTGATGATCGGCGAGATCGGTGGTGACGCCGAGGAGCGGGCCGCAGACTTCATCAAGACCAACGTGTCCAAG
CCGGTCGTCGGCTATGTCGCCGGATTTACCGCACCCGAAGGCAAGACGATGGGCCACGCCGGCGCCATCGTCTCCGGCTC
GTCTGGCACAGCGGCGGCCAAGCAAGAGGCCCTGGAGGCCGCCGGTGTGAAGGTCGGCAAGACCCCATCGGCGACCGCGG
CGCTGGCCCGGGAGATCTTGCTCAGTCTCTAG

Upstream 100 bases:

>100_bases
CCTGACCGAGGCCAACCACCCCCTGGTGACACTGGTGGCGACGATGGACGAAGCCGCCGACAAGGCCGCTGAGCTGGCGA
GCGCCTGAGCGAAAGGACCC

Downstream 100 bases:

>100_bases
GGCGAGCAGACGCATAAGCCCCCGCACGCTCGGCGTGTCGGGGGCTTATGCGTCTGCTCGCCCTATACGCAACAGGCCAA
CTTGGCGGCCAGCCGCTCCA

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRLIKLPVFGSVAEAMEKTGADV
SIIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPG
PIGLVSKSGTLTYQMMFELRDLGFSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKLIVMIGEIGGDAEERAADFIKTNVSK
PVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREILLSL

Sequences:

>Translated_303_residues
MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRLIKLPVFGSVAEAMEKTGADV
SIIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPG
PIGLVSKSGTLTYQMMFELRDLGFSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKLIVMIGEIGGDAEERAADFIKTNVSK
PVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREILLSL
>Mature_302_residues
THMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRLIKLPVFGSVAEAMEKTGADVS
IIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPGP
IGLVSKSGTLTYQMMFELRDLGFSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKLIVMIGEIGGDAEERAADFIKTNVSKP
VVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREILLSL

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family

Homologues:

Organism=Homo sapiens, GI109452591, Length=295, Percent_Identity=48.4745762711864, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI38569423, Length=255, Percent_Identity=32.9411764705882, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI38569421, Length=255, Percent_Identity=32.9411764705882, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1786949, Length=283, Percent_Identity=55.1236749116608, Blast_Score=288, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17550194, Length=295, Percent_Identity=51.1864406779661, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17553126, Length=306, Percent_Identity=48.6928104575163, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17557344, Length=245, Percent_Identity=29.3877551020408, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17551266, Length=251, Percent_Identity=29.8804780876494, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324716, Length=295, Percent_Identity=46.7796610169492, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI21356559, Length=308, Percent_Identity=47.4025974025974, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI28574296, Length=295, Percent_Identity=48.135593220339, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI281363477, Length=253, Percent_Identity=30.8300395256917, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281363475, Length=253, Percent_Identity=30.8300395256917, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281363473, Length=253, Percent_Identity=30.8300395256917, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SUCD_MYCBO (Q7U0Z0)

Other databases:

- EMBL:   BX248337
- RefSeq:   NP_854634.1
- ProteinModelPortal:   Q7U0Z0
- SMR:   Q7U0Z0
- EnsemblBacteria:   EBMYCT00000016319
- GeneID:   1093059
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0977
- GeneTree:   EBGT00050000016700
- HOGENOM:   HBG615372
- OMA:   ADAICEA
- ProtClustDB:   PRK05678
- BioCyc:   MBOV233413:MB0977-MONOMER
- BRENDA:   6.2.1.5
- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:3.40.50.261
- PIRSF:   PIRSF001553
- PRINTS:   PR01798
- SMART:   SM00881
- TIGRFAMs:   TIGR01019

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 31201; Mature: 31070

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS01216 SUCCINYL_COA_LIG_1; PS00399 SUCCINYL_COA_LIG_2

Important sites: ACT_SITE 259-259

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRL
CCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCEEEECCCCCEE
IKLPVFGSVAEAMEKTGADVSIIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYA
EEECCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCEEE
WAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPGPIGLVSKSGTLTYQMMFELR
EEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEHHHH
DLGFSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKLIVMIGEIGGDAEERAADFIKTNVSK
HCCCEEEECCCCCCEEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCC
PVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREIL
CEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LSL
HCC
>Mature Secondary Structure 
THMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRL
CCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCEEEECCCCCEE
IKLPVFGSVAEAMEKTGADVSIIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYA
EEECCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCEEE
WAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPGPIGLVSKSGTLTYQMMFELR
EEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEHHHH
DLGFSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKLIVMIGEIGGDAEERAADFIKTNVSK
HCCCEEEECCCCCCEEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCC
PVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREIL
CEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LSL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972