Definition Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome.
Accession NC_008769
Length 4,374,522

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The map label for this gene is sucC

Identifier: 121636876

GI number: 121636876

Start: 1092441

End: 1093604

Strand: Direct

Name: sucC

Synonym: BCG_1005

Alternate gene names: 121636876

Gene position: 1092441-1093604 (Clockwise)

Preceding gene: 121636874

Following gene: 121636877

Centisome position: 24.97

GC content: 63.66

Gene sequence:

>1164_bases
ATGGATCTTTTCGAGTATCAAGCCAAGGAGTTATTCGCCAAGCACAACGTGCCCAGCACGCCGGGTCGGGTGACCGACAC
AGCCGAGGGTGCCAAGGCTATCGCCACGGAGATCGGGCGTCCGGTGATGGTCAAAGCGCAGGTCAAGATCGGCGGCCGGG
GCAAGGCCGGTGGCGTCAAATACGCCGCGACCCCACAAGACGCGTACGAGCACGCCAAGAACATCCTCGGCCTGGACATC
AAAGGACACATCGTCAAGAAACTGCTGGTCGCTGAGGCTAGCGATATCGCCGAGGAGTACTACCTATCCTTCCTGCTCGA
CCGGGCCAACCGCACCTACCTGGCGATGTGCTCGGTGGAGGGCGGCATGGAGATCGAAGAGGTAGCGGCCACCAAACCCG
AGCGGCTCGCCAAAGTCCCGGTGAATGCCGTCAAGGGCGTTGACCTAGATTTCGCGCGGTCCATCGCCGAACAGGGTCAT
CTTCCGGCCGAGGTGCTCGACACCGCAGCGGTCACCATCGCCAAGCTGTGGGAGCTCTTCGTCGCCGAGGACGCGACGCT
GGTTGAGGTCAACCCGTTGGTGCGGACGCCTGACCACAAGATCCTCGCGCTGGATGCCAAGATCACCCTCGACGGCAACG
CCGATTTCCGTCAGCCTGGCCATGCCGAGTTCGAGGATCGAGCTGCCACCGATCCACTGGAGTTGAAGGCCAAGGAGCAC
GACCTCAACTACGTCAAGCTGGACGGTCAGGTGGGGATCATCGGCAATGGCGCGGGCTTGGCGATGTCGACTCTCGACGT
CGTCGCGTATGCCGGTGAGAAGCACGGCGGAGTCAAGCCGGCCAACTTCCTGGATATCGGCGGCGGCGCTTCGGCCGAGG
TGATGGCCGCGGGTCTGGACGTGGTGCTGGGCGACCAGCAGGTCAAGAGCGTGTTCGTCAACGTCTTCGGTGGCATCACC
TCGTGCGATGCGGTGGCGACCGGGATCGTCAAGGCGCTGGGCATGCTGGGTGACGAAGCCAACAAGCCGCTGGTGGTTCG
GCTCGACGGCAACAACGTCGAGGAAGGCCGTCGCATCCTGACCGAGGCCAACCACCCCCTGGTGACACTGGTGGCGACGA
TGGACGAAGCCGCCGACAAGGCCGCTGAGCTGGCGAGCGCCTGA

Upstream 100 bases:

>100_bases
AGTTAATCGGCGGTCTCGATACAGTTCTCCGTGCGAGTCGCCGATTTCGGCACCGCCTACCTATTGGTCGAGCAGTAAGC
CGAGCGAAGACGGTGAGCCC

Downstream 100 bases:

>100_bases
GCGAAAGGACCCATGACTCACATGTCCATATTTCTGAGCAGGGACAACAAGGTCATTGTGCAGGGCATCACCGGCAGTGA
GGCCACCGTCCATACCGCGC

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MDLFEYQAKELFAKHNVPSTPGRVTDTAEGAKAIATEIGRPVMVKAQVKIGGRGKAGGVKYAATPQDAYEHAKNILGLDI
KGHIVKKLLVAEASDIAEEYYLSFLLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVPVNAVKGVDLDFARSIAEQGH
LPAEVLDTAAVTIAKLWELFVAEDATLVEVNPLVRTPDHKILALDAKITLDGNADFRQPGHAEFEDRAATDPLELKAKEH
DLNYVKLDGQVGIIGNGAGLAMSTLDVVAYAGEKHGGVKPANFLDIGGGASAEVMAAGLDVVLGDQQVKSVFVNVFGGIT
SCDAVATGIVKALGMLGDEANKPLVVRLDGNNVEEGRRILTEANHPLVTLVATMDEAADKAAELASA

Sequences:

>Translated_387_residues
MDLFEYQAKELFAKHNVPSTPGRVTDTAEGAKAIATEIGRPVMVKAQVKIGGRGKAGGVKYAATPQDAYEHAKNILGLDI
KGHIVKKLLVAEASDIAEEYYLSFLLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVPVNAVKGVDLDFARSIAEQGH
LPAEVLDTAAVTIAKLWELFVAEDATLVEVNPLVRTPDHKILALDAKITLDGNADFRQPGHAEFEDRAATDPLELKAKEH
DLNYVKLDGQVGIIGNGAGLAMSTLDVVAYAGEKHGGVKPANFLDIGGGASAEVMAAGLDVVLGDQQVKSVFVNVFGGIT
SCDAVATGIVKALGMLGDEANKPLVVRLDGNNVEEGRRILTEANHPLVTLVATMDEAADKAAELASA
>Mature_387_residues
MDLFEYQAKELFAKHNVPSTPGRVTDTAEGAKAIATEIGRPVMVKAQVKIGGRGKAGGVKYAATPQDAYEHAKNILGLDI
KGHIVKKLLVAEASDIAEEYYLSFLLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVPVNAVKGVDLDFARSIAEQGH
LPAEVLDTAAVTIAKLWELFVAEDATLVEVNPLVRTPDHKILALDAKITLDGNADFRQPGHAEFEDRAATDPLELKAKEH
DLNYVKLDGQVGIIGNGAGLAMSTLDVVAYAGEKHGGVKPANFLDIGGGASAEVMAAGLDVVLGDQQVKSVFVNVFGGIT
SCDAVATGIVKALGMLGDEANKPLVVRLDGNNVEEGRRILTEANHPLVTLVATMDEAADKAAELASA

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI157779135, Length=390, Percent_Identity=37.6923076923077, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI11321583, Length=400, Percent_Identity=35, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI294862256, Length=370, Percent_Identity=38.1081081081081, Blast_Score=231, Evalue=9e-61,
Organism=Escherichia coli, GI1786948, Length=385, Percent_Identity=41.2987012987013, Blast_Score=263, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17567829, Length=400, Percent_Identity=34.75, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17539378, Length=398, Percent_Identity=35.427135678392, Blast_Score=235, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6321683, Length=402, Percent_Identity=37.3134328358209, Blast_Score=250, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21356231, Length=397, Percent_Identity=35.5163727959698, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI161078106, Length=402, Percent_Identity=36.0696517412935, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24645208, Length=402, Percent_Identity=36.0696517412935, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI281361397, Length=403, Percent_Identity=35.9801488833747, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI281361395, Length=403, Percent_Identity=35.9801488833747, Blast_Score=224, Evalue=7e-59,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SUCC_MYCBO (Q7U0Z1)

Other databases:

- EMBL:   BX248337
- RefSeq:   NP_854633.1
- ProteinModelPortal:   Q7U0Z1
- SMR:   Q7U0Z1
- EnsemblBacteria:   EBMYCT00000016599
- GeneID:   1093061
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0976
- GeneTree:   EBGT00050000017263
- HOGENOM:   HBG315432
- OMA:   MADGAEK
- ProtClustDB:   PRK00696
- BioCyc:   MBOV233413:MB0976-MONOMER
- BRENDA:   6.2.1.5
- HAMAP:   MF_00558
- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.261
- PANTHER:   PTHR11815
- TIGRFAMs:   TIGR01016

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 40898; Mature: 40898

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50975 ATP_GRASP; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MDLFEYQAKELFAKHNVPSTPGRVTDTAEGAKAIATEIGRPVMVKAQVKIGGRGKAGGVK
CCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEE
YAATPQDAYEHAKNILGLDIKGHIVKKLLVAEASDIAEEYYLSFLLDRANRTYLAMCSVE
EECCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
GGMEIEEVAATKPERLAKVPVNAVKGVDLDFARSIAEQGHLPAEVLDTAAVTIAKLWELF
CCCCHHHHHCCCHHHHHHCCHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VAEDATLVEVNPLVRTPDHKILALDAKITLDGNADFRQPGHAEFEDRAATDPLELKAKEH
HCCCCEEEEECCCEECCCCEEEEEEEEEEECCCCCCCCCCCCCCCHHCCCCCCEEEEECC
DLNYVKLDGQVGIIGNGAGLAMSTLDVVAYAGEKHGGVKPANFLDIGGGASAEVMAAGLD
CCCEEEECCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCHHHHHCCCE
VVLGDQQVKSVFVNVFGGITSCDAVATGIVKALGMLGDEANKPLVVRLDGNNVEEGRRIL
EEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHH
TEANHPLVTLVATMDEAADKAAELASA
HCCCCCEEEEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLFEYQAKELFAKHNVPSTPGRVTDTAEGAKAIATEIGRPVMVKAQVKIGGRGKAGGVK
CCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEE
YAATPQDAYEHAKNILGLDIKGHIVKKLLVAEASDIAEEYYLSFLLDRANRTYLAMCSVE
EECCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
GGMEIEEVAATKPERLAKVPVNAVKGVDLDFARSIAEQGHLPAEVLDTAAVTIAKLWELF
CCCCHHHHHCCCHHHHHHCCHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VAEDATLVEVNPLVRTPDHKILALDAKITLDGNADFRQPGHAEFEDRAATDPLELKAKEH
HCCCCEEEEECCCEECCCCEEEEEEEEEEECCCCCCCCCCCCCCCHHCCCCCCEEEEECC
DLNYVKLDGQVGIIGNGAGLAMSTLDVVAYAGEKHGGVKPANFLDIGGGASAEVMAAGLD
CCCEEEECCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCHHHHHCCCE
VVLGDQQVKSVFVNVFGGITSCDAVATGIVKALGMLGDEANKPLVVRLDGNNVEEGRRIL
EEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHH
TEANHPLVTLVATMDEAADKAAELASA
HCCCCCEEEEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972