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The map label for this gene is 121636837

Identifier: 121636837

GI number: 121636837

Start: 1049202

End: 1050440

Strand: Reverse

Name: 121636837

Synonym: BCG_0966c

Alternate gene names: NA

Gene position: 1050440-1049202 (Counterclockwise)

Preceding gene: 121636838

Following gene: 121636836

Centisome position: 24.01

GC content: 67.23

Gene sequence:

>1239_bases
ATGGACGACGGTGTCTGGATTCTCGGCGGCTATCAGAGCGATTTTGCTCGCAACCTCAGCAAAGAGAACCGCGACTTCGC
CGACCTGACTAGGGAGGTCGTCGACGGCACGCTCACCGCGGCCAAGGTGGACGCCGCCGACCTAGCCGCTGCGGGAGTCG
TCCACGTCGCGAACGCCTTCGGCGAGATGTTCGCCCGTCAAGGCCACCTCGGCGCGATGCCGGCCACTGTCTGCGACGAT
CTCTGGGACACGCCGGCCACCCGGCACGAGGCCGCGTGCGCATCCGGCAGCGTGGCGACGCTCGCGGCGATGGCCGACCT
GCGATCAGGCGCGTACCGTGTCGCGCTCGTCGTGGGCCTAGAGCTGGAGAAGACCGTGCCCGGCGACACCGCGGCCGAGC
ATCTGAGTGCCGCGGCCTGGACCGGGCACGAAGGAGCCGAGGCCCGCTACTTATGGCCGTCGATGTTCGCTCAGGTCGCC
GACGAATACGACCGGCGATACGGTTTGGATGACACTCACCTGCGGGCCATCGCTCAACTCAACTTCGCCAACGCGCGCCG
CAACCCCAACGCGCAGACCCGCGGCTGGACGATCCCCGACCCGATCACCGACGACGACGCGACCAACCCTCTTACCGAAG
GCCGGCTGCGACGGTTTGATTGCAGCCAGATGACCGACGGCGGCGCGGGATTGGTCCTGGTCAGCGATGCCTATCTGCGC
GACCATCGCGACGCGCGCCCGATCGGCCGCATCGACGGCTGGGGACATCGCACCGTCGGGTTGGGTCTGCGGCAGAAACT
GGACCGCGTCGCCCAGGGCGACTCGGCCCCCTACCTACTGCCGCACGTGCGGGCCACAGTGCTGGACGCCCTGCGCCGCG
CCCGGGTGACCCTCGACGATCTGGACGGGATCGAGGTGCACGACTGCTTCACCCCCAGCGAATACCTGGCCATCGATCAC
ATCGGGTTGACCGGCCCCGGGGAATCTTGGAAGGCCATCGAGAACGGAGAGATCGAGATCGGCGGGCGGCTACCCATCAA
CCCCAGCGGAGGACTGATCGGTGGCGGACATCCGGTCGGGGCTTCCGGTGTGCGGATGCTGCTCGACGCGGCCAAACAGG
TGAGCGGCATTGCCGGTGACTATCAGGTCGAGAACGCCGAAGCGTTCGGCACGCTGAATTTCGGTGGCAGCACGGCCACC
ACGGTCAGTTTCGTTGTCAGCACCACACGAGGATCGTGA

Upstream 100 bases:

>100_bases
CGCGGTAAAAGTCCGGCAACCGTTCGTCGCCGCGCGGAAAATGCCTGGTGAGCGTGGCTATCCGACGGGCCGTTCACACC
GCTTGTAGTAGCGTACGGCT

Downstream 100 bases:

>100_bases
AATGGACATCACGATTGTCGGCAAGTACTTGTCGACCCTTCCCGAAGACGACGACCACCCCTATCGCACCGGTCCGTGGC
GACCACAGACCACCGAATGG

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MDDGVWILGGYQSDFARNLSKENRDFADLTREVVDGTLTAAKVDAADLAAAGVVHVANAFGEMFARQGHLGAMPATVCDD
LWDTPATRHEAACASGSVATLAAMADLRSGAYRVALVVGLELEKTVPGDTAAEHLSAAAWTGHEGAEARYLWPSMFAQVA
DEYDRRYGLDDTHLRAIAQLNFANARRNPNAQTRGWTIPDPITDDDATNPLTEGRLRRFDCSQMTDGGAGLVLVSDAYLR
DHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSAPYLLPHVRATVLDALRRARVTLDDLDGIEVHDCFTPSEYLAIDH
IGLTGPGESWKAIENGEIEIGGRLPINPSGGLIGGGHPVGASGVRMLLDAAKQVSGIAGDYQVENAEAFGTLNFGGSTAT
TVSFVVSTTRGS

Sequences:

>Translated_412_residues
MDDGVWILGGYQSDFARNLSKENRDFADLTREVVDGTLTAAKVDAADLAAAGVVHVANAFGEMFARQGHLGAMPATVCDD
LWDTPATRHEAACASGSVATLAAMADLRSGAYRVALVVGLELEKTVPGDTAAEHLSAAAWTGHEGAEARYLWPSMFAQVA
DEYDRRYGLDDTHLRAIAQLNFANARRNPNAQTRGWTIPDPITDDDATNPLTEGRLRRFDCSQMTDGGAGLVLVSDAYLR
DHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSAPYLLPHVRATVLDALRRARVTLDDLDGIEVHDCFTPSEYLAIDH
IGLTGPGESWKAIENGEIEIGGRLPINPSGGLIGGGHPVGASGVRMLLDAAKQVSGIAGDYQVENAEAFGTLNFGGSTAT
TVSFVVSTTRGS
>Mature_412_residues
MDDGVWILGGYQSDFARNLSKENRDFADLTREVVDGTLTAAKVDAADLAAAGVVHVANAFGEMFARQGHLGAMPATVCDD
LWDTPATRHEAACASGSVATLAAMADLRSGAYRVALVVGLELEKTVPGDTAAEHLSAAAWTGHEGAEARYLWPSMFAQVA
DEYDRRYGLDDTHLRAIAQLNFANARRNPNAQTRGWTIPDPITDDDATNPLTEGRLRRFDCSQMTDGGAGLVLVSDAYLR
DHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSAPYLLPHVRATVLDALRRARVTLDDLDGIEVHDCFTPSEYLAIDH
IGLTGPGESWKAIENGEIEIGGRLPINPSGGLIGGGHPVGASGVRMLLDAAKQVSGIAGDYQVENAEAFGTLNFGGSTAT
TVSFVVSTTRGS

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=421, Percent_Identity=23.9904988123515, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI302344760, Length=417, Percent_Identity=22.7817745803357, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI302344767, Length=337, Percent_Identity=24.6290801186944, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI302344762, Length=288, Percent_Identity=25, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI55956775, Length=247, Percent_Identity=24.6963562753036, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17537653, Length=405, Percent_Identity=26.9135802469136, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI19921506, Length=412, Percent_Identity=24.0291262135922, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585051, Length=412, Percent_Identity=24.0291262135922, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 43875; Mature: 43875

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDGVWILGGYQSDFARNLSKENRDFADLTREVVDGTLTAAKVDAADLAAAGVVHVANAF
CCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHH
GEMFARQGHLGAMPATVCDDLWDTPATRHEAACASGSVATLAAMADLRSGAYRVALVVGL
HHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEEE
ELEKTVPGDTAAEHLSAAAWTGHEGAEARYLWPSMFAQVADEYDRRYGLDDTHLRAIAQL
EECCCCCCCHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHH
NFANARRNPNAQTRGWTIPDPITDDDATNPLTEGRLRRFDCSQMTDGGAGLVLVSDAYLR
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCHHHHCCHHHCCCCCCCEEEEECHHHH
DHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSAPYLLPHVRATVLDALRRARVTLDD
CCCCCCCCCCCCCCCCCEECHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCC
LDGIEVHDCFTPSEYLAIDHIGLTGPGESWKAIENGEIEIGGRLPINPSGGLIGGGHPVG
CCCCEEEECCCCCHHEEEEECCCCCCCCCCCEECCCCEEECCEECCCCCCCCCCCCCCCC
ASGVRMLLDAAKQVSGIAGDYQVENAEAFGTLNFGGSTATTVSFVVSTTRGS
HHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCCEEEEEEEEECCCC
>Mature Secondary Structure
MDDGVWILGGYQSDFARNLSKENRDFADLTREVVDGTLTAAKVDAADLAAAGVVHVANAF
CCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHH
GEMFARQGHLGAMPATVCDDLWDTPATRHEAACASGSVATLAAMADLRSGAYRVALVVGL
HHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEEE
ELEKTVPGDTAAEHLSAAAWTGHEGAEARYLWPSMFAQVADEYDRRYGLDDTHLRAIAQL
EECCCCCCCHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHH
NFANARRNPNAQTRGWTIPDPITDDDATNPLTEGRLRRFDCSQMTDGGAGLVLVSDAYLR
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCHHHHCCHHHCCCCCCCEEEEECHHHH
DHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSAPYLLPHVRATVLDALRRARVTLDD
CCCCCCCCCCCCCCCCCEECHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCC
LDGIEVHDCFTPSEYLAIDHIGLTGPGESWKAIENGEIEIGGRLPINPSGGLIGGGHPVG
CCCCEEEECCCCCHHEEEEECCCCCCCCCCCEECCCCEEECCEECCCCCCCCCCCCCCCC
ASGVRMLLDAAKQVSGIAGDYQVENAEAFGTLNFGGSTATTVSFVVSTTRGS
HHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCCEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]