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The map label for this gene is pdc

Identifier: 121636776

GI number: 121636776

Start: 979942

End: 981624

Strand: Reverse

Name: pdc

Synonym: BCG_0905c

Alternate gene names: 121636776

Gene position: 981624-979942 (Counterclockwise)

Preceding gene: 121636781

Following gene: 121636774

Centisome position: 22.44

GC content: 66.07

Gene sequence:

>1683_bases
GTGACACCCCAGAAGAGCGATGCCTGCAGCGATCCCGTCTACACCGTCGGCGACTACCTACTCGACCGGCTCGCCGAACT
CGGCGTCTCTGAGATCTTCGGCGTTCCCGGCGACTACAACCTGCAATTCCTCGACCACATCGTGGCCCACCCGACCATCC
GGTGGGTGGGCAGCGCCAACGAACTGAATGCCGGGTATGCCGCCGACGGGTACGGGCGGCTGCGTGGGATGTCAGCGGTG
GTAACGACATTCGGGGTCGGCGAGCTCTCGGTGACCAATGCGATCGCGGGCAGTTACGCCGAGCATGTGCCAGTGGTGCA
CATTGTTGGCGGCCCGACCAAAGACGCCCAGGGCACTCGCCGGGCATTGCATCATTCCCTCGGCGACGGCGACTTCGAGC
ACTTTCTCCGGATCAGCCGTGAAATCACCTGTGCCCAAGCCAATCTCATGCCGGCAACGGCCGGTAGAGAAATAGATCGG
GTGCTGTCCGAGGTACGGGAGCAGAAGCGTCCAGGATATATATTGCTGTCCAGCGACGTAGCACGCTTCCCCACTGAACC
GCCCGCTGCGCCGTTGCCCCGCTACCCCGGCGGCACCAGCCCGCGCGCGCTGTCGCTGTTCACCAAGGCCGCCATCGAAC
TCATTGCCGACCACCAGTTGACGGTGCTCGCCGATCTGTTGGTTCATCGCCTGCAGGCCGTCAAAGAACTCGAGGCGCTG
TTGGCCGCCGACGTGGTGCCGCACGCCACGTTGATGTGGGGGAAGAGCCTGCTCGACGAGAGCTCGCCGAACTTCCTGGG
AATCTACGCCGGCGCGGCCAGCGCCGAACGGGTGCGCGCCGCGATCGAAGGGGCGCCGGTGCTGGTGACCGCCGGAGTGG
TGTTCACCGACATGGTCAGCGGCTTCTTCAGCCAGCGGATCGACCCGGCCCGGACCATCGACATCGGGCAATACCAGAGC
AGCGTGGCCGACCAGGTGTTCGCACCACTGGAAATGAGTGCCGCGCTGCAGGCGCTGGCCACCATCCTGACCGGGCGCGG
AATCAGTTCGCCGCCGGTGGTACCGCCGCCCGCCGAACCGCCGCCGGCGATGCCGGCGCGCGATGAGCCGCTCACCCAGC
AGATGGTGTGGGACCGGGTTTGCTCAGCGCTCACACCCGGAAACGTGGTGCTCGCCGACCAGGGGACGTCGTTCTACGGC
ATGGCGGACCACCGGTTGCCGCAAGGAGTGACCTTTATCGGCCAACCCTTGTGGGGCTCAATCGGTTACACGCTGCCCGC
GGCAGTCGGGGCCGCGGTTGCGCATCCGGACCGCCGTACGGTGCTGTTGATCGGCGACGGGGCCGCACAATTGACCGTGC
AGGAACTCGGCACGTTCTCCCGCGAAGGGCTGTCCCCGGTCATCGTGGTGGTCAACAACGATGGTTACACGGTCGAACGG
GCCATCCACGGCGAGACGGCCCCGTACAACGACATCGTGAGCTGGAATTGGACCGAGCTTCCCAGCGCGCTGGGTGTGAC
CAATCACCTCGCGTTCCGTGCCCAAACCTATGGCCAACTCGACGACGCCCTCACCGTCGCCGCGGCACGGCGGGACCGGA
TGGTGCTCGTCGAGGTGGTGTTGCCGCGGCTCGAGATCCCCCGCCTGCTTGGCCAACTCGTGGGATCCATGGCGCCGCAG
TGA

Upstream 100 bases:

>100_bases
TTCGATAACTATGTCGCGCGACTCCTTGATGGCCATGGCCGCACGATAGCGAATCGGCGTCCAGTCGGGAATAGCCTCAA
TCCGGCGTACGGTCGTCTTC

Downstream 100 bases:

>100_bases
GGTCGCTGACCCGGGCCGGGCCGAGTGCCCAGCGATGCGCTCACTGCAGCGCCTCGATCCGCATCATGTCGAAGAACCGG
CCGACGAACAGCGGTGGGTA

Product: putative pyruvate or indole-3-pyruvate decarboxylase pdc

Products: aldehyde; CO2

Alternate protein names: KDC

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MTPQKSDACSDPVYTVGDYLLDRLAELGVSEIFGVPGDYNLQFLDHIVAHPTIRWVGSANELNAGYAADGYGRLRGMSAV
VTTFGVGELSVTNAIAGSYAEHVPVVHIVGGPTKDAQGTRRALHHSLGDGDFEHFLRISREITCAQANLMPATAGREIDR
VLSEVREQKRPGYILLSSDVARFPTEPPAAPLPRYPGGTSPRALSLFTKAAIELIADHQLTVLADLLVHRLQAVKELEAL
LAADVVPHATLMWGKSLLDESSPNFLGIYAGAASAERVRAAIEGAPVLVTAGVVFTDMVSGFFSQRIDPARTIDIGQYQS
SVADQVFAPLEMSAALQALATILTGRGISSPPVVPPPAEPPPAMPARDEPLTQQMVWDRVCSALTPGNVVLADQGTSFYG
MADHRLPQGVTFIGQPLWGSIGYTLPAAVGAAVAHPDRRTVLLIGDGAAQLTVQELGTFSREGLSPVIVVVNNDGYTVER
AIHGETAPYNDIVSWNWTELPSALGVTNHLAFRAQTYGQLDDALTVAAARRDRMVLVEVVLPRLEIPRLLGQLVGSMAPQ

Sequences:

>Translated_560_residues
MTPQKSDACSDPVYTVGDYLLDRLAELGVSEIFGVPGDYNLQFLDHIVAHPTIRWVGSANELNAGYAADGYGRLRGMSAV
VTTFGVGELSVTNAIAGSYAEHVPVVHIVGGPTKDAQGTRRALHHSLGDGDFEHFLRISREITCAQANLMPATAGREIDR
VLSEVREQKRPGYILLSSDVARFPTEPPAAPLPRYPGGTSPRALSLFTKAAIELIADHQLTVLADLLVHRLQAVKELEAL
LAADVVPHATLMWGKSLLDESSPNFLGIYAGAASAERVRAAIEGAPVLVTAGVVFTDMVSGFFSQRIDPARTIDIGQYQS
SVADQVFAPLEMSAALQALATILTGRGISSPPVVPPPAEPPPAMPARDEPLTQQMVWDRVCSALTPGNVVLADQGTSFYG
MADHRLPQGVTFIGQPLWGSIGYTLPAAVGAAVAHPDRRTVLLIGDGAAQLTVQELGTFSREGLSPVIVVVNNDGYTVER
AIHGETAPYNDIVSWNWTELPSALGVTNHLAFRAQTYGQLDDALTVAAARRDRMVLVEVVLPRLEIPRLLGQLVGSMAPQ
>Mature_559_residues
TPQKSDACSDPVYTVGDYLLDRLAELGVSEIFGVPGDYNLQFLDHIVAHPTIRWVGSANELNAGYAADGYGRLRGMSAVV
TTFGVGELSVTNAIAGSYAEHVPVVHIVGGPTKDAQGTRRALHHSLGDGDFEHFLRISREITCAQANLMPATAGREIDRV
LSEVREQKRPGYILLSSDVARFPTEPPAAPLPRYPGGTSPRALSLFTKAAIELIADHQLTVLADLLVHRLQAVKELEALL
AADVVPHATLMWGKSLLDESSPNFLGIYAGAASAERVRAAIEGAPVLVTAGVVFTDMVSGFFSQRIDPARTIDIGQYQSS
VADQVFAPLEMSAALQALATILTGRGISSPPVVPPPAEPPPAMPARDEPLTQQMVWDRVCSALTPGNVVLADQGTSFYGM
ADHRLPQGVTFIGQPLWGSIGYTLPAAVGAAVAHPDRRTVLLIGDGAAQLTVQELGTFSREGLSPVIVVVNNDGYTVERA
IHGETAPYNDIVSWNWTELPSALGVTNHLAFRAQTYGQLDDALTVAAARRDRMVLVEVVLPRLEIPRLLGQLVGSMAPQ

Specific function: Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family

Homologues:

Organism=Escherichia coli, GI1790104, Length=478, Percent_Identity=23.0125523012552, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321524, Length=547, Percent_Identity=37.4771480804388, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6323073, Length=546, Percent_Identity=36.996336996337, Blast_Score=342, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6323163, Length=546, Percent_Identity=36.4468864468864, Blast_Score=333, Evalue=6e-92,
Organism=Saccharomyces cerevisiae, GI6320123, Length=551, Percent_Identity=32.3049001814882, Blast_Score=320, Evalue=5e-88,
Organism=Saccharomyces cerevisiae, GI6320588, Length=605, Percent_Identity=29.9173553719008, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6323755, Length=515, Percent_Identity=25.8252427184466, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDC_MYCBO (Q7U140)

Other databases:

- EMBL:   BX248336
- RefSeq:   NP_854534.1
- HSSP:   P06169
- ProteinModelPortal:   Q7U140
- SMR:   Q7U140
- EnsemblBacteria:   EBMYCT00000016646
- GeneID:   1092749
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0876c
- GeneTree:   EBGT00050000014643
- HOGENOM:   HBG479104
- OMA:   ADQGTAA
- ProtClustDB:   CLSK790786
- BioCyc:   MBOV233413:MB0876C-MONOMER
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766
- PIRSF:   PIRSF036565

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N

EC number: 4.1.1.1

Molecular weight: Translated: 59784; Mature: 59653

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00187 TPP_ENZYMES

Important sites: BINDING 61-61

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPQKSDACSDPVYTVGDYLLDRLAELGVSEIFGVPGDYNLQFLDHIVAHPTIRWVGSAN
CCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHCCCEEEECCCC
ELNAGYAADGYGRLRGMSAVVTTFGVGELSVTNAIAGSYAEHVPVVHIVGGPTKDAQGTR
CCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHH
RALHHSLGDGDFEHFLRISREITCAQANLMPATAGREIDRVLSEVREQKRPGYILLSSDV
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCH
ARFPTEPPAAPLPRYPGGTSPRALSLFTKAAIELIADHQLTVLADLLVHRLQAVKELEAL
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LAADVVPHATLMWGKSLLDESSPNFLGIYAGAASAERVRAAIEGAPVLVTAGVVFTDMVS
HHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCEEEEHHHHHHHHHH
GFFSQRIDPARTIDIGQYQSSVADQVFAPLEMSAALQALATILTGRGISSPPVVPPPAEP
HHHHHCCCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PPAMPARDEPLTQQMVWDRVCSALTPGNVVLADQGTSFYGMADHRLPQGVTFIGQPLWGS
CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCCCCCCCCEECCCCCCC
IGYTLPAAVGAAVAHPDRRTVLLIGDGAAQLTVQELGTFSREGLSPVIVVVNNDGYTVER
CCCHHHHHHHHHHCCCCCCEEEEEECCCHHEEHHHHCCHHHCCCCEEEEEECCCCEEEEE
AIHGETAPYNDIVSWNWTELPSALGVTNHLAFRAQTYGQLDDALTVAAARRDRMVLVEVV
EECCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEHHH
LPRLEIPRLLGQLVGSMAPQ
HCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TPQKSDACSDPVYTVGDYLLDRLAELGVSEIFGVPGDYNLQFLDHIVAHPTIRWVGSAN
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHCCCEEEECCCC
ELNAGYAADGYGRLRGMSAVVTTFGVGELSVTNAIAGSYAEHVPVVHIVGGPTKDAQGTR
CCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHH
RALHHSLGDGDFEHFLRISREITCAQANLMPATAGREIDRVLSEVREQKRPGYILLSSDV
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCH
ARFPTEPPAAPLPRYPGGTSPRALSLFTKAAIELIADHQLTVLADLLVHRLQAVKELEAL
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LAADVVPHATLMWGKSLLDESSPNFLGIYAGAASAERVRAAIEGAPVLVTAGVVFTDMVS
HHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCEEEEHHHHHHHHHH
GFFSQRIDPARTIDIGQYQSSVADQVFAPLEMSAALQALATILTGRGISSPPVVPPPAEP
HHHHHCCCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PPAMPARDEPLTQQMVWDRVCSALTPGNVVLADQGTSFYGMADHRLPQGVTFIGQPLWGS
CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCCCCCCCCEECCCCCCC
IGYTLPAAVGAAVAHPDRRTVLLIGDGAAQLTVQELGTFSREGLSPVIVVVNNDGYTVER
CCCHHHHHHHHHHCCCCCCEEEEEECCCHHEEHHHHCCHHHCCCCEEEEEECCCCEEEEE
AIHGETAPYNDIVSWNWTELPSALGVTNHLAFRAQTYGQLDDALTVAAARRDRMVLVEVV
EECCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEHHH
LPRLEIPRLLGQLVGSMAPQ
HCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-oxo acid

Specific reaction: A 2-oxo acid = an aldehyde + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972