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The map label for this gene is desA1

Identifier: 121636748

GI number: 121636748

Start: 948155

End: 949171

Strand: Reverse

Name: desA1

Synonym: BCG_0877c

Alternate gene names: 121636748

Gene position: 949171-948155 (Counterclockwise)

Preceding gene: 121636749

Following gene: 121636747

Centisome position: 21.7

GC content: 61.65

Gene sequence:

>1017_bases
ATGTCAGCCAAGCTGACCGACCTGCAGCTGCTGCACGAACTTGAACCGGTCGTCGAGAAGTACCTGAACCGGCACCTGAG
CATGCACAAGCCCTGGAACCCGCACGACTACATCCCGTGGTCGGACGGGAAGAACTACTACGCGCTCGGCGGGCAGGATT
GGGACCCCGACCAGAGCAAGCTTTCTGATGTCGCCCAGGTGGCGATGGTGCAGAACCTGGTCACCGAGGACAACCTGCCG
TCGTATCACCGCGAGATCGCGATGAACATGGGCATGGACGGCGCGTGGGGGCAGTGGGTCAACCGTTGGACCGCCGAGGA
GAATCGGCACGGCATCGCGCTGCGCGACTACCTGGTGGTGACCCGATCGGTCGACCCTGTCGAGTTGGAGAAACTTCGCC
TCGAGGTAGTCAACCGGGGCTTCAGCCCAGGCCAAAACCACCAGGGCCACTATTTCGCGGAGAGCCTCACCGACTCCGTC
CTCTATGTCAGTTTCCAGGAACTGGCAACCCGGATTTCGCACCGCAATACCGGCAAGGCATGTAACGACCCCGTCGCCGA
CCAGCTCATGGCCAAGATCTCGGCAGACGAGAATCTGCACATGATCTTCTACCGCGACGTCAGCGAGGCCGCGTTCGACC
TCGTGCCCAACCAGGCCATGAAGTCGCTGCACCTGATTTTGAGCCACTTCCAGATGCCCGGCTTCCAAGTACCCGAGTTC
CGGCGCAAAGCCGTGGTCATCGCCGTCGGGGGTGTCTACGACCCGCGCATCCACCTCGACGAAGTCGTCATGCCGGTACT
GAAGAAATGGCGTATCTTCGAGCGCGAGGACTTCACCGGCGAGGGGGCTAAGCTGCGCGACGAGCTGGCCCTGGTGATCA
AGGACCTCGAGCTGGCCTGCGACAAGTTCGAGGTGTCCAAGCAACGCCAACTCGACCGGGAAGCCCGTACGGGCAAGAAG
GTCAGCGCACACGAGCTGCATAAAACCGCTGGCAAACTGGCGATGAGCCGTCGTTAG

Upstream 100 bases:

>100_bases
TGCTGGCAGCTCAACATGCCGCGCGAAGCCCAAACTTGATGCTACCGAGAGGCACAGATATATTGACTGCAACCATTAGA
CACAGATAACTGGAGGCGCC

Downstream 100 bases:

>100_bases
CCCGGCGACGATGCAGAGCGCGCAGCGCGATGAGCAGGAGGCGGGCAATCCAACCCAGCCCGGCGACGATGCAGAGCGCG
CAGCGCGATGAGCAGGAGGC

Product: putative acyl-[acyl-carrier protein] desaturase desA1

Products: NA

Alternate protein names: DES; Putative acyl-ACP desaturase desA1

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYALGGQDWDPDQSKLSDVAQVAMVQNLVTEDNLP
SYHREIAMNMGMDGAWGQWVNRWTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQGHYFAESLTDSV
LYVSFQELATRISHRNTGKACNDPVADQLMAKISADENLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEF
RRKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLELACDKFEVSKQRQLDREARTGKK
VSAHELHKTAGKLAMSRR

Sequences:

>Translated_338_residues
MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYALGGQDWDPDQSKLSDVAQVAMVQNLVTEDNLP
SYHREIAMNMGMDGAWGQWVNRWTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQGHYFAESLTDSV
LYVSFQELATRISHRNTGKACNDPVADQLMAKISADENLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEF
RRKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLELACDKFEVSKQRQLDREARTGKK
VSAHELHKTAGKLAMSRR
>Mature_337_residues
SAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYALGGQDWDPDQSKLSDVAQVAMVQNLVTEDNLPS
YHREIAMNMGMDGAWGQWVNRWTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQGHYFAESLTDSVL
YVSFQELATRISHRNTGKACNDPVADQLMAKISADENLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEFR
RKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLELACDKFEVSKQRQLDREARTGKKV
SAHELHKTAGKLAMSRR

Specific function: Could be involved in mycobacterial fatty acid biosynthesis

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fatty acid desaturase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DESA1_MYCTU (Q50824)

Other databases:

- EMBL:   U49839
- EMBL:   BX842574
- EMBL:   AE000516
- PIR:   H70810
- RefSeq:   NP_335274.1
- RefSeq:   YP_177758.1
- ProteinModelPortal:   Q50824
- SMR:   Q50824
- EnsemblBacteria:   EBMYCT00000000249
- EnsemblBacteria:   EBMYCT00000071195
- GeneID:   885444
- GeneID:   926149
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0846
- KEGG:   mtu:Rv0824c
- TIGR:   MT0846
- TubercuList:   Rv0824c
- GeneTree:   EBGT00050000016016
- HOGENOM:   HBG566522
- OMA:   KMPGYTI
- ProtClustDB:   CLSK881167
- BRENDA:   1.14.19.2
- GO:   GO:0005829
- GO:   GO:0040007
- InterPro:   IPR005067
- InterPro:   IPR009078
- InterPro:   IPR012348
- Gene3D:   G3DSA:1.10.620.20
- PIRSF:   PIRSF000346

Pfam domain/function: PF03405 FA_desaturase_2; SSF47240 Ferritin/RR_like

EC number: NA

Molecular weight: Translated: 38771; Mature: 38639

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYALGGQDWDPDQSK
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHH
LSDVAQVAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQWVNRWTAEENRHGIALRDYLVV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEHEEEE
TRSVDPVELEKLRLEVVNRGFSPGQNHQGHYFAESLTDSVLYVSFQELATRISHRNTGKA
ECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
CNDPVADQLMAKISADENLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEF
CCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCC
RRKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLELAC
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
DKFEVSKQRQLDREARTGKKVSAHELHKTAGKLAMSRR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYALGGQDWDPDQSK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHH
LSDVAQVAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQWVNRWTAEENRHGIALRDYLVV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEHEEEE
TRSVDPVELEKLRLEVVNRGFSPGQNHQGHYFAESLTDSVLYVSFQELATRISHRNTGKA
ECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
CNDPVADQLMAKISADENLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEF
CCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCC
RRKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLELAC
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
DKFEVSKQRQLDREARTGKKVSAHELHKTAGKLAMSRR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036