BacMap

Definition	Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome.
Accession	NC_008769
Length	4,374,522

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The map label for this gene is dnaJ1 [H]

Identifier: 121636266

GI number: 121636266

Start: 453379

End: 454566

Strand: Direct

Name: dnaJ1 [H]

Synonym: BCG_0391

Alternate gene names: 121636266

Gene position: 453379-454566 (Clockwise)

Preceding gene: 121636265

Following gene: 121636267

Centisome position: 10.36

GC content: 67.68

Gene sequence:

>1188_bases
ATGGCCCAAAGGGAATGGGTCGAAAAAGACTTCTACCAGGAGCTGGGCGTCTCCTCTGATGCCAGTCCTGAAGAGATCAA
ACGTGCCTATCGGAAGTTGGCGCGCGACCTGCATCCGGACGCGAACCCGGGCAACCCGGCCGCCGGCGAACGGTTCAAGG
CGGTTTCGGAGGCGCATAACGTGCTGTCGGATCCGGCCAAGCGCAAGGAGTACGACGAAACCCGCCGCCTGTTCGCCGGC
GGCGGGTTCGGCGGCCGTCGGTTCGACAGCGGCTTTGGGGGCGGGTTCGGCGGCTTCGGGGTCGGTGGAGACGGCGCCGA
GTTCAACCTCAACGACTTGTTCGACGCCGCCAGCCGAACCGGCGGTACCACCATCGGTGACTTGTTCGGTGGCTTGTTCG
GACGCGGTGGCAGCGCCCGTCCCAGCCGCCCGCGACGCGGCAACGACCTGGAGACCGAGACCGAGTTGGATTTCGTGGAG
GCCGCCAAGGGCGTGGCGATGCCGCTGCGATTAACCAGCCCGGCGCCGTGCACCAACTGCCATGGCAGCGGGGCCCGGCC
AGGCACCAGCCCAAAGGTGTGTCCCACTTGCAACGGGTCGGGCGTGATCAACCGCAATCAGGGCGCGTTCGGCTTCTCCG
AGCCGTGCACCGACTGCCGAGGTAGCGGCTCGATCATCGAGCACCCCTGCGAGGAGTGCAAAGGCACCGGCGTGACCACC
CGCACCCGAACCATCAACGTGCGGATCCCGCCCGGTGTCGAGGATGGGCAGCGCATCCGGCTAGCCGGTCAGGGCGAGGC
CGGGTTGCGCGGCGCTCCCTCGGGGGATCTCTACGTGGCGGTGCATGTGCGGCCCGACAAGATCTTCGGCCGCGACGGCG
ACGACCTCACCGTCACCGTTCCGGTCAGCTTCACCGAATTGGCTTTGGGCTCGACGCTGTCGGTGCCTACCCTGGACGGC
ACGGTCGGGGTCCGGGTGCCCAAAGGCACCGCTGACGGCCGCATTCTGCGTGTGCGCGGACGCGGTGTGCCCAAGCGCAG
TGGGGGTAGCGGCGACCTACTTGTCACCGTGAAGGTGGCCGTGCCGCCCAATTTGGCAGGCGCCGCTCAGGAAGCTCTGG
AAGCCTATGCGGCGGCGGAGCGGTCCAGTGGTTTCAACCCGCGGGCCGGATGGGCAGGTAATCGCTGA

Upstream 100 bases:

>100_bases
CTGACCAGGGCAATAGCGCCGACACCTTGGGCGAACAGGCAGAATCAGAACCGTCGGGCAGTTAACAACAAAAGAGGAAG
GCGAGAGGGGGTGACGCGAC

Downstream 100 bases:

>100_bases
TGGCGAAGAACCCAAAGGACGGGGAATCCCGGACGTTTTTGATCTCGGTAGCCGCCGAGCTAGCCGGCATGCATGCACAG
ACCCTGCGTACCTACGATCG

Product: chaperone protein DnaJ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAG
GGFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVE
AAKGVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTT
RTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVAVHVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDG
TVGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR

Sequences:

>Translated_395_residues
MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAG
GGFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVE
AAKGVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTT
RTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVAVHVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDG
TVGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR
>Mature_394_residues
AQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAGG
GFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVEA
AKGVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTTR
TRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVAVHVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDGT
VGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR

Specific function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion. Unfolded proteins bind initially to dnaJ; upon

COG id: COG0484

COG function: function code O; DnaJ-class molecular chaperone with C-terminal Zn finger domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain [H]

Homologues:

Organism=Homo sapiens, GI205360838, Length=376, Percent_Identity=33.2446808510638, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI205360840, Length=376, Percent_Identity=33.2446808510638, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI194328758, Length=367, Percent_Identity=30.5177111716621, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI194328760, Length=367, Percent_Identity=30.5177111716621, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI4504511, Length=369, Percent_Identity=29.5392953929539, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI5031741, Length=367, Percent_Identity=30.2452316076294, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI7706495, Length=377, Percent_Identity=29.4429708222812, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI194328762, Length=333, Percent_Identity=27.027027027027, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI68077166, Length=103, Percent_Identity=44.6601941747573, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI68077168, Length=103, Percent_Identity=44.6601941747573, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4885495, Length=65, Percent_Identity=58.4615384615385, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI29126218, Length=84, Percent_Identity=44.047619047619, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI23503241, Length=64, Percent_Identity=57.8125, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI17388799, Length=65, Percent_Identity=58.4615384615385, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI194306642, Length=108, Percent_Identity=43.5185185185185, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI194306640, Length=108, Percent_Identity=43.5185185185185, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI45504382, Length=84, Percent_Identity=39.2857142857143, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI201862587, Length=65, Percent_Identity=53.8461538461538, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI201862518, Length=65, Percent_Identity=53.8461538461538, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI56549115, Length=65, Percent_Identity=53.8461538461538, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI5453690, Length=64, Percent_Identity=56.25, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI6631085, Length=65, Percent_Identity=55.3846153846154, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI24308127, Length=132, Percent_Identity=34.0909090909091, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI47777312, Length=89, Percent_Identity=50.561797752809, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI72534740, Length=66, Percent_Identity=51.5151515151515, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI8922563, Length=87, Percent_Identity=37.9310344827586, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI22749377, Length=65, Percent_Identity=55.3846153846154, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI21553335, Length=65, Percent_Identity=52.3076923076923, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786197, Length=370, Percent_Identity=42.4324324324324, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1787235, Length=390, Percent_Identity=33.5897435897436, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17553096, Length=383, Percent_Identity=30.2872062663185, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17553098, Length=383, Percent_Identity=30.5483028720627, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17507263, Length=374, Percent_Identity=31.283422459893, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17554644, Length=136, Percent_Identity=41.1764705882353, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17563890, Length=200, Percent_Identity=30, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI212645553, Length=64, Percent_Identity=51.5625, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17534355, Length=65, Percent_Identity=49.2307692307692, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17538236, Length=130, Percent_Identity=37.6923076923077, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532378, Length=157, Percent_Identity=26.7515923566879, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324265, Length=367, Percent_Identity=32.425068119891, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6321094, Length=395, Percent_Identity=32.9113924050633, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323870, Length=369, Percent_Identity=31.7073170731707, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323119, Length=391, Percent_Identity=26.0869565217391, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324252, Length=446, Percent_Identity=23.0941704035874, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322194, Length=98, Percent_Identity=45.9183673469388, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320888, Length=115, Percent_Identity=38.2608695652174, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323813, Length=140, Percent_Identity=42.8571428571429, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45552813, Length=390, Percent_Identity=32.3076923076923, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45549272, Length=390, Percent_Identity=32.3076923076923, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45552811, Length=390, Percent_Identity=32.5641025641026, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24646562, Length=376, Percent_Identity=28.4574468085106, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646560, Length=376, Percent_Identity=28.4574468085106, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646558, Length=376, Percent_Identity=28.4574468085106, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646556, Length=376, Percent_Identity=28.4574468085106, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357547, Length=376, Percent_Identity=28.4574468085106, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20129487, Length=376, Percent_Identity=29.5212765957447, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24584014, Length=376, Percent_Identity=29.5212765957447, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28574949, Length=378, Percent_Identity=26.1904761904762, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI19920464, Length=149, Percent_Identity=32.8859060402685, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24658562, Length=64, Percent_Identity=56.25, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24658555, Length=64, Percent_Identity=56.25, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24654066, Length=65, Percent_Identity=53.8461538461538, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24654070, Length=65, Percent_Identity=53.8461538461538, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24654068, Length=65, Percent_Identity=53.8461538461538, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24654072, Length=65, Percent_Identity=53.8461538461538, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24641698, Length=125, Percent_Identity=33.6, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641696, Length=125, Percent_Identity=33.6, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24645889, Length=89, Percent_Identity=37.0786516853933, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161077138, Length=64, Percent_Identity=53.125, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737735, Length=84, Percent_Identity=40.4761904761905, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28574723, Length=84, Percent_Identity=40.4761904761905, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21358273, Length=64, Percent_Identity=56.25, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24668523, Length=84, Percent_Identity=40.4761904761905, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI85726398, Length=65, Percent_Identity=50.7692307692308, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012724
- InterPro:   IPR002939
- InterPro:   IPR001623
- InterPro:   IPR018253
- InterPro:   IPR008971
- InterPro:   IPR015609
- InterPro:   IPR003095
- InterPro:   IPR001305 [H]

Pfam domain/function: PF00226 DnaJ; PF01556 DnaJ_C; PF00684 DnaJ_CXXCXGXG [H]

EC number: NA

Molecular weight: Translated: 41315; Mature: 41184

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00636 DNAJ_1 ; PS50076 DNAJ_2 ; PS00637 DNAJ_CXXCXGXG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHN
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
VLSDPAKRKEYDETRRLFAGGGFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRT
HHCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVEAAKGVAMPLRLTSPAPCTNC
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCC
HGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTT
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEE
RTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVAVHVRPDKIFGRDGDDLTVTV
EEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEECHHHCCCCCCCEEEEE
PVSFTELALGSTLSVPTLDGTVGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVA
ECCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEE
VPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPGNPAAGERFKAVSEAHN
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
VLSDPAKRKEYDETRRLFAGGGFGGRRFDSGFGGGFGGFGVGGDGAEFNLNDLFDAASRT
HHCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVEAAKGVAMPLRLTSPAPCTNC
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCC
HGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTDCRGSGSIIEHPCEECKGTGVTT
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEE
RTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVAVHVRPDKIFGRDGDDLTVTV
EEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEECHHHCCCCCCCEEEEE
PVSFTELALGSTLSVPTLDGTVGVRVPKGTADGRILRVRGRGVPKRSGGSGDLLVTVKVA
ECCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEE
VPPNLAGAAQEALEAYAAAERSSGFNPRAGWAGNR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]