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The map label for this gene is kefC [H]

Identifier: 120613413

GI number: 120613413

Start: 5339130

End: 5341115

Strand: Direct

Name: kefC [H]

Synonym: Aave_4786

Alternate gene names: 120613413

Gene position: 5339130-5341115 (Clockwise)

Preceding gene: 120613408

Following gene: 120613414

Centisome position: 99.75

GC content: 70.29

Gene sequence:

>1986_bases
ATGTCCTCCCTCGCCTTGACGCTGCTCTACCTGCTGGCCGCCGTGCTGGGCGTGGTGGCCTGCCGCAGCCTCAAGCTGCC
GCCGATGCTCGGCTACCTGGCCGCGGGCATCCTGATCGGCCCGCACGCGCTCGCGCTCACCCAGAACTCCGAGGGAGTGC
GCCACCTGGGGGAGTTCGGGGTGGTGTTCCTGATGTTTTCCATCGGCCTGGAGTTCAGCCTGTCGAAGCTGCGCGCCATG
CGGCGGTTCGTGTTCGGGCTGGGCCTGCTGCAGGTGGCGCTCACCCTCACCGCCGGCATGGTGGGGATGCTGCTGCTGTC
GCATTTCGCGGGCGGGCTGTGGCGCATGGGCTGGCAGACCGCGCTGGCGCTCGGCGGCACCCTGGTCATGAGCAGCACGG
CCATCGTGGTCAAGCTGATGAGCGAGCGCGCCGAGCTGGAAAGCGAGCACGGCCGCCGCGTACTGGGCGTGCTCCTGTTC
CAGGATCTGGCCGTGGTGCCCCTGCTGGTCCTCATTCCCGCCCTGGGCTCCTCGCCCGAACGGCTGCTGGTGGCGCTCGG
GCTCGCCCTGCTGAAGGCCACCGTGCTCGTGGGCGTCCTGCTGGTGGGAGGCCAGCGCGTGATGCGCTGGTGGCTCACCC
TGGTGGCGCGGCGCAAGAGCGACGAACTCTTCATGCTGAACCTGCTGCTCATCACGCTGGGCCTCGCCTGGCTGACCGAG
GCGGCCGGGCTGTCCCTGGCGCTGGGCGCCTTCATCGCGGGCGTGCTGGTGTCCGAGACGGAATACCGGCACCAGGTGGG
CACGGACATCCGTCCCTTCCACGACGTGCTCCTCGGGCTCTTCTTCATCACCGTGGGCATGATGCTGGACTGGCACATCC
TGCTGGAACGCTGGGCGCTGGTGCTGGTGCTGCTGACAGTGCCCCTGCTGCTCAAGGCCGGCGTCATCCTGCTGCTGGCG
CGCGGCATGGGCGCCACCACGGGCGTCTCGCTGCGCACCGGCCTCTACCTCGCGCAGGCCGGCGAGTTCGGCTTCGTGCT
GCTCTCTCTCACGCAGGAGCACGGCCTGGTCGAGCCAGCGCTCATGAACCCCGTGCTGGCCGCGATGGTGCTGTCCATGC
TGGCGACGCCTTTCCTGATCCAGTACAGCAACCCGATCGTGATGAAGCTGGTGGCCAGCGACTGGCTGCAGCAGTCGCTG
CAGATGACCACCATCGCGCGCAAGGCGATCAACACCAGCGGCCACGTGCTCATCTGCGGCTACGGCCGCTGCGGCCAGAA
CCTCGCCCGCATGCTGGAGCGCGAGCACATCCCCTACATGGCGCTGGACCTCGACCCCGATCGCGTCCGGCAGGCGGCCG
CCGCGGGCGACTCCGTGGTGTATGGCGACGCCACGCGGCTGCAGGCGCTGATGGCCGCCGGCCTGGTGCGGGCCAGCGCC
GTGGCGGTGACCTACCTCGACATTCCAGCCACCCTCAAGGTGCTGGCCAACACCCGGGCGCATGCGCCCCAGGTGCCCGT
CGTGGTCCGCACGCAGGACGACCTGTACCTCGACAAGCTGCAGGCGGCCGGCGCCACCGAAGTCGTGCCCGAGGCCATCG
AAGGCTCGCTCATGCTCGCGAGCCATGCGCTGGCCCTGGTGGGCGTGCCCATGCGGCGGGTGCTGCGGCTGGTACAGGAC
CAGCGCGAAGCCCGCTACAACCTGCTGCGCGGCTACTTCCACGGCGCCGACGACGACACGGCCTCCGAGCGCGACCAGGA
GCGCCTCGCCACGGTGACCCTGCCGCCCGGCGCCGGCACCGTGGGCCGGCCACTGTCTGAACTGCCGCTGCACGCCATGG
GCGTGCGGGCGGTCAACCTGCGCCACAAGGATGGGCGCAGCTCCACCCCCACCGACGACAGCGTGCTCTCCGAAGGCGAT
ACGCTGGTGATCTCCGGCCACCCCACGGCCCTGGCCCTGGCGGAAGACGCGCTGCTGCGCGGCTGA

Upstream 100 bases:

>100_bases
CCGCGGGCCCGAAAGCCCTCCGCGGCCCGCGTCACGGTGCCTCTGGGGCGTCCGGCAGGGAAACCCCCGTGAAACCGCCC
GCGCTCGGCTAGCATCGGGC

Downstream 100 bases:

>100_bases
AGGCCGCCCGGGCCGGCGCGGCCGGGAACGCCCGGCACAGCGGCAGGCTCTAAACTGCCGCCCTTTCCCGCCGCGCGCGC
CGTGGCCCATCCCTTTTCCC

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MSSLALTLLYLLAAVLGVVACRSLKLPPMLGYLAAGILIGPHALALTQNSEGVRHLGEFGVVFLMFSIGLEFSLSKLRAM
RRFVFGLGLLQVALTLTAGMVGMLLLSHFAGGLWRMGWQTALALGGTLVMSSTAIVVKLMSERAELESEHGRRVLGVLLF
QDLAVVPLLVLIPALGSSPERLLVALGLALLKATVLVGVLLVGGQRVMRWWLTLVARRKSDELFMLNLLLITLGLAWLTE
AAGLSLALGAFIAGVLVSETEYRHQVGTDIRPFHDVLLGLFFITVGMMLDWHILLERWALVLVLLTVPLLLKAGVILLLA
RGMGATTGVSLRTGLYLAQAGEFGFVLLSLTQEHGLVEPALMNPVLAAMVLSMLATPFLIQYSNPIVMKLVASDWLQQSL
QMTTIARKAINTSGHVLICGYGRCGQNLARMLEREHIPYMALDLDPDRVRQAAAAGDSVVYGDATRLQALMAAGLVRASA
VAVTYLDIPATLKVLANTRAHAPQVPVVVRTQDDLYLDKLQAAGATEVVPEAIEGSLMLASHALALVGVPMRRVLRLVQD
QREARYNLLRGYFHGADDDTASERDQERLATVTLPPGAGTVGRPLSELPLHAMGVRAVNLRHKDGRSSTPTDDSVLSEGD
TLVISGHPTALALAEDALLRG

Sequences:

>Translated_661_residues
MSSLALTLLYLLAAVLGVVACRSLKLPPMLGYLAAGILIGPHALALTQNSEGVRHLGEFGVVFLMFSIGLEFSLSKLRAM
RRFVFGLGLLQVALTLTAGMVGMLLLSHFAGGLWRMGWQTALALGGTLVMSSTAIVVKLMSERAELESEHGRRVLGVLLF
QDLAVVPLLVLIPALGSSPERLLVALGLALLKATVLVGVLLVGGQRVMRWWLTLVARRKSDELFMLNLLLITLGLAWLTE
AAGLSLALGAFIAGVLVSETEYRHQVGTDIRPFHDVLLGLFFITVGMMLDWHILLERWALVLVLLTVPLLLKAGVILLLA
RGMGATTGVSLRTGLYLAQAGEFGFVLLSLTQEHGLVEPALMNPVLAAMVLSMLATPFLIQYSNPIVMKLVASDWLQQSL
QMTTIARKAINTSGHVLICGYGRCGQNLARMLEREHIPYMALDLDPDRVRQAAAAGDSVVYGDATRLQALMAAGLVRASA
VAVTYLDIPATLKVLANTRAHAPQVPVVVRTQDDLYLDKLQAAGATEVVPEAIEGSLMLASHALALVGVPMRRVLRLVQD
QREARYNLLRGYFHGADDDTASERDQERLATVTLPPGAGTVGRPLSELPLHAMGVRAVNLRHKDGRSSTPTDDSVLSEGD
TLVISGHPTALALAEDALLRG
>Mature_660_residues
SSLALTLLYLLAAVLGVVACRSLKLPPMLGYLAAGILIGPHALALTQNSEGVRHLGEFGVVFLMFSIGLEFSLSKLRAMR
RFVFGLGLLQVALTLTAGMVGMLLLSHFAGGLWRMGWQTALALGGTLVMSSTAIVVKLMSERAELESEHGRRVLGVLLFQ
DLAVVPLLVLIPALGSSPERLLVALGLALLKATVLVGVLLVGGQRVMRWWLTLVARRKSDELFMLNLLLITLGLAWLTEA
AGLSLALGAFIAGVLVSETEYRHQVGTDIRPFHDVLLGLFFITVGMMLDWHILLERWALVLVLLTVPLLLKAGVILLLAR
GMGATTGVSLRTGLYLAQAGEFGFVLLSLTQEHGLVEPALMNPVLAAMVLSMLATPFLIQYSNPIVMKLVASDWLQQSLQ
MTTIARKAINTSGHVLICGYGRCGQNLARMLEREHIPYMALDLDPDRVRQAAAAGDSVVYGDATRLQALMAAGLVRASAV
AVTYLDIPATLKVLANTRAHAPQVPVVVRTQDDLYLDKLQAAGATEVVPEAIEGSLMLASHALALVGVPMRRVLRLVQDQ
REARYNLLRGYFHGADDDTASERDQERLATVTLPPGAGTVGRPLSELPLHAMGVRAVNLRHKDGRSSTPTDDSVLSEGDT
LVISGHPTALALAEDALLRG

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=361, Percent_Identity=30.4709141274238, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1786232, Length=553, Percent_Identity=37.0705244122966, Blast_Score=281, Evalue=1e-76,
Organism=Escherichia coli, GI1789749, Length=545, Percent_Identity=36.1467889908257, Blast_Score=262, Evalue=5e-71,
Organism=Escherichia coli, GI1786685, Length=529, Percent_Identity=29.8676748582231, Blast_Score=201, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 70993; Mature: 70862

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLALTLLYLLAAVLGVVACRSLKLPPMLGYLAAGILIGPHALALTQNSEGVRHLGEFG
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
VVFLMFSIGLEFSLSKLRAMRRFVFGLGLLQVALTLTAGMVGMLLLSHFAGGLWRMGWQT
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ALALGGTLVMSSTAIVVKLMSERAELESEHGRRVLGVLLFQDLAVVPLLVLIPALGSSPE
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RLLVALGLALLKATVLVGVLLVGGQRVMRWWLTLVARRKSDELFMLNLLLITLGLAWLTE
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AAGLSLALGAFIAGVLVSETEYRHQVGTDIRPFHDVLLGLFFITVGMMLDWHILLERWAL
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLVLLTVPLLLKAGVILLLARGMGATTGVSLRTGLYLAQAGEFGFVLLSLTQEHGLVEPA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCCEEEEEEHHHCCCCCHH
LMNPVLAAMVLSMLATPFLIQYSNPIVMKLVASDWLQQSLQMTTIARKAINTSGHVLICG
HHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
YGRCGQNLARMLEREHIPYMALDLDPDRVRQAAAAGDSVVYGDATRLQALMAAGLVRASA
CCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHH
VAVTYLDIPATLKVLANTRAHAPQVPVVVRTQDDLYLDKLQAAGATEVVPEAIEGSLMLA
HEEEEECCHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHCCCHHHH
SHALALVGVPMRRVLRLVQDQREARYNLLRGYFHGADDDTASERDQERLATVTLPPGAGT
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEEEECCCCCC
VGRPLSELPLHAMGVRAVNLRHKDGRSSTPTDDSVLSEGDTLVISGHPTALALAEDALLR
CCCCHHHCCHHHHCEEEEEEECCCCCCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHC
G
C
>Mature Secondary Structure 
SSLALTLLYLLAAVLGVVACRSLKLPPMLGYLAAGILIGPHALALTQNSEGVRHLGEFG
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
VVFLMFSIGLEFSLSKLRAMRRFVFGLGLLQVALTLTAGMVGMLLLSHFAGGLWRMGWQT
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ALALGGTLVMSSTAIVVKLMSERAELESEHGRRVLGVLLFQDLAVVPLLVLIPALGSSPE
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RLLVALGLALLKATVLVGVLLVGGQRVMRWWLTLVARRKSDELFMLNLLLITLGLAWLTE
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AAGLSLALGAFIAGVLVSETEYRHQVGTDIRPFHDVLLGLFFITVGMMLDWHILLERWAL
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLVLLTVPLLLKAGVILLLARGMGATTGVSLRTGLYLAQAGEFGFVLLSLTQEHGLVEPA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCCEEEEEEHHHCCCCCHH
LMNPVLAAMVLSMLATPFLIQYSNPIVMKLVASDWLQQSLQMTTIARKAINTSGHVLICG
HHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
YGRCGQNLARMLEREHIPYMALDLDPDRVRQAAAAGDSVVYGDATRLQALMAAGLVRASA
CCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHH
VAVTYLDIPATLKVLANTRAHAPQVPVVVRTQDDLYLDKLQAAGATEVVPEAIEGSLMLA
HEEEEECCHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHCCCHHHH
SHALALVGVPMRRVLRLVQDQREARYNLLRGYFHGADDDTASERDQERLATVTLPPGAGT
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEEEECCCCCC
VGRPLSELPLHAMGVRAVNLRHKDGRSSTPTDDSVLSEGDTLVISGHPTALALAEDALLR
CCCCHHHCCHHHHCEEEEEEECCCCCCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA