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The map label for this gene is lrp [H]

Identifier: 120613278

GI number: 120613278

Start: 5174977

End: 5175453

Strand: Direct

Name: lrp [H]

Synonym: Aave_4647

Alternate gene names: 120613278

Gene position: 5174977-5175453 (Clockwise)

Preceding gene: 120613272

Following gene: 120613279

Centisome position: 96.68

GC content: 66.88

Gene sequence:

>477_bases
ATGGAAGAACTCGACAAATTCGACATCGCCATCCTCGCGGAACTGCAGGCCGATGCACGGCTGACGAACGCCGAGCTGGC
GCAGCGCGTGGGCCTCTCCGCCGCCCCGTGCTGGCGACGCGTGCGGGCCCTGGAAGAGGCGGGCTTCATCAAGGGCTACC
ACGCGGAGATCGATCGCCACCGGATCGGCCTGGGCGTGCTGGCCTTCGTGCGGCTGGATGCCGACCGCAGCACCGGCGGC
CTCACGCGCGAGATGGAAGAGGCCATCGCCAAGATCCCGGAAGTGGTCGCCTGCCACTACATCAGCGGCACCGGGACGTT
CGAGTTGCAGGTGGTGGCGCGCGACCTGGAGAGCTTTTCGCAATTTGCGCGCGGCGTGCTGCTGAACCTGCCCAACGTGA
AGGACATGCACACGAGCTTTTCGCTGGGGGAGGTGAAGGCGGGAGGGGCGCTGCCGCTGGCGCATTTGCAGCGATGA

Upstream 100 bases:

>100_bases
TTTGCATGCCAGTGTAGGCACGACCGAAGGATATGTCCTTTCGTTTTCATGCCGTGTTTACCCTCGTTTCAGAAAGATCC
TTTCTGAAAACAATAAAGGA

Downstream 100 bases:

>100_bases
CGATGAATTCGAGTAACTGCCTCAAGGCTATGCACCCTTTCTGGAAAGTCATCTGGACAGCAGGCAGTGTGGCCTGCGTG
ACCGCCATCGCTACCGGCCA

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MEELDKFDIAILAELQADARLTNAELAQRVGLSAAPCWRRVRALEEAGFIKGYHAEIDRHRIGLGVLAFVRLDADRSTGG
LTREMEEAIAKIPEVVACHYISGTGTFELQVVARDLESFSQFARGVLLNLPNVKDMHTSFSLGEVKAGGALPLAHLQR

Sequences:

>Translated_158_residues
MEELDKFDIAILAELQADARLTNAELAQRVGLSAAPCWRRVRALEEAGFIKGYHAEIDRHRIGLGVLAFVRLDADRSTGG
LTREMEEAIAKIPEVVACHYISGTGTFELQVVARDLESFSQFARGVLLNLPNVKDMHTSFSLGEVKAGGALPLAHLQR
>Mature_158_residues
MEELDKFDIAILAELQADARLTNAELAQRVGLSAAPCWRRVRALEEAGFIKGYHAEIDRHRIGLGVLAFVRLDADRSTGG
LTREMEEAIAKIPEVVACHYISGTGTFELQVVARDLESFSQFARGVLLNLPNVKDMHTSFSLGEVKAGGALPLAHLQR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=150, Percent_Identity=37.3333333333333, Blast_Score=113, Evalue=5e-27,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=30, Blast_Score=94, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17327; Mature: 17327

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELDKFDIAILAELQADARLTNAELAQRVGLSAAPCWRRVRALEEAGFIKGYHAEIDRH
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
RIGLGVLAFVRLDADRSTGGLTREMEEAIAKIPEVVACHYISGTGTFELQVVARDLESFS
HHHHHHHEEEEECCCCCCCCCHHHHHHHHHHCHHHHHHEEECCCCCEEEHHHHHHHHHHH
QFARGVLLNLPNVKDMHTSFSLGEVKAGGALPLAHLQR
HHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCHHHHCC
>Mature Secondary Structure
MEELDKFDIAILAELQADARLTNAELAQRVGLSAAPCWRRVRALEEAGFIKGYHAEIDRH
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
RIGLGVLAFVRLDADRSTGGLTREMEEAIAKIPEVVACHYISGTGTFELQVVARDLESFS
HHHHHHHEEEEECCCCCCCCCHHHHHHHHHHCHHHHHHEEECCCCCEEEHHHHHHHHHHH
QFARGVLLNLPNVKDMHTSFSLGEVKAGGALPLAHLQR
HHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]