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The map label for this gene is gapA [H]

Identifier: 120613221

GI number: 120613221

Start: 5106866

End: 5107867

Strand: Direct

Name: gapA [H]

Synonym: Aave_4588

Alternate gene names: 120613221

Gene position: 5106866-5107867 (Clockwise)

Preceding gene: 120613220

Following gene: 120613223

Centisome position: 95.41

GC content: 64.67

Gene sequence:

>1002_bases
ATGACCATCAAGATCGGTATCAACGGCTTCGGCCGCATCGGCCGCAACGTGCTGCGCTCGGCCGTGCAGAACTTCAGCGA
CATCGAAGTCGTGGGCATCAACGACCTGCTGGAGCCCGACTACCTGGCCTACATGCTGCAGTACGACTCGGTGCACGGCC
GCTTCGAGGGCACCGTGTCGGTCGAGGGCAATACGCTGGTGGTGAACGGCAAGAAGATCCGCCTGACGCAGGAACGCGAT
CCGGCCAACCTGAAGTGGGGCGAGATCGGCGCCGAGGTGGTGATCGAGTCCACGGGTCTGTTCCTCGACAAGACGACGGC
CCAGAAGCACCTGGACGCGGGCGCGAAGAAGGTCGTGCTGTCGGCGCCTTCCAAGGACGACACGCCGATGTTCGTCTATG
GCGTGAACCACGACACGTACGCCGGCCAGGCCATCATCTCCAACGCCTCGTGCACCACGAACTGCCTGGCCCCCGTGGCC
AAGGTGCTCAACGACAAGTGGGGCATCAAGCGCGGCCTGATGACCACGGTGCACGCCGCCACGGCCACGCAGAAGACGGT
GGACGGCCCCTCCAACAAGGACTGGCGCGGCGGCCGCGGCATCCTGGAGAACATCATCCCCTCCTCCACCGGCGCCGCCA
AGGCCGTGGGCGTGGTGATTCCCGCGCTGAACAAGAAGCTGACCGGCATGTCCTTCCGCGTGCCCACCTCCGACGTGTCG
GTGGTGGACCTGACGGTGGAGCTGGAGAAGGCCGCCACGTACGAAGAGATCAAGGCCGAGATGAAGGCCCAGTCCGAAGG
CGCACTGAAGGGCGTGCTGGGCTACACGGAAGACAAGGTGGTCGCCACCGACTTCCGCGGTGACGCACGCACCTCCATCT
TCGACGCCGATGCCGGCATCGCGCTGGACGGCACCTTCGTGAAGGTCGTCTCCTGGTACGACAACGAGTGGGGTTACTCC
AACAAGTGCCTGGAAATGGTGCGCGTGGTCGCGGGCAAGTAA

Upstream 100 bases:

>100_bases
ACCGGAAAGAATACGACTGAGCTTCATCCCTCCTGCAGAAATACATCACCGCGGAATTCATTGTTTCCATCCTTTCTTTC
ACTTCCATAAAGGACTACCC

Downstream 100 bases:

>100_bases
GCCGCTACCCATGCCGGGCCGCCGCGAGGCGGTTCAGGCGCGATCGAAGCCCGGGGCCTGCGGCCGCCGGGCTTTTTCAT
GGGCGCTCGTGCCCGCCGCC

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MTIKIGINGFGRIGRNVLRSAVQNFSDIEVVGINDLLEPDYLAYMLQYDSVHGRFEGTVSVEGNTLVVNGKKIRLTQERD
PANLKWGEIGAEVVIESTGLFLDKTTAQKHLDAGAKKVVLSAPSKDDTPMFVYGVNHDTYAGQAIISNASCTTNCLAPVA
KVLNDKWGIKRGLMTTVHAATATQKTVDGPSNKDWRGGRGILENIIPSSTGAAKAVGVVIPALNKKLTGMSFRVPTSDVS
VVDLTVELEKAATYEEIKAEMKAQSEGALKGVLGYTEDKVVATDFRGDARTSIFDADAGIALDGTFVKVVSWYDNEWGYS
NKCLEMVRVVAGK

Sequences:

>Translated_333_residues
MTIKIGINGFGRIGRNVLRSAVQNFSDIEVVGINDLLEPDYLAYMLQYDSVHGRFEGTVSVEGNTLVVNGKKIRLTQERD
PANLKWGEIGAEVVIESTGLFLDKTTAQKHLDAGAKKVVLSAPSKDDTPMFVYGVNHDTYAGQAIISNASCTTNCLAPVA
KVLNDKWGIKRGLMTTVHAATATQKTVDGPSNKDWRGGRGILENIIPSSTGAAKAVGVVIPALNKKLTGMSFRVPTSDVS
VVDLTVELEKAATYEEIKAEMKAQSEGALKGVLGYTEDKVVATDFRGDARTSIFDADAGIALDGTFVKVVSWYDNEWGYS
NKCLEMVRVVAGK
>Mature_332_residues
TIKIGINGFGRIGRNVLRSAVQNFSDIEVVGINDLLEPDYLAYMLQYDSVHGRFEGTVSVEGNTLVVNGKKIRLTQERDP
ANLKWGEIGAEVVIESTGLFLDKTTAQKHLDAGAKKVVLSAPSKDDTPMFVYGVNHDTYAGQAIISNASCTTNCLAPVAK
VLNDKWGIKRGLMTTVHAATATQKTVDGPSNKDWRGGRGILENIIPSSTGAAKAVGVVIPALNKKLTGMSFRVPTSDVSV
VDLTVELEKAATYEEIKAEMKAQSEGALKGVLGYTEDKVVATDFRGDARTSIFDADAGIALDGTFVKVVSWYDNEWGYSN
KCLEMVRVVAGK

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=333, Percent_Identity=61.2612612612613, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI7657116, Length=329, Percent_Identity=55.6231003039514, Blast_Score=383, Evalue=1e-106,
Organism=Escherichia coli, GI1788079, Length=327, Percent_Identity=73.0886850152905, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1789295, Length=329, Percent_Identity=38.2978723404255, Blast_Score=249, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI32566163, Length=337, Percent_Identity=61.4243323442137, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17568413, Length=337, Percent_Identity=61.4243323442137, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17534677, Length=337, Percent_Identity=58.7537091988131, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17534679, Length=337, Percent_Identity=58.7537091988131, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6322409, Length=331, Percent_Identity=64.0483383685801, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321631, Length=331, Percent_Identity=62.8398791540785, Blast_Score=418, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6322468, Length=331, Percent_Identity=62.5377643504532, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI85725000, Length=332, Percent_Identity=61.144578313253, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI22023983, Length=332, Percent_Identity=61.144578313253, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI17933600, Length=332, Percent_Identity=60.5421686746988, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI18110149, Length=332, Percent_Identity=60.5421686746988, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI19922412, Length=325, Percent_Identity=60.6153846153846, Blast_Score=388, Evalue=1e-108,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 35852; Mature: 35721

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKIGINGFGRIGRNVLRSAVQNFSDIEVVGINDLLEPDYLAYMLQYDSVHGRFEGTVS
CEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHEEEEEECCCCCEEEEEEE
VEGNTLVVNGKKIRLTQERDPANLKWGEIGAEVVIESTGLFLDKTTAQKHLDAGAKKVVL
ECCCEEEEECEEEEEECCCCCCCCCHHCCCCEEEEEECCCEEECCHHHHHHCCCCCEEEE
SAPSKDDTPMFVYGVNHDTYAGQAIISNASCTTNCLAPVAKVLNDKWGIKRGLMTTVHAA
ECCCCCCCCEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TATQKTVDGPSNKDWRGGRGILENIIPSSTGAAKAVGVVIPALNKKLTGMSFRVPTSDVS
HHCHHCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHEEEEECCCCCCCCCEEECCCCCCE
VVDLTVELEKAATYEEIKAEMKAQSEGALKGVLGYTEDKVVATDFRGDARTSIFDADAGI
EEEEEEEECHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEECCCCCCCEEEECCCCE
ALDGTFVKVVSWYDNEWGYSNKCLEMVRVVAGK
EECCEEEEEEEEECCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TIKIGINGFGRIGRNVLRSAVQNFSDIEVVGINDLLEPDYLAYMLQYDSVHGRFEGTVS
EEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHEEEEEECCCCCEEEEEEE
VEGNTLVVNGKKIRLTQERDPANLKWGEIGAEVVIESTGLFLDKTTAQKHLDAGAKKVVL
ECCCEEEEECEEEEEECCCCCCCCCHHCCCCEEEEEECCCEEECCHHHHHHCCCCCEEEE
SAPSKDDTPMFVYGVNHDTYAGQAIISNASCTTNCLAPVAKVLNDKWGIKRGLMTTVHAA
ECCCCCCCCEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TATQKTVDGPSNKDWRGGRGILENIIPSSTGAAKAVGVVIPALNKKLTGMSFRVPTSDVS
HHCHHCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHEEEEECCCCCCCCCEEECCCCCCE
VVDLTVELEKAATYEEIKAEMKAQSEGALKGVLGYTEDKVVATDFRGDARTSIFDADAGI
EEEEEEEECHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEECCCCCCCEEEECCCCE
ALDGTFVKVVSWYDNEWGYSNKCLEMVRVVAGK
EECCEEEEEEEEECCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852; 8366033 [H]