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The map label for this gene is lrhA [H]

Identifier: 120613223

GI number: 120613223

Start: 5109381

End: 5110337

Strand: Direct

Name: lrhA [H]

Synonym: Aave_4590

Alternate gene names: 120613223

Gene position: 5109381-5110337 (Clockwise)

Preceding gene: 120613221

Following gene: 120613224

Centisome position: 95.45

GC content: 72.94

Gene sequence:

>957_bases
ATGGCCCGCACCCTCTACGACCTCGACGTGCTGCGCACCTTCACCACCGGCGTGGCACTCGGAAGCTTCGTGCGCGCCGC
GGACAGGCTGGGGCGCTCCACTTCGGCGGTGAGCGCGCAATTGAAGAAGCTGGAATCGCAGGCGGGCACGCCCCTGCTGC
GCAAGTCCGGCCGCGGCCTGGTGCTCACCGAGGCCGGCGAAATCCTGCTGGCCTATGCCCGCCGCCTGCTCGACCTGAAC
GACGAAGCCGCCGCCGCCGTGAGCGGCAGCCCGCTGCACGGGCTGGTCCGCCTGGGCCTGCAGGAAGATCTGGGTGAGAC
GCTGCTGCCCGGGGTGCTGGGGCGTTTCGCGCGGGCGCATCCGCAGGTGCGTATCGAGGTCTGCGCGGCCCGCAGCACCG
AACTGCGCGAGCGGTTCGCCGTGGGCCAGCTGGACCTGGCACTGCTTTGGGATGCGGGCATCGATCTGTCGTGCATGCGG
GCCGAGCGGATCATTCGCCAGCCCCTGCACTGGATCGGCCCGGCCGGCGCGGACACGCTGGACGAAGCCCCCTGGTGGCA
GGGCCGGCATGCGCTCACGCCATCGAGCCGGCCGCCGCTGCCGCTGGTGCTGCTCGAAGACCCCTGCCCCCTGCGGCGCA
TCGTCACGACCGCGCTGGATCACGCGGGCCTGCCCTGGCGCCACGCCTTCCACAGCAGCAGCCTGGGCGCGATGTGGGCG
GCGACGGCGGCGGGGCTGGGGCTTTCCGTGCGCACGTCCTTCGGCCTTCCGGCGCACGTCAGGCCCCTGTCGGCCTCGGC
CTGCGGACTGCCCGAGCTCCCGTCCATGGAGCTGGTGCTGGGACGCGCCCGGGACCCGCTGGATGCCGCCTCGGAGCGGC
TGGCCGCGTTGCTGCTGGATGCCGTGCGGGAGCACATGGGCTTTTCCGGCAAGGGCGGCATCGTGCCGGCCGCCTGA

Upstream 100 bases:

>100_bases
ATGCGGCGCAGTGTCCGCGCCCGCGACCATTCTGAAAATCAGAAAATAATGGCGCCATCATCCTGATTTTCAGGACGGTT
CCACCCAGGAAGCCCACATC

Downstream 100 bases:

>100_bases
CGTTCCGGCGACCGGGCCTGTAACCGTAAGAAACGGCCCACGGCGCCTGCTGCGCTGCACCTACGCGGCCGGCCGGGGCG
GCTGCCAACAATCGGAAACC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MARTLYDLDVLRTFTTGVALGSFVRAADRLGRSTSAVSAQLKKLESQAGTPLLRKSGRGLVLTEAGEILLAYARRLLDLN
DEAAAAVSGSPLHGLVRLGLQEDLGETLLPGVLGRFARAHPQVRIEVCAARSTELRERFAVGQLDLALLWDAGIDLSCMR
AERIIRQPLHWIGPAGADTLDEAPWWQGRHALTPSSRPPLPLVLLEDPCPLRRIVTTALDHAGLPWRHAFHSSSLGAMWA
ATAAGLGLSVRTSFGLPAHVRPLSASACGLPELPSMELVLGRARDPLDAASERLAALLLDAVREHMGFSGKGGIVPAA

Sequences:

>Translated_318_residues
MARTLYDLDVLRTFTTGVALGSFVRAADRLGRSTSAVSAQLKKLESQAGTPLLRKSGRGLVLTEAGEILLAYARRLLDLN
DEAAAAVSGSPLHGLVRLGLQEDLGETLLPGVLGRFARAHPQVRIEVCAARSTELRERFAVGQLDLALLWDAGIDLSCMR
AERIIRQPLHWIGPAGADTLDEAPWWQGRHALTPSSRPPLPLVLLEDPCPLRRIVTTALDHAGLPWRHAFHSSSLGAMWA
ATAAGLGLSVRTSFGLPAHVRPLSASACGLPELPSMELVLGRARDPLDAASERLAALLLDAVREHMGFSGKGGIVPAA
>Mature_317_residues
ARTLYDLDVLRTFTTGVALGSFVRAADRLGRSTSAVSAQLKKLESQAGTPLLRKSGRGLVLTEAGEILLAYARRLLDLND
EAAAAVSGSPLHGLVRLGLQEDLGETLLPGVLGRFARAHPQVRIEVCAARSTELRERFAVGQLDLALLWDAGIDLSCMRA
ERIIRQPLHWIGPAGADTLDEAPWWQGRHALTPSSRPPLPLVLLEDPCPLRRIVTTALDHAGLPWRHAFHSSSLGAMWAA
TAAGLGLSVRTSFGLPAHVRPLSASACGLPELPSMELVLGRARDPLDAASERLAALLLDAVREHMGFSGKGGIVPAA

Specific function: Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788626, Length=299, Percent_Identity=34.1137123745819, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1787806, Length=170, Percent_Identity=28.2352941176471, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788748, Length=258, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790399, Length=252, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI48994962, Length=143, Percent_Identity=32.8671328671329, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788481, Length=201, Percent_Identity=28.8557213930348, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1790208, Length=144, Percent_Identity=30.5555555555556, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33940; Mature: 33808

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTLYDLDVLRTFTTGVALGSFVRAADRLGRSTSAVSAQLKKLESQAGTPLLRKSGRGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHCCCEE
VLTEAGEILLAYARRLLDLNDEAAAAVSGSPLHGLVRLGLQEDLGETLLPGVLGRFARAH
EEECCHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PQVRIEVCAARSTELRERFAVGQLDLALLWDAGIDLSCMRAERIIRQPLHWIGPAGADTL
CCEEEEEECCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
DEAPWWQGRHALTPSSRPPLPLVLLEDPCPLRRIVTTALDHAGLPWRHAFHSSSLGAMWA
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHCCCCCHHHHH
ATAAGLGLSVRTSFGLPAHVRPLSASACGLPELPSMELVLGRARDPLDAASERLAALLLD
HHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHH
AVREHMGFSGKGGIVPAA
HHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
ARTLYDLDVLRTFTTGVALGSFVRAADRLGRSTSAVSAQLKKLESQAGTPLLRKSGRGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHCCCEE
VLTEAGEILLAYARRLLDLNDEAAAAVSGSPLHGLVRLGLQEDLGETLLPGVLGRFARAH
EEECCHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PQVRIEVCAARSTELRERFAVGQLDLALLWDAGIDLSCMRAERIIRQPLHWIGPAGADTL
CCEEEEEECCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
DEAPWWQGRHALTPSSRPPLPLVLLEDPCPLRRIVTTALDHAGLPWRHAFHSSSLGAMWA
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHCCCCCHHHHH
ATAAGLGLSVRTSFGLPAHVRPLSASACGLPELPSMELVLGRARDPLDAASERLAALLLD
HHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHH
AVREHMGFSGKGGIVPAA
HHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]