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The map label for this gene is purK [H]

Identifier: 120613196

GI number: 120613196

Start: 5079932

End: 5081110

Strand: Direct

Name: purK [H]

Synonym: Aave_4563

Alternate gene names: 120613196

Gene position: 5079932-5081110 (Clockwise)

Preceding gene: 120613195

Following gene: 120613197

Centisome position: 94.9

GC content: 73.03

Gene sequence:

>1179_bases
ATGACGATGCCCGGCTCCTCGCAGCACCCCATCCTTCCCGGCGCCACCCTCGGCGTGCTGGGCGGCGGCCAGCTGGGCCG
CATGTTCGCCCATGCCGCCCAGGCCATGGGCTACTTCACGGCGGTCCTGGATCCCGACGCCGAAAGCCCCGCCGGCCGCA
TCAGCCACCACCACATCCGTACGGCCTACGAGGATCCGGATGGATTGGCGCGCCTGGCCGCCCTGTCGGACGCCGTCACC
ACGGAGTTCGAGAACGTGCCCGCGCAGGCGCTGCGCATGCTCGGCGCCGAGCGCCCCGTGGCACCTGCGGCCGACGCCGT
GGCGATCGCCCAGGACCGCGCTCGGGAGAAGGCGCATTTCGTGGCCTGCGGCGTGCCGTGCGCGCCCTATGCCGTGATCG
AGACGCCGGGGCAGCTGGAAGCCGTGCCGGCCGGGCTGCTGCCGGGCATTCTCAAGACCGCCCGGCTCGGCTACGACGGC
AAGGGCCAGGCCCGTGTGGCCACCGCCGGGGAACTCGCATCCGCGTGGGAGGCGATGGGCCGCGTGCCCTGCGTGCTTGA
AAAGCGCCTGCCGCTGGCTTTCGAGTGCTCGGTGATCGTGGCGCGCGGCCACGACGGCGCGTGCGTGCACCTGCCGGTGC
AGCGCAACCTGCACCGCGACGGCATCCTGGCGGTGACCGAGGTGCACGCAGGCAACGTGCCGGAGCCGGTCGCGCGGCAG
GCCATCGCCGCGGCCCGGTCCGTCGCGGAGGGGCTGGGCTATACGGGCGTGCTGTGCGTGGAATTCTTCGTTCTCGAAGA
CGGCTCCCTGGTGGTCAACGAGATCGCTCCGCGCCCCCACAACAGCGGCCACTACAGCCAGAACGCCTGCGACGTTTCGC
AGTTCGAGCTGCAGGTGCGGGCCATGGCGCGGCTGCCGCTGACGCCTCCGCGCCAGCACAGCGCCGCCGTGATGCTGAAC
CTGCTGGGCGATCTCTGGTTCGCCCGCGGAGCGGCGGCCAGCGCGCCGGACTGGGCCGCCGTGCTGGCCCTGCCGGGCAC
CCACCTGCACCTGTACGGCAAGGCCGAGGCCAAGCCGGGCCGCAAGATGGGCCACCTGAACGTCACCGCGCCCACCGCGG
AAGCCGCACGCGCCACGGCGCTGCAGGCCGCCGCGCTGCTGGGCATCGCCGCGTTCTGA

Upstream 100 bases:

>100_bases
TGCTGGCTAACGAGAACCCGGCCCTGCGCGAGCGGCTGGAGGCATTCCGCCAGGAGCAGACCGCGGCGGCTCGCGGGATG
GCGCTTCCGACCGAAGCGGC

Downstream 100 bases:

>100_bases
GGCCACCGCCATGATCCTCGACGGCCGGCTCCCCTCTTCCATCGATGCGGCGGCCCGGGCGCTGCGGGCCGGCAGGCTGC
TGGGCCTGCCCACGGAAACC

Product: phosphoribosylaminoimidazole carboxylase ATPase

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTMPGSSQHPILPGATLGVLGGGQLGRMFAHAAQAMGYFTAVLDPDAESPAGRISHHHIRTAYEDPDGLARLAALSDAVT
TEFENVPAQALRMLGAERPVAPAADAVAIAQDRAREKAHFVACGVPCAPYAVIETPGQLEAVPAGLLPGILKTARLGYDG
KGQARVATAGELASAWEAMGRVPCVLEKRLPLAFECSVIVARGHDGACVHLPVQRNLHRDGILAVTEVHAGNVPEPVARQ
AIAAARSVAEGLGYTGVLCVEFFVLEDGSLVVNEIAPRPHNSGHYSQNACDVSQFELQVRAMARLPLTPPRQHSAAVMLN
LLGDLWFARGAAASAPDWAAVLALPGTHLHLYGKAEAKPGRKMGHLNVTAPTAEAARATALQAAALLGIAAF

Sequences:

>Translated_392_residues
MTMPGSSQHPILPGATLGVLGGGQLGRMFAHAAQAMGYFTAVLDPDAESPAGRISHHHIRTAYEDPDGLARLAALSDAVT
TEFENVPAQALRMLGAERPVAPAADAVAIAQDRAREKAHFVACGVPCAPYAVIETPGQLEAVPAGLLPGILKTARLGYDG
KGQARVATAGELASAWEAMGRVPCVLEKRLPLAFECSVIVARGHDGACVHLPVQRNLHRDGILAVTEVHAGNVPEPVARQ
AIAAARSVAEGLGYTGVLCVEFFVLEDGSLVVNEIAPRPHNSGHYSQNACDVSQFELQVRAMARLPLTPPRQHSAAVMLN
LLGDLWFARGAAASAPDWAAVLALPGTHLHLYGKAEAKPGRKMGHLNVTAPTAEAARATALQAAALLGIAAF
>Mature_391_residues
TMPGSSQHPILPGATLGVLGGGQLGRMFAHAAQAMGYFTAVLDPDAESPAGRISHHHIRTAYEDPDGLARLAALSDAVTT
EFENVPAQALRMLGAERPVAPAADAVAIAQDRAREKAHFVACGVPCAPYAVIETPGQLEAVPAGLLPGILKTARLGYDGK
GQARVATAGELASAWEAMGRVPCVLEKRLPLAFECSVIVARGHDGACVHLPVQRNLHRDGILAVTEVHAGNVPEPVARQA
IAAARSVAEGLGYTGVLCVEFFVLEDGSLVVNEIAPRPHNSGHYSQNACDVSQFELQVRAMARLPLTPPRQHSAAVMLNL
LGDLWFARGAAASAPDWAAVLALPGTHLHLYGKAEAKPGRKMGHLNVTAPTAEAARATALQAAALLGIAAF

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=364, Percent_Identity=36.2637362637363, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1788155, Length=396, Percent_Identity=28.2828282828283, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324702, Length=372, Percent_Identity=33.3333333333333, Blast_Score=210, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40889; Mature: 40758

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPGSSQHPILPGATLGVLGGGQLGRMFAHAAQAMGYFTAVLDPDAESPAGRISHHHIR
CCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHH
TAYEDPDGLARLAALSDAVTTEFENVPAQALRMLGAERPVAPAADAVAIAQDRAREKAHF
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEE
VACGVPCAPYAVIETPGQLEAVPAGLLPGILKTARLGYDGKGQARVATAGELASAWEAMG
EEECCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHC
RVPCVLEKRLPLAFECSVIVARGHDGACVHLPVQRNLHRDGILAVTEVHAGNVPEPVARQ
CCCEEHHCCCCEEEEEEEEEEECCCCCEEEECHHCCCCCCCCEEEEEECCCCCCCHHHHH
AIAAARSVAEGLGYTGVLCVEFFVLEDGSLVVNEIAPRPHNSGHYSQNACDVSQFELQVR
HHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
AMARLPLTPPRQHSAAVMLNLLGDLWFARGAAASAPDWAAVLALPGTHLHLYGKAEAKPG
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEECCCCCCC
RKMGHLNVTAPTAEAARATALQAAALLGIAAF
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TMPGSSQHPILPGATLGVLGGGQLGRMFAHAAQAMGYFTAVLDPDAESPAGRISHHHIR
CCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHH
TAYEDPDGLARLAALSDAVTTEFENVPAQALRMLGAERPVAPAADAVAIAQDRAREKAHF
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEE
VACGVPCAPYAVIETPGQLEAVPAGLLPGILKTARLGYDGKGQARVATAGELASAWEAMG
EEECCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHC
RVPCVLEKRLPLAFECSVIVARGHDGACVHLPVQRNLHRDGILAVTEVHAGNVPEPVARQ
CCCEEHHCCCCEEEEEEEEEEECCCCCEEEECHHCCCCCCCCEEEEEECCCCCCCHHHHH
AIAAARSVAEGLGYTGVLCVEFFVLEDGSLVVNEIAPRPHNSGHYSQNACDVSQFELQVR
HHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
AMARLPLTPPRQHSAAVMLNLLGDLWFARGAAASAPDWAAVLALPGTHLHLYGKAEAKPG
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEECCCCCCC
RKMGHLNVTAPTAEAARATALQAAALLGIAAF
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]