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The map label for this gene is purE [H]

Identifier: 120613195

GI number: 120613195

Start: 5079438

End: 5079935

Strand: Direct

Name: purE [H]

Synonym: Aave_4562

Alternate gene names: 120613195

Gene position: 5079438-5079935 (Clockwise)

Preceding gene: 120613192

Following gene: 120613196

Centisome position: 94.89

GC content: 69.08

Gene sequence:

>498_bases
ATGAAACCCATCCAGATCGGCGTGGTCATGGGCTCCAGCAGCGACTGGGAGACCATGCAGCACGCAGTGCAGATTCTCCA
GCAATTCGACATCGCCCACGAAGCACGCGTGGTCTCGGCGCACCGCATGCCCGACGACATGTTCGCCTATGCCGAGTCGG
CGGCGCAGCGTGGCCTGAAGGCGATCATCGCCGGCGCGGGGGGCGCGGCCCACCTGCCGGGCATGATCGCGGCCAAGACC
ACGGTGCCCGTTCTGGGCGTGCCGGTGGCCAGCCGGCATCTGCAGGGCGTCGATTCGCTGCACAGCATCGTGCAGATGCC
CAAGGGCATTCCCGTGGCCACGTTCGCGATCGGCACGGCCGGCGCGGCCAATGCGGCCCTTTTCGCCGTCGCCCTGCTGG
CTAACGAGAACCCGGCCCTGCGCGAGCGGCTGGAGGCATTCCGCCAGGAGCAGACCGCGGCGGCTCGCGGGATGGCGCTT
CCGACCGAAGCGGCATGA

Upstream 100 bases:

>100_bases
TGTGCAGCAGGCGGAGGCTTGTCCCGCGGACGGGACGCGCCAAAAGTAAAATCCCGGGTTCCACTCAGGCGGGTGCGCGC
GGCGCGCAGCCCCACTCCAC

Downstream 100 bases:

>100_bases
CGATGCCCGGCTCCTCGCAGCACCCCATCCTTCCCGGCGCCACCCTCGGCGTGCTGGGCGGCGGCCAGCTGGGCCGCATG
TTCGCCCATGCCGCCCAGGC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MKPIQIGVVMGSSSDWETMQHAVQILQQFDIAHEARVVSAHRMPDDMFAYAESAAQRGLKAIIAGAGGAAHLPGMIAAKT
TVPVLGVPVASRHLQGVDSLHSIVQMPKGIPVATFAIGTAGAANAALFAVALLANENPALRERLEAFRQEQTAAARGMAL
PTEAA

Sequences:

>Translated_165_residues
MKPIQIGVVMGSSSDWETMQHAVQILQQFDIAHEARVVSAHRMPDDMFAYAESAAQRGLKAIIAGAGGAAHLPGMIAAKT
TVPVLGVPVASRHLQGVDSLHSIVQMPKGIPVATFAIGTAGAANAALFAVALLANENPALRERLEAFRQEQTAAARGMAL
PTEAA
>Mature_165_residues
MKPIQIGVVMGSSSDWETMQHAVQILQQFDIAHEARVVSAHRMPDDMFAYAESAAQRGLKAIIAGAGGAAHLPGMIAAKT
TVPVLGVPVASRHLQGVDSLHSIVQMPKGIPVATFAIGTAGAANAALFAVALLANENPALRERLEAFRQEQTAAARGMAL
PTEAA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=151, Percent_Identity=61.5894039735099, Blast_Score=160, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324702, Length=164, Percent_Identity=51.8292682926829, Blast_Score=156, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17185; Mature: 17185

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIQIGVVMGSSSDWETMQHAVQILQQFDIAHEARVVSAHRMPDDMFAYAESAAQRGLK
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AIIAGAGGAAHLPGMIAAKTTVPVLGVPVASRHLQGVDSLHSIVQMPKGIPVATFAIGTA
HHHCCCCCCHHCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
GAANAALFAVALLANENPALRERLEAFRQEQTAAARGMALPTEAA
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKPIQIGVVMGSSSDWETMQHAVQILQQFDIAHEARVVSAHRMPDDMFAYAESAAQRGLK
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AIIAGAGGAAHLPGMIAAKTTVPVLGVPVASRHLQGVDSLHSIVQMPKGIPVATFAIGTA
HHHCCCCCCHHCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
GAANAALFAVALLANENPALRERLEAFRQEQTAAARGMALPTEAA
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]