Click here to switch to the map view.

The map label for this gene is purC [H]

Identifier: 120613192

GI number: 120613192

Start: 5076614

End: 5077540

Strand: Direct

Name: purC [H]

Synonym: Aave_4559

Alternate gene names: 120613192

Gene position: 5076614-5077540 (Clockwise)

Preceding gene: 120613188

Following gene: 120613195

Centisome position: 94.84

GC content: 69.58

Gene sequence:

>927_bases
ATGACCCTGCCCAGCCCCCCCGCCCTGCACACCTCGTCCCTGGCTTCGCTGCCGCTGCTCGCACGCGGCAAGGTCCGCGA
CAACTACGCCGTGGGCGACGACCGCATCCTCATGGTGGCGAGCGACCGGATCTCGGCGTTCGACGTGATCATGGGCGAGC
CGATCCCGGGCAAGGGCGAGCTGCTGACGAAGATGGCGCTGTTCTGGTTCGACAAGCTCGGCCACCTCTGCCCCAACCAC
CTGACGGGCGGAGCGCCGGAAAGCGTGGTGTCGCCCGAAGAGGCCGCGCAGGTGCGCGGCCGCTCCATGCTCGTGCAGCG
GCTGCGCCCGATTCCCGTGGAGGCCGTGGTGCGCGGCTATCTCGCGGGCAGCGGCTGGAAGGAGTACCAGGCCACGCGCT
CGGTCTGCGGCGTGCAGCTGCCCGAAGGGCTGACGAACGCGTCGCGCCTGCCGCAGCCCATCTACACGCCGGCCGCCAAG
GCCGCCGTGGGCGAGCACGACGAGAACATCACGTTCGAGCGCACCGTGGAGATGGTGGGCATCGACCTCGCCACGAAGAT
CCGCGACACGAGCATCGCGCTGTACGAGGCCGCGGCCGCGATCGCGCTGGAAAAGGGCATGATCATTGCCGACACCAAGT
TCGAGTTCGGCCTGGCTCCCGACGGCACGCTGGTGCTGATGGACGAGGTGCTCACTCCCGACAGCTCGCGCTACTGGCCC
GTGGAAGGCTACGAGGCGGCCCTGGCCGCCGGGGAGAATCCGCCCAGCTACGACAAGCAGTTCGTGCGCGACTGGCTGGA
GCAGGCCCAGGTGAACGGCGCTCCCTGGAACAAGTCCGCTCCCGCGCCGCGCCTGCCCCGAGAGGTGATCGAGAAGACGG
CCGCGAAGTACCGCGAAGCCCTGGAGCGCCTCACTGGCGGCCAGTGA

Upstream 100 bases:

>100_bases
ACAATGCACAGGCTGTACGGCAGGGCGCGCCCTAGAATCCGGGCAGCCCCGGCGCCCTCCCGGCCGGGGCCGGATTACCG
CCTGCAACCCTTTTCACACC

Downstream 100 bases:

>100_bases
ACGGGCCGGGGCCCTGCTCCGTCACTTCAGGCGCAGTTCGGGGGCCTCGAAGCGCAGCAGGACCTTTTCCTTGCCCGGCC
CATCGGCCCGGGCGAGCACA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTLPSPPALHTSSLASLPLLARGKVRDNYAVGDDRILMVASDRISAFDVIMGEPIPGKGELLTKMALFWFDKLGHLCPNH
LTGGAPESVVSPEEAAQVRGRSMLVQRLRPIPVEAVVRGYLAGSGWKEYQATRSVCGVQLPEGLTNASRLPQPIYTPAAK
AAVGEHDENITFERTVEMVGIDLATKIRDTSIALYEAAAAIALEKGMIIADTKFEFGLAPDGTLVLMDEVLTPDSSRYWP
VEGYEAALAAGENPPSYDKQFVRDWLEQAQVNGAPWNKSAPAPRLPREVIEKTAAKYREALERLTGGQ

Sequences:

>Translated_308_residues
MTLPSPPALHTSSLASLPLLARGKVRDNYAVGDDRILMVASDRISAFDVIMGEPIPGKGELLTKMALFWFDKLGHLCPNH
LTGGAPESVVSPEEAAQVRGRSMLVQRLRPIPVEAVVRGYLAGSGWKEYQATRSVCGVQLPEGLTNASRLPQPIYTPAAK
AAVGEHDENITFERTVEMVGIDLATKIRDTSIALYEAAAAIALEKGMIIADTKFEFGLAPDGTLVLMDEVLTPDSSRYWP
VEGYEAALAAGENPPSYDKQFVRDWLEQAQVNGAPWNKSAPAPRLPREVIEKTAAKYREALERLTGGQ
>Mature_307_residues
TLPSPPALHTSSLASLPLLARGKVRDNYAVGDDRILMVASDRISAFDVIMGEPIPGKGELLTKMALFWFDKLGHLCPNHL
TGGAPESVVSPEEAAQVRGRSMLVQRLRPIPVEAVVRGYLAGSGWKEYQATRSVCGVQLPEGLTNASRLPQPIYTPAAKA
AVGEHDENITFERTVEMVGIDLATKIRDTSIALYEAAAAIALEKGMIIADTKFEFGLAPDGTLVLMDEVLTPDSSRYWPV
EGYEAALAAGENPPSYDKQFVRDWLEQAQVNGAPWNKSAPAPRLPREVIEKTAAKYREALERLTGGQ

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=302, Percent_Identity=46.0264900662252, Blast_Score=270, Evalue=2e-73,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 33436; Mature: 33304

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPSPPALHTSSLASLPLLARGKVRDNYAVGDDRILMVASDRISAFDVIMGEPIPGKGE
CCCCCCCCCCHHHHHHCCHHCCCCCCCCEECCCCEEEEEECCCCCCHHHHCCCCCCCCHH
LLTKMALFWFDKLGHLCPNHLTGGAPESVVSPEEAAQVRGRSMLVQRLRPIPVEAVVRGY
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LAGSGWKEYQATRSVCGVQLPEGLTNASRLPQPIYTPAAKAAVGEHDENITFERTVEMVG
HCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHH
IDLATKIRDTSIALYEAAAAIALEKGMIIADTKFEFGLAPDGTLVLMDEVLTPDSSRYWP
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCEEEEEHHCCCCCCCCCC
VEGYEAALAAGENPPSYDKQFVRDWLEQAQVNGAPWNKSAPAPRLPREVIEKTAAKYREA
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LERLTGGQ
HHHHCCCC
>Mature Secondary Structure 
TLPSPPALHTSSLASLPLLARGKVRDNYAVGDDRILMVASDRISAFDVIMGEPIPGKGE
CCCCCCCCCHHHHHHCCHHCCCCCCCCEECCCCEEEEEECCCCCCHHHHCCCCCCCCHH
LLTKMALFWFDKLGHLCPNHLTGGAPESVVSPEEAAQVRGRSMLVQRLRPIPVEAVVRGY
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LAGSGWKEYQATRSVCGVQLPEGLTNASRLPQPIYTPAAKAAVGEHDENITFERTVEMVG
HCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHH
IDLATKIRDTSIALYEAAAAIALEKGMIIADTKFEFGLAPDGTLVLMDEVLTPDSSRYWP
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCEEEEEHHCCCCCCCCCC
VEGYEAALAAGENPPSYDKQFVRDWLEQAQVNGAPWNKSAPAPRLPREVIEKTAAKYREA
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LERLTGGQ
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA