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The map label for this gene is yegE [C]

Identifier: 120613183

GI number: 120613183

Start: 5069611

End: 5071101

Strand: Direct

Name: yegE [C]

Synonym: Aave_4550

Alternate gene names: 120613183

Gene position: 5069611-5071101 (Clockwise)

Preceding gene: 120613157

Following gene: 120613188

Centisome position: 94.71

GC content: 72.5

Gene sequence:

>1491_bases
ATGGAAGACACCCAAAGAATGGAATCCGTGGATTCCGCTGCTGCGCTGGCAGCACCCGTCCCCGGCAGCGAGGCCCGGCC
GCCTCCGCGTAGGGAGCCCCCCTGGCCGGATTTGCTGCTCGGCATGGGCGGTGAAGCCTGCGCGGTCTTCGCGCTCGACG
CCCAGGGCCGGTTCATCTACGCCAGCGAGGGAACGGGCCTGTTGCTGGGACGGCCGGCCGCGTCCCTGCCTGGCCAGCGC
ATGGCGGACGTGTTGGCATACCCTCCGTCCGACGTCCACCTGTACCGGCTGCTGCTCGGAGGCGCTCTGCCCGCGGCGGC
CTCCGGCTACCGCTGCGAAACGCTGCTGCACCCCCTGGACGCCACGCCGCTCTGGGTACAGGCGGTGCTGCATCCGTCGC
ACGGGTTGATGACAGGCATGCTGATCGACATCACGGCCACGAAGGTGCGCGAACGGCTGCAGCACCGGGTTCTCGACGCG
ATGGCGCATGACCTGCCCCTGCCCGACATCGCCTCCGGCCTGTGCGAAGACATCGAAGCCATGCTGCCGGGGGTCGCCGT
GTCGGTGCTGGAACTGGACGGGCAGCACCGGTTGCGGTGCCTGGCTGCGCCCAGGCTGGAGGACGTGCTGGCAGCCCACG
CCGACGGCCAGCCCGCCGGGCCGGACGCGGGCACCGGCGGCGCGGCCGTCTGGCAAACAGCCTCGGCAGCTTGCACCGAC
ATCGCCGCCGACCCGCGTTGGGCTCCGTGGCGCGAACCGCTGGCGGCACGGGGCTTCACGGTCTGCTGGTCGGCCCCGGT
CCTCGACCGCGACGGACACCTCCTGGGCTCCTTCACCCTGCATGGCCGAAGGGCCCTGGGCTGCGACGGACTGCCCCGGC
ACGCGCTGGAAGCGGGAGCGCGGCTATCCGCCCTGCTGCTGGAGCGCGAGCGCGCCCAGCAGAGCTTTCGCCGCCTGGCC
TACCAGGACGCCGTCACCGGGCTGCCCAACCGGGCGTTTCTACTGGAAGCCACGGAGCGCCTGATCCGCGAGGCGCGCCG
GGAAGGACACTCCCTGGCGATCGCCTTCATCGATCTGGACCGGTTCAAGCAGGTGAACGACCAGCTGGGCCACCGGGCCG
GCGACGACCTGCTGCGCGAAGTGGCGCAGCGGCTGCAGGGCGCCTCGCGACGGGCCGACATCGTGGCCCGCATCGGGGGC
GATGAATTCGCCGCGGTACTGCCCCGGTGCGGCAGCCGGGAGGCAGCCGCGGCCGCGCGCCGGCTGCTGGAGGCCGCGGT
GCGCCCCGTGATGCTCCATGGCAGGTGCTGGAGCCTGGGCGCCAGCATCGGCATCGCCCAGTACCCCCGCGACGGTACGA
ACGCCGCCACGCTGCTGCACCACGCGGACCTGGCCATGTATGCCGCCAAGCGGGCAGGCGGCCAGCGCCTGAGCGTCTTC
CGGGGCAAGACACCGGGCGCCCCGGTGGTGCGCGAGGTCCTGGACGGGTGA

Upstream 100 bases:

>100_bases
CGGATGGAACCATTTGCTATGATGATTTCATACCAATTGCTGACAATAGTAGCCGATTCGCACGTACGACGGCACGACTC
TCGTGGGAGGCGAGCGCAGC

Downstream 100 bases:

>100_bases
GCGGCACCCCACCGCCGGCGAGGAGCGCCCCGGCAGGCGGATCAGGGGCGCGCGGCGGCAGCGGCCGGCGGGGAGGCCTC
GGGCTCGGCCACGAATCCGA

Product: diguanylate cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MEDTQRMESVDSAAALAAPVPGSEARPPPRREPPWPDLLLGMGGEACAVFALDAQGRFIYASEGTGLLLGRPAASLPGQR
MADVLAYPPSDVHLYRLLLGGALPAAASGYRCETLLHPLDATPLWVQAVLHPSHGLMTGMLIDITATKVRERLQHRVLDA
MAHDLPLPDIASGLCEDIEAMLPGVAVSVLELDGQHRLRCLAAPRLEDVLAAHADGQPAGPDAGTGGAAVWQTASAACTD
IAADPRWAPWREPLAARGFTVCWSAPVLDRDGHLLGSFTLHGRRALGCDGLPRHALEAGARLSALLLERERAQQSFRRLA
YQDAVTGLPNRAFLLEATERLIREARREGHSLAIAFIDLDRFKQVNDQLGHRAGDDLLREVAQRLQGASRRADIVARIGG
DEFAAVLPRCGSREAAAAARRLLEAAVRPVMLHGRCWSLGASIGIAQYPRDGTNAATLLHHADLAMYAAKRAGGQRLSVF
RGKTPGAPVVREVLDG

Sequences:

>Translated_496_residues
MEDTQRMESVDSAAALAAPVPGSEARPPPRREPPWPDLLLGMGGEACAVFALDAQGRFIYASEGTGLLLGRPAASLPGQR
MADVLAYPPSDVHLYRLLLGGALPAAASGYRCETLLHPLDATPLWVQAVLHPSHGLMTGMLIDITATKVRERLQHRVLDA
MAHDLPLPDIASGLCEDIEAMLPGVAVSVLELDGQHRLRCLAAPRLEDVLAAHADGQPAGPDAGTGGAAVWQTASAACTD
IAADPRWAPWREPLAARGFTVCWSAPVLDRDGHLLGSFTLHGRRALGCDGLPRHALEAGARLSALLLERERAQQSFRRLA
YQDAVTGLPNRAFLLEATERLIREARREGHSLAIAFIDLDRFKQVNDQLGHRAGDDLLREVAQRLQGASRRADIVARIGG
DEFAAVLPRCGSREAAAAARRLLEAAVRPVMLHGRCWSLGASIGIAQYPRDGTNAATLLHHADLAMYAAKRAGGQRLSVF
RGKTPGAPVVREVLDG
>Mature_496_residues
MEDTQRMESVDSAAALAAPVPGSEARPPPRREPPWPDLLLGMGGEACAVFALDAQGRFIYASEGTGLLLGRPAASLPGQR
MADVLAYPPSDVHLYRLLLGGALPAAASGYRCETLLHPLDATPLWVQAVLHPSHGLMTGMLIDITATKVRERLQHRVLDA
MAHDLPLPDIASGLCEDIEAMLPGVAVSVLELDGQHRLRCLAAPRLEDVLAAHADGQPAGPDAGTGGAAVWQTASAACTD
IAADPRWAPWREPLAARGFTVCWSAPVLDRDGHLLGSFTLHGRRALGCDGLPRHALEAGARLSALLLERERAQQSFRRLA
YQDAVTGLPNRAFLLEATERLIREARREGHSLAIAFIDLDRFKQVNDQLGHRAGDDLLREVAQRLQGASRRADIVARIGG
DEFAAVLPRCGSREAAAAARRLLEAAVRPVMLHGRCWSLGASIGIAQYPRDGTNAATLLHHADLAMYAAKRAGGQRLSVF
RGKTPGAPVVREVLDG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MHYT domain [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=195, Percent_Identity=35.8974358974359, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI87081977, Length=233, Percent_Identity=31.7596566523605, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1787541, Length=175, Percent_Identity=34.8571428571429, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI145693134, Length=225, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI87081921, Length=442, Percent_Identity=22.6244343891403, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87082007, Length=168, Percent_Identity=32.7380952380952, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786584, Length=167, Percent_Identity=29.3413173652695, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081881, Length=174, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788085, Length=190, Percent_Identity=26.3157894736842, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1787816, Length=156, Percent_Identity=32.0512820512821, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787802, Length=164, Percent_Identity=28.6585365853659, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081974, Length=112, Percent_Identity=35.7142857142857, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787262, Length=169, Percent_Identity=28.4023668639053, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788956, Length=164, Percent_Identity=35.3658536585366, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 53058; Mature: 53058

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDTQRMESVDSAAALAAPVPGSEARPPPRREPPWPDLLLGMGGEACAVFALDAQGRFIY
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEEEEEECCCCEEE
ASEGTGLLLGRPAASLPGQRMADVLAYPPSDVHLYRLLLGGALPAAASGYRCETLLHPLD
ECCCCEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCC
ATPLWVQAVLHPSHGLMTGMLIDITATKVRERLQHRVLDAMAHDLPLPDIASGLCEDIEA
CCHHHHHHHHCCCCCHHHHHEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
MLPGVAVSVLELDGQHRLRCLAAPRLEDVLAAHADGQPAGPDAGTGGAAVWQTASAACTD
HCCHHEEEEEECCCCHHEEECCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IAADPRWAPWREPLAARGFTVCWSAPVLDRDGHLLGSFTLHGRRALGCDGLPRHALEAGA
CCCCCCCCCCCCCHHHCCEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHCH
RLSALLLERERAQQSFRRLAYQDAVTGLPNRAFLLEATERLIREARREGHSLAIAFIDLD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEHH
RFKQVNDQLGHRAGDDLLREVAQRLQGASRRADIVARIGGDEFAAVLPRCGSREAAAAAR
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHEEEEECCHHHHHHHCCCCCHHHHHHHH
RLLEAAVRPVMLHGRCWSLGASIGIAQYPRDGTNAATLLHHADLAMYAAKRAGGQRLSVF
HHHHHHHHHHEECCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEE
RGKTPGAPVVREVLDG
CCCCCCCHHHHHHHCC
>Mature Secondary Structure
MEDTQRMESVDSAAALAAPVPGSEARPPPRREPPWPDLLLGMGGEACAVFALDAQGRFIY
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEEEEEECCCCEEE
ASEGTGLLLGRPAASLPGQRMADVLAYPPSDVHLYRLLLGGALPAAASGYRCETLLHPLD
ECCCCEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCC
ATPLWVQAVLHPSHGLMTGMLIDITATKVRERLQHRVLDAMAHDLPLPDIASGLCEDIEA
CCHHHHHHHHCCCCCHHHHHEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
MLPGVAVSVLELDGQHRLRCLAAPRLEDVLAAHADGQPAGPDAGTGGAAVWQTASAACTD
HCCHHEEEEEECCCCHHEEECCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IAADPRWAPWREPLAARGFTVCWSAPVLDRDGHLLGSFTLHGRRALGCDGLPRHALEAGA
CCCCCCCCCCCCCHHHCCEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHCH
RLSALLLERERAQQSFRRLAYQDAVTGLPNRAFLLEATERLIREARREGHSLAIAFIDLD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEHH
RFKQVNDQLGHRAGDDLLREVAQRLQGASRRADIVARIGGDEFAAVLPRCGSREAAAAAR
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHEEEEECCHHHHHHHCCCCCHHHHHHHH
RLLEAAVRPVMLHGRCWSLGASIGIAQYPRDGTNAATLLHHADLAMYAAKRAGGQRLSVF
HHHHHHHHHHEECCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEE
RGKTPGAPVVREVLDG
CCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]