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The map label for this gene is proA

Identifier: 120613178

GI number: 120613178

Start: 5062532

End: 5063812

Strand: Reverse

Name: proA

Synonym: Aave_4545

Alternate gene names: 120613178

Gene position: 5063812-5062532 (Counterclockwise)

Preceding gene: 120613179

Following gene: 120613177

Centisome position: 94.6

GC content: 68.46

Gene sequence:

>1281_bases
ATGAACGCGCAGCACATCGCCGAAACCCTCCACGCCCTCGGATCCCAGGCCAAGGCCGCCTCCGCGCTGATGGCCCGGGC
GCCATCGGCCGTCAAGAACCGTGCGCTGCTGGCGCTGGCCCGCCGCCTGCGCGACAACACCACCGCCCTGCAGGCGGACA
ACGCCCGCGATCTCGAGCGCGCCCGGGCTGCCGGCCTCGCCGAACCCATGGTGGACCGGCTCAAGCTCACTCCCAAGGTT
CTGGAGACCTGCGCCCTGGGCTGCGAACAACTCGCGACGATGGGCGACGTGATCGGCGAGATCTCCGGCATGCGCCAGCA
GCCCAGCGGCATCCGCGTCGGCCAGATGCGCGTGCCGATCGGCGTCTTCGGCATGATCTACGAAAGCCGCCCCAACGTGA
CCATCGAGGCCGCCTCGCTGAGCATCAAGAGCGGCAACGCCTGCATCCTGCGGGGAGGTTCCGAGGCCATCGATTCCAAT
CGTGCCCTCGCGCGCCTCGTGCAGGAGGCGCTCGAGGAAGCCGGCCTGCCCGGCGATGCCGTGCAGCTCGTGCAGACCAC
CGACCGCGAGGCCGTGGGCCACCTCATCGCCATGCCGCAGTACGTGGACGTCATCATCCCCCGCGGCGGCAAGGGCCTGA
TCGAACGCATCAGCCGCGATGCCAAGGTGCCCGTCATCAAGCACCTGGACGGCAACTGCCATACCTACGTGGACGACCCC
TGCGATGTCGCCATGGCCGTGAAGGTGGCCGACAACGCCAAGACGCAGAAGTACAGCCCCTGCAATGCCAGCGAGGGGCT
GCTCGTCGCGCGTGGCGTGGCCGCCGAATTCCTCCCCCGGATCGGCGCCGTCTATGCGGCCAAGGGCGTGGAGATGCGCG
GCTGCCCGGAGACCCTGGCCCTGCTGGCCGGCGTGCCTGGGGCTACGCTCGTACACGCCACCGAACAGGACTGGTCCGAG
GAATACCTGGCGCCCATCATCAGCATCAAGGTGGTGGAGGGCCTGGACGAAGCCATTGCCCACATCAACCGCTACGGCAG
CCACCACACCGACGCCATCCTCACGCGGGACCACATGCATGCCCAGCGCTTCCTGCGGGAAGTGGACTCGGCCAGCGTCA
TGGTGAACGCCAGCACCCGCTTCGCCGACGGGTTCGAGTATGGCCTGGGCGCCGAGATCGGCATCAGCACCGACAAATTC
CATGCGCGCGGCCCGGTGGGCATCGAAGGGCTCACCTCGCTCAAATGGGTGGTGCTCGGCGAGGGCGACATCCGCGCCTG
A

Upstream 100 bases:

>100_bases
TGGTCGTCATGGCGCGCGAGGGTAGCAAAACCGGGACGTGCCGCCTGGCGGGGAAACCCGCGCCGGGCGGGCAACGCAGC
GATGCGTCAAAATCACGCCC

Downstream 100 bases:

>100_bases
GCGGCCGCCTGCGGGCCTCCAGCCTCCAAACCCCTTCATCGTTCCTGCCGCATGAAGATCATCATCCTGGGCGCGGGCCG
CGTGGGCGAGAGCGTGGCCG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNAQHIAETLHALGSQAKAASALMARAPSAVKNRALLALARRLRDNTTALQADNARDLERARAAGLAEPMVDRLKLTPKV
LETCALGCEQLATMGDVIGEISGMRQQPSGIRVGQMRVPIGVFGMIYESRPNVTIEAASLSIKSGNACILRGGSEAIDSN
RALARLVQEALEEAGLPGDAVQLVQTTDREAVGHLIAMPQYVDVIIPRGGKGLIERISRDAKVPVIKHLDGNCHTYVDDP
CDVAMAVKVADNAKTQKYSPCNASEGLLVARGVAAEFLPRIGAVYAAKGVEMRGCPETLALLAGVPGATLVHATEQDWSE
EYLAPIISIKVVEGLDEAIAHINRYGSHHTDAILTRDHMHAQRFLREVDSASVMVNASTRFADGFEYGLGAEIGISTDKF
HARGPVGIEGLTSLKWVVLGEGDIRA

Sequences:

>Translated_426_residues
MNAQHIAETLHALGSQAKAASALMARAPSAVKNRALLALARRLRDNTTALQADNARDLERARAAGLAEPMVDRLKLTPKV
LETCALGCEQLATMGDVIGEISGMRQQPSGIRVGQMRVPIGVFGMIYESRPNVTIEAASLSIKSGNACILRGGSEAIDSN
RALARLVQEALEEAGLPGDAVQLVQTTDREAVGHLIAMPQYVDVIIPRGGKGLIERISRDAKVPVIKHLDGNCHTYVDDP
CDVAMAVKVADNAKTQKYSPCNASEGLLVARGVAAEFLPRIGAVYAAKGVEMRGCPETLALLAGVPGATLVHATEQDWSE
EYLAPIISIKVVEGLDEAIAHINRYGSHHTDAILTRDHMHAQRFLREVDSASVMVNASTRFADGFEYGLGAEIGISTDKF
HARGPVGIEGLTSLKWVVLGEGDIRA
>Mature_426_residues
MNAQHIAETLHALGSQAKAASALMARAPSAVKNRALLALARRLRDNTTALQADNARDLERARAAGLAEPMVDRLKLTPKV
LETCALGCEQLATMGDVIGEISGMRQQPSGIRVGQMRVPIGVFGMIYESRPNVTIEAASLSIKSGNACILRGGSEAIDSN
RALARLVQEALEEAGLPGDAVQLVQTTDREAVGHLIAMPQYVDVIIPRGGKGLIERISRDAKVPVIKHLDGNCHTYVDDP
CDVAMAVKVADNAKTQKYSPCNASEGLLVARGVAAEFLPRIGAVYAAKGVEMRGCPETLALLAGVPGATLVHATEQDWSE
EYLAPIISIKVVEGLDEAIAHINRYGSHHTDAILTRDHMHAQRFLREVDSASVMVNASTRFADGFEYGLGAEIGISTDKF
HARGPVGIEGLTSLKWVVLGEGDIRA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=419, Percent_Identity=37.4701670644391, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI62912457, Length=419, Percent_Identity=37.4701670644391, Blast_Score=257, Evalue=2e-68,
Organism=Escherichia coli, GI1786438, Length=417, Percent_Identity=45.083932853717, Blast_Score=352, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17569969, Length=390, Percent_Identity=40, Blast_Score=277, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI17569967, Length=390, Percent_Identity=40, Blast_Score=277, Evalue=6e-75,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=35.1288056206089, Blast_Score=271, Evalue=1e-73,
Organism=Drosophila melanogaster, GI21357643, Length=413, Percent_Identity=38.498789346247, Blast_Score=262, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_ACIAC (A1TVU4)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972856.1
- ProteinModelPortal:   A1TVU4
- SMR:   A1TVU4
- STRING:   A1TVU4
- GeneID:   4667910
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_4545
- NMPDR:   fig|397945.5.peg.3914
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- PhylomeDB:   A1TVU4
- ProtClustDB:   PRK00197
- BioCyc:   AAVE397945:AAVE_4545-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45428; Mature: 45428

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAQHIAETLHALGSQAKAASALMARAPSAVKNRALLALARRLRDNTTALQADNARDLER
CCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHH
ARAAGLAEPMVDRLKLTPKVLETCALGCEQLATMGDVIGEISGMRQQPSGIRVGQMRVPI
HHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECEEECCH
GVFGMIYESRPNVTIEAASLSIKSGNACILRGGSEAIDSNRALARLVQEALEEAGLPGDA
HHEEHEEECCCCEEEEEEEEEEECCCEEEEECCCHHHHCHHHHHHHHHHHHHHCCCCHHH
VQLVQTTDREAVGHLIAMPQYVDVIIPRGGKGLIERISRDAKVPVIKHLDGNCHTYVDDP
HHHHHHCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCCCEECCCCCCCCCCCC
CDVAMAVKVADNAKTQKYSPCNASEGLLVARGVAAEFLPRIGAVYAAKGVEMRGCPETLA
CCEEEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LLAGVPGATLVHATEQDWSEEYLAPIISIKVVEGLDEAIAHINRYGSHHTDAILTRDHMH
HHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
AQRFLREVDSASVMVNASTRFADGFEYGLGAEIGISTDKFHARGPVGIEGLTSLKWVVLG
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEC
EGDIRA
CCCCCC
>Mature Secondary Structure
MNAQHIAETLHALGSQAKAASALMARAPSAVKNRALLALARRLRDNTTALQADNARDLER
CCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHH
ARAAGLAEPMVDRLKLTPKVLETCALGCEQLATMGDVIGEISGMRQQPSGIRVGQMRVPI
HHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECEEECCH
GVFGMIYESRPNVTIEAASLSIKSGNACILRGGSEAIDSNRALARLVQEALEEAGLPGDA
HHEEHEEECCCCEEEEEEEEEEECCCEEEEECCCHHHHCHHHHHHHHHHHHHHCCCCHHH
VQLVQTTDREAVGHLIAMPQYVDVIIPRGGKGLIERISRDAKVPVIKHLDGNCHTYVDDP
HHHHHHCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCCCEECCCCCCCCCCCC
CDVAMAVKVADNAKTQKYSPCNASEGLLVARGVAAEFLPRIGAVYAAKGVEMRGCPETLA
CCEEEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LLAGVPGATLVHATEQDWSEEYLAPIISIKVVEGLDEAIAHINRYGSHHTDAILTRDHMH
HHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
AQRFLREVDSASVMVNASTRFADGFEYGLGAEIGISTDKFHARGPVGIEGLTSLKWVVLG
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEC
EGDIRA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA