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The map label for this gene is holA [H]

Identifier: 120613179

GI number: 120613179

Start: 5064331

End: 5065377

Strand: Reverse

Name: holA [H]

Synonym: Aave_4546

Alternate gene names: 120613179

Gene position: 5065377-5064331 (Counterclockwise)

Preceding gene: 120613180

Following gene: 120613178

Centisome position: 94.63

GC content: 69.63

Gene sequence:

>1047_bases
ATGCAGATCGCGCTGAACCAGTTGGTCGCCCACCTCCAGAAGGGGGTACGCCCGCTCTACACGCTCCATGGCGATGAGCC
GCTGCTGCAACAGGAGGCCGCGGATGCCATCCGCGCCGCCGCGCGCGGGCAGGGCTACACCGAGCGCAGCAGCCACACCG
TGGCCGGTGCGCACTTCGACTGGAGCGCGGTACTGGCGGCGGGCGGTTCGCTATCGCTTTTCGCGGACAAGCAGATCGTG
GAAATCCGCATTCCCTCGGGCAAGCCGGGCAAGGACGGCGGCGCGGCCCTGCAGCAGATCGCCACGGCCGCCGCAGGCAA
CGAAGGCACGCTGACGCTCGTCGTGCTGCCGCGCCTGGACAAGGCCACGCGCACCGGCGCCTGGTTCTCGGCCCTGGACC
GCGAGGGCGTGAGCGTGCAGATCGACCCGGTGGAGCGCGTCGCCCTGCCGCAGTGGATCGCGCAGCGCCTGGCGGCGCAG
GGCCAGCGCGTGGCCGCGGGGGAAGAAGGCCAGCGCACGCTCCAGTTCTTCGCAGACCGGGTGGAGGGCAACCTGCTGGC
CGCACACCAGGAAGTCCAGAAGCTCGCCCTGCTGCATCCGCCTGGCGAACTCTCCTGGGCGCAGGTCGAAGCCGCCGTGC
TCAATGTGGCACGCTACGACGTCTTCAAGCTTTCCGAGGCCGTGCTGTCCGGCCAGGTGGCGCGCATGCAGCGCATGCTC
GACGGCCTGCAGGCCGAAGGCGAGGCCGAGGTACTGGTCCACTGGGCCCTCGCCGAAGACATCCGGTCCCTGAAGCGCGT
GAAGGATGCGGTGAATGCCGGCAAGCCCCTGCCCATGGCCCTGCGCGAAAACCGCGTCTGGGGGACGAAAGAGCGGCTCT
TCGAGCGCATCGTGCCCCGTTTTTCCGATGCCGCCGCATCGCGCCTGCTGCAGTCCGCCCACATCGTGGACGGCATCGTG
AAGGGGCTCAAGGTGCCCGACTGGCCCGCCGATGGCTGGCAGGCACTGCACCGCCTGGCGCTGCAGCTGTGCAAGGCAGT
GAAGTGA

Upstream 100 bases:

>100_bases
CAGACCGATCTCGTGCAGCAGTTGCTGCGGCGTCTGGCCGCGGCGCGCATGCAATGAGAATGGTATGGCCGCTCCCCTGC
GGGGCAGGTCGTGCATCGCC

Downstream 100 bases:

>100_bases
ACACCCCCTGAGTCGCCTGCGGCGCCTTCCCCCTCAAGGGGGACGACGCCAGCAGCCCGGCGAAGCCGGCTCTGCGGCGT
CTGCTGGCGTGGCCTGCTCC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MQIALNQLVAHLQKGVRPLYTLHGDEPLLQQEAADAIRAAARGQGYTERSSHTVAGAHFDWSAVLAAGGSLSLFADKQIV
EIRIPSGKPGKDGGAALQQIATAAAGNEGTLTLVVLPRLDKATRTGAWFSALDREGVSVQIDPVERVALPQWIAQRLAAQ
GQRVAAGEEGQRTLQFFADRVEGNLLAAHQEVQKLALLHPPGELSWAQVEAAVLNVARYDVFKLSEAVLSGQVARMQRML
DGLQAEGEAEVLVHWALAEDIRSLKRVKDAVNAGKPLPMALRENRVWGTKERLFERIVPRFSDAAASRLLQSAHIVDGIV
KGLKVPDWPADGWQALHRLALQLCKAVK

Sequences:

>Translated_348_residues
MQIALNQLVAHLQKGVRPLYTLHGDEPLLQQEAADAIRAAARGQGYTERSSHTVAGAHFDWSAVLAAGGSLSLFADKQIV
EIRIPSGKPGKDGGAALQQIATAAAGNEGTLTLVVLPRLDKATRTGAWFSALDREGVSVQIDPVERVALPQWIAQRLAAQ
GQRVAAGEEGQRTLQFFADRVEGNLLAAHQEVQKLALLHPPGELSWAQVEAAVLNVARYDVFKLSEAVLSGQVARMQRML
DGLQAEGEAEVLVHWALAEDIRSLKRVKDAVNAGKPLPMALRENRVWGTKERLFERIVPRFSDAAASRLLQSAHIVDGIV
KGLKVPDWPADGWQALHRLALQLCKAVK
>Mature_348_residues
MQIALNQLVAHLQKGVRPLYTLHGDEPLLQQEAADAIRAAARGQGYTERSSHTVAGAHFDWSAVLAAGGSLSLFADKQIV
EIRIPSGKPGKDGGAALQQIATAAAGNEGTLTLVVLPRLDKATRTGAWFSALDREGVSVQIDPVERVALPQWIAQRLAAQ
GQRVAAGEEGQRTLQFFADRVEGNLLAAHQEVQKLALLHPPGELSWAQVEAAVLNVARYDVFKLSEAVLSGQVARMQRML
DGLQAEGEAEVLVHWALAEDIRSLKRVKDAVNAGKPLPMALRENRVWGTKERLFERIVPRFSDAAASRLLQSAHIVDGIV
KGLKVPDWPADGWQALHRLALQLCKAVK

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=339, Percent_Identity=30.9734513274336, Blast_Score=125, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37731; Mature: 37731

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIALNQLVAHLQKGVRPLYTLHGDEPLLQQEAADAIRAAARGQGYTERSSHTVAGAHFD
CCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
WSAVLAAGGSLSLFADKQIVEIRIPSGKPGKDGGAALQQIATAAAGNEGTLTLVVLPRLD
HHHHHHCCCCEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCC
KATRTGAWFSALDREGVSVQIDPVERVALPQWIAQRLAAQGQRVAAGEEGQRTLQFFADR
CHHHCCHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHH
VEGNLLAAHQEVQKLALLHPPGELSWAQVEAAVLNVARYDVFKLSEAVLSGQVARMQRML
HCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGLQAEGEAEVLVHWALAEDIRSLKRVKDAVNAGKPLPMALRENRVWGTKERLFERIVPR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHC
FSDAAASRLLQSAHIVDGIVKGLKVPDWPADGWQALHRLALQLCKAVK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQIALNQLVAHLQKGVRPLYTLHGDEPLLQQEAADAIRAAARGQGYTERSSHTVAGAHFD
CCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
WSAVLAAGGSLSLFADKQIVEIRIPSGKPGKDGGAALQQIATAAAGNEGTLTLVVLPRLD
HHHHHHCCCCEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCC
KATRTGAWFSALDREGVSVQIDPVERVALPQWIAQRLAAQGQRVAAGEEGQRTLQFFADR
CHHHCCHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHH
VEGNLLAAHQEVQKLALLHPPGELSWAQVEAAVLNVARYDVFKLSEAVLSGQVARMQRML
HCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGLQAEGEAEVLVHWALAEDIRSLKRVKDAVNAGKPLPMALRENRVWGTKERLFERIVPR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHC
FSDAAASRLLQSAHIVDGIVKGLKVPDWPADGWQALHRLALQLCKAVK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]