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The map label for this gene is trkH [H]

Identifier: 120613176

GI number: 120613176

Start: 5059500

End: 5060996

Strand: Reverse

Name: trkH [H]

Synonym: Aave_4543

Alternate gene names: 120613176

Gene position: 5060996-5059500 (Counterclockwise)

Preceding gene: 120613177

Following gene: 120613175

Centisome position: 94.55

GC content: 66.87

Gene sequence:

>1497_bases
ATGTCCGTGCCTTCCGCGCTTTCCGAGGCCCTGCCGGATCTGCTGCCGGTGCTGCGCGTGTTCGGCGCGTTGCTCGCGAT
GTTCTCCTGGGCCCTGGCCGTTCCCCTGGGTGCATCCTTGTGGGCAGGGGAAGGCCTGTGGCCGGTCTATGCCGCCAGCC
TGGGGTTCGCTCTCGCATGCGGTGTCGCACTCTGGCTCGGCCTGCGCCGGCACGCACGGGAATTGCAACCCCGCCACGGG
GTCATGCTCGTGTCGCTGGTCTGGCTGCTGCTGCCGCTGTTCGCATCCCTGCCGCTCATGGGGGCGCTCCATGCCATCGA
TCGCCCCATCGGCTTCACCCATGCCTACTTCGAGGCCGTCTCCGGGCTCACCACCACCGGCGCGACCGTACTGTCCGGGC
TCGACTCGCTGCCCCTGTCGGTCAACATCTGGCGCACCTTCATGCAATGGATCGGCGGCATGGGCATCCTGATCCTGGCC
GTCGCCGTGCTGCCGCTCCTTGGCGTGGGCGGCAGCCAGCTTTTCAAGGCCGAAGCCGCGGGCCCCGTCAAGGATACCAA
GCTCACTCCCCGCATGACCCAGACGGCCAAGGGACTCTGGGGCGTGTACGTCGTGTTCTCCCTGGTCTGCGCGCTCGCGT
TCTGGGCTGGCGGCATGGTGGTTCCGGATGCGCTGATGCACATGTTCGCCACGGTGAGCCTCGGAGGGCTGTCACCCTAC
GACGCCAGCTTCGGCCACTTCCACTCGCCCCTGCTGGAAGCGATTGCCATCGTCTTCATGGTGCTGGCCAGCTGCAACTT
CGCGCTGTATTTCGTCGCCCTGCGCAAAGGGCACTGGCGCACCTGCTGGCGCGATCCCGAACTGCGTGCGACCGTGTGCA
CCCTGCTCGGCAGCGGCCTTTTCGTGGCGCTGCTGCTCTGGTTCAAAGGCATCTACGGGCCCCTGGACGCGTTGCGGCAC
GGAATGTTCCACACCGTGTCCGTGGCCACCACCACCGGCTTCGCCACCACCGACTACCTCGGATGGCCGGTATTCGCCCC
GGTCTTCCTGCTCATGCTGTCCGGCGTGGCGACCAGTGCCGGCTCCACGGGCGGGGGCATCAAGATGGTCCGTGTGCTCA
TCCTCCTGCAGCAGGCGCGCCGCGAGATGACGCGGCTCGTGCACCCACGCGCGGTGCAGCCCGTGCGCCTGGGCGCTACC
GTGGTCGAGAACCGGATGATCTTCGCCGTGCTGGCCTACATGCTGGTCTATGGCGCCACCATCACGGTGCTCAGCATGGT
TCTGCTTCTCACCGATCTGGACGTCGTCACTGCCTTCAGCGCCGTGATCGCCAGCGTCCACTGCACCGGCCCGGGCCTGG
GCCTCATCGGTCCCGCTGCCAATTACGCCGTTCTCACCGATTTCCAGCTCTGGGTCTGCACGCTCGCCATGCTGCTCGGC
CGGCTTGAGATCCTCAGTTTCATGGCGCTGTTGACGCCTGCCTTCTGGCGGCGCTGA

Upstream 100 bases:

>100_bases
TCGAAAGCGGCGACCATGTCGTCTTCTTCCTCCCGAACAAGCGGCTGGTGCGCGAAGTGGAAAAGGCCTTCCGCGTGAGC
GCGACGTTTTTCTGATCGCG

Downstream 100 bases:

>100_bases
CGGGTGGAACTTCGCGGCGCGGAGTGCTTGCGAACCGGGCCCGCGCCCCCAAATCCCTACAATCGACTCCGCTTTCGGCG
CAATGCCGTCTTCGCCGCTT

Product: cation transporter

Products: Proton [Cytoplasm]; K (I) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSVPSALSEALPDLLPVLRVFGALLAMFSWALAVPLGASLWAGEGLWPVYAASLGFALACGVALWLGLRRHARELQPRHG
VMLVSLVWLLLPLFASLPLMGALHAIDRPIGFTHAYFEAVSGLTTTGATVLSGLDSLPLSVNIWRTFMQWIGGMGILILA
VAVLPLLGVGGSQLFKAEAAGPVKDTKLTPRMTQTAKGLWGVYVVFSLVCALAFWAGGMVVPDALMHMFATVSLGGLSPY
DASFGHFHSPLLEAIAIVFMVLASCNFALYFVALRKGHWRTCWRDPELRATVCTLLGSGLFVALLLWFKGIYGPLDALRH
GMFHTVSVATTTGFATTDYLGWPVFAPVFLLMLSGVATSAGSTGGGIKMVRVLILLQQARREMTRLVHPRAVQPVRLGAT
VVENRMIFAVLAYMLVYGATITVLSMVLLLTDLDVVTAFSAVIASVHCTGPGLGLIGPAANYAVLTDFQLWVCTLAMLLG
RLEILSFMALLTPAFWRR

Sequences:

>Translated_498_residues
MSVPSALSEALPDLLPVLRVFGALLAMFSWALAVPLGASLWAGEGLWPVYAASLGFALACGVALWLGLRRHARELQPRHG
VMLVSLVWLLLPLFASLPLMGALHAIDRPIGFTHAYFEAVSGLTTTGATVLSGLDSLPLSVNIWRTFMQWIGGMGILILA
VAVLPLLGVGGSQLFKAEAAGPVKDTKLTPRMTQTAKGLWGVYVVFSLVCALAFWAGGMVVPDALMHMFATVSLGGLSPY
DASFGHFHSPLLEAIAIVFMVLASCNFALYFVALRKGHWRTCWRDPELRATVCTLLGSGLFVALLLWFKGIYGPLDALRH
GMFHTVSVATTTGFATTDYLGWPVFAPVFLLMLSGVATSAGSTGGGIKMVRVLILLQQARREMTRLVHPRAVQPVRLGAT
VVENRMIFAVLAYMLVYGATITVLSMVLLLTDLDVVTAFSAVIASVHCTGPGLGLIGPAANYAVLTDFQLWVCTLAMLLG
RLEILSFMALLTPAFWRR
>Mature_497_residues
SVPSALSEALPDLLPVLRVFGALLAMFSWALAVPLGASLWAGEGLWPVYAASLGFALACGVALWLGLRRHARELQPRHGV
MLVSLVWLLLPLFASLPLMGALHAIDRPIGFTHAYFEAVSGLTTTGATVLSGLDSLPLSVNIWRTFMQWIGGMGILILAV
AVLPLLGVGGSQLFKAEAAGPVKDTKLTPRMTQTAKGLWGVYVVFSLVCALAFWAGGMVVPDALMHMFATVSLGGLSPYD
ASFGHFHSPLLEAIAIVFMVLASCNFALYFVALRKGHWRTCWRDPELRATVCTLLGSGLFVALLLWFKGIYGPLDALRHG
MFHTVSVATTTGFATTDYLGWPVFAPVFLLMLSGVATSAGSTGGGIKMVRVLILLQQARREMTRLVHPRAVQPVRLGATV
VENRMIFAVLAYMLVYGATITVLSMVLLLTDLDVVTAFSAVIASVHCTGPGLGLIGPAANYAVLTDFQLWVCTLAMLLGR
LEILSFMALLTPAFWRR

Specific function: Low-affinity potassium transport system. Interacts with trk system potassium uptake protein trkA and requires trkE for transport activity [H]

COG id: COG0168

COG function: function code P; Trk-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trkH potassium transport family [H]

Homologues:

Organism=Escherichia coli, GI48994987, Length=484, Percent_Identity=40.2892561983471, Blast_Score=338, Evalue=5e-94,
Organism=Escherichia coli, GI1787626, Length=478, Percent_Identity=34.9372384937238, Blast_Score=290, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003445
- InterPro:   IPR004772 [H]

Pfam domain/function: PF02386 TrkH [H]

EC number: NA

Molecular weight: Translated: 53486; Mature: 53354

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVPSALSEALPDLLPVLRVFGALLAMFSWALAVPLGASLWAGEGLWPVYAASLGFALAC
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Periplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Periplasm] = Proton [Cytoplasm] + K (I) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]