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The map label for this gene is hemE [H]

Identifier: 120613104

GI number: 120613104

Start: 4965941

End: 4967080

Strand: Direct

Name: hemE [H]

Synonym: Aave_4469

Alternate gene names: 120613104

Gene position: 4965941-4967080 (Clockwise)

Preceding gene: 120613103

Following gene: 120613105

Centisome position: 92.77

GC content: 71.32

Gene sequence:

>1140_bases
ATGCCCGCCATGAGTTTCGCCCCGCTCCAGAACGACACCTTCCTGCGCGCCTGCCGGCGCCAGGCCACCGACTACACGCC
CCTGTGGCTGATGCGCCAGGCCGGCCGCTACCTGCCCGAATACAAGGCCACGCGCGCGCGCGCGGGCAGTTTCATGGGGC
TGGCCACCAACGTGGATTACGCGACCGAGGTCACGCTGCAGCCTTTGGAGCGGTTTCCGCTGGATGCGGCGATCCTGTTC
TCCGACATCCTGACGGTGCCGGACGCGATGGGCCTGGGCCTGTCGTTCGCCGAGGGCGAGGGTCCGCGCTTCGCGCGTGT
GGTGCGCGACGAGGCCGCCGTGGCCGAACTCGCCGTGCCGGACATGGAGAAGCTGCGCTACGTGTTCGACGCCGTGACCT
CCATCCGCCGGGCGCTGGACGGCCGGGTGCCGCTGATCGGTTTTTCCGGCAGCCCCTGGACGCTGGCCTGCTACATGGTG
GAAGGCTCTGGGTCAGACGACTACCGGCTGGTGAAGACGCTGATGTATTCCCGGCCGGACCTGATGCACCGCATCCTGGC
CATCAATGCCGACGCCGTGGCGGCCTACCTGAACGCGCAGATCGACGCGGGCGCGCAGGCGGTGATGGTGTTCGACAGCT
GGGGCGGCGTGCTGGCCGACGGCGCCTTCCAGGAGTTCAGCCTGGCCTACACCACGCGCGTGCTGGCGCAGCTGAAGCGC
ACCGGCGTGGACGGCACCGACGTGCCGCGCATCGTGTTCACCAAGGGCGGTGCGCTGTGGCTGGAAGACATGAAGGGCCT
GGACTGCGAGGTCCTGGGCCTGGACTGGACAGCCAACCTGGCCCGCGCCCGCGCGCTCGTGGGCGGCGCGGTGGGCGGCC
CCGGCAAGGCGCTGCAGGGCAACATCGACCCGAACGTGCTGTTCGCGCCGCCGGAGGCGATCGCCGCCCAGGCGCGCGCG
GTGCTGGACCGTTTCGGCGCCCCGCATACGGACCGCGGCACCACCGGCCCCACGCACATCTTCAACCTGGGCCACGGCAT
CAGCCAGCACACGCCGCCGGAGCACGTCGCCGCCCTGGTGGAGGCGGTGCATGGCCACTCGCGGGCGATGCGCGCGGCGG
CGGGCACGGGCCGCGCCTGA

Upstream 100 bases:

>100_bases
GGCGGGCGGCGGGGTGCGGCACCGGGCGGCGGGCCCGCGGCTTGATCTGGGGCAAGACCGGCCGGGCCGCGGGCGCAGGG
CGGCGGCGGGCCCTGCGACA

Downstream 100 bases:

>100_bases
AGCGGGCAGCCGCGCGCCGGCCCGGCCGTACGGTGCACGGCCGGGCATCCACCGCACCCTGACTTATGCACACCGCCGGC
ACCAGGGCGGTGCAGCCGTG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MPAMSFAPLQNDTFLRACRRQATDYTPLWLMRQAGRYLPEYKATRARAGSFMGLATNVDYATEVTLQPLERFPLDAAILF
SDILTVPDAMGLGLSFAEGEGPRFARVVRDEAAVAELAVPDMEKLRYVFDAVTSIRRALDGRVPLIGFSGSPWTLACYMV
EGSGSDDYRLVKTLMYSRPDLMHRILAINADAVAAYLNAQIDAGAQAVMVFDSWGGVLADGAFQEFSLAYTTRVLAQLKR
TGVDGTDVPRIVFTKGGALWLEDMKGLDCEVLGLDWTANLARARALVGGAVGGPGKALQGNIDPNVLFAPPEAIAAQARA
VLDRFGAPHTDRGTTGPTHIFNLGHGISQHTPPEHVAALVEAVHGHSRAMRAAAGTGRA

Sequences:

>Translated_379_residues
MPAMSFAPLQNDTFLRACRRQATDYTPLWLMRQAGRYLPEYKATRARAGSFMGLATNVDYATEVTLQPLERFPLDAAILF
SDILTVPDAMGLGLSFAEGEGPRFARVVRDEAAVAELAVPDMEKLRYVFDAVTSIRRALDGRVPLIGFSGSPWTLACYMV
EGSGSDDYRLVKTLMYSRPDLMHRILAINADAVAAYLNAQIDAGAQAVMVFDSWGGVLADGAFQEFSLAYTTRVLAQLKR
TGVDGTDVPRIVFTKGGALWLEDMKGLDCEVLGLDWTANLARARALVGGAVGGPGKALQGNIDPNVLFAPPEAIAAQARA
VLDRFGAPHTDRGTTGPTHIFNLGHGISQHTPPEHVAALVEAVHGHSRAMRAAAGTGRA
>Mature_378_residues
PAMSFAPLQNDTFLRACRRQATDYTPLWLMRQAGRYLPEYKATRARAGSFMGLATNVDYATEVTLQPLERFPLDAAILFS
DILTVPDAMGLGLSFAEGEGPRFARVVRDEAAVAELAVPDMEKLRYVFDAVTSIRRALDGRVPLIGFSGSPWTLACYMVE
GSGSDDYRLVKTLMYSRPDLMHRILAINADAVAAYLNAQIDAGAQAVMVFDSWGGVLADGAFQEFSLAYTTRVLAQLKRT
GVDGTDVPRIVFTKGGALWLEDMKGLDCEVLGLDWTANLARARALVGGAVGGPGKALQGNIDPNVLFAPPEAIAAQARAV
LDRFGAPHTDRGTTGPTHIFNLGHGISQHTPPEHVAALVEAVHGHSRAMRAAAGTGRA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=372, Percent_Identity=46.505376344086, Blast_Score=308, Evalue=6e-84,
Organism=Escherichia coli, GI2367337, Length=357, Percent_Identity=57.1428571428571, Blast_Score=394, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6320252, Length=369, Percent_Identity=36.3143631436314, Blast_Score=239, Evalue=6e-64,
Organism=Drosophila melanogaster, GI19921920, Length=366, Percent_Identity=39.0710382513661, Blast_Score=247, Evalue=8e-66,
Organism=Drosophila melanogaster, GI221330099, Length=363, Percent_Identity=39.1184573002755, Blast_Score=246, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 40716; Mature: 40585

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAMSFAPLQNDTFLRACRRQATDYTPLWLMRQAGRYLPEYKATRARAGSFMGLATNVDY
CCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCC
ATEVTLQPLERFPLDAAILFSDILTVPDAMGLGLSFAEGEGPRFARVVRDEAAVAELAVP
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHCCCCEECCCCCCHHHHHHHHHHHHHHHCCC
DMEKLRYVFDAVTSIRRALDGRVPLIGFSGSPWTLACYMVEGSGSDDYRLVKTLMYSRPD
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCHH
LMHRILAINADAVAAYLNAQIDAGAQAVMVFDSWGGVLADGAFQEFSLAYTTRVLAQLKR
HHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
TGVDGTDVPRIVFTKGGALWLEDMKGLDCEVLGLDWTANLARARALVGGAVGGPGKALQG
CCCCCCCCCEEEEECCCEEEEHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEC
NIDPNVLFAPPEAIAAQARAVLDRFGAPHTDRGTTGPTHIFNLGHGISQHTPPEHVAALV
CCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEECCCCCCCCCCHHHHHHHH
EAVHGHSRAMRAAAGTGRA
HHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PAMSFAPLQNDTFLRACRRQATDYTPLWLMRQAGRYLPEYKATRARAGSFMGLATNVDY
CCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCC
ATEVTLQPLERFPLDAAILFSDILTVPDAMGLGLSFAEGEGPRFARVVRDEAAVAELAVP
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHCCCCEECCCCCCHHHHHHHHHHHHHHHCCC
DMEKLRYVFDAVTSIRRALDGRVPLIGFSGSPWTLACYMVEGSGSDDYRLVKTLMYSRPD
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCHH
LMHRILAINADAVAAYLNAQIDAGAQAVMVFDSWGGVLADGAFQEFSLAYTTRVLAQLKR
HHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
TGVDGTDVPRIVFTKGGALWLEDMKGLDCEVLGLDWTANLARARALVGGAVGGPGKALQG
CCCCCCCCCEEEEECCCEEEEHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEC
NIDPNVLFAPPEAIAAQARAVLDRFGAPHTDRGTTGPTHIFNLGHGISQHTPPEHVAALV
CCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEECCCCCCCCCCHHHHHHHH
EAVHGHSRAMRAAAGTGRA
HHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA