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The map label for this gene is qor [C]

Identifier: 120613090

GI number: 120613090

Start: 4951031

End: 4952083

Strand: Direct

Name: qor [C]

Synonym: Aave_4454

Alternate gene names: 120613090

Gene position: 4951031-4952083 (Clockwise)

Preceding gene: 120613088

Following gene: 120613091

Centisome position: 92.49

GC content: 73.22

Gene sequence:

>1053_bases
ATGAAAGCCGTCGGCTATTTCACCCCCCATGCCCTCGATGCCGCCACCGGCCAGGGCCTGCAGGACTTCTCCGATCTGCC
CGCGCCCGTGCCGCGCCCGCACGACCTGCTGGTGCGCGTGCGCGCCGTCTCCGTGAACCCGGTGGACACCAAGGTGCGCG
CGAGCGCCGCGCCCGCCGAGGCCGGCCAGCCCAAGGTGCTCGGCTGGGATGCGGTCGGCACCGTGGAGGCGCTGGGCGCC
GAAGTGCGTGGTTTCGCCGTGGGCGACCGCGTGTTCTATGCCGGCGCCATCGACCGCCCCGGCACGAATGCCGAGCTGCA
TGCGGTGGATGCGCGCATCGCCGCCCATGCGCCGGCCACCTGGACCGATGCCGAAGCCGCCGCCGTGCCGCTCACCGCCA
TCACGGCCTGGGAGCTGCTGTTCGACCGCCTGGGCGTGCCCCGCCACCCGCAGACGGTGGATGGCCCCGTGCCGACAGCG
GCCGACGCACCGGTGCTGCTGGTGGTGGGCGGCGCGGGCGGCGTGGGTTCGATGCTCATCCAGATCGCGCGCCAGCTCAC
CGGCCTGCGCGTGGTCGCCACCGCCTCGCGCCCGGAAACCCGCCAGTGGTGCCTGGACCTGGGCGCGCATGCGGTCATCG
ACCACCGCGAGCCCTTCGCGCCGCAGCTCGCGGCCCTGGGCATCGGGGCCGTCGATGCGGTGGCCAGCCTCACCCACACG
CCGCAATACCTGGCGCAGTACGTCGAATGCCTGCGCCCGCAAGGCCGCATCGCGGTGATCGACGACATGCCCTCGCTCGA
CGTGATGCCGCTCAAGCGCAAGAGCATCTCGCTGCACTGGGAGATGATGTTCACGCGCCCGATGTTCGGCACGCCCGACA
TGGCCGCGCAGGGCCGACTGCTGGCCGAAGTGGCGGAACTCGCCCGCGCGGGCCGCCTGCGCAGCACGCTCACCGACACC
CTGGGCCCGCTCTCGGCCGCCACGCTGCGCGAGGCGCACGCCCGCATCGAGAGCGGCCGGACCATCGGCAAGCTGGTGCT
GGTAGCCCCCTGA

Upstream 100 bases:

>100_bases
TTTTGAATCACCAGAATCAGGGCAGCCCTTCCGTGGCGCCCGACCGATCCCGGGCGATCCGCGCCATGCCGTTGCCACTA
ACCCTCAGAAAGGACTCCCC

Downstream 100 bases:

>100_bases
GGCGCTTCGCGCCATCCCCCAGGGGACGCCGCCAGTGGCCCGGCAAAGCCGGTTCCACGGCGTCCGCTGGCATGGCCTGC
TCCGCGGCCTTCGGACAGGG

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKAVGYFTPHALDAATGQGLQDFSDLPAPVPRPHDLLVRVRAVSVNPVDTKVRASAAPAEAGQPKVLGWDAVGTVEALGA
EVRGFAVGDRVFYAGAIDRPGTNAELHAVDARIAAHAPATWTDAEAAAVPLTAITAWELLFDRLGVPRHPQTVDGPVPTA
ADAPVLLVVGGAGGVGSMLIQIARQLTGLRVVATASRPETRQWCLDLGAHAVIDHREPFAPQLAALGIGAVDAVASLTHT
PQYLAQYVECLRPQGRIAVIDDMPSLDVMPLKRKSISLHWEMMFTRPMFGTPDMAAQGRLLAEVAELARAGRLRSTLTDT
LGPLSAATLREAHARIESGRTIGKLVLVAP

Sequences:

>Translated_350_residues
MKAVGYFTPHALDAATGQGLQDFSDLPAPVPRPHDLLVRVRAVSVNPVDTKVRASAAPAEAGQPKVLGWDAVGTVEALGA
EVRGFAVGDRVFYAGAIDRPGTNAELHAVDARIAAHAPATWTDAEAAAVPLTAITAWELLFDRLGVPRHPQTVDGPVPTA
ADAPVLLVVGGAGGVGSMLIQIARQLTGLRVVATASRPETRQWCLDLGAHAVIDHREPFAPQLAALGIGAVDAVASLTHT
PQYLAQYVECLRPQGRIAVIDDMPSLDVMPLKRKSISLHWEMMFTRPMFGTPDMAAQGRLLAEVAELARAGRLRSTLTDT
LGPLSAATLREAHARIESGRTIGKLVLVAP
>Mature_350_residues
MKAVGYFTPHALDAATGQGLQDFSDLPAPVPRPHDLLVRVRAVSVNPVDTKVRASAAPAEAGQPKVLGWDAVGTVEALGA
EVRGFAVGDRVFYAGAIDRPGTNAELHAVDARIAAHAPATWTDAEAAAVPLTAITAWELLFDRLGVPRHPQTVDGPVPTA
ADAPVLLVVGGAGGVGSMLIQIARQLTGLRVVATASRPETRQWCLDLGAHAVIDHREPFAPQLAALGIGAVDAVASLTHT
PQYLAQYVECLRPQGRIAVIDDMPSLDVMPLKRKSISLHWEMMFTRPMFGTPDMAAQGRLLAEVAELARAGRLRSTLTDT
LGPLSAATLREAHARIESGRTIGKLVLVAP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=343, Percent_Identity=27.9883381924198, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI194239674, Length=249, Percent_Identity=28.5140562248996, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI13236495, Length=249, Percent_Identity=28.5140562248996, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI194239676, Length=194, Percent_Identity=32.4742268041237, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI24308257, Length=350, Percent_Identity=23.4285714285714, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1790485, Length=187, Percent_Identity=29.9465240641711, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507255, Length=241, Percent_Identity=31.1203319502075, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71987554, Length=205, Percent_Identity=30.2439024390244, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36912; Mature: 36912

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVGYFTPHALDAATGQGLQDFSDLPAPVPRPHDLLVRVRAVSVNPVDTKVRASAAPAE
CCCCCCCCCCHHCHHCCCCCHHHHCCCCCCCCCHHEEEEEEEEECCCCCCCCCCCCCCCC
AGQPKVLGWDAVGTVEALGAEVRGFAVGDRVFYAGAIDRPGTNAELHAVDARIAAHAPAT
CCCCCEEECCCHHHHHHHCCHHCEEEECCEEEEEECCCCCCCCCEEEEEHHHHHHCCCCC
WTDAEAAAVPLTAITAWELLFDRLGVPRHPQTVDGPVPTAADAPVLLVVGGAGGVGSMLI
CCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHH
QIARQLTGLRVVATASRPETRQWCLDLGAHAVIDHREPFAPQLAALGIGAVDAVASLTHT
HHHHHHCCEEEEEECCCCCHHHHHHHCCCCEEECCCCCCCCHHHHHCCCHHHHHHHHCCC
PQYLAQYVECLRPQGRIAVIDDMPSLDVMPLKRKSISLHWEMMFTRPMFGTPDMAAQGRL
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHCCHH
LAEVAELARAGRLRSTLTDTLGPLSAATLREAHARIESGRTIGKLVLVAP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MKAVGYFTPHALDAATGQGLQDFSDLPAPVPRPHDLLVRVRAVSVNPVDTKVRASAAPAE
CCCCCCCCCCHHCHHCCCCCHHHHCCCCCCCCCHHEEEEEEEEECCCCCCCCCCCCCCCC
AGQPKVLGWDAVGTVEALGAEVRGFAVGDRVFYAGAIDRPGTNAELHAVDARIAAHAPAT
CCCCCEEECCCHHHHHHHCCHHCEEEECCEEEEEECCCCCCCCCEEEEEHHHHHHCCCCC
WTDAEAAAVPLTAITAWELLFDRLGVPRHPQTVDGPVPTAADAPVLLVVGGAGGVGSMLI
CCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHH
QIARQLTGLRVVATASRPETRQWCLDLGAHAVIDHREPFAPQLAALGIGAVDAVASLTHT
HHHHHHCCEEEEEECCCCCHHHHHHHCCCCEEECCCCCCCCHHHHHCCCHHHHHHHHCCC
PQYLAQYVECLRPQGRIAVIDDMPSLDVMPLKRKSISLHWEMMFTRPMFGTPDMAAQGRL
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHCCHH
LAEVAELARAGRLRSTLTDTLGPLSAATLREAHARIESGRTIGKLVLVAP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA