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The map label for this gene is acdA [H]

Identifier: 120611835

GI number: 120611835

Start: 3505101

End: 3506270

Strand: Reverse

Name: acdA [H]

Synonym: Aave_3176

Alternate gene names: 120611835

Gene position: 3506270-3505101 (Counterclockwise)

Preceding gene: 120611836

Following gene: 120611834

Centisome position: 65.5

GC content: 73.85

Gene sequence:

>1170_bases
ATGGCGGACGTGACTTATCTCGACTGGCCGTTCTTCGAGCCGCGGCATGCGCAGCTGGCCCGCGACCTGGATGCCTGGGC
ACAGGCCCATCTGCATGCTCAGCACGGCCCCGACGTGGACGCCGAATGCCGCGCCCTGGTGCGCGCGCTCGGCGAGGGCG
GCTGGCTGCGCCATGCCGTGGGCGAATCCGGCGCCGCGATCGACACCCGCACGCTCTGCCTGATCCGCGAGACGCTGGCG
CGCCATTCGGGCCTGGCGGATTTCGCATTCGCCATGCAGGGCCTGGGCAGCGGGGCGATCAGCCTGCACGGCACGCCGGA
GCAGCGCGCGCGCTACCTCGAGCGCGTGGCGCGCGGCGAGGCCATCGCCGCCTTCGCGCTCTCGGAGCCCGAGGCCGGCT
CCGACGTCGCGGCCATGGGCTGCACGGCGCGCGCCGAGGGCGACGGGTACGTGCTCGACGGCGAGAAGACGTGGATCTCC
AACGGCGGCATCGCCGACTTCTACGTGGTGTTCGCGCGCACCGGCGAGGCGCCCGGCGCGCGCGGCATCAGCGCCTTCAT
CGTCGATGCCGACGCGCCGGGCTTCTCGGTTGCCGGGCGCATCGAGGTGATCGCGCCGCACCCGCTCGCGCGCCTGCGCT
TCGACGGCTGCCGCGTGCCCGCTGCGCAGCGCCTGGGTGCGCCCGGCGAGGGCTTCAAGGTGGCCATGCGCACGCTGGAC
GTGTTCCGCACCTCCGTGGCCGCGGCGGCGCTGGGCTTCGCGCGGCGCGCGATGGACGAGGCGCTGTCGCGCGCCACCAC
GCGCCGCATGTTCGGCGGCGTGCTGGCCGACTTCCAGCTCACCCAGGCGAAGCTCGCGCAGATGGCCACGGCCATCGACA
GCGCGGCGCTGCTCACCTACCGCGCCGCCTGGCTGCGCGACCGCGGCGCGGTCGTCACGCGCGAGGCCGCCATGGCCAAG
ATGACGGCCACCGAGAACGCGCAGCAGGTGATCGATGCGGCAGTGCAGCTTTTCGGGGGGCTCGGCGTGGTGAGCGGGCA
GCCGGTGGAACGCCTCTACCGCGAGATCCGCGCCCTGCGCATCTACGAAGGGGCCACCGAGGTGCAGCAGCTCATCATCG
GCCGCGACCTGCTCAAGTCCGCGGCGGTTGCCGGGGCCGCCGCCGGCTGA

Upstream 100 bases:

>100_bases
GAGGCGCAGGCGCAGGCGATCTGCATGCTGACGGAGGATTTCTCTCGGGCCTACCGTGCGTTCGTCGCAAAACAGAAACC
GCGCTTCGAAGGAAACTGAC

Downstream 100 bases:

>100_bases
CGCCGCGCCTTGTGCACGACGGCCCTTTTGCACGACGGCTCATCGATCCGGAACCGGAAAGGACAAGGAAGACGCCATGC
ATGCCAGCGCCCACGTCGAT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MADVTYLDWPFFEPRHAQLARDLDAWAQAHLHAQHGPDVDAECRALVRALGEGGWLRHAVGESGAAIDTRTLCLIRETLA
RHSGLADFAFAMQGLGSGAISLHGTPEQRARYLERVARGEAIAAFALSEPEAGSDVAAMGCTARAEGDGYVLDGEKTWIS
NGGIADFYVVFARTGEAPGARGISAFIVDADAPGFSVAGRIEVIAPHPLARLRFDGCRVPAAQRLGAPGEGFKVAMRTLD
VFRTSVAAAALGFARRAMDEALSRATTRRMFGGVLADFQLTQAKLAQMATAIDSAALLTYRAAWLRDRGAVVTREAAMAK
MTATENAQQVIDAAVQLFGGLGVVSGQPVERLYREIRALRIYEGATEVQQLIIGRDLLKSAAVAGAAAG

Sequences:

>Translated_389_residues
MADVTYLDWPFFEPRHAQLARDLDAWAQAHLHAQHGPDVDAECRALVRALGEGGWLRHAVGESGAAIDTRTLCLIRETLA
RHSGLADFAFAMQGLGSGAISLHGTPEQRARYLERVARGEAIAAFALSEPEAGSDVAAMGCTARAEGDGYVLDGEKTWIS
NGGIADFYVVFARTGEAPGARGISAFIVDADAPGFSVAGRIEVIAPHPLARLRFDGCRVPAAQRLGAPGEGFKVAMRTLD
VFRTSVAAAALGFARRAMDEALSRATTRRMFGGVLADFQLTQAKLAQMATAIDSAALLTYRAAWLRDRGAVVTREAAMAK
MTATENAQQVIDAAVQLFGGLGVVSGQPVERLYREIRALRIYEGATEVQQLIIGRDLLKSAAVAGAAAG
>Mature_388_residues
ADVTYLDWPFFEPRHAQLARDLDAWAQAHLHAQHGPDVDAECRALVRALGEGGWLRHAVGESGAAIDTRTLCLIRETLAR
HSGLADFAFAMQGLGSGAISLHGTPEQRARYLERVARGEAIAAFALSEPEAGSDVAAMGCTARAEGDGYVLDGEKTWISN
GGIADFYVVFARTGEAPGARGISAFIVDADAPGFSVAGRIEVIAPHPLARLRFDGCRVPAAQRLGAPGEGFKVAMRTLDV
FRTSVAAAALGFARRAMDEALSRATTRRMFGGVLADFQLTQAKLAQMATAIDSAALLTYRAAWLRDRGAVVTREAAMAKM
TATENAQQVIDAAVQLFGGLGVVSGQPVERLYREIRALRIYEGATEVQQLIIGRDLLKSAAVAGAAAG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=343, Percent_Identity=42.2740524781341, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI4557231, Length=339, Percent_Identity=37.1681415929204, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI187960098, Length=339, Percent_Identity=37.1681415929204, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI226958412, Length=370, Percent_Identity=32.7027027027027, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI226958414, Length=307, Percent_Identity=34.8534201954397, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI4501859, Length=310, Percent_Identity=36.4516129032258, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI21361497, Length=295, Percent_Identity=37.6271186440678, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4557235, Length=294, Percent_Identity=38.4353741496599, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI76496475, Length=294, Percent_Identity=38.4353741496599, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI7656849, Length=367, Percent_Identity=32.425068119891, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=28.3819628647215, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI211971008, Length=289, Percent_Identity=33.5640138408304, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI48976061, Length=289, Percent_Identity=33.5640138408304, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI4503943, Length=350, Percent_Identity=29.1428571428571, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI38505218, Length=311, Percent_Identity=28.6173633440514, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI7669494, Length=338, Percent_Identity=28.698224852071, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1786223, Length=279, Percent_Identity=31.1827956989247, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI87081958, Length=281, Percent_Identity=31.6725978647687, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI87081702, Length=278, Percent_Identity=28.4172661870504, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082384, Length=277, Percent_Identity=29.6028880866426, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=342, Percent_Identity=36.5497076023392, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17569725, Length=350, Percent_Identity=36, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17570075, Length=341, Percent_Identity=36.6568914956012, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17538396, Length=319, Percent_Identity=35.1097178683386, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=292, Percent_Identity=35.6164383561644, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17508101, Length=362, Percent_Identity=32.8729281767956, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71985184, Length=293, Percent_Identity=38.9078498293515, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17506239, Length=275, Percent_Identity=35.2727272727273, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71990804, Length=223, Percent_Identity=36.322869955157, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71985192, Length=241, Percent_Identity=37.7593360995851, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17505929, Length=284, Percent_Identity=30.2816901408451, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17551932, Length=284, Percent_Identity=29.2253521126761, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17534353, Length=283, Percent_Identity=30.3886925795053, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI32563615, Length=180, Percent_Identity=34.4444444444444, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71982178, Length=218, Percent_Identity=31.1926605504587, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=28.8702928870293, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562446, Length=316, Percent_Identity=28.4810126582279, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI86563383, Length=275, Percent_Identity=28.7272727272727, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=275, Percent_Identity=28.7272727272727, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17540912, Length=292, Percent_Identity=26.3698630136986, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646207, Length=337, Percent_Identity=38.8724035608309, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI21356377, Length=341, Percent_Identity=38.41642228739, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24660351, Length=324, Percent_Identity=38.5802469135802, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24666513, Length=343, Percent_Identity=34.1107871720117, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=32.4538258575198, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI281363737, Length=294, Percent_Identity=36.734693877551, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI19920834, Length=298, Percent_Identity=30.5369127516779, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24652780, Length=259, Percent_Identity=24.3243243243243, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41261; Mature: 41130

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVTYLDWPFFEPRHAQLARDLDAWAQAHLHAQHGPDVDAECRALVRALGEGGWLRHAV
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEHHH
GESGAAIDTRTLCLIRETLARHSGLADFAFAMQGLGSGAISLHGTPEQRARYLERVARGE
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCC
AIAAFALSEPEAGSDVAAMGCTARAEGDGYVLDGEKTWISNGGIADFYVVFARTGEAPGA
CEEEEEECCCCCCCCHHHHCCCEEECCCCEEECCCEEEECCCCCEEEEEEEEECCCCCCC
RGISAFIVDADAPGFSVAGRIEVIAPHPLARLRFDGCRVPAAQRLGAPGEGFKVAMRTLD
CCCEEEEEECCCCCCEECCEEEEECCCCHHHHEECCCCCCHHHHCCCCCCHHHHHHHHHH
VFRTSVAAAALGFARRAMDEALSRATTRRMFGGVLADFQLTQAKLAQMATAIDSAALLTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAWLRDRGAVVTREAAMAKMTATENAQQVIDAAVQLFGGLGVVSGQPVERLYREIRALR
HHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
IYEGATEVQQLIIGRDLLKSAAVAGAAAG
HHCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ADVTYLDWPFFEPRHAQLARDLDAWAQAHLHAQHGPDVDAECRALVRALGEGGWLRHAV
CCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEHHH
GESGAAIDTRTLCLIRETLARHSGLADFAFAMQGLGSGAISLHGTPEQRARYLERVARGE
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCC
AIAAFALSEPEAGSDVAAMGCTARAEGDGYVLDGEKTWISNGGIADFYVVFARTGEAPGA
CEEEEEECCCCCCCCHHHHCCCEEECCCCEEECCCEEEECCCCCEEEEEEEEECCCCCCC
RGISAFIVDADAPGFSVAGRIEVIAPHPLARLRFDGCRVPAAQRLGAPGEGFKVAMRTLD
CCCEEEEEECCCCCCEECCEEEEECCCCHHHHEECCCCCCHHHHCCCCCCHHHHHHHHHH
VFRTSVAAAALGFARRAMDEALSRATTRRMFGGVLADFQLTQAKLAQMATAIDSAALLTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAWLRDRGAVVTREAAMAKMTATENAQQVIDAAVQLFGGLGVVSGQPVERLYREIRALR
HHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
IYEGATEVQQLIIGRDLLKSAAVAGAAAG
HHCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]