Click here to switch to the map view.

The map label for this gene is echA12 [H]

Identifier: 120611836

GI number: 120611836

Start: 3506272

End: 3507126

Strand: Reverse

Name: echA12 [H]

Synonym: Aave_3177

Alternate gene names: 120611836

Gene position: 3507126-3506272 (Counterclockwise)

Preceding gene: 120611837

Following gene: 120611835

Centisome position: 65.52

GC content: 70.76

Gene sequence:

>855_bases
ATGACCGAACCCCGCATCGATCCCCGGCTCGTCGCCGGCAACCGCCGGCCGCTCGCCGGCTACCGGGCCGAACACTTCCT
GTGGGACGTGCAGGTCGGCGTGGCCACGATCACGCTGAACCGGCCCGAGCGCAAGAACCCGCTCACCTTCGACAGCTATG
CCGAGCTGCGCGACCTGTTCCACGGCCTGCGGCTGGCCGACGACGTGCGGGCGGTGGTGCTGGCCGGCGCGGGCGGCAAT
TTCTGCTCGGGCGGCGACGTGCACGAGATCATCGGCCCGCTGGTCGCCTTGAAGGCGCCCGAGCTGCTGATGTTCACCCG
CATGACGGGCGAGCTGGTCAAGGCCATGCGCACCTGCCCGCAGCCGATCGTGGCGGCGGTGGACGGCGTGTGCGCCGGCG
CGGGCGCGATCATGGCGATGGCGTCGGACCTGCGCCTGGGCACGGCGCGCAGCAAGACGGCCTTCCTCTTCAACCGCGTG
GGGCTGGCGGGCTGCGACATGGGCGCCTGCGCGATGCTCCCGCGCATCGTCGGCCAGGGCCGCGCGAGCGAACTGCTCTA
CACCGGCCGCAGCCTGGGCGGGGAGGAGGGCGAGCGCTGGGGCTTCTTCAACCGCCTGTGCGAGGCCGATGCCCTGCTGC
CCGAGGCGCAGGCGCTCGCCGCGCAACTGGCCGAGGGGCCGGCCTTCGCCAACGGCATCACCAAGACCATGCTGCACCAG
GAGTGGGCCATGACCATCGAGCAGGCCATCGAGGCCGAGGCGCAGGCGCAGGCGATCTGCATGCTGACGGAGGATTTCTC
TCGGGCCTACCGTGCGTTCGTCGCAAAACAGAAACCGCGCTTCGAAGGAAACTGA

Upstream 100 bases:

>100_bases
AGCGGCAGGTCGCGGCCGGCGCGGACCCGGCCGCCCAGGCCCCGGGCGAGGCGGCCGGCCTTCCCGACACCCCATCGAAA
CGCAGCAGGAAATCCCTCCC

Downstream 100 bases:

>100_bases
CATGGCGGACGTGACTTATCTCGACTGGCCGTTCTTCGAGCCGCGGCATGCGCAGCTGGCCCGCGACCTGGATGCCTGGG
CACAGGCCCATCTGCATGCT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MTEPRIDPRLVAGNRRPLAGYRAEHFLWDVQVGVATITLNRPERKNPLTFDSYAELRDLFHGLRLADDVRAVVLAGAGGN
FCSGGDVHEIIGPLVALKAPELLMFTRMTGELVKAMRTCPQPIVAAVDGVCAGAGAIMAMASDLRLGTARSKTAFLFNRV
GLAGCDMGACAMLPRIVGQGRASELLYTGRSLGGEEGERWGFFNRLCEADALLPEAQALAAQLAEGPAFANGITKTMLHQ
EWAMTIEQAIEAEAQAQAICMLTEDFSRAYRAFVAKQKPRFEGN

Sequences:

>Translated_284_residues
MTEPRIDPRLVAGNRRPLAGYRAEHFLWDVQVGVATITLNRPERKNPLTFDSYAELRDLFHGLRLADDVRAVVLAGAGGN
FCSGGDVHEIIGPLVALKAPELLMFTRMTGELVKAMRTCPQPIVAAVDGVCAGAGAIMAMASDLRLGTARSKTAFLFNRV
GLAGCDMGACAMLPRIVGQGRASELLYTGRSLGGEEGERWGFFNRLCEADALLPEAQALAAQLAEGPAFANGITKTMLHQ
EWAMTIEQAIEAEAQAQAICMLTEDFSRAYRAFVAKQKPRFEGN
>Mature_283_residues
TEPRIDPRLVAGNRRPLAGYRAEHFLWDVQVGVATITLNRPERKNPLTFDSYAELRDLFHGLRLADDVRAVVLAGAGGNF
CSGGDVHEIIGPLVALKAPELLMFTRMTGELVKAMRTCPQPIVAAVDGVCAGAGAIMAMASDLRLGTARSKTAFLFNRVG
LAGCDMGACAMLPRIVGQGRASELLYTGRSLGGEEGERWGFFNRLCEADALLPEAQALAAQLAEGPAFANGITKTMLHQE
WAMTIEQAIEAEAQAQAICMLTEDFSRAYRAFVAKQKPRFEGN

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI70995211, Length=255, Percent_Identity=27.4509803921569, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI20127408, Length=188, Percent_Identity=27.6595744680851, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4502327, Length=287, Percent_Identity=25.4355400696864, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI194097323, Length=252, Percent_Identity=24.6031746031746, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI31542718, Length=248, Percent_Identity=22.5806451612903, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI68989263, Length=187, Percent_Identity=26.2032085561497, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787660, Length=266, Percent_Identity=33.0827067669173, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788597, Length=252, Percent_Identity=27.3809523809524, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI221142681, Length=259, Percent_Identity=26.2548262548263, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787659, Length=253, Percent_Identity=24.901185770751, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788682, Length=201, Percent_Identity=28.3582089552239, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790281, Length=207, Percent_Identity=22.7053140096618, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=247, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17536985, Length=263, Percent_Identity=25.0950570342205, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17540714, Length=227, Percent_Identity=27.3127753303965, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=253, Percent_Identity=25.6916996047431, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17554946, Length=254, Percent_Identity=24.8031496062992, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=250, Percent_Identity=25.2, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19920382, Length=280, Percent_Identity=28.2142857142857, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21357171, Length=261, Percent_Identity=27.9693486590038, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24653139, Length=258, Percent_Identity=29.4573643410853, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=26.5060240963855, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=26.5060240963855, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650670, Length=195, Percent_Identity=29.2307692307692, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19922422, Length=251, Percent_Identity=23.5059760956175, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 30671; Mature: 30540

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPRIDPRLVAGNRRPLAGYRAEHFLWDVQVGVATITLNRPERKNPLTFDSYAELRDLF
CCCCCCCCEEECCCCCCCCCCCHHHEEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHH
HGLRLADDVRAVVLAGAGGNFCSGGDVHEIIGPLVALKAPELLMFTRMTGELVKAMRTCP
HHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
QPIVAAVDGVCAGAGAIMAMASDLRLGTARSKTAFLFNRVGLAGCDMGACAMLPRIVGQG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCC
RASELLYTGRSLGGEEGERWGFFNRLCEADALLPEAQALAAQLAEGPAFANGITKTMLHQ
CHHHHHHHCHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
EWAMTIEQAIEAEAQAQAICMLTEDFSRAYRAFVAKQKPRFEGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TEPRIDPRLVAGNRRPLAGYRAEHFLWDVQVGVATITLNRPERKNPLTFDSYAELRDLF
CCCCCCCEEECCCCCCCCCCCHHHEEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHH
HGLRLADDVRAVVLAGAGGNFCSGGDVHEIIGPLVALKAPELLMFTRMTGELVKAMRTCP
HHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
QPIVAAVDGVCAGAGAIMAMASDLRLGTARSKTAFLFNRVGLAGCDMGACAMLPRIVGQG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCC
RASELLYTGRSLGGEEGERWGFFNRLCEADALLPEAQALAAQLAEGPAFANGITKTMLHQ
CHHHHHHHCHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
EWAMTIEQAIEAEAQAQAICMLTEDFSRAYRAFVAKQKPRFEGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]