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The map label for this gene is gcvT [H]

Identifier: 120611805

GI number: 120611805

Start: 3470867

End: 3471997

Strand: Direct

Name: gcvT [H]

Synonym: Aave_3145

Alternate gene names: 120611805

Gene position: 3470867-3471997 (Clockwise)

Preceding gene: 120611803

Following gene: 120611806

Centisome position: 64.84

GC content: 72.94

Gene sequence:

>1131_bases
ATGTCCGCCGAATCCGCCGTCCTGCACACCACCCCCCTGCACGCGCTGCACCTCGAACTCGGGGCCCGCATGGTGCCCTT
CGCCGGCTACTCCATGCCCGTGCAATACCCCGCCGGCCTGATGGCCGAGCACCTGCACACGCGGCAGGCCGCCGGTCTGT
TCGACGTCTCGCACATGGGCCAGCTGCGCCTCGTCGGCCCCGATGCCGCCGCGGCCTTCGAGACGCTGATCCCTGTGGAC
GTGATCGGGCTCGGCATCGGCAAACAGCGCTACGGCCTGCTGCTGAACGACGAAGGCGGCATCATCGACGACCTGATGTT
CGTGAACCGCGGCGACGACCTGTTCGTGATCGTGAACGGCGCCTGCAAGGCCGGCGACATCGCCCACATCCAGGAGCGCA
TCGGCGGCCGCTGCGAGGTCATCCCCCTGCCCGACCAGGCCCTGCTCGCCCTGCAGGGGCCGCAGGCCGCCGCGGCGCTC
GCGCGCCTGGCACCTGGCACCGCGTCCCTGGTCTTCATGACGGGCGGGCGCTTCGAGATCGCCGGCTGCGACTGCTATGT
GACGCGCAGCGGCTACACCGGCGAGGACGGCTTCGAGATCTCCGTGCCCGCCGCCCAGGCCGAGGCTCTGGCCCGCGCGC
TGCTGGCCCAGCCCGAGGTGAAGCCCATCGGCCTCGGCGCGCGCAACTCGCTGCGGCTGGAAGCCGGCCTGTGCCTCTAC
GGCAACGACATCGACACCACCACCACGCCGCCCGAGGCCGCGCTGAACTGGGCCATCCAGAAGGTACGGCGCACCGGCGG
CGCGCGCGCGGGGGGCTTCCCGGGCGCGGAGAAGGTGCTGGCGCAGATCGACGACCCCTCGCTGCTCGCCCGCCGCCGGG
TGGGACTGGTGGCGCGCGAGCGCGTGCCCGTGCGCGAGCACACCGCCCTGCAGAGCACGGACGGCGCGGCCATCGGCGAA
GTGACCAGCGGCCTGCTGGGCCCGAGCGTGAACCAGCCCATCGCCATGGCCTACGTGGCGCCGGAGTTCGCCGCGGCCGG
CACGGTGGTGCACGCGATCGTGCGCGGCAAGGCCGTGCCGATGGAGGTCGGCCCCATGCCGTTCCTGCCGCCCCGCTACC
ACCGCGGCTGA

Upstream 100 bases:

>100_bases
TGAATCTCTCAGGTAAAGCGGACAGCGGGCACAGGCGTGGCGCTTCGATGGCGGCACGCGCATCGTCCGTCCCTGCCTGA
CTGAAAGGCCCGCTCCGCCC

Downstream 100 bases:

>100_bases
CCGCGGCGCGCGCGAGCCTGCGCCCGGCCGCGCGCCGGCCGCGGCTACAGTCGCAGTCGCGGGCCCCCACCAGGGCCACG
CATTCTTTTTTTCGTTTTCC

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MSAESAVLHTTPLHALHLELGARMVPFAGYSMPVQYPAGLMAEHLHTRQAAGLFDVSHMGQLRLVGPDAAAAFETLIPVD
VIGLGIGKQRYGLLLNDEGGIIDDLMFVNRGDDLFVIVNGACKAGDIAHIQERIGGRCEVIPLPDQALLALQGPQAAAAL
ARLAPGTASLVFMTGGRFEIAGCDCYVTRSGYTGEDGFEISVPAAQAEALARALLAQPEVKPIGLGARNSLRLEAGLCLY
GNDIDTTTTPPEAALNWAIQKVRRTGGARAGGFPGAEKVLAQIDDPSLLARRRVGLVARERVPVREHTALQSTDGAAIGE
VTSGLLGPSVNQPIAMAYVAPEFAAAGTVVHAIVRGKAVPMEVGPMPFLPPRYHRG

Sequences:

>Translated_376_residues
MSAESAVLHTTPLHALHLELGARMVPFAGYSMPVQYPAGLMAEHLHTRQAAGLFDVSHMGQLRLVGPDAAAAFETLIPVD
VIGLGIGKQRYGLLLNDEGGIIDDLMFVNRGDDLFVIVNGACKAGDIAHIQERIGGRCEVIPLPDQALLALQGPQAAAAL
ARLAPGTASLVFMTGGRFEIAGCDCYVTRSGYTGEDGFEISVPAAQAEALARALLAQPEVKPIGLGARNSLRLEAGLCLY
GNDIDTTTTPPEAALNWAIQKVRRTGGARAGGFPGAEKVLAQIDDPSLLARRRVGLVARERVPVREHTALQSTDGAAIGE
VTSGLLGPSVNQPIAMAYVAPEFAAAGTVVHAIVRGKAVPMEVGPMPFLPPRYHRG
>Mature_375_residues
SAESAVLHTTPLHALHLELGARMVPFAGYSMPVQYPAGLMAEHLHTRQAAGLFDVSHMGQLRLVGPDAAAAFETLIPVDV
IGLGIGKQRYGLLLNDEGGIIDDLMFVNRGDDLFVIVNGACKAGDIAHIQERIGGRCEVIPLPDQALLALQGPQAAAALA
RLAPGTASLVFMTGGRFEIAGCDCYVTRSGYTGEDGFEISVPAAQAEALARALLAQPEVKPIGLGARNSLRLEAGLCLYG
NDIDTTTTPPEAALNWAIQKVRRTGGARAGGFPGAEKVLAQIDDPSLLARRRVGLVARERVPVREHTALQSTDGAAIGEV
TSGLLGPSVNQPIAMAYVAPEFAAAGTVVHAIVRGKAVPMEVGPMPFLPPRYHRG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=382, Percent_Identity=45.2879581151832, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI257796258, Length=358, Percent_Identity=45.8100558659218, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI257796254, Length=376, Percent_Identity=42.8191489361702, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI257796256, Length=322, Percent_Identity=43.7888198757764, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI24797151, Length=330, Percent_Identity=24.2424242424242, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI197927446, Length=325, Percent_Identity=26.4615384615385, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI21361378, Length=325, Percent_Identity=26.4615384615385, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1789272, Length=371, Percent_Identity=34.7708894878706, Blast_Score=168, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17560118, Length=382, Percent_Identity=40.5759162303665, Blast_Score=240, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6320222, Length=388, Percent_Identity=38.9175257731959, Blast_Score=259, Evalue=7e-70,
Organism=Drosophila melanogaster, GI20129441, Length=381, Percent_Identity=43.3070866141732, Blast_Score=275, Evalue=5e-74,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39449; Mature: 39318

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAESAVLHTTPLHALHLELGARMVPFAGYSMPVQYPAGLMAEHLHTRQAAGLFDVSHMG
CCCCCCEEEECCCCEEEHHHCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCEEECCCCC
QLRLVGPDAAAAFETLIPVDVIGLGIGKQRYGLLLNDEGGIIDDLMFVNRGDDLFVIVNG
CEEEECCCHHHHHHHHCCHHHEEECCCCHHCEEEECCCCCEEEHEEEEECCCCEEEEEEC
ACKAGDIAHIQERIGGRCEVIPLPDQALLALQGPQAAAALARLAPGTASLVFMTGGRFEI
CCCCCCHHHHHHHHCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCEEEEEEECCEEEE
AGCDCYVTRSGYTGEDGFEISVPAAQAEALARALLAQPEVKPIGLGARNSLRLEAGLCLY
ECCEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEEEEEEE
GNDIDTTTTPPEAALNWAIQKVRRTGGARAGGFPGAEKVLAQIDDPSLLARRRVGLVARE
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCHHHHC
RVPVREHTALQSTDGAAIGEVTSGLLGPSVNQPIAMAYVAPEFAAAGTVVHAIVRGKAVP
CCCCHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCC
MEVGPMPFLPPRYHRG
EECCCCCCCCCCCCCC
>Mature Secondary Structure 
SAESAVLHTTPLHALHLELGARMVPFAGYSMPVQYPAGLMAEHLHTRQAAGLFDVSHMG
CCCCCEEEECCCCEEEHHHCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCEEECCCCC
QLRLVGPDAAAAFETLIPVDVIGLGIGKQRYGLLLNDEGGIIDDLMFVNRGDDLFVIVNG
CEEEECCCHHHHHHHHCCHHHEEECCCCHHCEEEECCCCCEEEHEEEEECCCCEEEEEEC
ACKAGDIAHIQERIGGRCEVIPLPDQALLALQGPQAAAALARLAPGTASLVFMTGGRFEI
CCCCCCHHHHHHHHCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCEEEEEEECCEEEE
AGCDCYVTRSGYTGEDGFEISVPAAQAEALARALLAQPEVKPIGLGARNSLRLEAGLCLY
ECCEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEEEEEEE
GNDIDTTTTPPEAALNWAIQKVRRTGGARAGGFPGAEKVLAQIDDPSLLARRRVGLVARE
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCHHHHC
RVPVREHTALQSTDGAAIGEVTSGLLGPSVNQPIAMAYVAPEFAAAGTVVHAIVRGKAVP
CCCCHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCC
MEVGPMPFLPPRYHRG
EECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA