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The map label for this gene is map [H]

Identifier: 120611760

GI number: 120611760

Start: 3423301

End: 3424116

Strand: Direct

Name: map [H]

Synonym: Aave_3100

Alternate gene names: 120611760

Gene position: 3423301-3424116 (Clockwise)

Preceding gene: 120611756

Following gene: 120611761

Centisome position: 63.95

GC content: 65.81

Gene sequence:

>816_bases
ATGAGCATCACCATCAAGTCCGCCGAGGAAATCGCCGGCATGCGCGAAGCCTGCCGCCTGGCTTCGGAAGTGCTGGACTA
CATCACGCCCCACATCCGTCCCGGCATCACCACGAACGACGTGGACCGGCTCGCCGCCGAGTGCATGGCCGCGCAGGGCA
CCATCTCGGCCACCATCGGCTACCAGCCGCCGGGCTACCCGCCCTACCCCAAGTCGCTCTGCACCTCGCTCAACCACGTG
GTCTGCCACGGGATACCGAACGACAAGCCCCTCAAGAAGGGCGACATCATGAACGTGGACGTCACCGTCATCACCAAGGA
CGGCTGGTACGGCGACAACAGCCGCATGTACCTGATCGGCGACGTCTCCATCGCCGCGAAGCGCCTGTGCCAGCTCACCT
TCGAGGCGATGTGGCTGGGCATCCTGCAGGTGAAGCCGGGAGCGCGCCTGGGCGACATCGGCCACGCCATCCAGAAATTC
GCCGAAGGCCACGGCCTGTCTGTCGTGCGCGAATTCTGCGGCCACGGCATCGGCAAGAAATTCCACGAAGAGCCCCAGGT
GCTGCACTACGGCCGCCCCGGCACGCTCGAGGAACTGGTGCCGGGCATGACCTTCACCATCGAGCCCATGCTCAACGCCG
GCCGCCGCGAGGTCAAGGAGCACGGCAACGACGGCTGGACCATCGTCACCAAGGACCACAGCCTGTCCGCCCAGTGGGAG
CACACGGTGCTCGTGACCGAAACGGGCTACGAAGTCCTCACCCTGTCGGCCGGTTCTCCCCCGCTGCCTCCGTTCGTCAC
CGCCGTGAAGACCTGA

Upstream 100 bases:

>100_bases
CGGCGCAGCCCGCCATTTTACCGGGCCGGCGGCTTCGGCTGGCCACCGTTGCCATCGCCCCGTTGAGGCGCCGGACGGCC
CCCGATGGGATAATCCCGCC

Downstream 100 bases:

>100_bases
CGGCTGCGCCGGCGCGCACAGGCGCAGCATGGTTCTTGCTTGCGGTGCGGCCATGTCCGCCCACCGCTCCACGACGCCCC
CATCGCCCCTTTCCCCGCCC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSITIKSAEEIAGMREACRLASEVLDYITPHIRPGITTNDVDRLAAECMAAQGTISATIGYQPPGYPPYPKSLCTSLNHV
VCHGIPNDKPLKKGDIMNVDVTVITKDGWYGDNSRMYLIGDVSIAAKRLCQLTFEAMWLGILQVKPGARLGDIGHAIQKF
AEGHGLSVVREFCGHGIGKKFHEEPQVLHYGRPGTLEELVPGMTFTIEPMLNAGRREVKEHGNDGWTIVTKDHSLSAQWE
HTVLVTETGYEVLTLSAGSPPLPPFVTAVKT

Sequences:

>Translated_271_residues
MSITIKSAEEIAGMREACRLASEVLDYITPHIRPGITTNDVDRLAAECMAAQGTISATIGYQPPGYPPYPKSLCTSLNHV
VCHGIPNDKPLKKGDIMNVDVTVITKDGWYGDNSRMYLIGDVSIAAKRLCQLTFEAMWLGILQVKPGARLGDIGHAIQKF
AEGHGLSVVREFCGHGIGKKFHEEPQVLHYGRPGTLEELVPGMTFTIEPMLNAGRREVKEHGNDGWTIVTKDHSLSAQWE
HTVLVTETGYEVLTLSAGSPPLPPFVTAVKT
>Mature_270_residues
SITIKSAEEIAGMREACRLASEVLDYITPHIRPGITTNDVDRLAAECMAAQGTISATIGYQPPGYPPYPKSLCTSLNHVV
CHGIPNDKPLKKGDIMNVDVTVITKDGWYGDNSRMYLIGDVSIAAKRLCQLTFEAMWLGILQVKPGARLGDIGHAIQKFA
EGHGLSVVREFCGHGIGKKFHEEPQVLHYGRPGTLEELVPGMTFTIEPMLNAGRREVKEHGNDGWTIVTKDHSLSAQWEH
TVLVTETGYEVLTLSAGSPPLPPFVTAVKT

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=254, Percent_Identity=45.6692913385827, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI40385867, Length=253, Percent_Identity=38.7351778656126, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1786364, Length=257, Percent_Identity=55.2529182879377, Blast_Score=287, Evalue=6e-79,
Organism=Escherichia coli, GI1788728, Length=212, Percent_Identity=23.5849056603774, Blast_Score=61, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI71996291, Length=260, Percent_Identity=42.3076923076923, Blast_Score=204, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6323273, Length=261, Percent_Identity=40.6130268199234, Blast_Score=196, Evalue=4e-51,
Organism=Drosophila melanogaster, GI21355531, Length=264, Percent_Identity=43.9393939393939, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24583427, Length=253, Percent_Identity=40.7114624505929, Blast_Score=181, Evalue=6e-46,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29558; Mature: 29427

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITIKSAEEIAGMREACRLASEVLDYITPHIRPGITTNDVDRLAAECMAAQGTISATIG
CEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
YQPPGYPPYPKSLCTSLNHVVCHGIPNDKPLKKGDIMNVDVTVITKDGWYGDNSRMYLIG
CCCCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEEEEECCEECCCCCEEEEE
DVSIAAKRLCQLTFEAMWLGILQVKPGARLGDIGHAIQKFAEGHGLSVVREFCGHGIGKK
CHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCHH
FHEEPQVLHYGRPGTLEELVPGMTFTIEPMLNAGRREVKEHGNDGWTIVTKDHSLSAQWE
HCCCCCEEECCCCCCHHHHCCCCEEEECHHHHCHHHHHHHCCCCCCEEEEECCCCCCCCC
HTVLVTETGYEVLTLSAGSPPLPPFVTAVKT
EEEEEEECCCEEEEEECCCCCCCHHHHCCCC
>Mature Secondary Structure 
SITIKSAEEIAGMREACRLASEVLDYITPHIRPGITTNDVDRLAAECMAAQGTISATIG
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
YQPPGYPPYPKSLCTSLNHVVCHGIPNDKPLKKGDIMNVDVTVITKDGWYGDNSRMYLIG
CCCCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCCEEEEEEEEEEECCEECCCCCEEEEE
DVSIAAKRLCQLTFEAMWLGILQVKPGARLGDIGHAIQKFAEGHGLSVVREFCGHGIGKK
CHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCHH
FHEEPQVLHYGRPGTLEELVPGMTFTIEPMLNAGRREVKEHGNDGWTIVTKDHSLSAQWE
HCCCCCEEECCCCCCHHHHCCCCEEEECHHHHCHHHHHHHCCCCCCEEEEECCCCCCCCC
HTVLVTETGYEVLTLSAGSPPLPPFVTAVKT
EEEEEEECCCEEEEEECCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]