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The map label for this gene is ntcA [H]

Identifier: 120611737

GI number: 120611737

Start: 3389948

End: 3390667

Strand: Direct

Name: ntcA [H]

Synonym: Aave_3075

Alternate gene names: 120611737

Gene position: 3389948-3390667 (Clockwise)

Preceding gene: 120611736

Following gene: 120611738

Centisome position: 63.33

GC content: 66.39

Gene sequence:

>720_bases
ATGGACGACCCCATTCTTACCATCGAAGAACGAGAGGCGATCAATACCGGTCGCTGGTTTTCCTCCCTTTCCCCTTCGCT
GCGGCACGACATACTCCGATGCGCCTACGTCAAACGCTTCAAGGATGGCGGCCTGATCGCCGCCCGCGGCGATCCGCCCG
AGGAATGGATCGCCTGCGCGAAGGGCGCGGTGCGCGTGAGCTCCACGTCGATCTCCGGCAAGCAGATCACGCTGACCTAC
GTGGAGCCGGGCATCTGGTTCGGCGACGTGGCGATCTTCGACGGCGACCGTCGCACGCACGATGCCTACGCGCACGGGGA
CACCACCATCCTCTGCGTGGCCAAGGCGGATTTCCGCAAGATCCTGGCCACGCACGTGGAGTTCTACGAAGCGATGCTGC
GCCTGCATGCGCGGCGCATCCGCCAGCTCTACGGCCTGGTGGAGGATCTCAACACCCTGCCCTTGCGCGCGCGCCTGGCC
AAGCAGCTGCTGCACCTCGTGCGCAGCTACGGCATCCCCAGCCTGTCGCAGGGCGACGAGATCCGCATCGGCCTGCAGCT
GGCGCAGGAAGAACTGGCGCAGCTGCTGGGCGCATCGCGCCAGCGCGTGAACCAGGAACTGAAGGCCATGGAGCGCGAGG
ACGCCATCCGCATCGAGCCGGGCGGCCTGGTCGTGCGCGACCGTGACGTCCTGATGCGCATCGCCGAAGCCGACCACTGA

Upstream 100 bases:

>100_bases
TGCACAGACACGCGCGCGACATCCGCAGGCCCGCGGCCGCCGGGGGACCCGGTCCCGCGGGCGACAATGCTCCCGCCACC
AGTCACGCAAAAGACAGACC

Downstream 100 bases:

>100_bases
CGCCGACCTCCCTGCCGCCCACGCACCACCTGCCACGGAACCACCGCCCATGCCCTCTTACGAACACTTCACCGGCACCC
GCCCCGTTTCCGAGCAGCAT

Product: Crp/FNR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MDDPILTIEEREAINTGRWFSSLSPSLRHDILRCAYVKRFKDGGLIAARGDPPEEWIACAKGAVRVSSTSISGKQITLTY
VEPGIWFGDVAIFDGDRRTHDAYAHGDTTILCVAKADFRKILATHVEFYEAMLRLHARRIRQLYGLVEDLNTLPLRARLA
KQLLHLVRSYGIPSLSQGDEIRIGLQLAQEELAQLLGASRQRVNQELKAMEREDAIRIEPGGLVVRDRDVLMRIAEADH

Sequences:

>Translated_239_residues
MDDPILTIEEREAINTGRWFSSLSPSLRHDILRCAYVKRFKDGGLIAARGDPPEEWIACAKGAVRVSSTSISGKQITLTY
VEPGIWFGDVAIFDGDRRTHDAYAHGDTTILCVAKADFRKILATHVEFYEAMLRLHARRIRQLYGLVEDLNTLPLRARLA
KQLLHLVRSYGIPSLSQGDEIRIGLQLAQEELAQLLGASRQRVNQELKAMEREDAIRIEPGGLVVRDRDVLMRIAEADH
>Mature_239_residues
MDDPILTIEEREAINTGRWFSSLSPSLRHDILRCAYVKRFKDGGLIAARGDPPEEWIACAKGAVRVSSTSISGKQITLTY
VEPGIWFGDVAIFDGDRRTHDAYAHGDTTILCVAKADFRKILATHVEFYEAMLRLHARRIRQLYGLVEDLNTLPLRARLA
KQLLHLVRSYGIPSLSQGDEIRIGLQLAQEELAQLLGASRQRVNQELKAMEREDAIRIEPGGLVVRDRDVLMRIAEADH

Specific function: Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=202, Percent_Identity=23.2673267326733, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR022299
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 26926; Mature: 26926

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDPILTIEEREAINTGRWFSSLSPSLRHDILRCAYVKRFKDGGLIAARGDPPEEWIACA
CCCCEEEECCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHC
KGAVRVSSTSISGKQITLTYVEPGIWFGDVAIFDGDRRTHDAYAHGDTTILCVAKADFRK
CCCEEEECCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCEEEEEEEHHHHHH
ILATHVEFYEAMLRLHARRIRQLYGLVEDLNTLPLRARLAKQLLHLVRSYGIPSLSQGDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCE
IRIGLQLAQEELAQLLGASRQRVNQELKAMEREDAIRIEPGGLVVRDRDVLMRIAEADH
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECHHHHHHHHHCCC
>Mature Secondary Structure
MDDPILTIEEREAINTGRWFSSLSPSLRHDILRCAYVKRFKDGGLIAARGDPPEEWIACA
CCCCEEEECCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHC
KGAVRVSSTSISGKQITLTYVEPGIWFGDVAIFDGDRRTHDAYAHGDTTILCVAKADFRK
CCCEEEECCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCEEEEEEEHHHHHH
ILATHVEFYEAMLRLHARRIRQLYGLVEDLNTLPLRARLAKQLLHLVRSYGIPSLSQGDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCE
IRIGLQLAQEELAQLLGASRQRVNQELKAMEREDAIRIEPGGLVVRDRDVLMRIAEADH
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1630321 [H]