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The map label for this gene is cobB [H]

Identifier: 120611680

GI number: 120611680

Start: 3326629

End: 3327366

Strand: Reverse

Name: cobB [H]

Synonym: Aave_3017

Alternate gene names: 120611680

Gene position: 3327366-3326629 (Counterclockwise)

Preceding gene: 120611681

Following gene: 120611674

Centisome position: 62.16

GC content: 73.58

Gene sequence:

>738_bases
GTGACGCAGGAGGCCATGGAACGCCTGCGGTCCTGGGTGGCCGGGGCGCAGCGCATCCTGGTGCTGACCGGCGCCGGGAT
GAGCGCGGAATCCGGGGTGCCCACCTTCCGCGATGCCCATACGGGCCACTGGGCGAAGTTCCGCCCGGAGGAGATGGCCA
GCGAGGAAGGCTTCCGCGCCCGTCCCGGCACGGTGTGGACGTGGTACGAACACCGCCGGGCCCAGCTGGCTGCGGTGCAG
CCCAACGCCGGCCACCGTGCGCTGGCGGATTTCGCGCGTCGCCACCCTGAGCGGCTGACGGTCGCGACGCAGAACGTGGA
CGGCCTGCACCAGATGGCCGGCAGCGAGGGGGTGCTCTGCCTGCACGGCGACCTGCGCGCCAACCGCTGGCTGGATGCGC
CGCTGCCCTGCTGCGATGCCGATGCTGCCGTGCCGGGCTGCCCGCCCACCTGCGCCACCTGCGGCAATCTCCTGCGGCCG
GCCGTGGTCTGGTTCGGCGAGGAACTTCCGGCACGGTTGCTGGAGCAGGCGCAGGACGCTGCCCACGAGTGCGACCTGAT
GCTGTCCGTGGGGACCGCCGGCGTCGTCTATCCCGCCGCCGGCCTGGCGCATACCGCGCACCGGGCCGGCGCGCGCGTGG
CCATCGTCAATCCGGAACCCAGCGCGCTCGACGGCGTGGCGGACCTGCTGGTGCCCGGCACGGCGGCGCGGGTGCTGCCC
TTCGTCCTGGCCGGTTAA

Upstream 100 bases:

>100_bases
GGTTTCCATCCCGATGCGGGGAGCGGTGGAAAGCTTGAACGTGTCGGTGGCCAGCGGCGTGTGCCTCTACGAGGCGCTGC
GCCAGCGCGGGGGCTGATCC

Downstream 100 bases:

>100_bases
AGGGGCCGAGCCTCGTCGGGGGATTCCTCGCTGGCCTGGCTCAGCGCTTCCAGTGCGTCGGCGTCGAGCTGCAGGTGCGC
GGCGCGCACCAGGTCCTGCA

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MTQEAMERLRSWVAGAQRILVLTGAGMSAESGVPTFRDAHTGHWAKFRPEEMASEEGFRARPGTVWTWYEHRRAQLAAVQ
PNAGHRALADFARRHPERLTVATQNVDGLHQMAGSEGVLCLHGDLRANRWLDAPLPCCDADAAVPGCPPTCATCGNLLRP
AVVWFGEELPARLLEQAQDAAHECDLMLSVGTAGVVYPAAGLAHTAHRAGARVAIVNPEPSALDGVADLLVPGTAARVLP
FVLAG

Sequences:

>Translated_245_residues
MTQEAMERLRSWVAGAQRILVLTGAGMSAESGVPTFRDAHTGHWAKFRPEEMASEEGFRARPGTVWTWYEHRRAQLAAVQ
PNAGHRALADFARRHPERLTVATQNVDGLHQMAGSEGVLCLHGDLRANRWLDAPLPCCDADAAVPGCPPTCATCGNLLRP
AVVWFGEELPARLLEQAQDAAHECDLMLSVGTAGVVYPAAGLAHTAHRAGARVAIVNPEPSALDGVADLLVPGTAARVLP
FVLAG
>Mature_244_residues
TQEAMERLRSWVAGAQRILVLTGAGMSAESGVPTFRDAHTGHWAKFRPEEMASEEGFRARPGTVWTWYEHRRAQLAAVQP
NAGHRALADFARRHPERLTVATQNVDGLHQMAGSEGVLCLHGDLRANRWLDAPLPCCDADAAVPGCPPTCATCGNLLRPA
VVWFGEELPARLLEQAQDAAHECDLMLSVGTAGVVYPAAGLAHTAHRAGARVAIVNPEPSALDGVADLLVPGTAARVLPF
VLAG

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=250, Percent_Identity=39.6, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI6912664, Length=265, Percent_Identity=38.4905660377359, Blast_Score=157, Evalue=7e-39,
Organism=Homo sapiens, GI13787215, Length=240, Percent_Identity=40.4166666666667, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI6912662, Length=271, Percent_Identity=27.3062730627306, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI13775602, Length=220, Percent_Identity=27.7272727272727, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI13775600, Length=220, Percent_Identity=27.7272727272727, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI300797577, Length=254, Percent_Identity=27.9527559055118, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI7657575, Length=220, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI308199517, Length=225, Percent_Identity=39.5555555555556, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17567771, Length=274, Percent_Identity=25.5474452554745, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71990482, Length=275, Percent_Identity=26.1818181818182, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71990487, Length=277, Percent_Identity=25.9927797833935, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571445, Length=273, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24648389, Length=215, Percent_Identity=25.5813953488372, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28571443, Length=197, Percent_Identity=29.9492385786802, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571441, Length=197, Percent_Identity=29.9492385786802, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26129; Mature: 25998

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQEAMERLRSWVAGAQRILVLTGAGMSAESGVPTFRDAHTGHWAKFRPEEMASEEGFRA
CCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCC
RPGTVWTWYEHRRAQLAAVQPNAGHRALADFARRHPERLTVATQNVDGLHQMAGSEGVLC
CCCCEEEHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCEEE
LHGDLRANRWLDAPLPCCDADAAVPGCPPTCATCGNLLRPAVVWFGEELPARLLEQAQDA
EECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AHECDLMLSVGTAGVVYPAAGLAHTAHRAGARVAIVNPEPSALDGVADLLVPGTAARVLP
HHHCCEEEECCCCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHH
FVLAG
HHHCC
>Mature Secondary Structure 
TQEAMERLRSWVAGAQRILVLTGAGMSAESGVPTFRDAHTGHWAKFRPEEMASEEGFRA
CHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCC
RPGTVWTWYEHRRAQLAAVQPNAGHRALADFARRHPERLTVATQNVDGLHQMAGSEGVLC
CCCCEEEHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCEEE
LHGDLRANRWLDAPLPCCDADAAVPGCPPTCATCGNLLRPAVVWFGEELPARLLEQAQDA
EECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AHECDLMLSVGTAGVVYPAAGLAHTAHRAGARVAIVNPEPSALDGVADLLVPGTAARVLP
HHHCCEEEECCCCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHH
FVLAG
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]