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The map label for this gene is tolC [H]

Identifier: 120611482

GI number: 120611482

Start: 3090417

End: 3091826

Strand: Direct

Name: tolC [H]

Synonym: Aave_2818

Alternate gene names: 120611482

Gene position: 3090417-3091826 (Clockwise)

Preceding gene: 120611481

Following gene: 120611487

Centisome position: 57.73

GC content: 71.77

Gene sequence:

>1410_bases
ATGCCTGCCGCCCGAACGGTCCGCCCAACGGTTCATCAGCCAGGAAAGAGACGCTTGCCCGCCATGACTTCCCGACGCAC
GCATTTGCCCTCCCGCCGCGCCGCCGGCGCACTGGCCTTCGTCCTCGCGGCGGCGGCCGGGACCGCCTCCGCGCAGAGCC
TTCCGGCGCTCTACGAACTTGCGCAGGGCTACGACGCCCCACTGCAATCGGCGCTGGCCGACGCGCAGGCCGCGGGCAGC
CGCGCGGAACAGGCGCGTGCCGGCCTGCTTCCGAGCGCGGGGCTCTCGGCGGGCACCTCCTATACACGCACCGACGTGAA
CCGCCCGCCGGTGGACCTCGGCGCTCCGCAGCAGACGGCGGGCATCACGGCCTCGCAGCCGCTGTACCGCCCCGCCAACC
GCATCGCGTTCGAGCAGGGGCAGCGCGGTGCCGAGATCGCCCAGGCCCGGCTCGAAGCCGCGCGCCAGGATCTGGTCGTG
CGGCTGGCGCAGGCCTATTTCGACGTGCTGGCGGCCCGGGACAGCCTCACCTTCCTGCGGGCCCAGAAAGCCGCGGTGTC
GGAGCAGCGGGCCTCGGCGCAGCGCAACTTCGAGGTGGGCAACGCCACCATTACCGACACGCGCGAGGCGCAGGCCCGCT
TCGATCTCGTCGAAGCCCAGGAAATCGCGGCGGACAACGACCTGCGCGTGAAACAGCTCGCGCTGGAGCAGTTGGTGGGC
TGGCCGGGCGTATCTCCCCTGCCCCTCGCACAGCCCGTGCAACTGCCCGCCGTGACGCCGGCCGACGCGCAAGCATGGGT
GCGGACGGCGGACGAGTTGCAGCCACAACTGCGCCAGGCCGCCATCGCGCTGGACGTGGCGCGCCTGGAAACACGCAAGG
CCGAAACCGGCCACCTGCCCACGGTGGACTTGCAGGCGGGCTACAACGTGGTGCGCAACCCCAACGGCACCACCACGCTC
CCGCACGTCCACTCCACCGCCCGTGCCGCCACGGTCGGCGTGCAGATGACGCTGCCGCTGTTCGCGGGCTTCGCGGTGCA
GAACCGCATCCGCGAAACCCTCTCGCTGGAGGAAAAGGCGCGCGCGGATCTGGAAAACGCCCGCCGCACGGTGGCGCAGG
CCGTGCGCAGCGCCTTCTTCGGCGTGCAGTCCGGCCAGGGCCAGGTCCGTGCGCTGGAGGCCGCGGAGGCGTCGAGCCAG
AGCGCGCTGGAGGCCAACCGGCTGGGCTACCAGGTGGGCGTGCGGGTGAACATCGATGTGCTCAATGCGCAGAGCCAGCT
CTACCAGACCAAGCGCGACCTGGCCCAGGCGCGCTACAACGTGCTGCTGGGCACGCTCAAGCTGCGCCAGGCCGCGGGCA
CGCTGACCCCCGACGACCTGCGAGCGGTGGACGCGATCACCGCGCATTGA

Upstream 100 bases:

>100_bases
GGCGGCATCGACGCCTGGTCGCACGAGCGCGACCCCGGGGTGCCCCGCTACTGACATCGCGGTATCGGCTCCGCGCCCGT
CCTCCAGGAAGACGGGCGGG

Downstream 100 bases:

>100_bases
GACCGCCGGAGCCGGCGGGCGGCCCGAAGCGCCGCACCGCTGGCGAAGCGGCGCCGGGCCAAGCGCGTCACAACTGGTGC
GCCACCAGCTTGAAATCCGG

Product: TolC family type I secretion outer membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MPAARTVRPTVHQPGKRRLPAMTSRRTHLPSRRAAGALAFVLAAAAGTASAQSLPALYELAQGYDAPLQSALADAQAAGS
RAEQARAGLLPSAGLSAGTSYTRTDVNRPPVDLGAPQQTAGITASQPLYRPANRIAFEQGQRGAEIAQARLEAARQDLVV
RLAQAYFDVLAARDSLTFLRAQKAAVSEQRASAQRNFEVGNATITDTREAQARFDLVEAQEIAADNDLRVKQLALEQLVG
WPGVSPLPLAQPVQLPAVTPADAQAWVRTADELQPQLRQAAIALDVARLETRKAETGHLPTVDLQAGYNVVRNPNGTTTL
PHVHSTARAATVGVQMTLPLFAGFAVQNRIRETLSLEEKARADLENARRTVAQAVRSAFFGVQSGQGQVRALEAAEASSQ
SALEANRLGYQVGVRVNIDVLNAQSQLYQTKRDLAQARYNVLLGTLKLRQAAGTLTPDDLRAVDAITAH

Sequences:

>Translated_469_residues
MPAARTVRPTVHQPGKRRLPAMTSRRTHLPSRRAAGALAFVLAAAAGTASAQSLPALYELAQGYDAPLQSALADAQAAGS
RAEQARAGLLPSAGLSAGTSYTRTDVNRPPVDLGAPQQTAGITASQPLYRPANRIAFEQGQRGAEIAQARLEAARQDLVV
RLAQAYFDVLAARDSLTFLRAQKAAVSEQRASAQRNFEVGNATITDTREAQARFDLVEAQEIAADNDLRVKQLALEQLVG
WPGVSPLPLAQPVQLPAVTPADAQAWVRTADELQPQLRQAAIALDVARLETRKAETGHLPTVDLQAGYNVVRNPNGTTTL
PHVHSTARAATVGVQMTLPLFAGFAVQNRIRETLSLEEKARADLENARRTVAQAVRSAFFGVQSGQGQVRALEAAEASSQ
SALEANRLGYQVGVRVNIDVLNAQSQLYQTKRDLAQARYNVLLGTLKLRQAAGTLTPDDLRAVDAITAH
>Mature_468_residues
PAARTVRPTVHQPGKRRLPAMTSRRTHLPSRRAAGALAFVLAAAAGTASAQSLPALYELAQGYDAPLQSALADAQAAGSR
AEQARAGLLPSAGLSAGTSYTRTDVNRPPVDLGAPQQTAGITASQPLYRPANRIAFEQGQRGAEIAQARLEAARQDLVVR
LAQAYFDVLAARDSLTFLRAQKAAVSEQRASAQRNFEVGNATITDTREAQARFDLVEAQEIAADNDLRVKQLALEQLVGW
PGVSPLPLAQPVQLPAVTPADAQAWVRTADELQPQLRQAAIALDVARLETRKAETGHLPTVDLQAGYNVVRNPNGTTTLP
HVHSTARAATVGVQMTLPLFAGFAVQNRIRETLSLEEKARADLENARRTVAQAVRSAFFGVQSGQGQVRALEAAEASSQS
ALEANRLGYQVGVRVNIDVLNAQSQLYQTKRDLAQARYNVLLGTLKLRQAAGTLTPDDLRAVDAITAH

Specific function: May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI87082199, Length=429, Percent_Identity=31.4685314685315, Blast_Score=192, Evalue=6e-50,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 50114; Mature: 49983

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAARTVRPTVHQPGKRRLPAMTSRRTHLPSRRAAGALAFVLAAAAGTASAQSLPALYEL
CCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AQGYDAPLQSALADAQAAGSRAEQARAGLLPSAGLSAGTSYTRTDVNRPPVDLGAPQQTA
HCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHC
GITASQPLYRPANRIAFEQGQRGAEIAQARLEAARQDLVVRLAQAYFDVLAARDSLTFLR
CCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQKAAVSEQRASAQRNFEVGNATITDTREAQARFDLVEAQEIAADNDLRVKQLALEQLVG
HHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
WPGVSPLPLAQPVQLPAVTPADAQAWVRTADELQPQLRQAAIALDVARLETRKAETGHLP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TVDLQAGYNVVRNPNGTTTLPHVHSTARAATVGVQMTLPLFAGFAVQNRIRETLSLEEKA
EEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHH
RADLENARRTVAQAVRSAFFGVQSGQGQVRALEAAEASSQSALEANRLGYQVGVRVNIDV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCHHHHHHHHHCCEEEEEEEEEEE
LNAQSQLYQTKRDLAQARYNVLLGTLKLRQAAGTLTPDDLRAVDAITAH
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PAARTVRPTVHQPGKRRLPAMTSRRTHLPSRRAAGALAFVLAAAAGTASAQSLPALYEL
CCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AQGYDAPLQSALADAQAAGSRAEQARAGLLPSAGLSAGTSYTRTDVNRPPVDLGAPQQTA
HCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHC
GITASQPLYRPANRIAFEQGQRGAEIAQARLEAARQDLVVRLAQAYFDVLAARDSLTFLR
CCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQKAAVSEQRASAQRNFEVGNATITDTREAQARFDLVEAQEIAADNDLRVKQLALEQLVG
HHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
WPGVSPLPLAQPVQLPAVTPADAQAWVRTADELQPQLRQAAIALDVARLETRKAETGHLP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TVDLQAGYNVVRNPNGTTTLPHVHSTARAATVGVQMTLPLFAGFAVQNRIRETLSLEEKA
EEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHH
RADLENARRTVAQAVRSAFFGVQSGQGQVRALEAAEASSQSALEANRLGYQVGVRVNIDV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCHHHHHHHHHCCEEEEEEEEEEE
LNAQSQLYQTKRDLAQARYNVLLGTLKLRQAAGTLTPDDLRAVDAITAH
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]