Click here to switch to the map view.

The map label for this gene is msrA [H]

Identifier: 120611478

GI number: 120611478

Start: 3087854

End: 3088393

Strand: Reverse

Name: msrA [H]

Synonym: Aave_2814

Alternate gene names: 120611478

Gene position: 3088393-3087854 (Counterclockwise)

Preceding gene: 120611483

Following gene: 120611477

Centisome position: 57.7

GC content: 66.11

Gene sequence:

>540_bases
ATGGATTCTGAAACCATCACCCTGGGCGGAGGCTGCTTCTGGTGCACCGAGGCCGTCTTCGACCGCGTTCGAGGTGTCAC
GGACGTCGAGAGCGGCTATGCCAACGGCCAGGTGCCGCATCCGACCTACGAGCAGGTCTGCTCGGGCAGGACGGGCCATG
CGGAAGTGGTGCGGCTGACCTTCGACCCCGGGGTCATCGGCCTGCGGGAGATCCTGGAAATCTTCTTCGCCACCCACGAC
CCCACCACCCTCAACCGGCAGGGCAACGACGTGGGCACGCAGTACCGCAGCGGCATCTACACCGCCACGCCCGCGCAGCA
GGAGCTGGCGGAGGCCATGGTGCGGCAGATGTCGCAGGACCGGCTGTTCGGCGCGCCGATCGTCACCGAAGTGCAGCCGC
TGCAGTCGTACTGGCCGGCGGAGGACTACCACCAGGACTACTACCTGAACCATCCGGAGCAGGGCTACTGCGCCTTCGTC
GCGGGGCCGAAGGTGGAGAAATTCCGCAAGACGTTCGCGCGCTACCTCAAGCCCGAATAG

Upstream 100 bases:

>100_bases
CGGCGGAGCGTGGTGGCGTCAACGTGGCGGCGCGGACAATTCCCACAAGGGCCGGGCCGCCGTCTCCTTACCGTATCGTT
TCTTCACAGCGAGGTTTTCC

Downstream 100 bases:

>100_bases
CCACGGCCGGCCGCAGGCGTGCGGCTCGCATGCATAATGCAACACGATTGCATTAACAGGCTTGCATTGACAGGCCGCAC
GCCATGCCGATTCCAGCCGC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MDSETITLGGGCFWCTEAVFDRVRGVTDVESGYANGQVPHPTYEQVCSGRTGHAEVVRLTFDPGVIGLREILEIFFATHD
PTTLNRQGNDVGTQYRSGIYTATPAQQELAEAMVRQMSQDRLFGAPIVTEVQPLQSYWPAEDYHQDYYLNHPEQGYCAFV
AGPKVEKFRKTFARYLKPE

Sequences:

>Translated_179_residues
MDSETITLGGGCFWCTEAVFDRVRGVTDVESGYANGQVPHPTYEQVCSGRTGHAEVVRLTFDPGVIGLREILEIFFATHD
PTTLNRQGNDVGTQYRSGIYTATPAQQELAEAMVRQMSQDRLFGAPIVTEVQPLQSYWPAEDYHQDYYLNHPEQGYCAFV
AGPKVEKFRKTFARYLKPE
>Mature_179_residues
MDSETITLGGGCFWCTEAVFDRVRGVTDVESGYANGQVPHPTYEQVCSGRTGHAEVVRLTFDPGVIGLREILEIFFATHD
PTTLNRQGNDVGTQYRSGIYTATPAQQELAEAMVRQMSQDRLFGAPIVTEVQPLQSYWPAEDYHQDYYLNHPEQGYCAFV
AGPKVEKFRKTFARYLKPE

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=160, Percent_Identity=41.875, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI6912516, Length=160, Percent_Identity=41.875, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI208609993, Length=113, Percent_Identity=43.3628318584071, Blast_Score=94, Evalue=9e-20,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=42.7631578947368, Blast_Score=126, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=31.5068493150685, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=41.25, Blast_Score=120, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24664627, Length=164, Percent_Identity=32.3170731707317, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45553131, Length=158, Percent_Identity=31.6455696202532, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24664631, Length=164, Percent_Identity=31.7073170731707, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20149; Mature: 20149

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSETITLGGGCFWCTEAVFDRVRGVTDVESGYANGQVPHPTYEQVCSGRTGHAEVVRLT
CCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEE
FDPGVIGLREILEIFFATHDPTTLNRQGNDVGTQYRSGIYTATPAQQELAEAMVRQMSQD
ECCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEECCCCHHHHHHHHHHHHHHC
RLFGAPIVTEVQPLQSYWPAEDYHQDYYLNHPEQGYCAFVAGPKVEKFRKTFARYLKPE
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDSETITLGGGCFWCTEAVFDRVRGVTDVESGYANGQVPHPTYEQVCSGRTGHAEVVRLT
CCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEE
FDPGVIGLREILEIFFATHDPTTLNRQGNDVGTQYRSGIYTATPAQQELAEAMVRQMSQD
ECCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEECCCCHHHHHHHHHHHHHHC
RLFGAPIVTEVQPLQSYWPAEDYHQDYYLNHPEQGYCAFVAGPKVEKFRKTFARYLKPE
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]