Click here to switch to the map view.

The map label for this gene is lrp [H]

Identifier: 120610854

GI number: 120610854

Start: 2397461

End: 2397955

Strand: Reverse

Name: lrp [H]

Synonym: Aave_2180

Alternate gene names: 120610854

Gene position: 2397955-2397461 (Counterclockwise)

Preceding gene: 120610855

Following gene: 120610851

Centisome position: 44.8

GC content: 62.42

Gene sequence:

>495_bases
ATGACCGAAGCCTTCAAGATCGACCGACTGGACCTGCGCATCCTGGCGCAACTGCAGAAGAACGGGCGCATGACCAACGT
GGACCTCGCGGACGCGGTCGGCCTCTCGCCCAGCCCCTGCCTGATCCGCGTCAAGCGCCTGGAACAGGCGGGCTACATCG
CCGGCTACGGCGCCCACCTGCGCCTGGAGAAGCTCGGTGACACCCTCACCGTGTTCACCGAAGTCACCCTCTCGGACCAC
CGCCGCGAAGACTTCGCGCGCTTCGAGGCGGCGCTGCGCGAAGTGGACGAAGTGCTGGAATGCCACCTCGTGAGCGGCGG
CTATGACTACCTGCTGCGCTTCATCACGCGGGGCGTGAACCATTACCAGGAAGTGATCGAAGAGCTGCTGCAGCGCAACA
TCGGTATTGCGAAGTACTTCAGCTACATCGTCATCAAGTCGCCGTTCACCAAGACGCACTGTCCGATCGAGAGGTTGTTT
CCGCATCAGAGGTGA

Upstream 100 bases:

>100_bases
GATCCAGGGGCCGAACGGGTATAAATCCTGCTGCGCCCCTGCGGATCGCCATGTTGAATAGGCCATCCTTTCCCCTCTCT
TTACGCGCCTGGAGCCCGCG

Downstream 100 bases:

>100_bases
GTTTCTTTCGAGGGCGGGGGGCCGGGGCCACGCCCCGGCGGGCGCACATCCCGGCCCCCGGGAAAGAAATCACCCCGACA
ACGCCCGCCTCGCCACCTCG

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MTEAFKIDRLDLRILAQLQKNGRMTNVDLADAVGLSPSPCLIRVKRLEQAGYIAGYGAHLRLEKLGDTLTVFTEVTLSDH
RREDFARFEAALREVDEVLECHLVSGGYDYLLRFITRGVNHYQEVIEELLQRNIGIAKYFSYIVIKSPFTKTHCPIERLF
PHQR

Sequences:

>Translated_164_residues
MTEAFKIDRLDLRILAQLQKNGRMTNVDLADAVGLSPSPCLIRVKRLEQAGYIAGYGAHLRLEKLGDTLTVFTEVTLSDH
RREDFARFEAALREVDEVLECHLVSGGYDYLLRFITRGVNHYQEVIEELLQRNIGIAKYFSYIVIKSPFTKTHCPIERLF
PHQR
>Mature_163_residues
TEAFKIDRLDLRILAQLQKNGRMTNVDLADAVGLSPSPCLIRVKRLEQAGYIAGYGAHLRLEKLGDTLTVFTEVTLSDHR
REDFARFEAALREVDEVLECHLVSGGYDYLLRFITRGVNHYQEVIEELLQRNIGIAKYFSYIVIKSPFTKTHCPIERLFP
HQR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=140, Percent_Identity=43.5714285714286, Blast_Score=122, Evalue=9e-30,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=33.7748344370861, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1790182, Length=153, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18894; Mature: 18763

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAFKIDRLDLRILAQLQKNGRMTNVDLADAVGLSPSPCLIRVKRLEQAGYIAGYGAHL
CCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCEECCCCEE
RLEKLGDTLTVFTEVTLSDHRREDFARFEAALREVDEVLECHLVSGGYDYLLRFITRGVN
EHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HYQEVIEELLQRNIGIAKYFSYIVIKSPFTKTHCPIERLFPHQR
HHHHHHHHHHHCCCCHHHHHHHHHEECCCCCCCCCHHHCCCCCC
>Mature Secondary Structure 
TEAFKIDRLDLRILAQLQKNGRMTNVDLADAVGLSPSPCLIRVKRLEQAGYIAGYGAHL
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCEECCCCEE
RLEKLGDTLTVFTEVTLSDHRREDFARFEAALREVDEVLECHLVSGGYDYLLRFITRGVN
EHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HYQEVIEELLQRNIGIAKYFSYIVIKSPFTKTHCPIERLFPHQR
HHHHHHHHHHHCCCCHHHHHHHHHEECCCCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]