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The map label for this gene is folK [H]

Identifier: 120610654

GI number: 120610654

Start: 2144089

End: 2144607

Strand: Direct

Name: folK [H]

Synonym: Aave_1974

Alternate gene names: 120610654

Gene position: 2144089-2144607 (Clockwise)

Preceding gene: 120610653

Following gene: 120610656

Centisome position: 40.06

GC content: 73.8

Gene sequence:

>519_bases
ATGGGCGTGTCCCGGGAGCCGGTCCTGGCCGGCATCGGTCTGGGCGCCAATCTCGGGGATGCCCGGGCCGCGCTGGCCGG
GGCCGTGGCCGCGCTGGCCGGACTGCCGTCCACGTGCTTGCAGGCGGTGTCGTCGCTGTATGCGAGCGCTCCGGTGGATG
CGCAGGGCCCGGATTACCTGAATGCCGTGGCGCTGGTGTCCACCGGGCTGACAGCCCCGGCCTTGCTGGATGCGCTCCTG
GTCATCGAGGCCGATGCGGGGCGAGAGCGCCCCTACCGCAACGCGCCGCGCACGCTGGATCTCGACCTGCTCTTCTATGG
CGGCGCGCGCATCGCATCGCCGCGCCTGCTGGTGCCGCATCCGCGTGCGGACGAGCGGGCCTTCGTGCTGCGGCCCCTGG
CGGAAGTGGCGCCGCAGCGGGTGCCGGCCGCTGCACTCGAACGCGTGGCAGGCCAGCGCGTGGAAGTGGCCGCCGGACCC
GGCTGGAGCCCTAGTCCACCTTCGCGCCGGACGCCTTGA

Upstream 100 bases:

>100_bases
CTGGTGCCGTGAAGAAGCGCCGTCGGCGCCGCCGCAAGCCTGCGGGCGGGGGCGATGGCGCGCCCCAGGGCGCACCCGAC
GCCTGATGCCCGGGGCGGCC

Downstream 100 bases:

>100_bases
CCACCTGCTGGTACTTGGCGCGCTCGGATGCCATGAAGGCATCGAACTGCTCGGGCGTGGAAGACACCGGCTCGGCCATG
AGCGCGGTGAAGCGGGCCTT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MGVSREPVLAGIGLGANLGDARAALAGAVAALAGLPSTCLQAVSSLYASAPVDAQGPDYLNAVALVSTGLTAPALLDALL
VIEADAGRERPYRNAPRTLDLDLLFYGGARIASPRLLVPHPRADERAFVLRPLAEVAPQRVPAAALERVAGQRVEVAAGP
GWSPSPPSRRTP

Sequences:

>Translated_172_residues
MGVSREPVLAGIGLGANLGDARAALAGAVAALAGLPSTCLQAVSSLYASAPVDAQGPDYLNAVALVSTGLTAPALLDALL
VIEADAGRERPYRNAPRTLDLDLLFYGGARIASPRLLVPHPRADERAFVLRPLAEVAPQRVPAAALERVAGQRVEVAAGP
GWSPSPPSRRTP
>Mature_171_residues
GVSREPVLAGIGLGANLGDARAALAGAVAALAGLPSTCLQAVSSLYASAPVDAQGPDYLNAVALVSTGLTAPALLDALLV
IEADAGRERPYRNAPRTLDLDLLFYGGARIASPRLLVPHPRADERAFVLRPLAEVAPQRVPAAALERVAGQRVEVAAGPG
WSPSPPSRRTP

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=136, Percent_Identity=39.7058823529412, Blast_Score=91, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324073, Length=135, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17640; Mature: 17509

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVSREPVLAGIGLGANLGDARAALAGAVAALAGLPSTCLQAVSSLYASAPVDAQGPDYL
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHH
NAVALVSTGLTAPALLDALLVIEADAGRERPYRNAPRTLDLDLLFYGGARIASPRLLVPH
HHHHHHHCCCCHHHHHHHHHHEECCCCCCCCCCCCCCEEEEEEEEECCCEECCCEEECCC
PRADERAFVLRPLAEVAPQRVPAAALERVAGQRVEVAAGPGWSPSPPSRRTP
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GVSREPVLAGIGLGANLGDARAALAGAVAALAGLPSTCLQAVSSLYASAPVDAQGPDYL
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHH
NAVALVSTGLTAPALLDALLVIEADAGRERPYRNAPRTLDLDLLFYGGARIASPRLLVPH
HHHHHHHCCCCHHHHHHHHHHEECCCCCCCCCCCCCCEEEEEEEEECCCEECCCEEECCC
PRADERAFVLRPLAEVAPQRVPAAALERVAGQRVEVAAGPGWSPSPPSRRTP
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]