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The map label for this gene is lldD [H]

Identifier: 120610639

GI number: 120610639

Start: 2128616

End: 2129776

Strand: Direct

Name: lldD [H]

Synonym: Aave_1959

Alternate gene names: 120610639

Gene position: 2128616-2129776 (Clockwise)

Preceding gene: 120610638

Following gene: 120610640

Centisome position: 39.77

GC content: 67.53

Gene sequence:

>1161_bases
GTGAGTCCACTGTCCCGCATCACCTGCATCGAAGACCTGCGCACCGTCGCCCGCCGGCGCGTTCCGCGCATGTTCTACGA
CTATGCCGATTCCGGTTCCTACACGGAGAGCACCTATCGCGCCAACTCCGAGGATTTCCAGAAGATCAAGCTGCGCCAGC
GCGTGGCGGTGAACATGGAAAACCGCACCACGCGCACGCGGATGGTGGGGCAGGACGTGGCCATGCCGGTGGCGATAGCG
CCGACGGGCCTCACCGGCATGCAGCACGCCGACGGCGAGATCCTCGGTGCGCGCGCCGCGCGGGCCTTCGGCGTGCCGTT
CACGCTCTCCACCATGAGCATCTGCTCCATCGAGGATGTGGCGCAGCATGCGGGGCCGGGCTTCTGGTTCCAGGTGTACG
TGATGCGCGACCGCGACTTCGTCGAGCGCCTGATCGACCGCGCCAAGGCTGCCGGCGTCTCGGCGCTGCAGGTCACGCTG
GACCTGCAGATCCTCGGCCAGCGCCACAAGGACATCAAGAACGGGCTGTCCACGCCGCCCCGGCCCACGCTGGCCAACCT
GCTCGACCTGGCCACCAAGCCGCGCTGGTGCGCCGGCATGCTGGGCACGAAGCGGCGCAGCTTCGGCAACATCGTGGGCC
ATGCCGAGGGCGTGGGCGATCTTTCATCGCTGGCATCGTGGACGGCGGAGCAGTTCGACCCTCGCCTCAACTGGCGCGAC
ATCGAGTGGATCAAGAAGCGCTGGGGAGGCAAGCTCATCCTCAAGGGCATCATGGACGCGGACGACGCGCGGCTCGCGGT
GGAAACAGGCGCGGACGCCATCGTGGTCAGCAATCATGGCGGACGGCAGCTCGACGGCGCTCCTTCGTCCATCCATGCGC
TGCCGGCCATCGTGGAGGCCGTCGGCAAGGACATCGAGGTGTGGATGGACGGTGGCATCCGCGGAGGGCAGGACGTGCTC
AAGGCCTGGGCTCTGGGCGCGCGCGGCACGCTGATCGGGCGCAGCTTCCTGTACGGGCTGGGCGCCTTCGGCGAAGCGGG
CGTGACCCGGGCGCTGCAGATCATCCAGAAGGAGCTGGACATCACCATGGCCTTCTGCGGCCATACCGACATCCACCAGG
TGGACCGTTCCATCCTGTTGCCGTCCACCCTGCCTGCATGA

Upstream 100 bases:

>100_bases
AGCCCTTCCTGCAGTCGCCGCCGCTACGATGCCCCTGCCCGCGCACGCTCCCCAGGCAGGAGCCGGCCGCATGGCAGAAC
AATAACCAGGAGCGCCCATC

Downstream 100 bases:

>100_bases
AAGTGCCATCGGGGACGCCGTAGAGAGAGAGATGGCGGGCGAGCCAAAAAATAATTAATAAGAAACGAAATGTATTTTCA
TTTAGACCAGCTTTTCAGGG

Product: L-lactate dehydrogenase (cytochrome)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSPLSRITCIEDLRTVARRRVPRMFYDYADSGSYTESTYRANSEDFQKIKLRQRVAVNMENRTTRTRMVGQDVAMPVAIA
PTGLTGMQHADGEILGARAARAFGVPFTLSTMSICSIEDVAQHAGPGFWFQVYVMRDRDFVERLIDRAKAAGVSALQVTL
DLQILGQRHKDIKNGLSTPPRPTLANLLDLATKPRWCAGMLGTKRRSFGNIVGHAEGVGDLSSLASWTAEQFDPRLNWRD
IEWIKKRWGGKLILKGIMDADDARLAVETGADAIVVSNHGGRQLDGAPSSIHALPAIVEAVGKDIEVWMDGGIRGGQDVL
KAWALGARGTLIGRSFLYGLGAFGEAGVTRALQIIQKELDITMAFCGHTDIHQVDRSILLPSTLPA

Sequences:

>Translated_386_residues
MSPLSRITCIEDLRTVARRRVPRMFYDYADSGSYTESTYRANSEDFQKIKLRQRVAVNMENRTTRTRMVGQDVAMPVAIA
PTGLTGMQHADGEILGARAARAFGVPFTLSTMSICSIEDVAQHAGPGFWFQVYVMRDRDFVERLIDRAKAAGVSALQVTL
DLQILGQRHKDIKNGLSTPPRPTLANLLDLATKPRWCAGMLGTKRRSFGNIVGHAEGVGDLSSLASWTAEQFDPRLNWRD
IEWIKKRWGGKLILKGIMDADDARLAVETGADAIVVSNHGGRQLDGAPSSIHALPAIVEAVGKDIEVWMDGGIRGGQDVL
KAWALGARGTLIGRSFLYGLGAFGEAGVTRALQIIQKELDITMAFCGHTDIHQVDRSILLPSTLPA
>Mature_385_residues
SPLSRITCIEDLRTVARRRVPRMFYDYADSGSYTESTYRANSEDFQKIKLRQRVAVNMENRTTRTRMVGQDVAMPVAIAP
TGLTGMQHADGEILGARAARAFGVPFTLSTMSICSIEDVAQHAGPGFWFQVYVMRDRDFVERLIDRAKAAGVSALQVTLD
LQILGQRHKDIKNGLSTPPRPTLANLLDLATKPRWCAGMLGTKRRSFGNIVGHAEGVGDLSSLASWTAEQFDPRLNWRDI
EWIKKRWGGKLILKGIMDADDARLAVETGADAIVVSNHGGRQLDGAPSSIHALPAIVEAVGKDIEVWMDGGIRGGQDVLK
AWALGARGTLIGRSFLYGLGAFGEAGVTRALQIIQKELDITMAFCGHTDIHQVDRSILLPSTLPA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=383, Percent_Identity=37.3368146214099, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI54234014, Length=379, Percent_Identity=35.8839050131926, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI7705393, Length=379, Percent_Identity=35.8839050131926, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1790033, Length=384, Percent_Identity=43.4895833333333, Blast_Score=323, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI193208036, Length=378, Percent_Identity=37.037037037037, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI32566217, Length=295, Percent_Identity=34.5762711864407, Blast_Score=172, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6323587, Length=402, Percent_Identity=33.0845771144279, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI281363140, Length=375, Percent_Identity=36.2666666666667, Blast_Score=245, Evalue=5e-65,
Organism=Drosophila melanogaster, GI78707190, Length=375, Percent_Identity=36.2666666666667, Blast_Score=245, Evalue=5e-65,
Organism=Drosophila melanogaster, GI78707188, Length=375, Percent_Identity=36.2666666666667, Blast_Score=244, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42239; Mature: 42108

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLSRITCIEDLRTVARRRVPRMFYDYADSGSYTESTYRANSEDFQKIKLRQRVAVNME
CCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCC
NRTTRTRMVGQDVAMPVAIAPTGLTGMQHADGEILGARAARAFGVPFTLSTMSICSIEDV
CCHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCEEHHHHHHHCCCCEEECHHHHHHHHHH
AQHAGPGFWFQVYVMRDRDFVERLIDRAKAAGVSALQVTLDLQILGQRHKDIKNGLSTPP
HHHCCCCEEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHCCCCCC
RPTLANLLDLATKPRWCAGMLGTKRRSFGNIVGHAEGVGDLSSLASWTAEQFDPRLNWRD
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCH
IEWIKKRWGGKLILKGIMDADDARLAVETGADAIVVSNHGGRQLDGAPSSIHALPAIVEA
HHHHHHHCCCCEEEHHHCCCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
VGKDIEVWMDGGIRGGQDVLKAWALGARGTLIGRSFLYGLGAFGEAGVTRALQIIQKELD
HCCCEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
ITMAFCGHTDIHQVDRSILLPSTLPA
EEEEECCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SPLSRITCIEDLRTVARRRVPRMFYDYADSGSYTESTYRANSEDFQKIKLRQRVAVNME
CCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCC
NRTTRTRMVGQDVAMPVAIAPTGLTGMQHADGEILGARAARAFGVPFTLSTMSICSIEDV
CCHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCEEHHHHHHHCCCCEEECHHHHHHHHHH
AQHAGPGFWFQVYVMRDRDFVERLIDRAKAAGVSALQVTLDLQILGQRHKDIKNGLSTPP
HHHCCCCEEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHCCCCCC
RPTLANLLDLATKPRWCAGMLGTKRRSFGNIVGHAEGVGDLSSLASWTAEQFDPRLNWRD
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCH
IEWIKKRWGGKLILKGIMDADDARLAVETGADAIVVSNHGGRQLDGAPSSIHALPAIVEA
HHHHHHHCCCCEEEHHHCCCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
VGKDIEVWMDGGIRGGQDVLKAWALGARGTLIGRSFLYGLGAFGEAGVTRALQIIQKELD
HCCCEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
ITMAFCGHTDIHQVDRSILLPSTLPA
EEEEECCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA