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The map label for this gene is atoC [H]

Identifier: 120610581

GI number: 120610581

Start: 2059797

End: 2061218

Strand: Direct

Name: atoC [H]

Synonym: Aave_1901

Alternate gene names: 120610581

Gene position: 2059797-2061218 (Clockwise)

Preceding gene: 120610580

Following gene: 120610582

Centisome position: 38.48

GC content: 69.69

Gene sequence:

>1422_bases
ATGGGTTTGGCTCTGATCGTGGACGATGACGCCGATGCGGCGGACATGCTGGCGGCGCTGTGCAGCGCCGAGGGCTATCA
CGCCGCCACGGCGCATACGCTGGAGGCAGCGCGCAAGAAGATGGTGCTGCAGCCGCCGGACGTGGTGCTGCTCGACCTGC
ACCTGCCGGACGGCAACGGCCTGTCGTTCATGAACGAGCAATCGCTGCGTTCCAACACGCAGGTGGTGCTGGTCACGGGG
CACGCGACGCTGGAGACGTCGATCCAGGCGCTGCGCCTCGGCGCGGCCGACTACCTCGTGAAGCCCGTGAGCCTGCCGCA
GTTGCGCGGCGTGCTGTCGCGCGTGATGCCTCCCGCGGCGATCGCCGCGGAGATCGAATCCTGGCGCAAGACGGTGGACG
ATACCGGCCGGTTCGGCCACCTGGTGGGGCGCTCGGCCTGCATGCGGCGGGTGTACGAGCAGATCGCGCGCGTGGCCGGA
ACCTCGGTCACGGTGTTCGTGACCGGCGACAGCGGGACCGGCAAGGAGCTCGTGGCGCGCACGGTGCACGACCTGAGCCG
CCGGCGTTCGCAGCCCTTCCTGGCCATCAACTGCGGGGCGATATCGCCGCAGCTGATGGAGAGCGAGATCTTCGGCCACG
AGAAGGGCAGCTTCACGGGCGCGGAGCGGCAGCACCAGGGGTTCTTCGAGCGCGCGCACGGGGGCACGCTGTTCCTGGAC
GAGGTCACCGAAATGCCCATGGAGCTGCAGGTCAAGCTGCTGCGGGTGCTGGAAACCGGCACCTTCATGCGCGTGGGCTC
CACGGTGGAGCGGGCCACCGACGTGCGCATCGTGGCCGCGACCAACCGCGATCCCCTGTCCGCCGTGGCTGGCGGGGCCC
TGCGCGAGGACCTGTTCTACCGGCTCAACGTGTTCCCGATCGAGTTGCCGCCGCTGCGCGAGCGCGCCGAGGACATCGGG
CTGCTGAGTGCCCATTTCCTGGCGGCGATCGGGCAGAAGGAAGGCCGCCCCAAGCGGCTGGAGCCCGCCGCCCTCGAGCG
CCTGGAACGCTACCGCTGGCCGGGCAACGTGCGCGAACTGCGCAACGTGATGCAGCGTGCCTACGTGATGGCGGAGGGCG
ATGTGATCACGGCGCACTGGCTTCCGACCAACGGCGCCGAAGCCGATGCCGCGGCCGTTCCCGAAGGCCGGGCAGCGCGC
GCGCCCGTGGAGGACAACGGTGCCGAATCCGCGGGCCAGTTGCGGGTGGACGTGGGCACCTCGATCGCGGACGTGGAGCA
GCAGCTCATCCTGCGCACACTGCGGCACTTCGACAACCACAAGGAGCGCGCCGCGGCGGCCCTCGGCGTGAGCCTCAAGA
CCCTCTACAACAAGCTCAAGGCCTACGAGAGCACGGCTGCGGACTCCTCCTCCACGCGCTGA

Upstream 100 bases:

>100_bases
AACGCAATGGACCGCATGCCTTGACGGGTGCAGAGTCCACACGCATCTGTATTGGCGCGGTGCACGGACGGCCGCACTGC
GGCAAGCATCTGGAGGACTC

Downstream 100 bases:

>100_bases
ACGCGCAGGTCGCGACCGGTCCCGGCCTTCAGGGCACGCCGATTGCCCTGTATCTTTTGCCTGGCCGCCCCGCCAGGCGC
GCCCCTCTTGAGCCCGCCAC

Product: Fis family two component sigma-54 specific transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MGLALIVDDDADAADMLAALCSAEGYHAATAHTLEAARKKMVLQPPDVVLLDLHLPDGNGLSFMNEQSLRSNTQVVLVTG
HATLETSIQALRLGAADYLVKPVSLPQLRGVLSRVMPPAAIAAEIESWRKTVDDTGRFGHLVGRSACMRRVYEQIARVAG
TSVTVFVTGDSGTGKELVARTVHDLSRRRSQPFLAINCGAISPQLMESEIFGHEKGSFTGAERQHQGFFERAHGGTLFLD
EVTEMPMELQVKLLRVLETGTFMRVGSTVERATDVRIVAATNRDPLSAVAGGALREDLFYRLNVFPIELPPLRERAEDIG
LLSAHFLAAIGQKEGRPKRLEPAALERLERYRWPGNVRELRNVMQRAYVMAEGDVITAHWLPTNGAEADAAAVPEGRAAR
APVEDNGAESAGQLRVDVGTSIADVEQQLILRTLRHFDNHKERAAAALGVSLKTLYNKLKAYESTAADSSSTR

Sequences:

>Translated_473_residues
MGLALIVDDDADAADMLAALCSAEGYHAATAHTLEAARKKMVLQPPDVVLLDLHLPDGNGLSFMNEQSLRSNTQVVLVTG
HATLETSIQALRLGAADYLVKPVSLPQLRGVLSRVMPPAAIAAEIESWRKTVDDTGRFGHLVGRSACMRRVYEQIARVAG
TSVTVFVTGDSGTGKELVARTVHDLSRRRSQPFLAINCGAISPQLMESEIFGHEKGSFTGAERQHQGFFERAHGGTLFLD
EVTEMPMELQVKLLRVLETGTFMRVGSTVERATDVRIVAATNRDPLSAVAGGALREDLFYRLNVFPIELPPLRERAEDIG
LLSAHFLAAIGQKEGRPKRLEPAALERLERYRWPGNVRELRNVMQRAYVMAEGDVITAHWLPTNGAEADAAAVPEGRAAR
APVEDNGAESAGQLRVDVGTSIADVEQQLILRTLRHFDNHKERAAAALGVSLKTLYNKLKAYESTAADSSSTR
>Mature_472_residues
GLALIVDDDADAADMLAALCSAEGYHAATAHTLEAARKKMVLQPPDVVLLDLHLPDGNGLSFMNEQSLRSNTQVVLVTGH
ATLETSIQALRLGAADYLVKPVSLPQLRGVLSRVMPPAAIAAEIESWRKTVDDTGRFGHLVGRSACMRRVYEQIARVAGT
SVTVFVTGDSGTGKELVARTVHDLSRRRSQPFLAINCGAISPQLMESEIFGHEKGSFTGAERQHQGFFERAHGGTLFLDE
VTEMPMELQVKLLRVLETGTFMRVGSTVERATDVRIVAATNRDPLSAVAGGALREDLFYRLNVFPIELPPLRERAEDIGL
LSAHFLAAIGQKEGRPKRLEPAALERLERYRWPGNVRELRNVMQRAYVMAEGDVITAHWLPTNGAEADAAAVPEGRAARA
PVEDNGAESAGQLRVDVGTSIADVEQQLILRTLRHFDNHKERAAAALGVSLKTLYNKLKAYESTAADSSSTR

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=466, Percent_Identity=39.2703862660944, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1790437, Length=458, Percent_Identity=38.2096069868996, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI1790299, Length=471, Percent_Identity=38.2165605095541, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1788905, Length=405, Percent_Identity=38.0246913580247, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI1789233, Length=337, Percent_Identity=43.3234421364985, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI87082117, Length=243, Percent_Identity=48.559670781893, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI1789087, Length=240, Percent_Identity=51.25, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87082152, Length=233, Percent_Identity=45.0643776824034, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI87081872, Length=333, Percent_Identity=38.1381381381381, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1787583, Length=332, Percent_Identity=38.2530120481928, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1786524, Length=243, Percent_Identity=44.8559670781893, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789828, Length=204, Percent_Identity=37.2549019607843, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87081858, Length=325, Percent_Identity=27.3846153846154, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1786599, Length=137, Percent_Identity=29.1970802919708, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1787229, Length=104, Percent_Identity=34.6153846153846, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51483; Mature: 51352

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLALIVDDDADAADMLAALCSAEGYHAATAHTLEAARKKMVLQPPDVVLLDLHLPDGNG
CCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCC
LSFMNEQSLRSNTQVVLVTGHATLETSIQALRLGAADYLVKPVSLPQLRGVLSRVMPPAA
CCCCCCHHHCCCCEEEEEECCHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCHHH
IAAEIESWRKTVDDTGRFGHLVGRSACMRRVYEQIARVAGTSVTVFVTGDSGTGKELVAR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHH
TVHDLSRRRSQPFLAINCGAISPQLMESEIFGHEKGSFTGAERQHQGFFERAHGGTLFLD
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEH
EVTEMPMELQVKLLRVLETGTFMRVGSTVERATDVRIVAATNRDPLSAVAGGALREDLFY
HHHCCCHHHHHHHHHHHHCCCCEECCCHHHHHCCEEEEEECCCCCHHHHHCCHHHHHHHH
RLNVFPIELPPLRERAEDIGLLSAHFLAAIGQKEGRPKRLEPAALERLERYRWPGNVREL
EEEEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHH
RNVMQRAYVMAEGDVITAHWLPTNGAEADAAAVPEGRAARAPVEDNGAESAGQLRVDVGT
HHHHHHHHEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
SIADVEQQLILRTLRHFDNHKERAAAALGVSLKTLYNKLKAYESTAADSSSTR
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GLALIVDDDADAADMLAALCSAEGYHAATAHTLEAARKKMVLQPPDVVLLDLHLPDGNG
CEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCC
LSFMNEQSLRSNTQVVLVTGHATLETSIQALRLGAADYLVKPVSLPQLRGVLSRVMPPAA
CCCCCCHHHCCCCEEEEEECCHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCHHH
IAAEIESWRKTVDDTGRFGHLVGRSACMRRVYEQIARVAGTSVTVFVTGDSGTGKELVAR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHH
TVHDLSRRRSQPFLAINCGAISPQLMESEIFGHEKGSFTGAERQHQGFFERAHGGTLFLD
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEH
EVTEMPMELQVKLLRVLETGTFMRVGSTVERATDVRIVAATNRDPLSAVAGGALREDLFY
HHHCCCHHHHHHHHHHHHCCCCEECCCHHHHHCCEEEEEECCCCCHHHHHCCHHHHHHHH
RLNVFPIELPPLRERAEDIGLLSAHFLAAIGQKEGRPKRLEPAALERLERYRWPGNVREL
EEEEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHH
RNVMQRAYVMAEGDVITAHWLPTNGAEADAAAVPEGRAARAPVEDNGAESAGQLRVDVGT
HHHHHHHHEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
SIADVEQQLILRTLRHFDNHKERAAAALGVSLKTLYNKLKAYESTAADSSSTR
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]