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The map label for this gene is yhfN [H]

Identifier: 120610572

GI number: 120610572

Start: 2046788

End: 2048149

Strand: Reverse

Name: yhfN [H]

Synonym: Aave_1892

Alternate gene names: 120610572

Gene position: 2048149-2046788 (Counterclockwise)

Preceding gene: 120610576

Following gene: 120610571

Centisome position: 38.26

GC content: 70.26

Gene sequence:

>1362_bases
ATGCCGGTCCGCGAAGCCCTAAACTCCCGGTACATGCCTCCCGCCCCCGATACCGCCTCCTACTTCACCACGCCCGCCGG
CCTGCTGACCGCGGCCTTCGCCCTGCTGCTGGCCGCCGGCCTGCTGGTGCGCTTCTGGCTGGCGTCCCGGCAGATCCGGC
ACGTCGCGCGCCACCGCGGCACCGTCCCGGAGCCGTTCGCAGGGCGCATCCCCCTCGCCGCCCACCAGAAAGCCGCGGAC
TACACCATCGCCAGGGCCCGGCTGGGCATGCTGGAAGCCGCCCTGGGCGCTGCCGTGCTGCTGGGCTGGACGCTGCTGGG
CGGACTGAACGCGCTCAACCAGGCGCTGCTGTCCGTGCTGGACGGCGGCATGGTGCAGCAGATCGCATTGCTGGCGGCGT
TCGCGCTGGTGAGCGGGCTCATCGACCTGCCCCTCGCGGCCTACCAGACCTTCGTGCTCGAAGAGCGCTTCGGCTTCAAC
AAGACCACGCCGCGCCTCTGGCTGAAGGACCTGGCGCAGTCCACGCTGATGGGCGCCGTGATCGGGCTGCCGCTGGCCGC
GCTGATCCTCTGGCTCATGGGGGCCGCGGGCGCCCTGTGGTGGCTCTGGGCCTGGGGCGCCTGGGTGGCTTTCAGCCTGG
CGCTGATGGTGATCTATCCGCTGTTCATCGCGCCGCTCTTCAACCGCTTCCAGCCGCTGGAGGACGAATCCCTCAAGGCC
CGCGTCACGTCGCTCATGCAGCGCTGCGGCTTCGCGGCCAAGGGGCTGTTCGTGATGGACGGCAGCCGGCGCAGCGCCCA
TGCCAACGCGTACTTCACGGGCTTCGGGGCCGCGAAGCGGGTGGTGTTCTACGACACCCTGCTGCGCCAGCTCGGGCCGG
ACGAGGTCGAAGCCGTGCTCGCGCACGAACTCGGCCACTTCAAGCACCGCCACATCGCCAAGCGCATGGCGGGCGTGTTC
GCGATGGCACTGCTCGGTTTCGCGCTGCTGGGCTGGCTTTCGGGGCAGACCTGGTTCTACGAAGGCCTGGGCGTGCAGCC
CGCCGCCCTGCTCCCGGGCCAGCCGGCGGGCTCGGCCTCCAACGACGCGCTGGCGCTGCTGCTGTTCCTGCTGGCCACAC
CCGTGCTGACCTTCTTCGTCTCGCCGGTTTTCGCCCAGTTGTCGCGCCGCGACGAATTCGAGGCGGATGCCTATGCCATG
GCGCAGGCCGAAGGCAGCGCCCTCGCCTCCGCACTGCTCAAGCTCTACGAGGACAACGCCTCCACGCTCACGCCGGACCC
GGTGTACGCGGGGTTCTACTACTCCCACCCGCCGGCCGGCGAACGGCTGGCCCGCATGCCCCTTCCCCAGCCATCGACAT
GA

Upstream 100 bases:

>100_bases
AAGTTCAGGTCGGATTTGGGAAGGACGGGAGGGACGGAGACGGGTGCGGTATCGGACATGGCCCGGATTGTCTCCCAGGC
GGAACGCCCCTGCCGCCGCG

Downstream 100 bases:

>100_bases
CCTCTTCTTCCATGCTCACCAAGAAAGACTGGTCCGCCCACGCACGCCGTGCGCTCAGCCCCACCGAAATCGTCACGCGC
CTGGCGGACCTGCAGGGCTG

Product: Ste24 endopeptidase

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MPVREALNSRYMPPAPDTASYFTTPAGLLTAAFALLLAAGLLVRFWLASRQIRHVARHRGTVPEPFAGRIPLAAHQKAAD
YTIARARLGMLEAALGAAVLLGWTLLGGLNALNQALLSVLDGGMVQQIALLAAFALVSGLIDLPLAAYQTFVLEERFGFN
KTTPRLWLKDLAQSTLMGAVIGLPLAALILWLMGAAGALWWLWAWGAWVAFSLALMVIYPLFIAPLFNRFQPLEDESLKA
RVTSLMQRCGFAAKGLFVMDGSRRSAHANAYFTGFGAAKRVVFYDTLLRQLGPDEVEAVLAHELGHFKHRHIAKRMAGVF
AMALLGFALLGWLSGQTWFYEGLGVQPAALLPGQPAGSASNDALALLLFLLATPVLTFFVSPVFAQLSRRDEFEADAYAM
AQAEGSALASALLKLYEDNASTLTPDPVYAGFYYSHPPAGERLARMPLPQPST

Sequences:

>Translated_453_residues
MPVREALNSRYMPPAPDTASYFTTPAGLLTAAFALLLAAGLLVRFWLASRQIRHVARHRGTVPEPFAGRIPLAAHQKAAD
YTIARARLGMLEAALGAAVLLGWTLLGGLNALNQALLSVLDGGMVQQIALLAAFALVSGLIDLPLAAYQTFVLEERFGFN
KTTPRLWLKDLAQSTLMGAVIGLPLAALILWLMGAAGALWWLWAWGAWVAFSLALMVIYPLFIAPLFNRFQPLEDESLKA
RVTSLMQRCGFAAKGLFVMDGSRRSAHANAYFTGFGAAKRVVFYDTLLRQLGPDEVEAVLAHELGHFKHRHIAKRMAGVF
AMALLGFALLGWLSGQTWFYEGLGVQPAALLPGQPAGSASNDALALLLFLLATPVLTFFVSPVFAQLSRRDEFEADAYAM
AQAEGSALASALLKLYEDNASTLTPDPVYAGFYYSHPPAGERLARMPLPQPST
>Mature_452_residues
PVREALNSRYMPPAPDTASYFTTPAGLLTAAFALLLAAGLLVRFWLASRQIRHVARHRGTVPEPFAGRIPLAAHQKAADY
TIARARLGMLEAALGAAVLLGWTLLGGLNALNQALLSVLDGGMVQQIALLAAFALVSGLIDLPLAAYQTFVLEERFGFNK
TTPRLWLKDLAQSTLMGAVIGLPLAALILWLMGAAGALWWLWAWGAWVAFSLALMVIYPLFIAPLFNRFQPLEDESLKAR
VTSLMQRCGFAAKGLFVMDGSRRSAHANAYFTGFGAAKRVVFYDTLLRQLGPDEVEAVLAHELGHFKHRHIAKRMAGVFA
MALLGFALLGWLSGQTWFYEGLGVQPAALLPGQPAGSASNDALALLLFLLATPVLTFFVSPVFAQLSRRDEFEADAYAMA
QAEGSALASALLKLYEDNASTLTPDPVYAGFYYSHPPAGERLARMPLPQPST

Specific function: Unknown

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=363, Percent_Identity=31.9559228650138, Blast_Score=175, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17505484, Length=444, Percent_Identity=29.2792792792793, Blast_Score=177, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322577, Length=441, Percent_Identity=32.1995464852608, Blast_Score=205, Evalue=9e-54,
Organism=Drosophila melanogaster, GI19922414, Length=445, Percent_Identity=30.7865168539326, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI78707252, Length=426, Percent_Identity=28.4037558685446, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI78707254, Length=426, Percent_Identity=28.4037558685446, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24654305, Length=455, Percent_Identity=23.7362637362637, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: NA

Molecular weight: Translated: 49014; Mature: 48883

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCEECCCCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
PVREALNSRYMPPAPDTASYFTTPAGLLTAAFALLLAAGLLVRFWLASRQIRHVARHRG
CCHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC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CCCCCCCCEECCCCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]