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The map label for this gene is fbp

Identifier: 120610523

GI number: 120610523

Start: 1997875

End: 1998882

Strand: Reverse

Name: fbp

Synonym: Aave_1843

Alternate gene names: 120610523

Gene position: 1998882-1997875 (Counterclockwise)

Preceding gene: 120610524

Following gene: 120610521

Centisome position: 37.34

GC content: 64.58

Gene sequence:

>1008_bases
ATGGCACAACGCATCAGCCTCACCCGCTACCTCGTCGAGCAGCAGCGCGTCGATGGCCTCATCCCTTCCCAGCTGCGCCT
GCTGCTGGAGGTGGTGGCCCGCGCCTGCAAGCACATCAGCCACGCCGTGAACAAGGGCGCCCTCGGCGGCGTGCTGGGCT
CTGCATCCAGCGAGAACGTGCAGGGCGAGATCCAGAAGAAGCTGGACATCATCGCCAACGAAGTGCTCATCGAGGCCAAC
GAATGGGGCGGCCACCTGGCCGCCATGGCCTCGGAGGAGATGGACAGCATCTACGTGGTGCCCAACCGCTACCCGCAGGG
CGAGTACCTGCTGCTGTTCGACCCCCTGGACGGCTCCTCCAACATCGACGTGAACGTGAGCATCGGCACCATCTTCAGCG
TGCTGAAGAAGCCCGAGGGCCACCCCGGTGTGACCACCGAGGACTTCCTGCAGGCCGGCTCCAGCCAGGTGGCCGCCGGC
TACTGCATCTACGGCCCGCAGACCACGCTGGTGCTCACGGTGGGCGACGGCGTCGCGATGTTCACGCTCGACCGCGAGCA
GGGCTCGTTCGTGCTGGTGGAGGAGAACGTGAAGATCCCCGCCGATACCAGGGAATTCGCGATCAACATGAGCAACATGC
GCCACTGGGACGCCCCGGTGAAGCGCTACATCGACGAATGCCTGGCCGGCACGGAAGGCCCGCGCGAGAAGGACTTCAAC
ATGCGCTGGATCGCCAGCATGGTGGCGGACGTGCACCGCATCCTCACGCGCGGCGGCATCTTCCTCTACCCCTGGGACAA
GCGCGAGCCGAACAAGCCGGGCAAGCTGCGCCTGATGTACGAGGCCAACCCGATGTCCTGGCTGATCGAGCAGGCCGGCG
GCGCGGCGACCAACGGCAAGGAACGCATCCTGGACATCCAGCCGAAGCAGTTGCACGAACGCGTCAGCGTGATCCTCGGA
TCAAAAAATGAAGTGGAACGCGTGACACGCTACCATTCCGGTATATAA

Upstream 100 bases:

>100_bases
CTGTCCAACGACGTGCGCGAGGTGGTCGGCCGCGCGCTCGCCGACTGATCCGGCAGGCCGGACACCCCTTTCGAAAAAGA
ACCGAGAGATCCCACCGAAC

Downstream 100 bases:

>100_bases
TTCAATTCTTCGCCGGTGTAGCTCAGTCGGTAGAGCAGCTCATTCGTAATGAGAAGGTCGGGTGTTCGATTCATCTCTCC
GGCACCAAACAAAAAACCCC

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MAQRISLTRYLVEQQRVDGLIPSQLRLLLEVVARACKHISHAVNKGALGGVLGSASSENVQGEIQKKLDIIANEVLIEAN
EWGGHLAAMASEEMDSIYVVPNRYPQGEYLLLFDPLDGSSNIDVNVSIGTIFSVLKKPEGHPGVTTEDFLQAGSSQVAAG
YCIYGPQTTLVLTVGDGVAMFTLDREQGSFVLVEENVKIPADTREFAINMSNMRHWDAPVKRYIDECLAGTEGPREKDFN
MRWIASMVADVHRILTRGGIFLYPWDKREPNKPGKLRLMYEANPMSWLIEQAGGAATNGKERILDIQPKQLHERVSVILG
SKNEVERVTRYHSGI

Sequences:

>Translated_335_residues
MAQRISLTRYLVEQQRVDGLIPSQLRLLLEVVARACKHISHAVNKGALGGVLGSASSENVQGEIQKKLDIIANEVLIEAN
EWGGHLAAMASEEMDSIYVVPNRYPQGEYLLLFDPLDGSSNIDVNVSIGTIFSVLKKPEGHPGVTTEDFLQAGSSQVAAG
YCIYGPQTTLVLTVGDGVAMFTLDREQGSFVLVEENVKIPADTREFAINMSNMRHWDAPVKRYIDECLAGTEGPREKDFN
MRWIASMVADVHRILTRGGIFLYPWDKREPNKPGKLRLMYEANPMSWLIEQAGGAATNGKERILDIQPKQLHERVSVILG
SKNEVERVTRYHSGI
>Mature_334_residues
AQRISLTRYLVEQQRVDGLIPSQLRLLLEVVARACKHISHAVNKGALGGVLGSASSENVQGEIQKKLDIIANEVLIEANE
WGGHLAAMASEEMDSIYVVPNRYPQGEYLLLFDPLDGSSNIDVNVSIGTIFSVLKKPEGHPGVTTEDFLQAGSSQVAAGY
CIYGPQTTLVLTVGDGVAMFTLDREQGSFVLVEENVKIPADTREFAINMSNMRHWDAPVKRYIDECLAGTEGPREKDFNM
RWIASMVADVHRILTRGGIFLYPWDKREPNKPGKLRLMYEANPMSWLIEQAGGAATNGKERILDIQPKQLHERVSVILGS
KNEVERVTRYHSGI

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI22907028, Length=323, Percent_Identity=41.4860681114551, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI189083692, Length=324, Percent_Identity=42.5925925925926, Blast_Score=228, Evalue=4e-60,
Organism=Homo sapiens, GI16579888, Length=324, Percent_Identity=42.5925925925926, Blast_Score=228, Evalue=4e-60,
Organism=Escherichia coli, GI1790679, Length=328, Percent_Identity=46.3414634146341, Blast_Score=275, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17508131, Length=327, Percent_Identity=44.954128440367, Blast_Score=261, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6323409, Length=324, Percent_Identity=40.4320987654321, Blast_Score=254, Evalue=2e-68,
Organism=Drosophila melanogaster, GI45550998, Length=328, Percent_Identity=43.5975609756098, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI19921562, Length=328, Percent_Identity=43.5975609756098, Blast_Score=244, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_ACIAC (A1TN89)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_970201.1
- ProteinModelPortal:   A1TN89
- SMR:   A1TN89
- STRING:   A1TN89
- GeneID:   4668743
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1843
- NMPDR:   fig|397945.5.peg.1595
- eggNOG:   COG0158
- HOGENOM:   HBG731261
- OMA:   HWEAPVQ
- PhylomeDB:   A1TN89
- ProtClustDB:   PRK09293
- BioCyc:   AAVE397945:AAVE_1843-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 37145; Mature: 37014

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00124 FBPASE

Important sites: BINDING 209-209 BINDING 275-275

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQRISLTRYLVEQQRVDGLIPSQLRLLLEVVARACKHISHAVNKGALGGVLGSASSENV
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCC
QGEIQKKLDIIANEVLIEANEWGGHLAAMASEEMDSIYVVPNRYPQGEYLLLFDPLDGSS
HHHHHHHHHHHHHHHEEEECCCCCEEHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCC
NIDVNVSIGTIFSVLKKPEGHPGVTTEDFLQAGSSQVAAGYCIYGPQTTLVLTVGDGVAM
CEEEEEEHHHHHHHHHCCCCCCCCCHHHHHHCCCCCEECEEEEECCCEEEEEEECCCEEE
FTLDREQGSFVLVEENVKIPADTREFAINMSNMRHWDAPVKRYIDECLAGTEGPREKDFN
EEEECCCCCEEEEECCCCCCCCCHHHEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
MRWIASMVADVHRILTRGGIFLYPWDKREPNKPGKLRLMYEANPMSWLIEQAGGAATNGK
HHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCC
ERILDIQPKQLHERVSVILGSKNEVERVTRYHSGI
CEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AQRISLTRYLVEQQRVDGLIPSQLRLLLEVVARACKHISHAVNKGALGGVLGSASSENV
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCC
QGEIQKKLDIIANEVLIEANEWGGHLAAMASEEMDSIYVVPNRYPQGEYLLLFDPLDGSS
HHHHHHHHHHHHHHHEEEECCCCCEEHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCC
NIDVNVSIGTIFSVLKKPEGHPGVTTEDFLQAGSSQVAAGYCIYGPQTTLVLTVGDGVAM
CEEEEEEHHHHHHHHHCCCCCCCCCHHHHHHCCCCCEECEEEEECCCEEEEEEECCCEEE
FTLDREQGSFVLVEENVKIPADTREFAINMSNMRHWDAPVKRYIDECLAGTEGPREKDFN
EEEECCCCCEEEEECCCCCCCCCHHHEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
MRWIASMVADVHRILTRGGIFLYPWDKREPNKPGKLRLMYEANPMSWLIEQAGGAATNGK
HHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCC
ERILDIQPKQLHERVSVILGSKNEVERVTRYHSGI
CEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA