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The map label for this gene is ilvD1 [H]

Identifier: 120610191

GI number: 120610191

Start: 1668470

End: 1670329

Strand: Direct

Name: ilvD1 [H]

Synonym: Aave_1506

Alternate gene names: 120610191

Gene position: 1668470-1670329 (Clockwise)

Preceding gene: 120610190

Following gene: 120610193

Centisome position: 31.17

GC content: 68.28

Gene sequence:

>1860_bases
ATGCCCGCATACCGTTCCAAGACCTCCACTGCCGGACGCAACATGGCCGGTGCCCGCTCCCTGTGGCGCGCCACCGGCAT
GAAGGACGAAGACTTCAGCAAGCCGATCATCGCGGTGGTGAACTCGTTCACCCAGTTCGTGCCCGGCCACGTCCACCTGA
AGGACCTGGGCCAGCTCGTGGCCCGCGAGATCGAGGCGGCCGGCGGTGTCGCCAAGGAGTTCAACACCATCGCGGTGGAT
GACGGCATCGCGATGGGCCACGACGGCATGCTGTATTCGCTGCCCAGCCGCGACATCATCGCGGACTCGGTCGAGTACAT
GGTGAACGCGCACTGCGCCGACGCCATGGTCTGCATCTCCAACTGCGACAAGATCACGCCCGGCATGCTGATGGCCGCGA
TGCGCCTGAACATCCCCGTGGTGTTCGTCTCCGGCGGCCCCATGGAGGCCGGCAAGACGCGCCTGGCCAACCCCGTCACC
AAGACCATCGAGTTCAAGAAGCTCGACCTGGTGGACGCGATGGTGATCGCCGCCGACGACAAGTATTCCGACGCCGACGT
GGCCGAGGTGGAGCGCTCCGCCTGCCCCACCTGCGGTTCGTGCTCGGGCATGTTCACCGCCAATTCCATGAACTGCCTGA
CCGAGGCGCTGGGCCTGTCCCTGCCCGGCAACGGCACGGTGGTGGCCACGCACGCCGACCGCGAGCAGCTCTTCAAGCGC
GCCGGCCGCCGCATCGTGGAACTGGCCCGCCGGTACTACGAGCAGGACGACGAGCGGGTTCTGCCGCGCTCGGTGGGCTT
CAAGGCCTTCGAGAACGCGATGACGCTGGACATCGCGATGGGCGGCTCCACCAACACCATCCTGCACCTGCTGGCCATCG
CCCAGGAGGCCGGCATCGACTTCACCATGGCCGACATCGACCGCCTGTCGCGCGTGGTGCCGCAGCTGTGCAAGGTGGCG
CCCAACACCAACAAGTACCACATCGAGGACGTGCACCGCGCCGGGGGCATCATGGCCATCCTGGGCGAACTGGACCGCGC
GGGCCGCCTGCACACCGATGCGCCCACCGTGCACGCCCCCACGCTGGGCGACGCGCTCGCGCAGTGGGACATCACCCGCA
CGCAGGACGAGGCCGTGCGCCATTTCTACATGGCGGGCCCGGCCGGCATCCCGACGCAGGTGGCGTTCAGCCAGAACACG
CGCTGGCCCAGCCTGGACCTGGACCGCGCCGAGGGCTGCATCCGCTCCGTCGAGCATGCCTTCTCGAAGGAAGGGGGCCT
GGCCGTGCTGCGCGGCAACATCGCGCTGGATGGCTGCGTTGTCAAGACGGCCGGCGTGGACGAATCCATCCACGTGTTCG
AGGGCACGGCCCACGTGACCGAATCGCAGGACGAGGCGGTGGAGAACATCCTGGCCGACAAGGTCAAGGCCGGCGACATC
GTCATCGTGCGCTACGAAGGCCCCAAGGGCGGCCCCGGCATGCAGGAAATGCTCTACCCGACCAGCTACATCAAATCCAA
GGGCCTGGGCAAGGCCTGCGCGCTGCTGACCGACGGGCGCTTCTCGGGCGGCACCTCGGGCCTTTCGATCGGCCACTGCT
CGCCCGAGGCGGCGGCCGGCGGCGCGATCGGCCTGGTGCAGAACGGCGACCGCATCCGCATCGACATCCCCAATCGCACG
ATCGACGTGCTGGTGTCCGACGAGGAACTGGCCCGCCGCCGCGCCGAGCAGGATGCCAAGGGCTGGAAGCCCGCGAAGCC
GCGCCCGCGCAAGGTGTCGGCGGCGCTCAAGGCCTATGCCAAGCTGGTGATGTCGGCCGACAAGGGCGCGGTGCGCGACC
TGTCGCTGCTGGACGACTGA

Upstream 100 bases:

>100_bases
CCGGGCCGCGATAGTCGTGCCGCCCGGCGGGGGAAGGCACTGGAGGATAATTCCGCGTCGCCGAGCGACCGCCCCTCCAA
CCGCTTTCCCCTGATCCACG

Downstream 100 bases:

>100_bases
CCGCGCGGGGCTGCCTGCCGCGCGGCAGGCAGCCGCTGCCGGGCGAAAAAAAGCCGCACCGGCGACGGTGCGGCTTTGTT
CCATGGGGGCGCGCCACGGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 1 [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MPAYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKTRLANPVT
KTIEFKKLDLVDAMVIAADDKYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
AGRRIVELARRYYEQDDERVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGIDFTMADIDRLSRVVPQLCKVA
PNTNKYHIEDVHRAGGIMAILGELDRAGRLHTDAPTVHAPTLGDALAQWDITRTQDEAVRHFYMAGPAGIPTQVAFSQNT
RWPSLDLDRAEGCIRSVEHAFSKEGGLAVLRGNIALDGCVVKTAGVDESIHVFEGTAHVTESQDEAVENILADKVKAGDI
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVQNGDRIRIDIPNRT
IDVLVSDEELARRRAEQDAKGWKPAKPRPRKVSAALKAYAKLVMSADKGAVRDLSLLDD

Sequences:

>Translated_619_residues
MPAYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKTRLANPVT
KTIEFKKLDLVDAMVIAADDKYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
AGRRIVELARRYYEQDDERVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGIDFTMADIDRLSRVVPQLCKVA
PNTNKYHIEDVHRAGGIMAILGELDRAGRLHTDAPTVHAPTLGDALAQWDITRTQDEAVRHFYMAGPAGIPTQVAFSQNT
RWPSLDLDRAEGCIRSVEHAFSKEGGLAVLRGNIALDGCVVKTAGVDESIHVFEGTAHVTESQDEAVENILADKVKAGDI
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVQNGDRIRIDIPNRT
IDVLVSDEELARRRAEQDAKGWKPAKPRPRKVSAALKAYAKLVMSADKGAVRDLSLLDD
>Mature_618_residues
PAYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKTRLANPVTK
TIEFKKLDLVDAMVIAADDKYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKRA
GRRIVELARRYYEQDDERVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGIDFTMADIDRLSRVVPQLCKVAP
NTNKYHIEDVHRAGGIMAILGELDRAGRLHTDAPTVHAPTLGDALAQWDITRTQDEAVRHFYMAGPAGIPTQVAFSQNTR
WPSLDLDRAEGCIRSVEHAFSKEGGLAVLRGNIALDGCVVKTAGVDESIHVFEGTAHVTESQDEAVENILADKVKAGDIV
IVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVQNGDRIRIDIPNRTI
DVLVSDEELARRRAEQDAKGWKPAKPRPRKVSAALKAYAKLVMSADKGAVRDLSLLDD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=621, Percent_Identity=74.0740740740741, Blast_Score=937, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=542, Percent_Identity=29.8892988929889, Blast_Score=195, Evalue=9e-51,
Organism=Escherichia coli, GI2367371, Length=534, Percent_Identity=30.7116104868914, Blast_Score=188, Evalue=8e-49,
Organism=Escherichia coli, GI1786464, Length=561, Percent_Identity=30.8377896613191, Blast_Score=182, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=614, Percent_Identity=36.8078175895765, Blast_Score=349, Evalue=7e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 66382; Mature: 66250

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKTRLANPVTKTIEFKKLDLVDAMVIAADD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHEEEEEEECC
KYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
CCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHH
AGRRIVELARRYYEQDDERVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGID
HHHHHHHHHHHHHCCCCCCCCCHHHCHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCC
FTMADIDRLSRVVPQLCKVAPNTNKYHIEDVHRAGGIMAILGELDRAGRLHTDAPTVHAP
EEHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
TLGDALAQWDITRTQDEAVRHFYMAGPAGIPTQVAFSQNTRWPSLDLDRAEGCIRSVEHA
CHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
FSKEGGLAVLRGNIALDGCVVKTAGVDESIHVFEGTAHVTESQDEAVENILADKVKAGDI
HCCCCCEEEEECCEEECCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCE
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAG
EEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCC
GAIGLVQNGDRIRIDIPNRTIDVLVSDEELARRRAEQDAKGWKPAKPRPRKVSAALKAYA
CEEEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
KLVMSADKGAVRDLSLLDD
HHHHHCCCCCCCCHHHCCC
>Mature Secondary Structure 
PAYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKTRLANPVTKTIEFKKLDLVDAMVIAADD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHEEEEEEECC
KYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
CCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHH
AGRRIVELARRYYEQDDERVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGID
HHHHHHHHHHHHHCCCCCCCCCHHHCHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCC
FTMADIDRLSRVVPQLCKVAPNTNKYHIEDVHRAGGIMAILGELDRAGRLHTDAPTVHAP
EEHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
TLGDALAQWDITRTQDEAVRHFYMAGPAGIPTQVAFSQNTRWPSLDLDRAEGCIRSVEHA
CHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
FSKEGGLAVLRGNIALDGCVVKTAGVDESIHVFEGTAHVTESQDEAVENILADKVKAGDI
HCCCCCEEEEECCEEECCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCE
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAG
EEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCC
GAIGLVQNGDRIRIDIPNRTIDVLVSDEELARRRAEQDAKGWKPAKPRPRKVSAALKAYA
CEEEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
KLVMSADKGAVRDLSLLDD
HHHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA