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The map label for this gene is glpK

Identifier: 120609302

GI number: 120609302

Start: 658866

End: 660386

Strand: Reverse

Name: glpK

Synonym: Aave_0602

Alternate gene names: 120609302

Gene position: 660386-658866 (Counterclockwise)

Preceding gene: 120609303

Following gene: 120609301

Centisome position: 12.34

GC content: 71.66

Gene sequence:

>1521_bases
ATGACCTATCTGCTCGCCCTCGACCAAGGCACCTCCAGCTCGCGCAGCATCGTGTTCGACGAGCGCGGGCACATCGTCGC
GCAGGCGCAGCAGGAGCTGCCGCAGATCTACCCGCAGCCCGGCTGGGTGGAGCACGACCCGGTGGACATCTGGCGCACGC
AGATCGCCACGGCGCGGCAGGCGCTCGCGCAGGCGAACATAGGCCCCGGCGACGTGCGGGCGCTGGGCATCACCAACCAG
CGCGAGACGACGGTGCTGTGGAACCGCCGCACCGGGCAGCCCGTGCACCACGCCATCGTCTGGCAGGACCGGCGGGCCGA
GCCGCTGTGCGCCGAGCTGCGAGAACAGGGCCACGAGCCGATGATCCAGGAGCGCACCGGGCTGCGCATCGACGCGTATT
TCTCGGCGACCAAGCTGCGCTGGCTGCTGGACCAGGTGCCTGGTGCGCGCGCCGCCGCCGAGGCCGGCGAGCTGGCTTTC
GGCACGGTGGACAGCTGGCTGATCTGGCAGCTGACGGGCGGCAAGGTGCACGTGACCGACGTGAGCAATGCCTCGCGCAC
CATGCTGTTCAATGTCCATTCCAACGACTGGGATGACGATCTCCTGGCGCTGCTGCGCATCCCCCGGAAGCTGCTGCCGC
GCGTGCAGCCTTCGGCGAGCGACTTCGGCGCCACGGACGCAGCGCTGCTGGGCGGCGCCATCCCGATCGGCGGGGTGGCG
GGCGACCAGCAGAGCGCGCTGTTCGGCCAGGCGTGTTTCACCGCCGGCATGGCCAAGAACACCTACGGCACGGGCTGCTT
CATGCTGATGCACACCGGCAGCAGTTTCCAGACCTCGCGCAACGGCCTGCTGACGACCAGCGCGGCGCAGATCGCTCCCC
GAACCGGCGCGGGCCACGGGGCGCCGGAGCCGGCCTTCGCCATGGAAGGCAGCGTGTTCGTGGGTGGCGCGGTGGTGCAA
TGGCTGCGCGACGGGCTGCGCGCCATATCGAGCAGCAGCGAGGTGCAGTCGCTGGCCGAGAGCGTGCCGGACTCCGGCGG
CGTGATGATGGTGCCGGCCTTCACCGGGCTGGGCGCGCCGTATTGGAAGCCTGACGCCCGGGGCACCATCACCGGCCTTA
CCCGCGGCACGACCATCGCCCACATCGCGCGCGCGGCGCTGGAGAGCATCGCCTACCAGAGCGCGGCGCTGCTGCAGGCG
ATGAGCCGCGACGCGGTGGCCGCCGGCGGCGCGCCCGTGAGCGAGCTGCGGGTGGACGGCGGCGCCTGCGTGAACGACCT
GCTGATGCAGTTCCAGGCCGACCTGCTGGGCATTCCCGTGGTGCGGCCGGCGGTGATCGAGACCACTGCGCTGGGAGCCG
CCTACCTGGCGGGTCTCTCCAGCGGGGTCTATGCGGGCACGGAAGCCCTGTCCGCGCTGTGGCGCGCCGAGCGTCGGTTC
CTGCCCACGCTGAGCGCCGCGCGCGCCCAGGAATGCATGGCGCGCTGGGAGCATGCGGTGCGCCAGGCCGCGCTGGACTG
A

Upstream 100 bases:

>100_bases
TTTCCTGCCCTGCTGCGCGACGCCGGGGTGGAACTCGACGTGGCGGAGTGAGCCCGCCATCTCCCCCTCCCATTTCAACA
TCGCATACCCCCCGGACGCC

Downstream 100 bases:

>100_bases
CCGGGAGGAAGCGCTACCATCCGGTGCCGCGGCCCGCGGCGGCGCGTCCGTCGCGGGCCTTCCCTTCTTCCACGGCCGCC
CGCCGGCCCCGCCCTTTCGC

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MTYLLALDQGTSSSRSIVFDERGHIVAQAQQELPQIYPQPGWVEHDPVDIWRTQIATARQALAQANIGPGDVRALGITNQ
RETTVLWNRRTGQPVHHAIVWQDRRAEPLCAELREQGHEPMIQERTGLRIDAYFSATKLRWLLDQVPGARAAAEAGELAF
GTVDSWLIWQLTGGKVHVTDVSNASRTMLFNVHSNDWDDDLLALLRIPRKLLPRVQPSASDFGATDAALLGGAIPIGGVA
GDQQSALFGQACFTAGMAKNTYGTGCFMLMHTGSSFQTSRNGLLTTSAAQIAPRTGAGHGAPEPAFAMEGSVFVGGAVVQ
WLRDGLRAISSSSEVQSLAESVPDSGGVMMVPAFTGLGAPYWKPDARGTITGLTRGTTIAHIARAALESIAYQSAALLQA
MSRDAVAAGGAPVSELRVDGGACVNDLLMQFQADLLGIPVVRPAVIETTALGAAYLAGLSSGVYAGTEALSALWRAERRF
LPTLSAARAQECMARWEHAVRQAALD

Sequences:

>Translated_506_residues
MTYLLALDQGTSSSRSIVFDERGHIVAQAQQELPQIYPQPGWVEHDPVDIWRTQIATARQALAQANIGPGDVRALGITNQ
RETTVLWNRRTGQPVHHAIVWQDRRAEPLCAELREQGHEPMIQERTGLRIDAYFSATKLRWLLDQVPGARAAAEAGELAF
GTVDSWLIWQLTGGKVHVTDVSNASRTMLFNVHSNDWDDDLLALLRIPRKLLPRVQPSASDFGATDAALLGGAIPIGGVA
GDQQSALFGQACFTAGMAKNTYGTGCFMLMHTGSSFQTSRNGLLTTSAAQIAPRTGAGHGAPEPAFAMEGSVFVGGAVVQ
WLRDGLRAISSSSEVQSLAESVPDSGGVMMVPAFTGLGAPYWKPDARGTITGLTRGTTIAHIARAALESIAYQSAALLQA
MSRDAVAAGGAPVSELRVDGGACVNDLLMQFQADLLGIPVVRPAVIETTALGAAYLAGLSSGVYAGTEALSALWRAERRF
LPTLSAARAQECMARWEHAVRQAALD
>Mature_505_residues
TYLLALDQGTSSSRSIVFDERGHIVAQAQQELPQIYPQPGWVEHDPVDIWRTQIATARQALAQANIGPGDVRALGITNQR
ETTVLWNRRTGQPVHHAIVWQDRRAEPLCAELREQGHEPMIQERTGLRIDAYFSATKLRWLLDQVPGARAAAEAGELAFG
TVDSWLIWQLTGGKVHVTDVSNASRTMLFNVHSNDWDDDLLALLRIPRKLLPRVQPSASDFGATDAALLGGAIPIGGVAG
DQQSALFGQACFTAGMAKNTYGTGCFMLMHTGSSFQTSRNGLLTTSAAQIAPRTGAGHGAPEPAFAMEGSVFVGGAVVQW
LRDGLRAISSSSEVQSLAESVPDSGGVMMVPAFTGLGAPYWKPDARGTITGLTRGTTIAHIARAALESIAYQSAALLQAM
SRDAVAAGGAPVSELRVDGGACVNDLLMQFQADLLGIPVVRPAVIETTALGAAYLAGLSSGVYAGTEALSALWRAERRFL
PTLSAARAQECMARWEHAVRQAALD

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family

Homologues:

Organism=Homo sapiens, GI4504007, Length=511, Percent_Identity=46.3796477495108, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI189409120, Length=511, Percent_Identity=46.3796477495108, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI41393575, Length=511, Percent_Identity=45.9882583170254, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI42794763, Length=517, Percent_Identity=45.8413926499033, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI88196792, Length=521, Percent_Identity=33.7811900191939, Blast_Score=309, Evalue=4e-84,
Organism=Escherichia coli, GI1790361, Length=502, Percent_Identity=53.1872509960159, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1790005, Length=517, Percent_Identity=25.7253384912959, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787789, Length=518, Percent_Identity=27.2200772200772, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789987, Length=466, Percent_Identity=26.3948497854077, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789168, Length=495, Percent_Identity=23.6363636363636, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=512, Percent_Identity=41.2109375, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71986140, Length=528, Percent_Identity=25.7575757575758, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71986147, Length=298, Percent_Identity=29.5302013422819, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321755, Length=479, Percent_Identity=41.7536534446764, Blast_Score=334, Evalue=2e-92,
Organism=Drosophila melanogaster, GI17864214, Length=470, Percent_Identity=43.4042553191489, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24655555, Length=517, Percent_Identity=38.6847195357834, Blast_Score=354, Evalue=7e-98,
Organism=Drosophila melanogaster, GI24655560, Length=517, Percent_Identity=38.6847195357834, Blast_Score=354, Evalue=7e-98,
Organism=Drosophila melanogaster, GI24655570, Length=517, Percent_Identity=38.6847195357834, Blast_Score=354, Evalue=7e-98,
Organism=Drosophila melanogaster, GI24655574, Length=517, Percent_Identity=38.6847195357834, Blast_Score=354, Evalue=7e-98,
Organism=Drosophila melanogaster, GI24655565, Length=517, Percent_Identity=38.6847195357834, Blast_Score=354, Evalue=7e-98,
Organism=Drosophila melanogaster, GI24654573, Length=395, Percent_Identity=45.3164556962025, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI19922058, Length=529, Percent_Identity=34.0264650283554, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24652871, Length=496, Percent_Identity=34.6774193548387, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24656367, Length=496, Percent_Identity=30.8467741935484, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI21357867, Length=512, Percent_Identity=30.2734375, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24656372, Length=332, Percent_Identity=31.6265060240964, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI45552909, Length=298, Percent_Identity=28.8590604026846, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): GLPK_ACIAC (A1TJR8)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_968980.1
- ProteinModelPortal:   A1TJR8
- SMR:   A1TJR8
- STRING:   A1TJR8
- GeneID:   4668657
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0602
- NMPDR:   fig|397945.5.peg.518
- eggNOG:   COG0554
- HOGENOM:   HBG511469
- OMA:   DSGVRLE
- PhylomeDB:   A1TJR8
- ProtClustDB:   CLSK897540
- BioCyc:   AAVE397945:AAVE_0602-MONOMER
- HAMAP:   MF_00186
- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999
- PANTHER:   PTHR10196
- PANTHER:   PTHR10196:SF9
- TIGRFAMs:   TIGR01311

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N

EC number: =2.7.1.30

Molecular weight: Translated: 53913; Mature: 53781

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00933 FGGY_KINASES_1; PS00445 FGGY_KINASES_2

Important sites: BINDING 11-11 BINDING 15-15 BINDING 81-81 BINDING 133-133 BINDING 242-242 BINDING 264-264 BINDING 316-316

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYLLALDQGTSSSRSIVFDERGHIVAQAQQELPQIYPQPGWVEHDPVDIWRTQIATARQ
CEEEEEECCCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
ALAQANIGPGDVRALGITNQRETTVLWNRRTGQPVHHAIVWQDRRAEPLCAELREQGHEP
HHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCHHEEEEECCCCCCHHHHHHHHCCCCC
MIQERTGLRIDAYFSATKLRWLLDQVPGARAAAEAGELAFGTVDSWLIWQLTGGKVHVTD
CHHHCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHCCCEEEECCCCEEEEEEECCEEEEEE
VSNASRTMLFNVHSNDWDDDLLALLRIPRKLLPRVQPSASDFGATDAALLGGAIPIGGVA
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
GDQQSALFGQACFTAGMAKNTYGTGCFMLMHTGSSFQTSRNGLLTTSAAQIAPRTGAGHG
CCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECHHHHCCCCCCCCC
APEPAFAMEGSVFVGGAVVQWLRDGLRAISSSSEVQSLAESVPDSGGVMMVPAFTGLGAP
CCCCCCEECCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCC
YWKPDARGTITGLTRGTTIAHIARAALESIAYQSAALLQAMSRDAVAAGGAPVSELRVDG
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHEECCC
GACVNDLLMQFQADLLGIPVVRPAVIETTALGAAYLAGLSSGVYAGTEALSALWRAERRF
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LPTLSAARAQECMARWEHAVRQAALD
CCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TYLLALDQGTSSSRSIVFDERGHIVAQAQQELPQIYPQPGWVEHDPVDIWRTQIATARQ
EEEEEECCCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
ALAQANIGPGDVRALGITNQRETTVLWNRRTGQPVHHAIVWQDRRAEPLCAELREQGHEP
HHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCHHEEEEECCCCCCHHHHHHHHCCCCC
MIQERTGLRIDAYFSATKLRWLLDQVPGARAAAEAGELAFGTVDSWLIWQLTGGKVHVTD
CHHHCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHCCCEEEECCCCEEEEEEECCEEEEEE
VSNASRTMLFNVHSNDWDDDLLALLRIPRKLLPRVQPSASDFGATDAALLGGAIPIGGVA
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
GDQQSALFGQACFTAGMAKNTYGTGCFMLMHTGSSFQTSRNGLLTTSAAQIAPRTGAGHG
CCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECHHHHCCCCCCCCC
APEPAFAMEGSVFVGGAVVQWLRDGLRAISSSSEVQSLAESVPDSGGVMMVPAFTGLGAP
CCCCCCEECCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCC
YWKPDARGTITGLTRGTTIAHIARAALESIAYQSAALLQAMSRDAVAAGGAPVSELRVDG
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHEECCC
GACVNDLLMQFQADLLGIPVVRPAVIETTALGAAYLAGLSSGVYAGTEALSALWRAERRF
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LPTLSAARAQECMARWEHAVRQAALD
CCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA