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The map label for this gene is creC [H]

Identifier: 120609020

GI number: 120609020

Start: 349588

End: 351039

Strand: Reverse

Name: creC [H]

Synonym: Aave_0317

Alternate gene names: 120609020

Gene position: 351039-349588 (Counterclockwise)

Preceding gene: 120609021

Following gene: 120609019

Centisome position: 6.56

GC content: 72.52

Gene sequence:

>1452_bases
ATGCGCCTCGGGCTGCGGCTGCTTTTCGCGTTCTTCCTCATCAACGGCATCGCGGCGTTCTTCGTGCTGCGGGTGTTCAC
GGCCGAGATCAAGCCCAGCGTGCGGGAGGTGATGGAGGACATGATGGTGGACACCGCCAACCTGCTGGCGGAGCTGGCGA
GCGACGACCTCGCGAGCGGGCGCCTGGCGGCCGGCGCGCAGAACAGCGATTTCGCGCGCCACGTGCAGCGCTACGCAAGC
CGGCCGGTCGATGCCTCCATCTGGGGGCTGTCCAAGCAGACGCTGGATTTCCGCATCTACGTGACCGATGCGCGCGGGCG
CGTGGTCTTCGATACCGAGCGGCGCGCCGTGGGCGATGACTATTCGCAGTGGCGCGACGTGGCCCGCACGCTGCGCGGTG
AATACGGCGCCCGCGCCACGCGCGACGTGCAGACCGACGACACCAGCGGCGTGATGTACGTGGCCGCGCCGATCTGGATC
GACGGCCCCCCGGGCGGCGAGCGGCGGATCGGGGGCGTGCTCACCGTCGCCAAGCCGACGCGCACGGTGCAGCGCTTCAT
CGACCGGGCCGAACGCAAGGTGCTGCAGGGCGGATTGCTGCTGCTCGCGCTCTCCGCGGCCGTGGGCGTGGCCGTCACCG
TGTGGACCGTGTGGCACGTACGCCGCCTGCGCGACTATGCCCTCAGCGTGCAGGCACCGGGCGACGGGGGCGGGCCGCCG
CCCGCCGTGCCGCGCGTGCCCGGAGAACTCGGCGACCTCGCGCGGGCCATGGACCACATGCGCGAACGCCTCGCGGGCCG
CGACTACATCGAGGGCTACGTGCGCGCCCTGACCCATGAACTCAAGAGCCCCGTGGCCGCCATCCGCGGCGCAGGCGAGT
TGCTGCAGGACGACCTGCCCGGGGACGATCGCCGGCAGTTCGCGGCCCAGGTGGTGGACCAGAGCGAACGGCTGCAGCGC
CTCGTGGACCGCCTGCTGGAGTTGAGCAAGCTGGAGCAGCGCCAGCACGCGGAGGCCGGCGCCGCACCGGTGGCCCTGCG
CGCCTGCGCCGAGGCGGCCCTGCGCCAGTGCGAGGCGCGGGCCTCCCAGCGCGGGGTGCGTCTGCAGCTGGAAGGGGACG
GAGGAAGCGGTCCCTGGGAGGCCGAACTCATCACCCTGGCCCTGGGCAACCTCATCGACAATGCCATCGACTTCTCGCCC
GAAGGCGGCACCGTGCGCGTGGTGCTGGACGGTGCCGCCGCTTCGGTGCAGGACGAAGGACCGGGGGTGCCGGACTACGC
CCTGCCCCGGCTGGGCGAGCGGTTCTTCACCACCGCACGGCCGGACGGCACGCGCAGCGGCTCGGGACTGGGGCTGGCGA
TCGTGAAACGGGTCATGGCGCTGCACGGCGGCCGGCTCGACGTGGCCAGCACCGCCCGGGGACTGCGGGCGACCCTGGTA
CTGGCCGGCTGA

Upstream 100 bases:

>100_bases
ACATCCATACCCACCGGGGCATGGGCTATTCACTAGAGGTATGAAGCCGCCCCTGACGCGCTTCGCGCCATCCCCCTTCC
GCTGGCAAGGAGCTTGACCC

Downstream 100 bases:

>100_bases
CGATCACCCCGGGGTGCGCAGGCCGGCGGCTCGCGCCGGGCCGGATGGCGGCGCACGCCACTTCACGCTCGCCTCACACG
CCTCATTTCCCCCTCACACC

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MRLGLRLLFAFFLINGIAAFFVLRVFTAEIKPSVREVMEDMMVDTANLLAELASDDLASGRLAAGAQNSDFARHVQRYAS
RPVDASIWGLSKQTLDFRIYVTDARGRVVFDTERRAVGDDYSQWRDVARTLRGEYGARATRDVQTDDTSGVMYVAAPIWI
DGPPGGERRIGGVLTVAKPTRTVQRFIDRAERKVLQGGLLLLALSAAVGVAVTVWTVWHVRRLRDYALSVQAPGDGGGPP
PAVPRVPGELGDLARAMDHMRERLAGRDYIEGYVRALTHELKSPVAAIRGAGELLQDDLPGDDRRQFAAQVVDQSERLQR
LVDRLLELSKLEQRQHAEAGAAPVALRACAEAALRQCEARASQRGVRLQLEGDGGSGPWEAELITLALGNLIDNAIDFSP
EGGTVRVVLDGAAASVQDEGPGVPDYALPRLGERFFTTARPDGTRSGSGLGLAIVKRVMALHGGRLDVASTARGLRATLV
LAG

Sequences:

>Translated_483_residues
MRLGLRLLFAFFLINGIAAFFVLRVFTAEIKPSVREVMEDMMVDTANLLAELASDDLASGRLAAGAQNSDFARHVQRYAS
RPVDASIWGLSKQTLDFRIYVTDARGRVVFDTERRAVGDDYSQWRDVARTLRGEYGARATRDVQTDDTSGVMYVAAPIWI
DGPPGGERRIGGVLTVAKPTRTVQRFIDRAERKVLQGGLLLLALSAAVGVAVTVWTVWHVRRLRDYALSVQAPGDGGGPP
PAVPRVPGELGDLARAMDHMRERLAGRDYIEGYVRALTHELKSPVAAIRGAGELLQDDLPGDDRRQFAAQVVDQSERLQR
LVDRLLELSKLEQRQHAEAGAAPVALRACAEAALRQCEARASQRGVRLQLEGDGGSGPWEAELITLALGNLIDNAIDFSP
EGGTVRVVLDGAAASVQDEGPGVPDYALPRLGERFFTTARPDGTRSGSGLGLAIVKRVMALHGGRLDVASTARGLRATLV
LAG
>Mature_483_residues
MRLGLRLLFAFFLINGIAAFFVLRVFTAEIKPSVREVMEDMMVDTANLLAELASDDLASGRLAAGAQNSDFARHVQRYAS
RPVDASIWGLSKQTLDFRIYVTDARGRVVFDTERRAVGDDYSQWRDVARTLRGEYGARATRDVQTDDTSGVMYVAAPIWI
DGPPGGERRIGGVLTVAKPTRTVQRFIDRAERKVLQGGLLLLALSAAVGVAVTVWTVWHVRRLRDYALSVQAPGDGGGPP
PAVPRVPGELGDLARAMDHMRERLAGRDYIEGYVRALTHELKSPVAAIRGAGELLQDDLPGDDRRQFAAQVVDQSERLQR
LVDRLLELSKLEQRQHAEAGAAPVALRACAEAALRQCEARASQRGVRLQLEGDGGSGPWEAELITLALGNLIDNAIDFSP
EGGTVRVVLDGAAASVQDEGPGVPDYALPRLGERFFTTARPDGTRSGSGLGLAIVKRVMALHGGRLDVASTARGLRATLV
LAG

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=483, Percent_Identity=42.0289855072464, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1786600, Length=259, Percent_Identity=33.2046332046332, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789403, Length=258, Percent_Identity=32.5581395348837, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786783, Length=246, Percent_Identity=29.6747967479675, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788393, Length=246, Percent_Identity=30.0813008130081, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788549, Length=211, Percent_Identity=27.9620853080569, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790551, Length=276, Percent_Identity=27.1739130434783, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790436, Length=201, Percent_Identity=28.3582089552239, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788279, Length=233, Percent_Identity=26.1802575107296, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI48994928, Length=230, Percent_Identity=25.6521739130435, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=27.1551724137931, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081816, Length=331, Percent_Identity=26.5861027190332, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52228; Mature: 52228

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLGLRLLFAFFLINGIAAFFVLRVFTAEIKPSVREVMEDMMVDTANLLAELASDDLASG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHCCC
RLAAGAQNSDFARHVQRYASRPVDASIWGLSKQTLDFRIYVTDARGRVVFDTERRAVGDD
CCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEEEECCCCEEEEECCCHHCCCC
YSQWRDVARTLRGEYGARATRDVQTDDTSGVMYVAAPIWIDGPPGGERRIGGVLTVAKPT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEEECCHH
RTVQRFIDRAERKVLQGGLLLLALSAAVGVAVTVWTVWHVRRLRDYALSVQAPGDGGGPP
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCC
PAVPRVPGELGDLARAMDHMRERLAGRDYIEGYVRALTHELKSPVAAIRGAGELLQDDLP
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
GDDRRQFAAQVVDQSERLQRLVDRLLELSKLEQRQHAEAGAAPVALRACAEAALRQCEAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ASQRGVRLQLEGDGGSGPWEAELITLALGNLIDNAIDFSPEGGTVRVVLDGAAASVQDEG
HHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
PGVPDYALPRLGERFFTTARPDGTRSGSGLGLAIVKRVMALHGGRLDVASTARGLRATLV
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCEEEEE
LAG
EEC
>Mature Secondary Structure
MRLGLRLLFAFFLINGIAAFFVLRVFTAEIKPSVREVMEDMMVDTANLLAELASDDLASG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCHHCCC
RLAAGAQNSDFARHVQRYASRPVDASIWGLSKQTLDFRIYVTDARGRVVFDTERRAVGDD
CCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEEEECCCCEEEEECCCHHCCCC
YSQWRDVARTLRGEYGARATRDVQTDDTSGVMYVAAPIWIDGPPGGERRIGGVLTVAKPT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEEECCHH
RTVQRFIDRAERKVLQGGLLLLALSAAVGVAVTVWTVWHVRRLRDYALSVQAPGDGGGPP
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCC
PAVPRVPGELGDLARAMDHMRERLAGRDYIEGYVRALTHELKSPVAAIRGAGELLQDDLP
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
GDDRRQFAAQVVDQSERLQRLVDRLLELSKLEQRQHAEAGAAPVALRACAEAALRQCEAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ASQRGVRLQLEGDGGSGPWEAELITLALGNLIDNAIDFSPEGGTVRVVLDGAAASVQDEG
HHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
PGVPDYALPRLGERFFTTARPDGTRSGSGLGLAIVKRVMALHGGRLDVASTARGLRATLV
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCEEEEE
LAG
EEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]