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The map label for this gene is sdaA [H]

Identifier: 120609005

GI number: 120609005

Start: 334070

End: 335458

Strand: Reverse

Name: sdaA [H]

Synonym: Aave_0302

Alternate gene names: 120609005

Gene position: 335458-334070 (Counterclockwise)

Preceding gene: 120609007

Following gene: 120609004

Centisome position: 6.27

GC content: 72.14

Gene sequence:

>1389_bases
ATGGCCATCAGCGTCTTCGACCTCTTCAAGATCGGCATCGGTCCGTCCAGCTCCCACACGGTGGGCCCCATGCGTGCCGC
CCGGCTGTTCACCCACGCCCTGGAGCACCAGGGCCTGCTCGCCGCCACGCGCCGCGTGGAGGCGGAGCTCTACGGCTCGC
TGGGCGCCACGGGCAAGGGCCACGGCAGCGATACCGCCGTGCTGCTGGGCCTCGCGGGGCACGAACCCGACACCGTGGAC
GTGGATCGCACCGGCGGCTACGTGGCCGACATCCGCACGGGCGGGCGCCTGCCGCTGGCCGGCCACCATCCGGTCGCCTT
CGACGAGCGGCGCGACCTGCGCTTCTATGCCCTCAAGACGCTGCCCTTCCATGCCAACGGGCTGCGCTTCGCCGCGCGCA
GCGATTCGGGAGATCTGCTGCACGAAGCCACCTATTACTCGGTGGGCGGCGGCTTCGTGGTGAGCGAAGCGGTGGCGGCG
GACGGATCCCGCCACAAGGTGGTGGCGCCCGACCCGTCGGTGCTGCCGCTGCCCTTCGGCGACGCGGCGGACCTGCTGCG
CCTCACGGCCATGCACGGCCTGGACATCGCGGGGGTCATGCGCGTCAACGAACGGCACTGGCGCACGGATGCGGAGATCG
ACGCCGGCCTGCTGGCCATCTGGCGCGCCATGCAGGGCTGCGTCGAGCGCGGCTGCCGCACCGAGGGCCTGCTGCCCGGG
GGATTCAAGGTGAAGCGGCGGGCGGCGGCCCTCGCGCGCCGGCTGGGAGACTTCGAACCCCGCCCGGCCGACCCGCTGCG
GGTGCTCGACTGGGTGAACCTCTGGGCGCTGGCCGTCAACGAGGAGAACGCCGCCGGCGGCCGCGTGGTCACCGCCCCGA
CCAACGGGGCCGCGGGTATCGTGCCGGCGGTGCTGCACTACTACGTGCACACGGCGCCTGGCGCCAGCGAGCGCGGCGTG
GTGGATTTCCTGCTCACGGCCGGGGCCATCGGCATCCTCTACAAGCAGAACGCGTCCATCAGCGGCGCGGAAGTCGGCTG
CCAGGGCGAGGTGGGCGTGGCCTGCTCGATGGCGGCGGGCGCACTGTGCGCGGCGCTGGGTGGCACGCCGGCCCAGGCGG
AGAACGCGGCGGAGATCGGCATGGAGCACCACCTGGGGCTCACCTGCGACCCCGTCGGCGGGCTGGTGCAGATCCCGTGC
ATCGAGCGCAACGCCATCGCCTCGGTCAAGGCGATCAACGCGGCGCGCATGGCGCTGCACGGCGACGGCACGCACTTCGT
GAGCCTGGACCAGGTCATCAAGACCATGCGCGAGACCGGGGCCGACATGCTCACCAAGTACAAGGAAACGGCCCGGGGCG
GCCTGGCGGTGAACATCGTGGAGTGCTGA

Upstream 100 bases:

>100_bases
TCGACAAGACTGCTAATGTATTCCTTTATGAAAGATCAATGGACCTGACGAAACTTGTTGCCTACGCTGTGCGCCCATCC
GCAGCATTGCACTCCGCCCC

Downstream 100 bases:

>100_bases
AAAGCCGCCCGCGAAGATCCGCGAGGGCGGGACCATCCGCATTTTCGAGGAGGCATGGCGCCATGCCCCGTCTTTATAAT
ATGTCCACTCCGTGACGCCC

Product: L-serine ammonia-lyase

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAISVFDLFKIGIGPSSSHTVGPMRAARLFTHALEHQGLLAATRRVEAELYGSLGATGKGHGSDTAVLLGLAGHEPDTVD
VDRTGGYVADIRTGGRLPLAGHHPVAFDERRDLRFYALKTLPFHANGLRFAARSDSGDLLHEATYYSVGGGFVVSEAVAA
DGSRHKVVAPDPSVLPLPFGDAADLLRLTAMHGLDIAGVMRVNERHWRTDAEIDAGLLAIWRAMQGCVERGCRTEGLLPG
GFKVKRRAAALARRLGDFEPRPADPLRVLDWVNLWALAVNEENAAGGRVVTAPTNGAAGIVPAVLHYYVHTAPGASERGV
VDFLLTAGAIGILYKQNASISGAEVGCQGEVGVACSMAAGALCAALGGTPAQAENAAEIGMEHHLGLTCDPVGGLVQIPC
IERNAIASVKAINAARMALHGDGTHFVSLDQVIKTMRETGADMLTKYKETARGGLAVNIVEC

Sequences:

>Translated_462_residues
MAISVFDLFKIGIGPSSSHTVGPMRAARLFTHALEHQGLLAATRRVEAELYGSLGATGKGHGSDTAVLLGLAGHEPDTVD
VDRTGGYVADIRTGGRLPLAGHHPVAFDERRDLRFYALKTLPFHANGLRFAARSDSGDLLHEATYYSVGGGFVVSEAVAA
DGSRHKVVAPDPSVLPLPFGDAADLLRLTAMHGLDIAGVMRVNERHWRTDAEIDAGLLAIWRAMQGCVERGCRTEGLLPG
GFKVKRRAAALARRLGDFEPRPADPLRVLDWVNLWALAVNEENAAGGRVVTAPTNGAAGIVPAVLHYYVHTAPGASERGV
VDFLLTAGAIGILYKQNASISGAEVGCQGEVGVACSMAAGALCAALGGTPAQAENAAEIGMEHHLGLTCDPVGGLVQIPC
IERNAIASVKAINAARMALHGDGTHFVSLDQVIKTMRETGADMLTKYKETARGGLAVNIVEC
>Mature_461_residues
AISVFDLFKIGIGPSSSHTVGPMRAARLFTHALEHQGLLAATRRVEAELYGSLGATGKGHGSDTAVLLGLAGHEPDTVDV
DRTGGYVADIRTGGRLPLAGHHPVAFDERRDLRFYALKTLPFHANGLRFAARSDSGDLLHEATYYSVGGGFVVSEAVAAD
GSRHKVVAPDPSVLPLPFGDAADLLRLTAMHGLDIAGVMRVNERHWRTDAEIDAGLLAIWRAMQGCVERGCRTEGLLPGG
FKVKRRAAALARRLGDFEPRPADPLRVLDWVNLWALAVNEENAAGGRVVTAPTNGAAGIVPAVLHYYVHTAPGASERGVV
DFLLTAGAIGILYKQNASISGAEVGCQGEVGVACSMAAGALCAALGGTPAQAENAAEIGMEHHLGLTCDPVGGLVQIPCI
ERNAIASVKAINAARMALHGDGTHFVSLDQVIKTMRETGADMLTKYKETARGGLAVNIVEC

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=459, Percent_Identity=55.5555555555556, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1788116, Length=461, Percent_Identity=54.4468546637744, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1789161, Length=462, Percent_Identity=54.5454545454545, Blast_Score=475, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48473; Mature: 48342

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISVFDLFKIGIGPSSSHTVGPMRAARLFTHALEHQGLLAATRRVEAELYGSLGATGKG
CEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC
HGSDTAVLLGLAGHEPDTVDVDRTGGYVADIRTGGRLPLAGHHPVAFDERRDLRFYALKT
CCCCEEEEEEECCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEE
LPFHANGLRFAARSDSGDLLHEATYYSVGGGFVVSEAVAADGSRHKVVAPDPSVLPLPFG
CCCCCCCEEEEECCCCCCHHHHEEEEECCCCEEEHHHHHCCCCCCEEECCCCCEEECCCC
DAADLLRLTAMHGLDIAGVMRVNERHWRTDAEIDAGLLAIWRAMQGCVERGCRTEGLLPG
CHHHHHHHHHHCCCCEEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
GFKVKRRAAALARRLGDFEPRPADPLRVLDWVNLWALAVNEENAAGGRVVTAPTNGAAGI
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEEEECCCCCCCCEEEECCCCCCCHH
VPAVLHYYVHTAPGASERGVVDFLLTAGAIGILYKQNASISGAEVGCQGEVGVACSMAAG
HHHHHHHHHHCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEHHHHHH
ALCAALGGTPAQAENAAEIGMEHHLGLTCDPVGGLVQIPCIERNAIASVKAINAARMALH
HHHHHHCCCCCCCCCHHHHCHHHCCCEEECCCCCEEEECCCCCCHHHHHHHHHHEEEEEE
GDGTHFVSLDQVIKTMRETGADMLTKYKETARGGLAVNIVEC
CCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEEC
>Mature Secondary Structure 
AISVFDLFKIGIGPSSSHTVGPMRAARLFTHALEHQGLLAATRRVEAELYGSLGATGKG
EEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC
HGSDTAVLLGLAGHEPDTVDVDRTGGYVADIRTGGRLPLAGHHPVAFDERRDLRFYALKT
CCCCEEEEEEECCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEE
LPFHANGLRFAARSDSGDLLHEATYYSVGGGFVVSEAVAADGSRHKVVAPDPSVLPLPFG
CCCCCCCEEEEECCCCCCHHHHEEEEECCCCEEEHHHHHCCCCCCEEECCCCCEEECCCC
DAADLLRLTAMHGLDIAGVMRVNERHWRTDAEIDAGLLAIWRAMQGCVERGCRTEGLLPG
CHHHHHHHHHHCCCCEEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
GFKVKRRAAALARRLGDFEPRPADPLRVLDWVNLWALAVNEENAAGGRVVTAPTNGAAGI
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEEEECCCCCCCCEEEECCCCCCCHH
VPAVLHYYVHTAPGASERGVVDFLLTAGAIGILYKQNASISGAEVGCQGEVGVACSMAAG
HHHHHHHHHHCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEHHHHHH
ALCAALGGTPAQAENAAEIGMEHHLGLTCDPVGGLVQIPCIERNAIASVKAINAARMALH
HHHHHHCCCCCCCCCHHHHCHHHCCCEEECCCCCEEEECCCCCCHHHHHHHHHHEEEEEE
GDGTHFVSLDQVIKTMRETGADMLTKYKETARGGLAVNIVEC
CCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]