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The map label for this gene is exoA [H]

Identifier: 120608991

GI number: 120608991

Start: 320103

End: 320897

Strand: Reverse

Name: exoA [H]

Synonym: Aave_0288

Alternate gene names: 120608991

Gene position: 320897-320103 (Counterclockwise)

Preceding gene: 120608994

Following gene: 120608988

Centisome position: 5.99

GC content: 65.16

Gene sequence:

>795_bases
TTGACCAGCCTGAACCTCAACGGCATCCGCTCCGCCGCCTCGAAGGGCGTGGAGGCCTGGATCGCCGAGACGCGGCCGGA
TTGTATTTGCGTGCAGGAGATCAAGGCGCAGTCCGCCGACATCGAAGGCCGTTTCGAGACCCTGGCGGGCCTCAAGGGGC
ATTTCCACTACGCGACCAAGAAGGGCTATTCGGGCGTGGGCATCTACACCCGCCACGAGCCGAGCGACGTGCGCGTGGGC
TACGGCTCCACCGAGTTCGACGCCGAGGGCCGCTACGTGGAAGCCCGCTTCGACACGCCTTCGCGCAAGCTGTCGATCAT
CAGCGCGTATTTTCCGAGCGGCTCGTCGGGGCCGGAGCGCCAGCTCGCGAAATTCCGCTTCCTGGCGGAATTCCACGTGC
ACCTGATGCGCGTGAAGGAAGAGCGCGAATTCATCCTCTGCGGCGACGTCAACATCGCCCACCAGCAGATCGACCTGAAG
AACTGGCGCAGCAACCAGAAGAACAGCGGCTTCCTGCCCGAAGAGCGCGAGTGGATGACAAAGTTGTTGCACAAGACCGA
CCCGGGCGGCGGCCTCGTGGACGTGTACCGCCTGCTGCAGCCCGACACCACCGAGACGGCCTACACCTGGTGGAGCAACC
GCGGGCAGGCCTATGCGAACAACGTGGGCTGGCGGCTGGACTACCACCTCGCCACCCCGGCGATCGCGGCCCTGGCGCGC
ACCGAGTCCATCTACAAGCAGCAGAAGTTCTCGGACCACGCGCCGATCACGGTGGGCTACGAGCTGGCGATCTGA

Upstream 100 bases:

>100_bases
TTCCTGGGCGAGGCGGTCCGCCGACGCGCCGTCTCCCGCCGTTTCCTCTCCCGTCCGCCGCCGCGCGCCGTCTGCCACCA
TGGATGCTTCCCTTTTCAAA

Downstream 100 bases:

>100_bases
GCCCAGATTCCAGGCGCCCGCCGGGTCAGTCCCAGGCCGGCGCCAGCCCTTCCGGGTCCACCAGCCGGCCGCCCCGGTCC
AGCGCGGCGATGCGCTGCAT

Product: exodeoxyribonuclease III Xth

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MTSLNLNGIRSAASKGVEAWIAETRPDCICVQEIKAQSADIEGRFETLAGLKGHFHYATKKGYSGVGIYTRHEPSDVRVG
YGSTEFDAEGRYVEARFDTPSRKLSIISAYFPSGSSGPERQLAKFRFLAEFHVHLMRVKEEREFILCGDVNIAHQQIDLK
NWRSNQKNSGFLPEEREWMTKLLHKTDPGGGLVDVYRLLQPDTTETAYTWWSNRGQAYANNVGWRLDYHLATPAIAALAR
TESIYKQQKFSDHAPITVGYELAI

Sequences:

>Translated_264_residues
MTSLNLNGIRSAASKGVEAWIAETRPDCICVQEIKAQSADIEGRFETLAGLKGHFHYATKKGYSGVGIYTRHEPSDVRVG
YGSTEFDAEGRYVEARFDTPSRKLSIISAYFPSGSSGPERQLAKFRFLAEFHVHLMRVKEEREFILCGDVNIAHQQIDLK
NWRSNQKNSGFLPEEREWMTKLLHKTDPGGGLVDVYRLLQPDTTETAYTWWSNRGQAYANNVGWRLDYHLATPAIAALAR
TESIYKQQKFSDHAPITVGYELAI
>Mature_263_residues
TSLNLNGIRSAASKGVEAWIAETRPDCICVQEIKAQSADIEGRFETLAGLKGHFHYATKKGYSGVGIYTRHEPSDVRVGY
GSTEFDAEGRYVEARFDTPSRKLSIISAYFPSGSSGPERQLAKFRFLAEFHVHLMRVKEEREFILCGDVNIAHQQIDLKN
WRSNQKNSGFLPEEREWMTKLLHKTDPGGGLVDVYRLLQPDTTETAYTWWSNRGQAYANNVGWRLDYHLATPAIAALART
ESIYKQQKFSDHAPITVGYELAI

Specific function: Major Apurinic-Apyrimidinic Endonuclease Of E.Coli. It Removes The Damaged DNA At Cytosines And Guanines By Cleaving On The 3' Side Of The Ap Site By A Beta-Elimination Reaction. It Exhibits 3'-5'-Exonuclease, 3'-Phosphomonoesterase, 3'-Repair Diesterase

COG id: COG0708

COG function: function code L; Exonuclease III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]

Homologues:

Organism=Homo sapiens, GI18375505, Length=260, Percent_Identity=35.7692307692308, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI18375503, Length=260, Percent_Identity=35.7692307692308, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI18375501, Length=260, Percent_Identity=35.7692307692308, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI18375507, Length=315, Percent_Identity=26.031746031746, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1788046, Length=269, Percent_Identity=30.4832713754647, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71989536, Length=257, Percent_Identity=30.7392996108949, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221330655, Length=264, Percent_Identity=34.0909090909091, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI17136678, Length=268, Percent_Identity=35.0746268656716, Blast_Score=143, Evalue=1e-34,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000097
- InterPro:   IPR020847
- InterPro:   IPR020848
- InterPro:   IPR005135
- InterPro:   IPR004808 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.11.2 [H]

Molecular weight: Translated: 29837; Mature: 29706

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLNLNGIRSAASKGVEAWIAETRPDCICVQEIKAQSADIEGRFETLAGLKGHFHYATK
CCCCCCCHHHHHHHCCHHHHHHCCCCCEEEHHHHHCCCCCCCCHHHHHHCCCCEEEEECC
KGYSGVGIYTRHEPSDVRVGYGSTEFDAEGRYVEARFDTPSRKLSIISAYFPSGSSGPER
CCCCCCCEEECCCCCCEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCHHH
QLAKFRFLAEFHVHLMRVKEEREFILCGDVNIAHQQIDLKNWRSNQKNSGFLPEEREWMT
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHEEEHHHHCCCCCCCCCCCHHHHHHH
KLLHKTDPGGGLVDVYRLLQPDTTETAYTWWSNRGQAYANNVGWRLDYHLATPAIAALAR
HHHHCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCEEEEEEEHHHHHHHHHH
TESIYKQQKFSDHAPITVGYELAI
HHHHHHHHHCCCCCCEEEEEEEEC
>Mature Secondary Structure 
TSLNLNGIRSAASKGVEAWIAETRPDCICVQEIKAQSADIEGRFETLAGLKGHFHYATK
CCCCCCHHHHHHHCCHHHHHHCCCCCEEEHHHHHCCCCCCCCHHHHHHCCCCEEEEECC
KGYSGVGIYTRHEPSDVRVGYGSTEFDAEGRYVEARFDTPSRKLSIISAYFPSGSSGPER
CCCCCCCEEECCCCCCEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCHHH
QLAKFRFLAEFHVHLMRVKEEREFILCGDVNIAHQQIDLKNWRSNQKNSGFLPEEREWMT
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHEEEHHHHCCCCCCCCCCCHHHHHHH
KLLHKTDPGGGLVDVYRLLQPDTTETAYTWWSNRGQAYANNVGWRLDYHLATPAIAALAR
HHHHCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCEEEEEEEHHHHHHHHHH
TESIYKQQKFSDHAPITVGYELAI
HHHHHHHHHCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]