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The map label for this gene is citT [C]

Identifier: 120608984

GI number: 120608984

Start: 312556

End: 314073

Strand: Reverse

Name: citT [C]

Synonym: Aave_0281

Alternate gene names: 120608984

Gene position: 314073-312556 (Counterclockwise)

Preceding gene: 120608985

Following gene: 120608979

Centisome position: 5.87

GC content: 70.29

Gene sequence:

>1518_bases
ATGACGACGTCGCCCGTCCCCTCGCCCTCCCCCGCCGCTCCGATCACTTCGCATCCGGAGCCCGACTCCCGCCGCAAGCT
CGGCTACCTGCTGCTTGCCCTGGGCCTGTATGCCCTGGTGCTGGCCCTGCCGACCCCGGCAGGGCTTTCGCCCTCGGGCC
AGGTCGCCCTCGGGCTGCTGGTGTTCGTGGTCACGCTGTGGATCAGCGAGTGCGTCTCGCCCGCCAACAGCGCGGTGCTG
CTCACCGGCATGGCGGTGGTGGGGTTGATGGGCAAGCCCCTCACGCCGGGCGCCAGGCCCATGGGTTCGGCCGATGCGCT
CACCGTGATGCTGGGCGGCTTCTCATCGACGGCCGTGCTGCTGGTGGCCGCCGCGCTGTTCCTGGCCGTGGCGCTCAAGC
ACACGGGGCTGGACCGCCGCGTGGCCCTGCTGGTGATGAGCCGGGTGGGCATCTCGCCCGCGCGGCTCACGCTGGGCGCG
ATGCTGGTGGGCTTCGTGCTGGCGCTGTTCATCCCCTCGGCCACTGCGCGCGTGGGCGCGGTGATACCGATCATGGTCGG
CATCACCGCGGCGCTCGGCCTGCCCGTGGGCAGCAGCCTGGGCGCCACGCTGATGATCGTGACGGCGCAGGCCTGCTCGA
TCTTCAACATCGCGGTGAAGACGGGCGCGGCGCAGAACCTCATCAGCCTGAACTTCATGCAGGGGGCCTTCGGGCACGGC
GTGACCTGGGGGCAGTGGTTCCTCGCCGCCCTGCCCTTCACCATCGGCATGTCGGTCGTGCTGTTCTTCGTGTCGCTGTG
GCTGCTGCGCCCCGAGGTGCCCGACTCCGAGGACGCCGCGGGCAACCTGCGCGAGCAACTGCGCGCCCTGGGCCCCGTCA
GCGCCCCGGAAAAGCGCCTGATCGCGGTGGCGCTGCTGCTGCTCGTGCTCTGGTCCACGGAAGGCACGCTGCACCCGTTC
GACACCACCACCACCACGCAGCTCGGCATCGCGCTGCTGCTCATGCCGCGCATCGGCGTCATGCATTGGGCACAGGCAGA
AAAGCTCGTGCCCTGGGGGACGGTGGTGCTGTTCGCTGCCTCGATCTCGCTCGGCACGCTGCTGCAGCGCACCGGTGCGG
CCGGCTGGCTGGCCCAGCAGACGCTGGGGCAGCTGGGGCTCGCGGCCCTGCCGGTGGTGTCGGTGATCGGCGCGCTGGCC
GTGTTCAGCATCGTGCTGCACCTGGGCTTCGCCTCCGCCACGGGCCTGGCCAGCACGCTGATCCCGATCTTCATCGCCTT
CGCGCAGACGCTGCCGGTCTCGAAGGAAACCGCGTTCGGCATCGTGCTCGTGCAGAGCTTCGTGGTGTCGTTCGGCTTCA
TCCTGCCGACGAACGCGCCGCAGAACATGCTGTGCTATGGCACGGGCGCGTTCGGCACGCTGCAGTTCGCCAAGGTGGGG
CTGCTGGTGACGCTGGCGGGCCTGGCGCTCATCCTGCTGCTGTCGGCCACGCTGTGGCCGTGGATGGGCGTGCTCTGA

Upstream 100 bases:

>100_bases
GGGTACGGGCATTCTTCCAGGCAGGCCTGATGGCACCGCGCAATCGGTCGTTTCCGATCCATGGCGGGCCACGGCCTCAC
CGTGAAAGAAAAGCTCCGCC

Downstream 100 bases:

>100_bases
CGGCGCGCGGGCGTCACGGGCGCCGGTTCAACCGCGCCGCGCGGCCTGGTAGAGGCCCTGCACGCGCGGCACGTTCTGCT
CCAGCTCGCGGATGCGGTCC

Product: anion transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTTSPVPSPSPAAPITSHPEPDSRRKLGYLLLALGLYALVLALPTPAGLSPSGQVALGLLVFVVTLWISECVSPANSAVL
LTGMAVVGLMGKPLTPGARPMGSADALTVMLGGFSSTAVLLVAAALFLAVALKHTGLDRRVALLVMSRVGISPARLTLGA
MLVGFVLALFIPSATARVGAVIPIMVGITAALGLPVGSSLGATLMIVTAQACSIFNIAVKTGAAQNLISLNFMQGAFGHG
VTWGQWFLAALPFTIGMSVVLFFVSLWLLRPEVPDSEDAAGNLREQLRALGPVSAPEKRLIAVALLLLVLWSTEGTLHPF
DTTTTTQLGIALLLMPRIGVMHWAQAEKLVPWGTVVLFAASISLGTLLQRTGAAGWLAQQTLGQLGLAALPVVSVIGALA
VFSIVLHLGFASATGLASTLIPIFIAFAQTLPVSKETAFGIVLVQSFVVSFGFILPTNAPQNMLCYGTGAFGTLQFAKVG
LLVTLAGLALILLLSATLWPWMGVL

Sequences:

>Translated_505_residues
MTTSPVPSPSPAAPITSHPEPDSRRKLGYLLLALGLYALVLALPTPAGLSPSGQVALGLLVFVVTLWISECVSPANSAVL
LTGMAVVGLMGKPLTPGARPMGSADALTVMLGGFSSTAVLLVAAALFLAVALKHTGLDRRVALLVMSRVGISPARLTLGA
MLVGFVLALFIPSATARVGAVIPIMVGITAALGLPVGSSLGATLMIVTAQACSIFNIAVKTGAAQNLISLNFMQGAFGHG
VTWGQWFLAALPFTIGMSVVLFFVSLWLLRPEVPDSEDAAGNLREQLRALGPVSAPEKRLIAVALLLLVLWSTEGTLHPF
DTTTTTQLGIALLLMPRIGVMHWAQAEKLVPWGTVVLFAASISLGTLLQRTGAAGWLAQQTLGQLGLAALPVVSVIGALA
VFSIVLHLGFASATGLASTLIPIFIAFAQTLPVSKETAFGIVLVQSFVVSFGFILPTNAPQNMLCYGTGAFGTLQFAKVG
LLVTLAGLALILLLSATLWPWMGVL
>Mature_504_residues
TTSPVPSPSPAAPITSHPEPDSRRKLGYLLLALGLYALVLALPTPAGLSPSGQVALGLLVFVVTLWISECVSPANSAVLL
TGMAVVGLMGKPLTPGARPMGSADALTVMLGGFSSTAVLLVAAALFLAVALKHTGLDRRVALLVMSRVGISPARLTLGAM
LVGFVLALFIPSATARVGAVIPIMVGITAALGLPVGSSLGATLMIVTAQACSIFNIAVKTGAAQNLISLNFMQGAFGHGV
TWGQWFLAALPFTIGMSVVLFFVSLWLLRPEVPDSEDAAGNLREQLRALGPVSAPEKRLIAVALLLLVLWSTEGTLHPFD
TTTTTQLGIALLLMPRIGVMHWAQAEKLVPWGTVVLFAASISLGTLLQRTGAAGWLAQQTLGQLGLAALPVVSVIGALAV
FSIVLHLGFASATGLASTLIPIFIAFAQTLPVSKETAFGIVLVQSFVVSFGFILPTNAPQNMLCYGTGAFGTLQFAKVGL
LVTLAGLALILLLSATLWPWMGVL

Specific function: Responsible For The Uptake Of Citrate In Exchange To The Efflux Of Succinate. Has A Relatively Broad Specificity For C(4)- Dicarboxylates And Tricarboxylates. [C]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. SODIT1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI301069349, Length=470, Percent_Identity=24.468085106383, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI29171306, Length=483, Percent_Identity=22.9813664596273, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4506979, Length=499, Percent_Identity=22.6452905811623, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI225637552, Length=482, Percent_Identity=22.8215767634855, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI225637549, Length=482, Percent_Identity=22.8215767634855, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI31795546, Length=322, Percent_Identity=22.9813664596273, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1786829, Length=492, Percent_Identity=26.0162601626016, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789444, Length=482, Percent_Identity=26.9709543568465, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1786986, Length=418, Percent_Identity=28.2296650717703, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71988385, Length=446, Percent_Identity=24.2152466367713, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32565804, Length=446, Percent_Identity=23.542600896861, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 52215; Mature: 52084

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSPVPSPSPAAPITSHPEPDSRRKLGYLLLALGLYALVLALPTPAGLSPSGQVALGLL
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
VFVVTLWISECVSPANSAVLLTGMAVVGLMGKPLTPGARPMGSADALTVMLGGFSSTAVL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEECCCCHHHHH
LVAAALFLAVALKHTGLDRRVALLVMSRVGISPARLTLGAMLVGFVLALFIPSATARVGA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VIPIMVGITAALGLPVGSSLGATLMIVTAQACSIFNIAVKTGAAQNLISLNFMQGAFGHG
HHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
VTWGQWFLAALPFTIGMSVVLFFVSLWLLRPEVPDSEDAAGNLREQLRALGPVSAPEKRL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
IAVALLLLVLWSTEGTLHPFDTTTTTQLGIALLLMPRIGVMHWAQAEKLVPWGTVVLFAA
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SISLGTLLQRTGAAGWLAQQTLGQLGLAALPVVSVIGALAVFSIVLHLGFASATGLASTL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPIFIAFAQTLPVSKETAFGIVLVQSFVVSFGFILPTNAPQNMLCYGTGAFGTLQFAKVG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHH
LLVTLAGLALILLLSATLWPWMGVL
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTSPVPSPSPAAPITSHPEPDSRRKLGYLLLALGLYALVLALPTPAGLSPSGQVALGLL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
VFVVTLWISECVSPANSAVLLTGMAVVGLMGKPLTPGARPMGSADALTVMLGGFSSTAVL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEECCCCHHHHH
LVAAALFLAVALKHTGLDRRVALLVMSRVGISPARLTLGAMLVGFVLALFIPSATARVGA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VIPIMVGITAALGLPVGSSLGATLMIVTAQACSIFNIAVKTGAAQNLISLNFMQGAFGHG
HHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
VTWGQWFLAALPFTIGMSVVLFFVSLWLLRPEVPDSEDAAGNLREQLRALGPVSAPEKRL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
IAVALLLLVLWSTEGTLHPFDTTTTTQLGIALLLMPRIGVMHWAQAEKLVPWGTVVLFAA
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SISLGTLLQRTGAAGWLAQQTLGQLGLAALPVVSVIGALAVFSIVLHLGFASATGLASTL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPIFIAFAQTLPVSKETAFGIVLVQSFVVSFGFILPTNAPQNMLCYGTGAFGTLQFAKVG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHH
LLVTLAGLALILLLSATLWPWMGVL
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8405966 [H]