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The map label for this gene is ggt [H]

Identifier: 120599162

GI number: 120599162

Start: 2719517

End: 2721256

Strand: Direct

Name: ggt [H]

Synonym: Sputw3181_2358

Alternate gene names: 120599162

Gene position: 2719517-2721256 (Clockwise)

Preceding gene: 120599160

Following gene: 120599170

Centisome position: 57.76

GC content: 46.9

Gene sequence:

>1740_bases
ATGCGTTCCGCAAGAACTTTTAGACCTCTTTTTCTCATCGTCGCGATGGCTTTGCCCTTGTTATCCTCTCCAAGCCTCTA
CGCAGATGAAGCGCCTATTTTCAGCCAAATGGCAACGGCACAGCCCGTATGGGCCAAACATGGCATGGTCGCCAGCCAAG
AAACACTCGCCAGTCGTACTGGCGTTGAGATCCTAAAACAAGGCGGTAATGCAGTTGATGCCGCCGTTGCTGTAGCCTTC
AGTTTGGCAGTTACCTTACCACGCGCTGGTAATATTGGTGGTGGTGGTTTTATGCTGGTGCATCTTGCCAAAGAAAACAA
AACCATTGCTATCGATTACCGTGAAATGGCGCCATCTAAAGCCAAAAAAGATATTTTCCTTGACGAAAATGGTGACGCAG
TCCAAAAGTTAAGCCGCGAACATGGGTTAGCCGTGGGAGTACCAGGAACCGTTATGGGCATGAGTTTAGCCCTTGAAAAG
TATGGAACCATGTCACTCGCACAAGTTACCGCCCCCGCGATTAAAATGGCGCAGGAAGGATTCAGTGTAACACCAGATCT
TGCCCAATCCCTTGCAGGACTGAAACGTCGTATGGCGCAATGGCCAACCACTGCGGCGATATTTTATAAAAACGACGGCA
GCGATTATCTGGTGGGTGATATTCTTAAACAGCCCGAACTCGCCCATTCACTACGCCTTATCGCTGAAAAAGGCACTAAA
GGATTTTATGAAGGGGAAACCGCCGTTAAGATTGTCAATGCTGTGCAAGATGCTGGCGGCATTATGACCTTAGACGACCT
TAAACATTATAAAGTCGTAGAACGTGAGCCTGTTCGTGGAGAATACCGTGGTTATCAGGTGGTATCCATGCCCCCCCCCT
CCTCTGGCGGCGTGCATATCATCCAAATGCTCAATGTGTTGCAACAATTCCCCATTGATAAACTTGGCCATAATACAGCA
CAAACCATTCATCTAATGGCTGAAACGATGAAATACGCCTATAGCGATCGTAGTGAATACTTAGGCGATCCTGACTTTTA
TAAAGTGCCAGTTAACGCGTTAACAAACGCTGACTATGCCCAAAAAATCGCCAGCAAGATTGCGATAAATAAGACAACCC
CAAGCAGTGAAATTAAACCGGGTAAACTGGCTCCCTATGAAAGCGATCAAACAACTCACTTCTCAGTGGTGGATAAATGG
GGCAATGCGGTATCAAACACTTACACCTTAAACTTCAGTTATGGTTCAGGTTTAGTGGCCAAAGGCACAGGCATTTTGCT
CAATAATGAAATGGATGATTTCTCAGCCAAACCTGGTGTACCCAATGGCTATGGTTTAGTAGGTGGTGATGCCAATGCGG
TCGAAGGTAACAAGCGGCCACTGAGTTCAATGAGCCCAACGATTGTGATGAAAGATGGTAAAGCCTTCCTTATCACAGGT
AGTCCTGGCGGCTCACGTATTATCACCACAACATTGCAAATCATTATGAATGTCATTGACCATGGTCTAAACATTGCCGA
GGCAAGTTATGCGGCGCGGGTACATCATCAATGGCAACCCGATGAATTACGAGTTGAGTCTAGCGTCAATCGCGATACCA
TTTCCCTGCTCGAAGCCAAAGGCCATAAAGTAACAGTGCAATCGGCGATGGGCAGTACTCAATCCATTATGGTGACCGAA
CAAGGTATTTTTGGCGCTTCAGATCCGCGTCATTCAGGTAGTGAAGCAGTTGGCTATTAA

Upstream 100 bases:

>100_bases
TTATCGTCCTTTAGTGATGTGAACAAGTATACGAGGTTGCAATTAAGCCTAATTCTCGGCACATTGCATAGTCATAATGA
AAATAAATTCAGGATTAAGT

Downstream 100 bases:

>100_bases
TTGCTAACAAAATGAATAGTATAGAGAATAGATCGAAAGATGGATCTGTTAACCCTTAAATGAACAGATCCATTCAAAAG
ACAGCAGCGATGACCCTATG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MRSARTFRPLFLIVAMALPLLSSPSLYADEAPIFSQMATAQPVWAKHGMVASQETLASRTGVEILKQGGNAVDAAVAVAF
SLAVTLPRAGNIGGGGFMLVHLAKENKTIAIDYREMAPSKAKKDIFLDENGDAVQKLSREHGLAVGVPGTVMGMSLALEK
YGTMSLAQVTAPAIKMAQEGFSVTPDLAQSLAGLKRRMAQWPTTAAIFYKNDGSDYLVGDILKQPELAHSLRLIAEKGTK
GFYEGETAVKIVNAVQDAGGIMTLDDLKHYKVVEREPVRGEYRGYQVVSMPPPSSGGVHIIQMLNVLQQFPIDKLGHNTA
QTIHLMAETMKYAYSDRSEYLGDPDFYKVPVNALTNADYAQKIASKIAINKTTPSSEIKPGKLAPYESDQTTHFSVVDKW
GNAVSNTYTLNFSYGSGLVAKGTGILLNNEMDDFSAKPGVPNGYGLVGGDANAVEGNKRPLSSMSPTIVMKDGKAFLITG
SPGGSRIITTTLQIIMNVIDHGLNIAEASYAARVHHQWQPDELRVESSVNRDTISLLEAKGHKVTVQSAMGSTQSIMVTE
QGIFGASDPRHSGSEAVGY

Sequences:

>Translated_579_residues
MRSARTFRPLFLIVAMALPLLSSPSLYADEAPIFSQMATAQPVWAKHGMVASQETLASRTGVEILKQGGNAVDAAVAVAF
SLAVTLPRAGNIGGGGFMLVHLAKENKTIAIDYREMAPSKAKKDIFLDENGDAVQKLSREHGLAVGVPGTVMGMSLALEK
YGTMSLAQVTAPAIKMAQEGFSVTPDLAQSLAGLKRRMAQWPTTAAIFYKNDGSDYLVGDILKQPELAHSLRLIAEKGTK
GFYEGETAVKIVNAVQDAGGIMTLDDLKHYKVVEREPVRGEYRGYQVVSMPPPSSGGVHIIQMLNVLQQFPIDKLGHNTA
QTIHLMAETMKYAYSDRSEYLGDPDFYKVPVNALTNADYAQKIASKIAINKTTPSSEIKPGKLAPYESDQTTHFSVVDKW
GNAVSNTYTLNFSYGSGLVAKGTGILLNNEMDDFSAKPGVPNGYGLVGGDANAVEGNKRPLSSMSPTIVMKDGKAFLITG
SPGGSRIITTTLQIIMNVIDHGLNIAEASYAARVHHQWQPDELRVESSVNRDTISLLEAKGHKVTVQSAMGSTQSIMVTE
QGIFGASDPRHSGSEAVGY
>Mature_579_residues
MRSARTFRPLFLIVAMALPLLSSPSLYADEAPIFSQMATAQPVWAKHGMVASQETLASRTGVEILKQGGNAVDAAVAVAF
SLAVTLPRAGNIGGGGFMLVHLAKENKTIAIDYREMAPSKAKKDIFLDENGDAVQKLSREHGLAVGVPGTVMGMSLALEK
YGTMSLAQVTAPAIKMAQEGFSVTPDLAQSLAGLKRRMAQWPTTAAIFYKNDGSDYLVGDILKQPELAHSLRLIAEKGTK
GFYEGETAVKIVNAVQDAGGIMTLDDLKHYKVVEREPVRGEYRGYQVVSMPPPSSGGVHIIQMLNVLQQFPIDKLGHNTA
QTIHLMAETMKYAYSDRSEYLGDPDFYKVPVNALTNADYAQKIASKIAINKTTPSSEIKPGKLAPYESDQTTHFSVVDKW
GNAVSNTYTLNFSYGSGLVAKGTGILLNNEMDDFSAKPGVPNGYGLVGGDANAVEGNKRPLSSMSPTIVMKDGKAFLITG
SPGGSRIITTTLQIIMNVIDHGLNIAEASYAARVHHQWQPDELRVESSVNRDTISLLEAKGHKVTVQSAMGSTQSIMVTE
QGIFGASDPRHSGSEAVGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=538, Percent_Identity=32.5278810408922, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI73915090, Length=538, Percent_Identity=32.5278810408922, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI73915096, Length=538, Percent_Identity=32.5278810408922, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI73915094, Length=538, Percent_Identity=32.5278810408922, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI113429324, Length=528, Percent_Identity=32.1969696969697, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI113429326, Length=532, Percent_Identity=31.5789473684211, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI109148539, Length=547, Percent_Identity=32.1755027422303, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI153266885, Length=547, Percent_Identity=27.7879341864717, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI153266901, Length=548, Percent_Identity=27.7372262773723, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI153266907, Length=546, Percent_Identity=26.5567765567766, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI30581157, Length=229, Percent_Identity=35.3711790393013, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI30581155, Length=229, Percent_Identity=35.3711790393013, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI218505805, Length=228, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI310124095, Length=228, Percent_Identity=32.0175438596491, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1789856, Length=541, Percent_Identity=60.9981515711645, Blast_Score=648, Evalue=0.0,
Organism=Caenorhabditis elegans, GI72000294, Length=543, Percent_Identity=32.2283609576427, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI212646519, Length=543, Percent_Identity=32.2283609576427, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17542894, Length=557, Percent_Identity=32.6750448833034, Blast_Score=231, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17506189, Length=536, Percent_Identity=30.7835820895522, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI193208245, Length=555, Percent_Identity=29.9099099099099, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI193208247, Length=555, Percent_Identity=29.9099099099099, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17564448, Length=423, Percent_Identity=27.1867612293144, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI72001497, Length=239, Percent_Identity=26.3598326359833, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI72001495, Length=239, Percent_Identity=26.3598326359833, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323330, Length=525, Percent_Identity=30.4761904761905, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI161077878, Length=541, Percent_Identity=31.4232902033272, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI45551474, Length=541, Percent_Identity=31.4232902033272, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24642670, Length=541, Percent_Identity=31.4232902033272, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24642666, Length=541, Percent_Identity=31.4232902033272, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI161077880, Length=541, Percent_Identity=31.4232902033272, Blast_Score=239, Evalue=5e-63,
Organism=Drosophila melanogaster, GI18859893, Length=537, Percent_Identity=32.7746741154562, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI161077496, Length=506, Percent_Identity=32.6086956521739, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI18859741, Length=546, Percent_Identity=28.2051282051282, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62141; Mature: 62141

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSARTFRPLFLIVAMALPLLSSPSLYADEAPIFSQMATAQPVWAKHGMVASQETLASRT
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCHHHHCCCCCCHHHHHHHH
GVEILKQGGNAVDAAVAVAFSLAVTLPRAGNIGGGGFMLVHLAKENKTIAIDYREMAPSK
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEHHHCCCCC
AKKDIFLDENGDAVQKLSREHGLAVGVPGTVMGMSLALEKYGTMSLAQVTAPAIKMAQEG
CCCCEEECCCCHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
FSVTPDLAQSLAGLKRRMAQWPTTAAIFYKNDGSDYLVGDILKQPELAHSLRLIAEKGTK
CCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHCCCC
GFYEGETAVKIVNAVQDAGGIMTLDDLKHYKVVEREPVRGEYRGYQVVSMPPPSSGGVHI
CCCCCCHHHHHHHHHHHCCCEEEHHHCHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHH
IQMLNVLQQFPIDKLGHNTAQTIHLMAETMKYAYSDRSEYLGDPDFYKVPVNALTNADYA
HHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEECHHHHCCCHHH
QKIASKIAINKTTPSSEIKPGKLAPYESDQTTHFSVVDKWGNAVSNTYTLNFSYGSGLVA
HHHHHHHEECCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHCCCCCCEEEEEEECCCCEEE
KGTGILLNNEMDDFSAKPGVPNGYGLVGGDANAVEGNKRPLSSMSPTIVMKDGKAFLITG
CCCEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTTLQIIMNVIDHGLNIAEASYAARVHHQWQPDELRVESSVNRDTISLLEAK
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHEEECCCCCHHHHHHHHCC
GHKVTVQSAMGSTQSIMVTEQGIFGASDPRHSGSEAVGY
CCEEEEHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRSARTFRPLFLIVAMALPLLSSPSLYADEAPIFSQMATAQPVWAKHGMVASQETLASRT
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCHHHHCCCCCCHHHHHHHH
GVEILKQGGNAVDAAVAVAFSLAVTLPRAGNIGGGGFMLVHLAKENKTIAIDYREMAPSK
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEHHHCCCCC
AKKDIFLDENGDAVQKLSREHGLAVGVPGTVMGMSLALEKYGTMSLAQVTAPAIKMAQEG
CCCCEEECCCCHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
FSVTPDLAQSLAGLKRRMAQWPTTAAIFYKNDGSDYLVGDILKQPELAHSLRLIAEKGTK
CCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHCCCC
GFYEGETAVKIVNAVQDAGGIMTLDDLKHYKVVEREPVRGEYRGYQVVSMPPPSSGGVHI
CCCCCCHHHHHHHHHHHCCCEEEHHHCHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHH
IQMLNVLQQFPIDKLGHNTAQTIHLMAETMKYAYSDRSEYLGDPDFYKVPVNALTNADYA
HHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEECHHHHCCCHHH
QKIASKIAINKTTPSSEIKPGKLAPYESDQTTHFSVVDKWGNAVSNTYTLNFSYGSGLVA
HHHHHHHEECCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHCCCCCCEEEEEEECCCCEEE
KGTGILLNNEMDDFSAKPGVPNGYGLVGGDANAVEGNKRPLSSMSPTIVMKDGKAFLITG
CCCEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTTLQIIMNVIDHGLNIAEASYAARVHHQWQPDELRVESSVNRDTISLLEAK
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHEEECCCCCHHHHHHHHCC
GHKVTVQSAMGSTQSIMVTEQGIFGASDPRHSGSEAVGY
CCEEEEHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]