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The map label for this gene is menA [H]

Identifier: 120599103

GI number: 120599103

Start: 2650489

End: 2651364

Strand: Direct

Name: menA [H]

Synonym: Sputw3181_2299

Alternate gene names: 120599103

Gene position: 2650489-2651364 (Clockwise)

Preceding gene: 120599099

Following gene: 120599105

Centisome position: 56.29

GC content: 47.37

Gene sequence:

>876_bases
ATGAATCCTTGGATTTTAGCCATAAGACCGCGCACGCTTCCTGCGGCAATAGGGCCATTATTAATTGGTAATATACTTGC
CTTACACCTTAACAGTTTTAGCTGGTTAATTGCTGCAACCTCCATGCTCTGCGCCATATTGTTGCAGGTTGCCGTTAACC
TTGCTAACGACTACTTTGATTTTAAAAATGGTATCGATACTGCTGAACGTATTGGCCCCATTCGCGTTACCCAAAGTGGT
ATGATCCCCGCAAATAGTGTGCGTAATGCCATGATATTGTGTCTTATCCTTGCTCTCGCTGTCGGTTCGTATCTGATTTG
GCACGGAGGCTGGCCCATCGCCATTCTCGCCGCCGCCGCTATTTTAGGTGCTCTTGGCTACAGCGGTGGCCCCTATCCCC
TCGCCTCCCATGGGCTCGGTGAAGTAGCGGCATTTGTCTTTTTTGGCTTAGTGGCAGTGGTGGGCAGTTATTATCTGCAG
GCGGGCGATACGACTATTAATGCGTGGTTATTAGGTTGTGCGATTGGCTTATTTAACGCTGCGATTATGTTGGTGAATAA
CACTCGCGACATCCGTACCGACACCCAAGCGGGCAAACATACTCTAGCGGTACGTATTGGCGAAGCTCAGGCAAAAGTGC
TTTATCAAGCCTTAATCTATTTGCCCTTTGGTCTAGTCATCGCTGGCTTTTTATTCGGTATTTTACCCGGTTTACCAGTA
CTACTTGCGGGATTATCTCTGCTTATTGCCCGCAAACTCAGTAGCGATTTTTATGCCGTTTCTGGTGAAGCCTTAAATCC
GTTACTCGGCCGCACAGCTAAGTTAACCATGATTTTCAGTACCTTGTTTAGCGTGGGTTTAGTGTTTACCGCATAA

Upstream 100 bases:

>100_bases
TTAAATGCGTTTATTAGATAGTGCTCACTTTCGAGCAAAATATTGTTATGCTACTCCTAATTAAATATCGATTTCTTTTT
CGAGATAACGACTGGACGCC

Downstream 100 bases:

>100_bases
GAGTAAATCCGCTAAGCTAATGCTACACCACAGCTCAATGCTGAATATAAAAAGGTTCATATCTTCGATAGATACGAACC
TTTTTTATTGGCCGCAGCAC

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MNPWILAIRPRTLPAAIGPLLIGNILALHLNSFSWLIAATSMLCAILLQVAVNLANDYFDFKNGIDTAERIGPIRVTQSG
MIPANSVRNAMILCLILALAVGSYLIWHGGWPIAILAAAAILGALGYSGGPYPLASHGLGEVAAFVFFGLVAVVGSYYLQ
AGDTTINAWLLGCAIGLFNAAIMLVNNTRDIRTDTQAGKHTLAVRIGEAQAKVLYQALIYLPFGLVIAGFLFGILPGLPV
LLAGLSLLIARKLSSDFYAVSGEALNPLLGRTAKLTMIFSTLFSVGLVFTA

Sequences:

>Translated_291_residues
MNPWILAIRPRTLPAAIGPLLIGNILALHLNSFSWLIAATSMLCAILLQVAVNLANDYFDFKNGIDTAERIGPIRVTQSG
MIPANSVRNAMILCLILALAVGSYLIWHGGWPIAILAAAAILGALGYSGGPYPLASHGLGEVAAFVFFGLVAVVGSYYLQ
AGDTTINAWLLGCAIGLFNAAIMLVNNTRDIRTDTQAGKHTLAVRIGEAQAKVLYQALIYLPFGLVIAGFLFGILPGLPV
LLAGLSLLIARKLSSDFYAVSGEALNPLLGRTAKLTMIFSTLFSVGLVFTA
>Mature_291_residues
MNPWILAIRPRTLPAAIGPLLIGNILALHLNSFSWLIAATSMLCAILLQVAVNLANDYFDFKNGIDTAERIGPIRVTQSG
MIPANSVRNAMILCLILALAVGSYLIWHGGWPIAILAAAAILGALGYSGGPYPLASHGLGEVAAFVFFGLVAVVGSYYLQ
AGDTTINAWLLGCAIGLFNAAIMLVNNTRDIRTDTQAGKHTLAVRIGEAQAKVLYQALIYLPFGLVIAGFLFGILPGLPV
LLAGLSLLIARKLSSDFYAVSGEALNPLLGRTAKLTMIFSTLFSVGLVFTA

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=297, Percent_Identity=28.2828282828283, Blast_Score=88, Evalue=7e-18,
Organism=Escherichia coli, GI1790365, Length=298, Percent_Identity=35.5704697986577, Blast_Score=147, Evalue=6e-37,
Organism=Drosophila melanogaster, GI17737429, Length=301, Percent_Identity=28.2392026578073, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 30725; Mature: 30725

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPWILAIRPRTLPAAIGPLLIGNILALHLNSFSWLIAATSMLCAILLQVAVNLANDYFD
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKNGIDTAERIGPIRVTQSGMIPANSVRNAMILCLILALAVGSYLIWHGGWPIAILAAAA
HHCCCCHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHH
ILGALGYSGGPYPLASHGLGEVAAFVFFGLVAVVGSYYLQAGDTTINAWLLGCAIGLFNA
HHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AIMLVNNTRDIRTDTQAGKHTLAVRIGEAQAKVLYQALIYLPFGLVIAGFLFGILPGLPV
HEEEEECCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LLAGLSLLIARKLSSDFYAVSGEALNPLLGRTAKLTMIFSTLFSVGLVFTA
HHHHHHHHHHHHHCCCCEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPWILAIRPRTLPAAIGPLLIGNILALHLNSFSWLIAATSMLCAILLQVAVNLANDYFD
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKNGIDTAERIGPIRVTQSGMIPANSVRNAMILCLILALAVGSYLIWHGGWPIAILAAAA
HHCCCCHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHH
ILGALGYSGGPYPLASHGLGEVAAFVFFGLVAVVGSYYLQAGDTTINAWLLGCAIGLFNA
HHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AIMLVNNTRDIRTDTQAGKHTLAVRIGEAQAKVLYQALIYLPFGLVIAGFLFGILPGLPV
HEEEEECCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LLAGLSLLIARKLSSDFYAVSGEALNPLLGRTAKLTMIFSTLFSVGLVFTA
HHHHHHHHHHHHHCCCCEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]