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The map label for this gene is metC [H]

Identifier: 120599093

GI number: 120599093

Start: 2637806

End: 2639005

Strand: Direct

Name: metC [H]

Synonym: Sputw3181_2289

Alternate gene names: 120599093

Gene position: 2637806-2639005 (Clockwise)

Preceding gene: 120599092

Following gene: 120599096

Centisome position: 56.02

GC content: 49.5

Gene sequence:

>1200_bases
ATGACAGACAAACATCGTCAAGCCACCCAAATCGTCAGCTTAGGTCGAGACAAAAAATGGACCAAAGGTGTGATTAATCC
ACCCGTATTTCGCGCTTCGACTATCGTCTTCGATACCATGGAAGACATGCGCCACGCCGCAAAAAATAAAACCAATGGCG
AGATGTTTTACGGCCGCCGTGGCACCCCAACCCATTTTGCCTTTCAAGCTGCGATTGCCCAATTAGAAGGCGGGGTCGGT
ACTGCGCTCTACCCTTCAGGCGCGGCAGCGATCAGTGCCGCACTACTGTCATTTTTAAAAACGGGCGATCATTTGTTGAT
GGTCGATAGCGTGTATGAACCCACGCGGGATCTGTGTACGCATATTCTCGCGGGCTTTGGTATTGAAACCACTTACTACG
ATCCCTTGATTGGCGCGGGCATTAGCGATCTTATTCGCCCCAATACTAAGGTGCTGTTTTTAGAGTCTCCGGGCTCAATC
ACCATGGAAGTGCAAGATGTGCCAACTTTGTGCCGTATCGCCCACGAACATGGGCTTGTCACTATACTAGACAACACTTG
GGCCTCGCCCATCAACAGCAAACCTTTCGAAATGGGAGTCGATATTTCCATTCAAGCGGCAACTAAATATATTGTCGGTC
ACTCGGATGTGATGATAGGCACCGCCACCGCTAACGAAAAATACTGGCCGCAACTGCGTGAACACAGCTATTTGATGGGG
CAAACCACCTCGCCAGATGATGTATACCTTGCCGCGCGCGGCCTGCGCACCTTAGGCGTGCGTATGGCGCAGCATGAAAA
AAATGCAATGCAAGTCGCTAATTGGTTGAAAACCCGCCCAGAAGTGGATCATCTGCGTCACCCCGCGTTTGATACATGCC
CTGGGCATGAGTTCTTTAAACGCGACTTTAGTGCCTCAAATGGTTTGTTTTCCTTTGTATTAAAGCAAGGTGATGCCGAT
GCGGTCACCGCGATGGTGGAAAATATGAGCCACTTTAAAATGGGCTTTTCTTGGGGGGGCTACGAGAGTCTAATTTTAGG
GATTTTCGGTATTGACAGGATCCGCTCGGCAACGAAATGGGATCCGAGTAAACCCTTAATCCGTTTGCATATTGGTTTAG
AAGATCCCGCCGATTTAATCGCCGATCTCAGTGCTGGATTTGAACGCTTTAACGCCGTTCTGACAGCTAAAGCGAAGTAA

Upstream 100 bases:

>100_bases
TAAATGCTAAGATGACCGCCATAACAAGGGATGAGTAAAAATTTGCCCAACCTACTGATTCAGCCTACTGATCCAACCTA
CATGCCAAGGTAATGCTTCT

Downstream 100 bases:

>100_bases
CTATGTCGCTTAGGCGCTCGATGCTAGCGGCATAAAACAAAAGGGGCGGAATGAAAATTCCGCCCCTTTTTATGCTTATG
CAACAGAAGATCTAAGCTAT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTDKHRQATQIVSLGRDKKWTKGVINPPVFRASTIVFDTMEDMRHAAKNKTNGEMFYGRRGTPTHFAFQAAIAQLEGGVG
TALYPSGAAAISAALLSFLKTGDHLLMVDSVYEPTRDLCTHILAGFGIETTYYDPLIGAGISDLIRPNTKVLFLESPGSI
TMEVQDVPTLCRIAHEHGLVTILDNTWASPINSKPFEMGVDISIQAATKYIVGHSDVMIGTATANEKYWPQLREHSYLMG
QTTSPDDVYLAARGLRTLGVRMAQHEKNAMQVANWLKTRPEVDHLRHPAFDTCPGHEFFKRDFSASNGLFSFVLKQGDAD
AVTAMVENMSHFKMGFSWGGYESLILGIFGIDRIRSATKWDPSKPLIRLHIGLEDPADLIADLSAGFERFNAVLTAKAK

Sequences:

>Translated_399_residues
MTDKHRQATQIVSLGRDKKWTKGVINPPVFRASTIVFDTMEDMRHAAKNKTNGEMFYGRRGTPTHFAFQAAIAQLEGGVG
TALYPSGAAAISAALLSFLKTGDHLLMVDSVYEPTRDLCTHILAGFGIETTYYDPLIGAGISDLIRPNTKVLFLESPGSI
TMEVQDVPTLCRIAHEHGLVTILDNTWASPINSKPFEMGVDISIQAATKYIVGHSDVMIGTATANEKYWPQLREHSYLMG
QTTSPDDVYLAARGLRTLGVRMAQHEKNAMQVANWLKTRPEVDHLRHPAFDTCPGHEFFKRDFSASNGLFSFVLKQGDAD
AVTAMVENMSHFKMGFSWGGYESLILGIFGIDRIRSATKWDPSKPLIRLHIGLEDPADLIADLSAGFERFNAVLTAKAK
>Mature_398_residues
TDKHRQATQIVSLGRDKKWTKGVINPPVFRASTIVFDTMEDMRHAAKNKTNGEMFYGRRGTPTHFAFQAAIAQLEGGVGT
ALYPSGAAAISAALLSFLKTGDHLLMVDSVYEPTRDLCTHILAGFGIETTYYDPLIGAGISDLIRPNTKVLFLESPGSIT
MEVQDVPTLCRIAHEHGLVTILDNTWASPINSKPFEMGVDISIQAATKYIVGHSDVMIGTATANEKYWPQLREHSYLMGQ
TTSPDDVYLAARGLRTLGVRMAQHEKNAMQVANWLKTRPEVDHLRHPAFDTCPGHEFFKRDFSASNGLFSFVLKQGDADA
VTAMVENMSHFKMGFSWGGYESLILGIFGIDRIRSATKWDPSKPLIRLHIGLEDPADLIADLSAGFERFNAVLTAKAK

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=340, Percent_Identity=33.5294117647059, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI299473759, Length=340, Percent_Identity=30.8823529411765, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI25453487, Length=339, Percent_Identity=30.0884955752212, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=52.1518987341772, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1790375, Length=391, Percent_Identity=31.9693094629156, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71980708, Length=372, Percent_Identity=31.7204301075269, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17538055, Length=378, Percent_Identity=30.4232804232804, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17560056, Length=376, Percent_Identity=30.8510638297872, Blast_Score=167, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6321170, Length=333, Percent_Identity=48.948948948949, Blast_Score=333, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6319307, Length=353, Percent_Identity=30.3116147308782, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321904, Length=386, Percent_Identity=24.0932642487047, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323333, Length=412, Percent_Identity=25, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321254, Length=417, Percent_Identity=25.1798561151079, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922554, Length=377, Percent_Identity=31.8302387267904, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44005; Mature: 43874

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKHRQATQIVSLGRDKKWTKGVINPPVFRASTIVFDTMEDMRHAAKNKTNGEMFYGRR
CCCCHHHHHHHHHCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCC
GTPTHFAFQAAIAQLEGGVGTALYPSGAAAISAALLSFLKTGDHLLMVDSVYEPTRDLCT
CCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
HILAGFGIETTYYDPLIGAGISDLIRPNTKVLFLESPGSITMEVQDVPTLCRIAHEHGLV
HHHHCCCCCCCCCCCHHHCCHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCEE
TILDNTWASPINSKPFEMGVDISIQAATKYIVGHSDVMIGTATANEKYWPQLREHSYLMG
EEECCCCCCCCCCCCCEECCCEEEEEHHEEEECCCCEEEEEECCCCCCCHHHHHCCEEEC
QTTSPDDVYLAARGLRTLGVRMAQHEKNAMQVANWLKTRPEVDHLRHPAFDTCPGHEFFK
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHH
RDFSASNGLFSFVLKQGDADAVTAMVENMSHFKMGFSWGGYESLILGIFGIDRIRSATKW
HHCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC
DPSKPLIRLHIGLEDPADLIADLSAGFERFNAVLTAKAK
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHCEEEEECCC
>Mature Secondary Structure 
TDKHRQATQIVSLGRDKKWTKGVINPPVFRASTIVFDTMEDMRHAAKNKTNGEMFYGRR
CCCHHHHHHHHHCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCC
GTPTHFAFQAAIAQLEGGVGTALYPSGAAAISAALLSFLKTGDHLLMVDSVYEPTRDLCT
CCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
HILAGFGIETTYYDPLIGAGISDLIRPNTKVLFLESPGSITMEVQDVPTLCRIAHEHGLV
HHHHCCCCCCCCCCCHHHCCHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCEE
TILDNTWASPINSKPFEMGVDISIQAATKYIVGHSDVMIGTATANEKYWPQLREHSYLMG
EEECCCCCCCCCCCCCEECCCEEEEEHHEEEECCCCEEEEEECCCCCCCHHHHHCCEEEC
QTTSPDDVYLAARGLRTLGVRMAQHEKNAMQVANWLKTRPEVDHLRHPAFDTCPGHEFFK
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHH
RDFSASNGLFSFVLKQGDADAVTAMVENMSHFKMGFSWGGYESLILGIFGIDRIRSATKW
HHCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC
DPSKPLIRLHIGLEDPADLIADLSAGFERFNAVLTAKAK
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3513164; 9278503; 3307782; 8831789 [H]