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The map label for this gene is adk

Identifier: 120598528

GI number: 120598528

Start: 1969181

End: 1969825

Strand: Direct

Name: adk

Synonym: Sputw3181_1711

Alternate gene names: 120598528

Gene position: 1969181-1969825 (Clockwise)

Preceding gene: 120598527

Following gene: 120598529

Centisome position: 41.82

GC content: 48.68

Gene sequence:

>645_bases
ATGCGCATTATCCTATTGGGCGCCCCAGGTGCCGGTAAAGGTACCCAAGCCCAGTTCATTATGGAACAGTATGGTATCCC
ACAAATTTCTACTGGCGATATGTTACGTGCCGCCGTTAAAGCCGGTACTCCGCTGGGTTTAGAAGCGAAAAAAGTGATGG
ATGCAGGCCAACTGGTTTCTGATGATCTGATCATTGGACTGGTGAAAGAGCGTATCGCACAGGACGACTGTGCTAAAGGT
TTTCTGTTAGACGGTTTCCCACGCACTATCCCACAAGCGGATGCGATGGCGGCAAACGGTATTAGCATTGATCACGTGAT
TGAAATCGATGTGCCCGACGAAGAAATTGTTAAGCGCATGAGCGGTCGTCGCGTTCATCCTGGTTCTGGTCGTGTTTACC
ATGTGGTGTTTAATCCACCTAAAGTGGAAGGTAAAGACGATGTGACCGGTGAAGATTTAGCGATTCGTCCCGATGATGAA
GAAGCGACAGTGCGTAAACGCCTCGCGATTTACCATGAGCAAACTAAACCGCTCGTTGAATACTACGGTAAAGTGGCAGC
CGCAGGCCAAACGAAGTACAACAAATTTGATGGTACTCAGTCAGTTGCTGCGGTGAGTGAGCAGCTTGCCAGTGTACTTA
AATAA

Upstream 100 bases:

>100_bases
TGAGGCTAAAGTCGAAGCTAAAAGCCTTCTCAATGGCGGCCAGATGTGCGAAGATCGCCGCCCTAAGAAGAATATCAATG
CGAAAAAGAGGACTCTTGAG

Downstream 100 bases:

>100_bases
GCCACATTAGCTAAATTCGAGAACAAGTTCTCATATTAAGAAAAAGCCTGCCTAAGCAGGCTTTTTTTATGTGTGACTGA
ATGTTAGCCTGCCGAGGTAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDDLIIGLVKERIAQDDCAKG
FLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDE
EATVRKRLAIYHEQTKPLVEYYGKVAAAGQTKYNKFDGTQSVAAVSEQLASVLK

Sequences:

>Translated_214_residues
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDDLIIGLVKERIAQDDCAKG
FLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDE
EATVRKRLAIYHEQTKPLVEYYGKVAAAGQTKYNKFDGTQSVAAVSEQLASVLK
>Mature_214_residues
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDDLIIGLVKERIAQDDCAKG
FLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDE
EATVRKRLAIYHEQTKPLVEYYGKVAAAGQTKYNKFDGTQSVAAVSEQLASVLK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=188, Percent_Identity=50, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI4502013, Length=188, Percent_Identity=50, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI19923437, Length=184, Percent_Identity=45.6521739130435, Blast_Score=169, Evalue=1e-42,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=39.8009950248756, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=39.8009950248756, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=39.8009950248756, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=39.8009950248756, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI22749187, Length=206, Percent_Identity=27.6699029126214, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI4502011, Length=212, Percent_Identity=29.2452830188679, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI28144899, Length=181, Percent_Identity=26.5193370165746, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI28144897, Length=181, Percent_Identity=26.5193370165746, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7706497, Length=221, Percent_Identity=26.6968325791855, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=25.8992805755396, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI237858799, Length=138, Percent_Identity=26.0869565217391, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=72.3004694835681, Blast_Score=316, Evalue=7e-88,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=46.8085106382979, Blast_Score=183, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17537943, Length=216, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=182, Percent_Identity=32.967032967033, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=187, Percent_Identity=26.2032085561497, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=190, Percent_Identity=50.5263157894737, Blast_Score=204, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6321018, Length=193, Percent_Identity=44.0414507772021, Blast_Score=151, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=27.8688524590164, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=51.0869565217391, Blast_Score=195, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=44.5652173913043, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=44.5652173913043, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI17647141, Length=181, Percent_Identity=30.939226519337, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24663208, Length=181, Percent_Identity=30.939226519337, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI221459597, Length=194, Percent_Identity=25.7731958762887, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356893, Length=194, Percent_Identity=25.7731958762887, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23099; Mature: 23099

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DDLIIGLVKERIAQDDCAKGFLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRM
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHCCCCCEEEEEEEECCHHHHHHHH
SGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDEEATVRKRLAIYHEQTKPLVE
HCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHH
YYGKVAAAGQTKYNKFDGTQSVAAVSEQLASVLK
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAQFIMEQYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DDLIIGLVKERIAQDDCAKGFLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVKRM
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHCCCCCEEEEEEEECCHHHHHHHH
SGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLAIRPDDEEATVRKRLAIYHEQTKPLVE
HCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHH
YYGKVAAAGQTKYNKFDGTQSVAAVSEQLASVLK
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA